The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform

Uwe A. Wittel - One of the best experts on this subject based on the ideXlab platform.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    Background To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. Methods In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Results Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma , 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate ( p  = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p  = 0.03). Age younger than 55 years significantly improved 5-year survival rate ( p  = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p  = 0.001). Surgery plus radiotherapy led to significantly improved survival ( p  = 0.04). Conclusions There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma, 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate (p = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p = 0.03). Age younger than 55 years significantly improved 5-year survival rate (p = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p = 0.001). Surgery plus radiotherapy led to significantly improved survival (p = 0.04). There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

Sven Hager - One of the best experts on this subject based on the ideXlab platform.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    Background To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. Methods In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Results Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma , 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate ( p  = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p  = 0.03). Age younger than 55 years significantly improved 5-year survival rate ( p  = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p  = 0.001). Surgery plus radiotherapy led to significantly improved survival ( p  = 0.04). Conclusions There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma, 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate (p = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p = 0.03). Age younger than 55 years significantly improved 5-year survival rate (p = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p = 0.001). Surgery plus radiotherapy led to significantly improved survival (p = 0.04). There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

Moulay Hassan Farih - One of the best experts on this subject based on the ideXlab platform.

  • primary Pleomorphic Undifferentiated Sarcoma a rare renal localization a case report
    Case reports in urology, 2012
    Co-Authors: Soufiane Mellas, Ahmed Amine Bouchikhi, Mohamedfadl Tazi, Abdelhak Khallouk, Jallaleddin Elammari, Mohamedjamal El Fassi, Naoufal Mellas, Moulay Hassan Farih
    Abstract:

    Undifferentiated Pleomorphic Sarcoma is known as a soft tissue Sarcoma. Very few cases of this tumor originating from the renal parenchyma or renal capsule have been reported. We report a case of a 70-year-old patient admitted for enormous ureterohydronephrosis and pyelonephritis due to a pelvic ureter lithiasis. After draining by ureteral double J catheter, a nephroureterectomy was performed for nonfunctional kidney confirmed by scintigraphy. The histopathological study shows a Pleomorphic Undifferentiated Sarcoma. The patient was sent to oncologists. Chemotherapy was proposed but the family decided to stop the treatment. The patient passed away 10 months later. Clinicians and pathologists should be aware of the very low occurrence of this renal tumor, which is extremely rare. Currently there is no consensus about its management. Our case extends the literature concerning this tumor.

  • Primary Pleomorphic Undifferentiated Sarcoma—a Rare Renal Localization: A Case Report
    Case reports in urology, 2012
    Co-Authors: Soufiane Mellas, Ahmed Amine Bouchikhi, Mohamedfadl Tazi, Abdelhak Khallouk, Jallaleddin Elammari, Mohamedjamal El Fassi, Naoufal Mellas, Moulay Hassan Farih
    Abstract:

    Undifferentiated Pleomorphic Sarcoma is known as a soft tissue Sarcoma. Very few cases of this tumor originating from the renal parenchyma or renal capsule have been reported. We report a case of a 70-year-old patient admitted for enormous ureterohydronephrosis and pyelonephritis due to a pelvic ureter lithiasis. After draining by ureteral double J catheter, a nephroureterectomy was performed for nonfunctional kidney confirmed by scintigraphy. The histopathological study shows a Pleomorphic Undifferentiated Sarcoma. The patient was sent to oncologists. Chemotherapy was proposed but the family decided to stop the treatment. The patient passed away 10 months later. Clinicians and pathologists should be aware of the very low occurrence of this renal tumor, which is extremely rare. Currently there is no consensus about its management. Our case extends the literature concerning this tumor.

Ulrich T. Hopt - One of the best experts on this subject based on the ideXlab platform.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    Background To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. Methods In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Results Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma , 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate ( p  = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p  = 0.03). Age younger than 55 years significantly improved 5-year survival rate ( p  = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p  = 0.001). Surgery plus radiotherapy led to significantly improved survival ( p  = 0.04). Conclusions There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma, 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate (p = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p = 0.03). Age younger than 55 years significantly improved 5-year survival rate (p = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p = 0.001). Surgery plus radiotherapy led to significantly improved survival (p = 0.04). There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

Karl Henne - One of the best experts on this subject based on the ideXlab platform.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    Background To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. Methods In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Results Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma , 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate ( p  = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p  = 0.03). Age younger than 55 years significantly improved 5-year survival rate ( p  = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p  = 0.001). Surgery plus radiotherapy led to significantly improved survival ( p  = 0.04). Conclusions There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.

  • Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue Sarcoma
    Radiation Oncology, 2017
    Co-Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt, Uwe A. Wittel
    Abstract:

    To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. In 53 patients who underwent surgery for retroperitoneal soft tissue Sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only. Histology showed 73.9% lipoSarcoma, 15.2% leiomyoSarcoma and 6.5% Pleomorphic Undifferentiated Sarcoma respectively. Low grade Sarcoma were observed in 52.2%, high grade Sarcoma in 47.8%. The latter showed a trend towards a decreased 5-year survival rate (p = 0.125). Margin status was: R0: 60.9%, R1: 23.9%, R2: 15.2%; leading to significant changes in 5-year survival rate (R0: 77.6%; R1: 70.0%; R2: 42.9%; p = 0.03). Age younger than 55 years significantly improved 5-year survival rate (p = 0.039). Patients receiving resection of multiple Sarcoma recurrence showed an almost identical improved 5-year survival rate compared to patients without recurrence (no recurrence: 100.0%; single recurrence: 35.0%; multiple recurrence: 91.7%; p = 0.001). Surgery plus radiotherapy led to significantly improved survival (p = 0.04). There is a significant benefit in terms of 5-year survival after surgery plus some form of radiotherapy and a good prognosis for patients when the recurrence from RSTS was resected. Age older than 55 years and incomplete resection lowered 5-year survival rate significantly.