The Experts below are selected from a list of 24738 Experts worldwide ranked by ideXlab platform
Daniel J Rader - One of the best experts on this subject based on the ideXlab platform.
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new insights into the regulation of hdl metabolism and reverse cholesterol transport
Circulation Research, 2005Co-Authors: Gary F Lewis, Daniel J RaderAbstract:The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating HDL synthesis, intravascular remodeling, and catabolism. The individual lipid and apolipoprotein components of HDL are mostly assembled after secretion, are frequently exchanged with or transferred to other lipoproteins, are actively remodeled within the Plasma Compartment, and are often cleared separately from one another. HDL is believed to play a key role in the process of reverse cholesterol transport (RCT), in which it promotes the efflux of excess cholesterol from peripheral tissues and returns it to the liver for biliary excretion. This review will emphasize 3 major evolving themes regarding HDL metabolism and RCT. The first theme is that HDL is a universal Plasma acceptor lipoprotein for cholesterol efflux from not only peripheral tissues but also hepatocytes, which are a major source of cholesterol efflux to HDL. Furth...
Howard Trachtman - One of the best experts on this subject based on the ideXlab platform.
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Physiology of the Developing Kidney: Sodium and Water Homeostasis and Its Disorders
Pediatric Nephrology, 2016Co-Authors: Nigel Madden, Howard TrachtmanAbstract:Salt and water are the stuff of life [1, 2]. The ancient and the modern voices have been invoked in the past to demonstrate that human beings intuitively appreciate the critical role played by sodium and water balance for the integrity of the Plasma Compartment and for continued existence on land. The third time around, I turn to a towering contemporary figure of our age as inspiration for this chapter. The material will review the physiological mechanisms involved in the control of sodium and water homeostasis. This knowledge will provide a basis for the analysis of the diseases that arise when these systems malfunction and a guide to the optimal therapy of conditions associated with excessive or deficient total body sodium and water.
Gary F Lewis - One of the best experts on this subject based on the ideXlab platform.
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new insights into the regulation of hdl metabolism and reverse cholesterol transport
Circulation Research, 2005Co-Authors: Gary F Lewis, Daniel J RaderAbstract:The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating HDL synthesis, intravascular remodeling, and catabolism. The individual lipid and apolipoprotein components of HDL are mostly assembled after secretion, are frequently exchanged with or transferred to other lipoproteins, are actively remodeled within the Plasma Compartment, and are often cleared separately from one another. HDL is believed to play a key role in the process of reverse cholesterol transport (RCT), in which it promotes the efflux of excess cholesterol from peripheral tissues and returns it to the liver for biliary excretion. This review will emphasize 3 major evolving themes regarding HDL metabolism and RCT. The first theme is that HDL is a universal Plasma acceptor lipoprotein for cholesterol efflux from not only peripheral tissues but also hepatocytes, which are a major source of cholesterol efflux to HDL. Furth...
Nigel Madden - One of the best experts on this subject based on the ideXlab platform.
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Physiology of the Developing Kidney: Sodium and Water Homeostasis and Its Disorders
Pediatric Nephrology, 2016Co-Authors: Nigel Madden, Howard TrachtmanAbstract:Salt and water are the stuff of life [1, 2]. The ancient and the modern voices have been invoked in the past to demonstrate that human beings intuitively appreciate the critical role played by sodium and water balance for the integrity of the Plasma Compartment and for continued existence on land. The third time around, I turn to a towering contemporary figure of our age as inspiration for this chapter. The material will review the physiological mechanisms involved in the control of sodium and water homeostasis. This knowledge will provide a basis for the analysis of the diseases that arise when these systems malfunction and a guide to the optimal therapy of conditions associated with excessive or deficient total body sodium and water.
J. Tillement - One of the best experts on this subject based on the ideXlab platform.
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Docetaxel serum protein binding with high affinity to alpha 1-acid glycoprotein.
Investigational New Drugs, 1996Co-Authors: C Urien, J. Barre, Christophe Morin, A Paccaly, G. Montay, J. TillementAbstract:The binding of docetaxel to human Plasma proteins was studied by ultrafiltration at 37 degrees C and pH 7.4. Docetaxel was extensively (> 98%) Plasma protein bound. At clinically relevant concentrations (1-5 micrograms/ml), the Plasma binding was concentration-independent. Lipoproteins, alpha1-acid glycoprotein and albumin were the main carriers of docetaxel in Plasma, and owing to the high interindividual variability of alpha1-acid glycoprotein Plasma concentration, particularly in cancer, it was concluded that alpha1-acid glycoprotein should be the main determinant of docetaxel Plasma binding variability. Drugs potentially coadministered with docetaxel (cisplatin, dexamethasone, doxorubicin, etoposide, vinblastine) did not modify the Plasma binding of docetaxel. In blood, docetaxel was found to be mainly located in the Plasma Compartment (less than 15% associated to erythrocytes).
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Docetaxel serum protein binding with high affinity to alpha 1-acid glycoprotein.
INVESTIGATIONAL NEW DRUGS, 1996Co-Authors: Saïk Urien, J. Barre, Christophe Morin, A Paccaly, G. Montay, J. TillementAbstract:The binding of docetaxel to human Plasma proteins was studied by ultrafiltration at 37°C and pH 7.4. Docetaxel was extensively (> 98%) Plasma protein bound. At clinically relevant concentrations (1–5 μg/ml), the Plasma binding was concentration-independent. Lipoproteins, alpha1-acid glycoprotein and albumin were the main carriers of docetaxel in Plasma, and owing to the high interindividual variability of alpha1-acid glycoprotein Plasma concentration, particularly in cancer, it was concluded that alpha1-acid glycoprotein should be the main determinant of docetaxel Plasma binding variability. Drugs potentially coadministered with docetaxel (cisplatin, dexamethasone, doxorubicin, etoposide, vinblastine) did not modify the Plasma binding of docetaxel. In blood, docetaxel was found to be mainly located in the Plasma Compartment (less than 15% associated to erythrocytes).