The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Tricia Ann Schurtz Sebghati - One of the best experts on this subject based on the ideXlab platform.
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77 – Klebsiella Pneumoniae
Molecular Medical Microbiology, 2002Co-Authors: Steven Clegg, Tricia Ann Schurtz SebghatiAbstract:Publisher Summary Klebsiella Pneumoniae (K. Pneumoniae) is an opportunistic pathogen frequently implicated in the infections of compromised or debilitated individuals. The ability of many K. Pneumoniae strains to resist the action of multiple antibiotics, including broad-spectrum cephalosporins and s lactams, is of great concern particularly in hospital environments where infection caused by this organism can present serious problems. Among the Enterobacteriaceae, K. Pneumoniae is a leading cause of nosocomially-acquired pneumonias, and recent epidemiological evidence suggests that the occurrence of Klebsiella infections may be significantly higher than previously believed. For these reasons, the factors responsible for mediating the virulence of the organism are widely investigated, and a number of bacterial attributes are implicated as factors that contribute to the pathogenicity of K. Pneumoniae. The increasing population of individuals susceptible to Klebsiella infection indicates that the design of therapeutic and immunoprophylactic agents are important. The application of molecular genetics and cellular biology to elucidate bacterial pathogenesis and interaction with the host provides important information about the pathogenetic mechanisms of K. Pneumoniae.
Susanna Esposito - One of the best experts on this subject based on the ideXlab platform.
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Macrolide-resistant Mycoplasma Pneumoniae in paediatric pneumonia
The European respiratory journal, 2011Co-Authors: Fabio Cardinale, Maria Chironna, R Dumke, A Binetti, Cristina Daleno, A. Sallustio, Antonia Valzano, Susanna EspositoAbstract:To the Editors: Mycoplasma Pneumoniae is one of the most common causes of bacterial community-acquired pneumonia (CAP) in paediatrics, and can lead to severe and long-lasting disease [1]. Macrolides are usually considered the first-choice antimicrobials for M. Pneumoniae CAP in children because the alternatives ( i.e. fluoroquinolones and tetracyclines) are not approved for use in the first years of life [2]. Recent studies from Japan and China have shown macrolide resistance in up to 80% of M. Pneumoniae strains [3, 4], but it has been detected in relatively few cases in the USA, France and Germany, and not at all in other European countries [5–7]. The mechanism of M. Pneumoniae macrolide resistance is related to point mutations in domain V of the 23S rRNA gene of M. Pneumoniae and macrolide resistance is usually detected at disease onset [4]. We here describe the first case of macrolide-resistant M. Pneumoniae detected during treatment with clarithromycin in an otherwise healthy child with CAP. An otherwise healthy 6-yr-old girl with an unremarkable medical history who had never travelled abroad was admitted in Bari, Italy, after suffering from a dry cough for 3 days with fever up to 40.5°C, accompanied by increasing malaise and dyspnoea. Upon admission, she was severely ill, with a high temperature, lethargy, an increased respiratory rate (60 breaths·min−1), tachycardia and normal blood pressure. Room air oximetry revealed 85% oxygen saturation, whereas arterial gas sampling showed severe hypoxaemia (50 mmHg) with hypocapnia and a normal pH. Other routine blood examinations revealed neutrophilia with increased C-reactive protein levels and a high erythrocyte sedimentation rate. A physical examination revealed diffuse crackles with reduced vesicular sounds on both lungs, and chest radiography showed an interstitial pattern with multiple “ground-glass” infiltrates. Blood, nasopharyngeal …
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Mycoplasma Pneumoniae and Chlamydia Pneumoniae infections in children with pneumonia
The European respiratory journal, 2001Co-Authors: Susanna Esposito, Francesco Blasi, F. Bellini, Luigi Allegra, Nicola PrincipiAbstract:The most common clinical signs, host responses and radiographic patterns were studied in 203 Italian children hospitalized for community-acquired pneumonia in order to clarify the role of clinical and radiological characteristics in the diagnosis of Mycoplasma Pneumoniae and/or Chlamydia Pneumoniae infections. Antibody measurements in paired sera and polymerase chain reaction on nasopharyngeal aspirates were used to establish the diagnoses of acute M. Pneumoniae and C. Pneumoniae infection, and the aetiologic data were correlated with the clinical, laboratory and radiographic data obtained on admission. No significant association was observed between evidence of M. Pneumoniae and/or C. Pneumoniae infection and periods of episode during the year, mean age of the study subjects, individual symptoms, physical findings or laboratory test results. Furthermore, no significant correlation was observed in relation to the radiological findings and M. Pneumoniae and/or C. Pneumoniae infection. This study shows that neither clinical findings nor laboratory parameters distinguished Mycoplasma Pneumoniae and/or Chlamydia Pneumoniae infection in children with pneumonia. Radiological findings also have a limited capacity to differentiate aetiologic agents. The priorities for future research include the development of rapid, easily accessible and cost-effective diagnostic tests useful for each episode of pneumonia in children.
