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Susanne Ruge - One of the best experts on this subject based on the ideXlab platform.

  • human Placental Lactogen and pregnancy associated plasma protein a in first trimester and subsequent fetal growth
    Acta Obstetricia et Gynecologica Scandinavica, 1995
    Co-Authors: Jan Fog Pedersen, Steen Sørensen, Susanne Ruge
    Abstract:

    Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p<0.01 andp<0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p<0.02).Conclusions. Higher levels of human Placental Lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe b...

  • Human Placental Lactogen and pregnancy‐associated plasma protein A in first trimester and subsequent fetal growth
    Acta Obstetricia et Gynecologica Scandinavica, 1995
    Co-Authors: Jan Fog Pedersen, Steen Sørensen, Susanne Ruge
    Abstract:

    Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p

  • Human Placental Lactogen and pregnancy-associated plasma protein A in first trimester and subsequent fetal growth
    Acta Obstetricia et Gynecologica Scandinavica, 1995
    Co-Authors: Jan Fog Pedersen, Steen Sørensen, Susanne Ruge
    Abstract:

    Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p

Gaetano Vacca - One of the best experts on this subject based on the ideXlab platform.

  • the role of nitric oxide in the peripheral vasoconstriction caused by human Placental Lactogen in anaesthetized pigs
    Experimental Physiology, 2006
    Co-Authors: Claudio Molinari, Elena Grossini, D A S G Mary, Nicola Surico, Flavio Ribichini, Gaetano Vacca
    Abstract:

    Regional intra-arterial infusion of human Placental Lactogen in anaesthetized pigs has been shown to cause coronary, renal and iliac vasoconstriction by antagonizing the vasodilatory effects of β2-adrenergic receptors. Since nitric oxide is known to modulate or mediate β2-adrenergic effects, the present study was planned in the same experimental model to determine the role of nitric oxide in the above vascular responses to human Placental Lactogen. In eight pigs anaesthetized with sodium pentobarbitone, changes in anterior descending coronary, left renal and left internal iliac blood flow caused by intra-arterial infusion of human Placental Lactogen at constant heart rate and arterial blood pressure were assessed using electromagnetic flowmeters. Intra-arterial infusion of the human Placental Lactogen caused decreases in coronary, renal and iliac blood flow which, respectively, averaged 16.7, 8.1 and 12.2% of the baseline values. The role of nitric oxide in this response was studied in the same pigs by repeating the experiments, after measured blood flows had returned to baseline values, following intra-arterial administration of Nω-nitro-l-arginine methyl ester (l-NAME). The subsequent intra-arterial infusion of human Placental Lactogen did not cause any significant changes in measured blood flows, even when performed after reversing the increase in arterial blood pressure and coronary, renal and iliac resistance caused by l-NAME with continuous intravenous infusion of papaverine. These results indicate that the coronary, renal and iliac vasoconstriction caused by human Placental Lactogen, known to involve antagonism of β2-adrenergic vasodilatory effects, was mediated by inhibition of nitric oxide release.

  • human Placental Lactogen decreases regional blood flow in anesthetized pigs
    Journal of Vascular Research, 2006
    Co-Authors: Elena Grossini, Claudio Molinari, D A S G Mary, Nicola Surico, Flavio Ribichini, A Battaglia, Gaetano Vacca
    Abstract:

    In 22 pigs anesthetized with sodium pentobarbitone, changes in blood flow caused by infusion of human Placental Lactogen into the left renal, external iliac, and anterior descending coronary arteries

Jan Fog Pedersen - One of the best experts on this subject based on the ideXlab platform.

  • human Placental Lactogen and pregnancy associated plasma protein a in first trimester and subsequent fetal growth
    Acta Obstetricia et Gynecologica Scandinavica, 1995
    Co-Authors: Jan Fog Pedersen, Steen Sørensen, Susanne Ruge
    Abstract:

    Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p<0.01 andp<0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p<0.02).Conclusions. Higher levels of human Placental Lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe b...

  • Human Placental Lactogen and pregnancy‐associated plasma protein A in first trimester and subsequent fetal growth
    Acta Obstetricia et Gynecologica Scandinavica, 1995
    Co-Authors: Jan Fog Pedersen, Steen Sørensen, Susanne Ruge
    Abstract:

    Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p

  • Human Placental Lactogen and pregnancy-associated plasma protein A in first trimester and subsequent fetal growth
    Acta Obstetricia et Gynecologica Scandinavica, 1995
    Co-Authors: Jan Fog Pedersen, Steen Sørensen, Susanne Ruge
    Abstract:

    Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p

Claudio Molinari - One of the best experts on this subject based on the ideXlab platform.

