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Frederick R. Masangkay - One of the best experts on this subject based on the ideXlab platform.
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Global prevalence and mortality of severe Plasmodium Malariae Infection: a systematic review and meta-analysis
Malaria Journal, 2020Co-Authors: Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez, Frederick R. MasangkayAbstract:Background Severe complications among patients with Plasmodium Malariae Infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. Malariae Infection in humans. Methods The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All research articles published on the severity and mortality of P. Malariae Infection cases in humans were retrieved from three public databases: PubMed, Scopus, and ISI Web of Science. The pooled prevalence estimate and 95% confidence interval (CI) of complications in patients with P. Malariae malaria was analysed using the random-effects model provided in Stata software. The pooled odds ratio (OR) and 95% CI of severe malaria for P. Malariae Infection and Plasmodium falciparum Infection were analysed using Review Manager software. Results Six studies were used to estimate the pooled prevalence of severe P. Malariae malaria. Out of 10,520 patients infected with P. Malariae , the pooled prevalence estimate of severe P. Malariae Infection was 3% (95% CI 2–5%), with high heterogeneity (I^2: 90.7%). Severe anaemia (3.32%), pulmonary complications (0.46%), and renal impairments (0.24%) were the most common severe complications found in patients with P. Malariae Infection. The pooled proportion of severe anaemia for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.74, 95% CI 0.22–2.45, I^2 = 98%). The pooled proportion of pulmonary complications was comparable between patients with P. Malariae Infection and those with P. falciparum Infection among the four included studies (OR: 1.44; 95% CI 0.17–12.31, I^2: 92%). For renal complications, the funnel plot showed that the pooled proportion of renal complications for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.94, 95% CI 0.18–4.93, I^2: 91%). The mortality rate of patients with P. Malariae Infection was 0.17% (18/10,502 cases). Conclusions This systematic review demonstrated that approximately two percent of patients with P. Malariae Infection developed severe complications, with a low mortality rate. Severe anaemia, pulmonary involvement, and renal impairment were the most common complications found in patients with P. Malariae Infection. Although a low prevalence and low mortality of P. Malariae Infection have been reported, patients with P. Malariae Infection need to be investigated for severe anaemia and, if present, treated aggressively to prevent anaemia-related death.
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Global prevalence and mortality of severe Plasmodium Malariae Infection: a systematic review and meta-analysis
Malaria journal, 2020Co-Authors: Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez, Frederick R. MasangkayAbstract:Severe complications among patients with Plasmodium Malariae Infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. Malariae Infection in humans. The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All research articles published on the severity and mortality of P. Malariae Infection cases in humans were retrieved from three public databases: PubMed, Scopus, and ISI Web of Science. The pooled prevalence estimate and 95% confidence interval (CI) of complications in patients with P. Malariae malaria was analysed using the random-effects model provided in Stata software. The pooled odds ratio (OR) and 95% CI of severe malaria for P. Malariae Infection and Plasmodium falciparum Infection were analysed using Review Manager software. Six studies were used to estimate the pooled prevalence of severe P. Malariae malaria. Out of 10,520 patients infected with P. Malariae, the pooled prevalence estimate of severe P. Malariae Infection was 3% (95% CI 2–5%), with high heterogeneity (I2: 90.7%). Severe anaemia (3.32%), pulmonary complications (0.46%), and renal impairments (0.24%) were the most common severe complications found in patients with P. Malariae Infection. The pooled proportion of severe anaemia for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.74, 95% CI 0.22–2.45, I2 = 98%). The pooled proportion of pulmonary complications was comparable between patients with P. Malariae Infection and those with P. falciparum Infection among the four included studies (OR: 1.44; 95% CI 0.17–12.31, I2: 92%). For renal complications, the funnel plot showed that the pooled proportion of renal complications for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.94, 95% CI 0.18–4.93, I2: 91%). The mortality rate of patients with P. Malariae Infection was 0.17% (18/10,502 cases). This systematic review demonstrated that approximately two percent of patients with P. Malariae Infection developed severe complications, with a low mortality rate. Severe anaemia, pulmonary involvement, and renal impairment were the most common complications found in patients with P. Malariae Infection. Although a low prevalence and low mortality of P. Malariae Infection have been reported, patients with P. Malariae Infection need to be investigated for severe anaemia and, if present, treated aggressively to prevent anaemia-related death.
Gilles Gargala - One of the best experts on this subject based on the ideXlab platform.