Nan-kai Wang - One of the best experts on this subject based on the ideXlab platform.
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Endogenous Klebsiella Endophthalmitis Associated with Klebsiella Pneumoniae Pneumonia
Ocular immunology and inflammation, 2009Co-Authors: Kuan-jen Chen, Yih-shiou Hwang, Yen-po Chen, Chi-chun Lai, Tun-lu Chen, Nan-kai WangAbstract:Purpose: To investigate the management, bacterial strains, antibiotic sensitivities, and visual outcomes in patients with Klebsiella Pneumoniae pneumonia and endogenous Klebsiella endophthalmitis. Methods: Data were collected for treatments, antibiotic sensitivity patterns, and final visual outcomes. Results: The study included 10 eyes of 9 patients with a median age of 42 years (range, 0–86 years). Diabetes mellitus was the most common comorbid risk factor (n = 5, 56%). Nine eyes (90%) were treated with intravitreal antibiotics, and one with pars plana vitrectomy and intravitreal antibiotics. One eye achieved a favorable visual acuity of 20/20; however, 6 eyes developed vision of no light perception, including 2 of evisceration. Two nosocomial K. Pneumoniae isolates were extended-spectrum-β -lactamase-producing strains, which demonstrated the resistance to amikacin and ceftazidime. Conclusions: Ophthalmologists and physicians should be aware of Klebsiella pneumonia as a possible cause of endogenous endop...
Donna M Crabb - One of the best experts on this subject based on the ideXlab platform.
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macrolide resistant mycoplasma Pneumoniae united states
Emerging Infectious Diseases, 2015Co-Authors: Xiaotian Zheng, Stella Lee, Rangaraj Selvarangan, Xuan Qin, Yiwei Tang, Jeffrey Stiles, Tao Hong, Kathleen Todd, Amy E Ratliff, Donna M CrabbAbstract:Macrolide-resistant Mycoplasma Pneumoniae (MRMP) is highly prevalent in Asia and is now being reported from Europe. Few data on MRMP are available in the United States. Using genotypic and phenotypic methods, we detected high-level MRMP in 13.2% of 91 M. Pneumoniae–positive specimens from 6 US locations.
Steven Clegg - One of the best experts on this subject based on the ideXlab platform.
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77 – Klebsiella Pneumoniae
Molecular Medical Microbiology, 2002Co-Authors: Steven Clegg, Tricia Ann Schurtz SebghatiAbstract:Publisher Summary Klebsiella Pneumoniae (K. Pneumoniae) is an opportunistic pathogen frequently implicated in the infections of compromised or debilitated individuals. The ability of many K. Pneumoniae strains to resist the action of multiple antibiotics, including broad-spectrum cephalosporins and s lactams, is of great concern particularly in hospital environments where infection caused by this organism can present serious problems. Among the Enterobacteriaceae, K. Pneumoniae is a leading cause of nosocomially-acquired pneumonias, and recent epidemiological evidence suggests that the occurrence of Klebsiella infections may be significantly higher than previously believed. For these reasons, the factors responsible for mediating the virulence of the organism are widely investigated, and a number of bacterial attributes are implicated as factors that contribute to the pathogenicity of K. Pneumoniae. The increasing population of individuals susceptible to Klebsiella infection indicates that the design of therapeutic and immunoprophylactic agents are important. The application of molecular genetics and cellular biology to elucidate bacterial pathogenesis and interaction with the host provides important information about the pathogenetic mechanisms of K. Pneumoniae.