  • the role of nitric oxide in the peripheral vasoconstriction caused by human Placental Lactogen in anaesthetized pigs
    Experimental Physiology, 2006
    Co-Authors: Claudio Molinari, Elena Grossini, D A S G Mary, Nicola Surico, Flavio Ribichini, Gaetano Vacca
    Abstract:

    Regional intra-arterial infusion of human Placental Lactogen in anaesthetized pigs has been shown to cause coronary, renal and iliac vasoconstriction by antagonizing the vasodilatory effects of β2-adrenergic receptors. Since nitric oxide is known to modulate or mediate β2-adrenergic effects, the present study was planned in the same experimental model to determine the role of nitric oxide in the above vascular responses to human Placental Lactogen. In eight pigs anaesthetized with sodium pentobarbitone, changes in anterior descending coronary, left renal and left internal iliac blood flow caused by intra-arterial infusion of human Placental Lactogen at constant heart rate and arterial blood pressure were assessed using electromagnetic flowmeters. Intra-arterial infusion of the human Placental Lactogen caused decreases in coronary, renal and iliac blood flow which, respectively, averaged 16.7, 8.1 and 12.2% of the baseline values. The role of nitric oxide in this response was studied in the same pigs by repeating the experiments, after measured blood flows had returned to baseline values, following intra-arterial administration of Nω-nitro-l-arginine methyl ester (l-NAME). The subsequent intra-arterial infusion of human Placental Lactogen did not cause any significant changes in measured blood flows, even when performed after reversing the increase in arterial blood pressure and coronary, renal and iliac resistance caused by l-NAME with continuous intravenous infusion of papaverine. These results indicate that the coronary, renal and iliac vasoconstriction caused by human Placental Lactogen, known to involve antagonism of β2-adrenergic vasodilatory effects, was mediated by inhibition of nitric oxide release.

  • The role of nitric oxide in the peripheral vasoconstriction caused by human Placental Lactogen in anaesthetized pigs
    Experimental Physiology, 2006
    Co-Authors: Claudio Molinari, Elena Grossini, D A S G Mary, Nicola Surico, Flavio Ribichini, Giovanni Vacca
    Abstract:

    Regional intra-arterial infusion of human Placental Lactogen in anaesthetized pigs has been shown to cause coronary, renal and iliac vasoconstriction by antagonizing the vasodilatory effects of beta2-adrenergic receptors. Since nitric oxide is known to modulate or mediate beta2-adrenergic effects, the present study was planned in the same experimental model to determine the role of nitric oxide in the above vascular responses to human Placental Lactogen. In eight pigs anaesthetized with sodium pentobarbitone, changes in anterior descending coronary, left renal and left internal iliac blood flow caused by intra-arterial infusion of human Placental Lactogen at constant heart rate and arterial blood pressure were assessed using electromagnetic flowmeters. Intra-arterial infusion of the human Placental Lactogen caused decreases in coronary, renal and iliac blood flow which, respectively, averaged 16.7, 8.1 and 12.2% of the baseline values. The role of nitric oxide in this response was studied in the same pigs by repeating the experiments, after measured blood flows had returned to baseline values, following intra-arterial administration of N(omega)-nitro-L-arginine methyl ester (L-NAME). The subsequent intra-arterial infusion of human Placental Lactogen did not cause any significant changes in measured blood flows, even when performed after reversing the increase in arterial blood pressure and coronary, renal and iliac resistance caused by L-NAME with continuous intravenous infusion of papaverine. These results indicate that the coronary, renal and iliac vasoconstriction caused by human Placental Lactogen, known to involve antagonism of beta2-adrenergic vasodilatory effects, was mediated by inhibition of nitric oxide release.

  • human Placental Lactogen decreases regional blood flow in anesthetized pigs
    Journal of Vascular Research, 2006
    Co-Authors: Elena Grossini, Claudio Molinari, D A S G Mary, Nicola Surico, Flavio Ribichini, A Battaglia, Gaetano Vacca
    Abstract:

    In 22 pigs anesthetized with sodium pentobarbitone, changes in blood flow caused by infusion of human Placental Lactogen into the left renal, external iliac, and anterior descending coronary arteries

Elena Grossini - One of the best experts on this subject based on the ideXlab platform.