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cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium Malariae Infection in two children from central african republic
Malaria Journal, 2017Co-Authors: Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-lise Bienvenu, Stéphane Picot, Gilles GargalaAbstract:Since several malaria parasite species are usually present in a particular area, co-Infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed Infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium Malariae co-Infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. Malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P Malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-Infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic Infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed Infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed Infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum species.
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Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium Malariae Infection in two children from Central African Republic
Malaria Journal, 2017Co-Authors: Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-lise Bienvenu, Stéphane Picot, Gilles GargalaAbstract:Background: Since several malaria parasite species are usually present in a particular area, co-Infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed Infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Case presentation: Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium Malariae co-Infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. Malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P Malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Conclusions: Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-Infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic Infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed Infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed Infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum species.
Manas Kotepui - One of the best experts on this subject based on the ideXlab platform.
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Global prevalence and mortality of severe Plasmodium Malariae Infection: a systematic review and meta-analysis
Malaria Journal, 2020Co-Authors: Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez, Frederick R. MasangkayAbstract:Background Severe complications among patients with Plasmodium Malariae Infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. Malariae Infection in humans. Methods The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All research articles published on the severity and mortality of P. Malariae Infection cases in humans were retrieved from three public databases: PubMed, Scopus, and ISI Web of Science. The pooled prevalence estimate and 95% confidence interval (CI) of complications in patients with P. Malariae malaria was analysed using the random-effects model provided in Stata software. The pooled odds ratio (OR) and 95% CI of severe malaria for P. Malariae Infection and Plasmodium falciparum Infection were analysed using Review Manager software. Results Six studies were used to estimate the pooled prevalence of severe P. Malariae malaria. Out of 10,520 patients infected with P. Malariae , the pooled prevalence estimate of severe P. Malariae Infection was 3% (95% CI 2–5%), with high heterogeneity (I^2: 90.7%). Severe anaemia (3.32%), pulmonary complications (0.46%), and renal impairments (0.24%) were the most common severe complications found in patients with P. Malariae Infection. The pooled proportion of severe anaemia for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.74, 95% CI 0.22–2.45, I^2 = 98%). The pooled proportion of pulmonary complications was comparable between patients with P. Malariae Infection and those with P. falciparum Infection among the four included studies (OR: 1.44; 95% CI 0.17–12.31, I^2: 92%). For renal complications, the funnel plot showed that the pooled proportion of renal complications for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.94, 95% CI 0.18–4.93, I^2: 91%). The mortality rate of patients with P. Malariae Infection was 0.17% (18/10,502 cases). Conclusions This systematic review demonstrated that approximately two percent of patients with P. Malariae Infection developed severe complications, with a low mortality rate. Severe anaemia, pulmonary involvement, and renal impairment were the most common complications found in patients with P. Malariae Infection. Although a low prevalence and low mortality of P. Malariae Infection have been reported, patients with P. Malariae Infection need to be investigated for severe anaemia and, if present, treated aggressively to prevent anaemia-related death.
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Global prevalence and mortality of severe Plasmodium Malariae Infection: a systematic review and meta-analysis
Malaria journal, 2020Co-Authors: Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez, Frederick R. MasangkayAbstract:Severe complications among patients with Plasmodium Malariae Infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. Malariae Infection in humans. The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All research articles published on the severity and mortality of P. Malariae Infection cases in humans were retrieved from three public databases: PubMed, Scopus, and ISI Web of Science. The pooled prevalence estimate and 95% confidence interval (CI) of complications in patients with P. Malariae malaria was analysed using the random-effects model provided in Stata software. The pooled odds ratio (OR) and 95% CI of severe malaria for P. Malariae Infection and Plasmodium falciparum Infection were analysed using Review Manager software. Six studies were used to estimate the pooled prevalence of severe P. Malariae malaria. Out of 10,520 patients infected with P. Malariae, the pooled prevalence estimate of severe P. Malariae Infection was 3% (95% CI 2–5%), with high heterogeneity (I2: 90.7%). Severe anaemia (3.32%), pulmonary complications (0.46%), and renal impairments (0.24%) were the most common severe complications found in patients with P. Malariae Infection. The pooled proportion of severe anaemia for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.74, 95% CI 0.22–2.45, I2 = 98%). The pooled proportion of pulmonary complications was comparable between patients with P. Malariae Infection and those with P. falciparum Infection among the four included studies (OR: 1.44; 95% CI 0.17–12.31, I2: 92%). For renal complications, the funnel plot showed that the pooled proportion of renal complications for P. Malariae Infection and P. falciparum Infection was comparable among the four included studies (OR: 0.94, 95% CI 0.18–4.93, I2: 91%). The mortality rate of patients with P. Malariae Infection was 0.17% (18/10,502 cases). This systematic review demonstrated that approximately two percent of patients with P. Malariae Infection developed severe complications, with a low mortality rate. Severe anaemia, pulmonary involvement, and renal impairment were the most common complications found in patients with P. Malariae Infection. Although a low prevalence and low mortality of P. Malariae Infection have been reported, patients with P. Malariae Infection need to be investigated for severe anaemia and, if present, treated aggressively to prevent anaemia-related death.
