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Park Sung-hye - One of the best experts on this subject based on the ideXlab platform.

  • Pleomorphic Xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult
    ELSEVIER GMBH URBAN & FISCHER VERLAG, 2009
    Co-Authors: Kim Bomi, Chung Chun-kee, Myung, Jae Kyung, Park Sung-hye
    Abstract:

    Brain tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event. We report a case of Pleomorphic Xanthoastrocytoma (PXA) arising in combination with Taylor-type IIB-focal cortical dysplasia. A 54-year-old male had been suffering from temporal lobe epilepsy for 40 years. Nine years ago (at the age of 45), a brain CT revealed a mass (I cm) in the uncal area, but the patient did not give consent to an operation. Later, he was admitted as an emergency case because of severe headache, and the tumor was removed. The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells. Therefore, the tumor was assumed to be associated with the brain, with Taylor-type-JIB focal cortical dysplasia. The patient`s condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord. He died 17 months after tumor removal. (C) 2008 Elsevier GmbH. All rights reserved.LOUIS DN, 2007, WHO CLASSIFICATION T, P33Gelpi E, 2005, NEUROPATHOLOGY, V25, P241Im SH, 2004, J NEURO-ONCOL, V66, P17Tekkok IH, 2004, PEDIATR NEUROSURG, V40, P171, DOI 10.1159/000081935BURGER PC, 2002, SURG PATHOLOGY NERVO, P215Koeller KK, 2001, RADIOGRAPHICS, V21, P1533Rosemberg S, 2000, CLIN NEUROPATHOL, V19, P238SEO IY, 1998, J KOREAN NEUROSURG S, V27, P516Lach B, 1996, CANCER, V78, P2551PRAYSON RA, 1993, EPILEPSIA, V34, P609

  • Pleomorphic Xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult
    'Elsevier BV', 2008
    Co-Authors: Kim Bomi, Chung Chun-kee, Myung, Jae Kyung, Park Sung-hye
    Abstract:

    Brain tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event. We report a case of Pleomorphic Xanthoastrocytoma (PXA) arising in combination with Taylor-type IIB-focal cortical dysplasia. A 54-year-old male had been suffering from temporal lobe epilepsy for 40 years. Nine years ago (at the age of 45), a brain CT revealed a mass (1cm) in the uncal area, but the patient did not give consent to an operation. Later, he was admitted as an emergency case because of severe headache, and the tumor was removed. The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells. Therefore, the tumor was assumed to be associated with the brain, with Taylor-type-IIB focal cortical dysplasia. The patient's condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord. He died 17 months after tumor removal

  • Pleomorphic Xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult
    'Elsevier BV', 2008
    Co-Authors: Kim Bomi, Chung Chun-kee, Myung, Jae Kyung, Park Sung-hye
    Abstract:

    Brain tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event. We report a case of Pleomorphic Xanthoastrocytoma (PXA) arising in combination with Taylor-type IIB-focal cortical dysplasia. A 54-year-old male had been suffering from temporal lobe epilepsy for 40 years. Nine years ago (at the age of 45), a brain CT revealed a mass (1cm) in the uncal area, but the patient did not give consent to an operation. Later, he was admitted as an emergency case because of severe headache, and the tumor was removed. The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells. Therefore, the tumor was assumed to be associated with the brain, with Taylor-type-IIB focal cortical dysplasia. The patient's condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord. He died 17 months after tumor removal.This workwassupportedbyagrantfromtheSeoul NationalUniversityHospital(04-2006-0770)

Thomas S Jacques - One of the best experts on this subject based on the ideXlab platform.

  • molecular pathological radiological and immune profiling of non brainstem pediatric high grade glioma from the herby phase ii randomized trial
    Cancer Cell, 2018
    Co-Authors: Ala Mackay, Felice Giangaspero, Anna Urford, Valeria Molinari, David T W Jones, Elisa Izquierdo, Jurriaa Ouwervisse, Christine Haberle, Torste Pietsch, Thomas S Jacques
    Abstract:

    Summary The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated with pathology, radiology, and immune profiling. In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency and somatic POLE / POLD1 mutations) and those biologically resembling Pleomorphic Xanthoastrocytoma ([PXA]-like, driven by BRAF _V600E or NF1 mutation) had significantly more CD8 + tumor-infiltrating lymphocytes, and longer survival with the addition of BEV. Histone H3 subgroups (hemispheric G34R/V and midline K27M) had a worse outcome and were immune cold. Future clinical trials will need to take into account the diversity represented by the term "HGG" in the pediatric population.

Kim Bomi - One of the best experts on this subject based on the ideXlab platform.