  • the role of nitric oxide in the peripheral vasoconstriction caused by human Placental Lactogen in anaesthetized pigs
    Experimental Physiology, 2006
    Co-Authors: Claudio Molinari, Elena Grossini, D A S G Mary, Nicola Surico, Flavio Ribichini, Gaetano Vacca
    Abstract:

    Regional intra-arterial infusion of human Placental Lactogen in anaesthetized pigs has been shown to cause coronary, renal and iliac vasoconstriction by antagonizing the vasodilatory effects of β2-adrenergic receptors. Since nitric oxide is known to modulate or mediate β2-adrenergic effects, the present study was planned in the same experimental model to determine the role of nitric oxide in the above vascular responses to human Placental Lactogen. In eight pigs anaesthetized with sodium pentobarbitone, changes in anterior descending coronary, left renal and left internal iliac blood flow caused by intra-arterial infusion of human Placental Lactogen at constant heart rate and arterial blood pressure were assessed using electromagnetic flowmeters. Intra-arterial infusion of the human Placental Lactogen caused decreases in coronary, renal and iliac blood flow which, respectively, averaged 16.7, 8.1 and 12.2% of the baseline values. The role of nitric oxide in this response was studied in the same pigs by repeating the experiments, after measured blood flows had returned to baseline values, following intra-arterial administration of Nω-nitro-l-arginine methyl ester (l-NAME). The subsequent intra-arterial infusion of human Placental Lactogen did not cause any significant changes in measured blood flows, even when performed after reversing the increase in arterial blood pressure and coronary, renal and iliac resistance caused by l-NAME with continuous intravenous infusion of papaverine. These results indicate that the coronary, renal and iliac vasoconstriction caused by human Placental Lactogen, known to involve antagonism of β2-adrenergic vasodilatory effects, was mediated by inhibition of nitric oxide release.

  • The role of nitric oxide in the peripheral vasoconstriction caused by human Placental Lactogen in anaesthetized pigs
    Experimental Physiology, 2006
    Co-Authors: Claudio Molinari, Elena Grossini, D A S G Mary, Nicola Surico, Flavio Ribichini, Giovanni Vacca
    Abstract:

    Regional intra-arterial infusion of human Placental Lactogen in anaesthetized pigs has been shown to cause coronary, renal and iliac vasoconstriction by antagonizing the vasodilatory effects of beta2-adrenergic receptors. Since nitric oxide is known to modulate or mediate beta2-adrenergic effects, the present study was planned in the same experimental model to determine the role of nitric oxide in the above vascular responses to human Placental Lactogen. In eight pigs anaesthetized with sodium pentobarbitone, changes in anterior descending coronary, left renal and left internal iliac blood flow caused by intra-arterial infusion of human Placental Lactogen at constant heart rate and arterial blood pressure were assessed using electromagnetic flowmeters. Intra-arterial infusion of the human Placental Lactogen caused decreases in coronary, renal and iliac blood flow which, respectively, averaged 16.7, 8.1 and 12.2% of the baseline values. The role of nitric oxide in this response was studied in the same pigs by repeating the experiments, after measured blood flows had returned to baseline values, following intra-arterial administration of N(omega)-nitro-L-arginine methyl ester (L-NAME). The subsequent intra-arterial infusion of human Placental Lactogen did not cause any significant changes in measured blood flows, even when performed after reversing the increase in arterial blood pressure and coronary, renal and iliac resistance caused by L-NAME with continuous intravenous infusion of papaverine. These results indicate that the coronary, renal and iliac vasoconstriction caused by human Placental Lactogen, known to involve antagonism of beta2-adrenergic vasodilatory effects, was mediated by inhibition of nitric oxide release.

  • human Placental Lactogen decreases regional blood flow in anesthetized pigs
    Journal of Vascular Research, 2006
    Co-Authors: Elena Grossini, Claudio Molinari, D A S G Mary, Nicola Surico, Flavio Ribichini, A Battaglia, Gaetano Vacca
    Abstract:

    In 22 pigs anesthetized with sodium pentobarbitone, changes in blood flow caused by infusion of human Placental Lactogen into the left renal, external iliac, and anterior descending coronary arteries