Stéphane Picot - One of the best experts on this subject based on the ideXlab platform.
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cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium Malariae Infection in two children from central african republic
Malaria Journal, 2017Co-Authors: Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-lise Bienvenu, Stéphane Picot, Gilles GargalaAbstract:Since several malaria parasite species are usually present in a particular area, co-Infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed Infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium Malariae co-Infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. Malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P Malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-Infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic Infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed Infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed Infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum species.
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Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium Malariae Infection in two children from Central African Republic
Malaria Journal, 2017Co-Authors: Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-lise Bienvenu, Stéphane Picot, Gilles GargalaAbstract:Background: Since several malaria parasite species are usually present in a particular area, co-Infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed Infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Case presentation: Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium Malariae co-Infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. Malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P Malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Conclusions: Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-Infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic Infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed Infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed Infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum species.
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Short report: prevalence and chloroquine sensitivity of Plasmodium Malariae in Madagascar.
The American journal of tropical medicine and hygiene, 2007Co-Authors: Céline Barnadas, Stéphane Picot, Arsène Ratsimbasoa, Hanitra Ranaivosoa, Didier Ralaizandry, Diamondra Raveloariseheno, Vony Rabekotonorina, Didier MenardAbstract:We report the results of clinical studies carried out at six sites in Madagascar, between January and October 2006. The aims were (i) to update our knowledge of the burden of Plasmodium Malariae Infection and (ii) to assess the therapeutic efficacy of chloroquine for uncomplicated quartan malaria. Our findings confirm that P. Malariae is the third leading cause of malaria, accounting for 1.1% of all malarial Infections. They also demonstrate that chlo- roquine—currently recommended for the home management of presumed malaria in children under the age of five years and commonly used by adults—remains highly effective in patients with uncomplicated P. Malariae Infection. Plasmodium Malariae, one of the four species of Plasmo- dium affecting humans, is found in tropical and subtropical regions, often in sympatry with other Plasmodium species, as in Madagascar. Its reported prevalence varies from less than 4% to more than 20% in endemic regions. 1-4 No accurate estimate of the prevalence of P. Malariae Infection worldwide is currently available, but it has been calculated that there are probably at least 60 million Infections per year, based on the prevalence of P. falciparum 5,6 and known underestimation of the prevalence of P. Malariae. 7,8 The clinical features associ- ated with febrile bouts of P. Malariae are generally milder than those caused by other species. 9 Fever displays quartan (4-day) periodicity, parasite density is usually considerably below 1000 parasites per ml of blood, and Infection is rarely life-threatening in the absence of complications, such as neph-
Cynthia Bichara - One of the best experts on this subject based on the ideXlab platform.
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cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium Malariae Infection in two children from central african republic
Malaria Journal, 2017Co-Authors: Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-lise Bienvenu, Stéphane Picot, Gilles GargalaAbstract:Since several malaria parasite species are usually present in a particular area, co-Infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed Infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium Malariae co-Infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. Malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P Malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-Infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic Infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed Infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed Infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum species.
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Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium Malariae Infection in two children from Central African Republic
Malaria Journal, 2017Co-Authors: Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-lise Bienvenu, Stéphane Picot, Gilles GargalaAbstract:Background: Since several malaria parasite species are usually present in a particular area, co-Infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed Infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Case presentation: Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium Malariae co-Infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. Malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P Malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Conclusions: Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-Infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic Infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed Infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed Infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum species.