  • Pleomorphic Xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult
    ELSEVIER GMBH URBAN & FISCHER VERLAG, 2009
    Co-Authors: Kim Bomi, Chung Chun-kee, Myung, Jae Kyung, Park Sung-hye
    Abstract:

    Brain tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event. We report a case of Pleomorphic Xanthoastrocytoma (PXA) arising in combination with Taylor-type IIB-focal cortical dysplasia. A 54-year-old male had been suffering from temporal lobe epilepsy for 40 years. Nine years ago (at the age of 45), a brain CT revealed a mass (I cm) in the uncal area, but the patient did not give consent to an operation. Later, he was admitted as an emergency case because of severe headache, and the tumor was removed. The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells. Therefore, the tumor was assumed to be associated with the brain, with Taylor-type-JIB focal cortical dysplasia. The patient`s condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord. He died 17 months after tumor removal. (C) 2008 Elsevier GmbH. All rights reserved.LOUIS DN, 2007, WHO CLASSIFICATION T, P33Gelpi E, 2005, NEUROPATHOLOGY, V25, P241Im SH, 2004, J NEURO-ONCOL, V66, P17Tekkok IH, 2004, PEDIATR NEUROSURG, V40, P171, DOI 10.1159/000081935BURGER PC, 2002, SURG PATHOLOGY NERVO, P215Koeller KK, 2001, RADIOGRAPHICS, V21, P1533Rosemberg S, 2000, CLIN NEUROPATHOL, V19, P238SEO IY, 1998, J KOREAN NEUROSURG S, V27, P516Lach B, 1996, CANCER, V78, P2551PRAYSON RA, 1993, EPILEPSIA, V34, P609

  • Pleomorphic Xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult
    'Elsevier BV', 2008
    Co-Authors: Kim Bomi, Chung Chun-kee, Myung, Jae Kyung, Park Sung-hye
    Abstract:

    Brain tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event. We report a case of Pleomorphic Xanthoastrocytoma (PXA) arising in combination with Taylor-type IIB-focal cortical dysplasia. A 54-year-old male had been suffering from temporal lobe epilepsy for 40 years. Nine years ago (at the age of 45), a brain CT revealed a mass (1cm) in the uncal area, but the patient did not give consent to an operation. Later, he was admitted as an emergency case because of severe headache, and the tumor was removed. The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells. Therefore, the tumor was assumed to be associated with the brain, with Taylor-type-IIB focal cortical dysplasia. The patient's condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord. He died 17 months after tumor removal

  • Pleomorphic Xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult
    'Elsevier BV', 2008
    Co-Authors: Kim Bomi, Chung Chun-kee, Myung, Jae Kyung, Park Sung-hye
    Abstract:

    Brain tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event. We report a case of Pleomorphic Xanthoastrocytoma (PXA) arising in combination with Taylor-type IIB-focal cortical dysplasia. A 54-year-old male had been suffering from temporal lobe epilepsy for 40 years. Nine years ago (at the age of 45), a brain CT revealed a mass (1cm) in the uncal area, but the patient did not give consent to an operation. Later, he was admitted as an emergency case because of severe headache, and the tumor was removed. The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells. Therefore, the tumor was assumed to be associated with the brain, with Taylor-type-IIB focal cortical dysplasia. The patient's condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord. He died 17 months after tumor removal.This workwassupportedbyagrantfromtheSeoul NationalUniversityHospital(04-2006-0770)

Paulo Henrique Aguiar - One of the best experts on this subject based on the ideXlab platform.

  • Malignant transformation of Pleomorphic Xanthoastrocytoma: case report Transformação maligna de xantoastrocitoma pleomórfico: relato de caso
    Academia Brasileira de Neurologia (ABNEURO), 2003
    Co-Authors: Oswaldo Ignácio De ,tella, Marco Antonio Herculano, João Norberto Stavale, Mirto Nelso Prandini, Paulo Henrique Aguiar
    Abstract:

    We report a case of a Pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which revealed a friable tumor, easily differentiated from the normal parenchyma, with cystic components. The histopathological examination demonstrated Pleomorphic Xanthoastrocytoma with malignant transformation. Histologically, the tumor at first procedure was composed of Pleomorphic astrocytes with multinucleated and foamy cells. A rare case of malignant transformation in Pleomorphic Xanthoastrocytoma is presented, discussed and illustrated in this paper.Um caso raro de transformação maligna de xantoastrocitoma pleomórfico é apresentado, discutido e ilustrado neste estudo. Descrevemos um caso de xantoastrocitoma pleomórfico diagnosticado como lesão isodensa no lobo fronto-temporal direito, em uma paciente de 26 anos. Na cirurgia, encontrou-se tumor mole, de cor amarelada, com cavidade cística. Cinco meses após o procedimento, a paciente foi submetida a nova intervenção que revelou um tumor friável, facilmente diferenciado do parênquima normal, com componentes císticos. O exame histopatológico demonstrou um xantoastrocitoma pleomórfico com transformação maligna. O tumor, no primeiro procedimento, era formado por astrócitos pleomórficos com células vacuolizadas e multinucleadas

  • Arq Neuropsiquiatr 2003;61(1):104-106 MALIGNANT TRANSFORMATION OF Pleomorphic Xanthoastrocytoma
    2002
    Co-Authors: Oswaldo Ignácio, Marco Antonio Herculano, João Norberto Stavale, Paulo Henrique Aguiar
    Abstract:

    ABSTRACT- We report a case of a Pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which revealed a friable tumor, easily differentiated from the normal parenchyma, with cystic components. The histopathological examination demonstrated Pleomorphic Xanthoastrocytoma with malignant transformation. Histologically, the tumor at first procedure was composed of Pleomorphic astrocytes with multinucleated and foamy cells. A rare case of malignant transformation in Pleomorphic Xanthoastrocytoma is presented, discussed and illustrated in this paper. KEY WORDS: Xanthoastrocytoma, astrocytoma, tumor, histopathology. Transformação maligna de xantoastrocitoma pleomórfico: relato de caso RESUMO- Um caso raro de transformação maligna de xantoastrocitoma pleomórfico é apresentado, discutido e ilustrado neste estudo. Descrevemos um caso de xantoastrocitoma pleomórfico diagnosticado como lesão isodensa no lobo fronto-temporal direito, em uma paciente de 26 anos. Na cirurgia, encontrou-se tumor mole, de cor amarelada, com cavidade cística. Cinco meses após o procedimento, a paciente foi submetida a nova intervenção que revelou um tumor friável, facilmente diferenciado do parênquima normal, co

Oswaldo Ignácio De ,tella - One of the best experts on this subject based on the ideXlab platform.

  • Malignant transformation of Pleomorphic Xanthoastrocytoma: case report
    Academia Brasileira de Neurologia - ABNEURO, 2003
    Co-Authors: Oswaldo Ignácio De ,tella, Herculano,marco Antonio, Prandini,mirto Nelso, Stavale,joão Norberto, Aguiar,paulo Henrique
    Abstract:

    We report a case of a Pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which revealed a friable tumor, easily differentiated from the normal parenchyma, with cystic components. The histopathological examination demonstrated Pleomorphic Xanthoastrocytoma with malignant transformation. Histologically, the tumor at first procedure was composed of Pleomorphic astrocytes with multinucleated and foamy cells. A rare case of malignant transformation in Pleomorphic Xanthoastrocytoma is presented, discussed and illustrated in this paper

  • Transformação maligna de xantoastrocitoma pleomórfico: relato de caso
    Academia Brasileira de Neurologia - ABNEURO, 2003
    Co-Authors: Oswaldo Ignácio De ,tella, Herculano,marco Antonio, Prandini,mirto Nelso, Stavale,joão Norberto, Aguiar,paulo Henrique
    Abstract:

    We report a case of a Pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which revealed a friable tumor, easily differentiated from the normal parenchyma, with cystic components. The histopathological examination demonstrated Pleomorphic Xanthoastrocytoma with malignant transformation. Histologically, the tumor at first procedure was composed of Pleomorphic astrocytes with multinucleated and foamy cells. A rare case of malignant transformation in Pleomorphic Xanthoastrocytoma is presented, discussed and illustrated in this paper.Um caso raro de transformação maligna de xantoastrocitoma pleomórfico é apresentado, discutido e ilustrado neste estudo. Descrevemos um caso de xantoastrocitoma pleomórfico diagnosticado como lesão isodensa no lobo fronto-temporal direito, em uma paciente de 26 anos. Na cirurgia, encontrou-se tumor mole, de cor amarelada, com cavidade cística. Cinco meses após o procedimento, a paciente foi submetida a nova intervenção que revelou um tumor friável, facilmente diferenciado do parênquima normal, com componentes císticos. O exame histopatológico demonstrou um xantoastrocitoma pleomórfico com transformação maligna. O tumor, no primeiro procedimento, era formado por astrócitos pleomórficos com células vacuolizadas e multinucleadas

  • Malignant transformation of Pleomorphic Xanthoastrocytoma: case report Transformação maligna de xantoastrocitoma pleomórfico: relato de caso
    Academia Brasileira de Neurologia (ABNEURO), 2003
    Co-Authors: Oswaldo Ignácio De ,tella, Marco Antonio Herculano, João Norberto Stavale, Mirto Nelso Prandini, Paulo Henrique Aguiar
    Abstract:

    We report a case of a Pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which revealed a friable tumor, easily differentiated from the normal parenchyma, with cystic components. The histopathological examination demonstrated Pleomorphic Xanthoastrocytoma with malignant transformation. Histologically, the tumor at first procedure was composed of Pleomorphic astrocytes with multinucleated and foamy cells. A rare case of malignant transformation in Pleomorphic Xanthoastrocytoma is presented, discussed and illustrated in this paper.Um caso raro de transformação maligna de xantoastrocitoma pleomórfico é apresentado, discutido e ilustrado neste estudo. Descrevemos um caso de xantoastrocitoma pleomórfico diagnosticado como lesão isodensa no lobo fronto-temporal direito, em uma paciente de 26 anos. Na cirurgia, encontrou-se tumor mole, de cor amarelada, com cavidade cística. Cinco meses após o procedimento, a paciente foi submetida a nova intervenção que revelou um tumor friável, facilmente diferenciado do parênquima normal, com componentes císticos. O exame histopatológico demonstrou um xantoastrocitoma pleomórfico com transformação maligna. O tumor, no primeiro procedimento, era formado por astrócitos pleomórficos com células vacuolizadas e multinucleadas