The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform
Arie Eisenman - One of the best experts on this subject based on the ideXlab platform.
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Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean
Toxicon, 2008Co-Authors: Yedidia Bentur, Daniel Golani, Jalal Ashkar, Yael Lurie, Yishai Levy, Zaher S. Azzam, Moni Litmanovich, Marina Golik, Bella Gurevych, Arie EisenmanAbstract:Abstract Background The Suez Canal permits migration of Fish from the Indo-Pacific Ocean to the Mediterranean Sea. This phenomenon (Lessepsian migration) has enabled Poisonous Fish species to colonize the Mediterranean Sea. Objective To report clinical tetrodotoxin poisoning after consumption of the Lessepsian immigrant Fish Lagocephalus sceleratus caught on the Israeli coast of the eastern Mediterranean. Case series Thirteen patients aged 26–70 years were admitted after consuming L. sceleratus . Signs of toxicity appeared within 1 h. The main manifestations included vomiting, diarrhea, headache, paraesthesias, slurred speech, muscle weakness, dyspnea, hypertension, tachycardia, respiratory arrest, seizures and coma. Treatment was supportive, including mechanical ventilation (two patients). Patients recovered within 4 days. All Fish were identified as L. sceleratus , a species known to contain tetrodotoxin. Discussion The diagnosis of tetrodotoxin poisoning was suggested by typical clinical manifestations together with temporal proximity to consumption of tetrodotoxin-containing Fish. To the best of our knowledge, this is the first case series of tetrodotoxin poisoning reported from the eastern Mediterranean and due to L. sceleratus . Man made disruption of the ecological balance has resulted in the spread of tetrodotoxin-containing Fish from the Indo-Pacific region to the Mediterranean Sea. Increased awareness is required to identify tetrodotoxin poisoning in an atypical fauna.
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An odd pilgrim in the Holy Land
American Journal of Emergency Medicine, 2008Co-Authors: Arie Eisenman, Victoria Rusetski, Diana Sharivker, Zehava Yona, Daniel GolaniAbstract:Abstract Fugu is a delicate dish prepared from Lagocephalus scleratus , a Poisonous Fish that contains tetrodotoxin—a very potent neurotoxin. It is usually confined to the Indo-Pacific Ocean where it is responsible for many accidental deaths each year. This very weird case report is about an Israeli couple that was poisoned by this Fish caught for the first time in the eastern Mediterranean Sea. The prompt identification of the yet unrecognized Fish by professional zoologists enabled an immediate effective treatment. This case represents another interesting manifestation of the globalization process our world undergoes and emphasizes, once again, the need of present emergency physicians to be aware of remote overseas medical problems. The article discusses the possible presumptions of the ways the Fish arrived to the Mediterranean Sea and elaborates a review on tetrodotoxin from historical, structural, biologic activity as well as the diagnostic and treatment means available today.
Arie Soroksky - One of the best experts on this subject based on the ideXlab platform.
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Severe Tetrodotoxin Poisoning after Consumption of Lagocephalus sceleratus (PufferFish, Fugu) Fished in Mediterranean Sea, Treated with Cholinesterase Inhibitor.
Case reports in critical care, 2012Co-Authors: Julia Kheifets, Boris Rozhavsky, Zehava Girsh Solomonovich, Rodman Marianna, Arie SorokskyAbstract:Lagocephalus sceleratus, or better known as the pufferFish, or fugu, is widespread in Asia and Indo-Pacific regions. It is a Poisonous Fish containing tetrodotoxin (TTX) which is a potent neurotoxin. In the Far East, fugu is considered a delicate dish, especially in Japan where it is prepared by experts. Nevertheless, poisoning from Lagocephalus sceleratus is not a rare event. Recent data from Japan indicate an incidence of 45 patients per year and a mortality rate of 11%. Mediterranean sea is not the natural habitat of Lagocephalus sceleratus. However, by now multiple reports have established a firm presence of Lagocephalus sceleratus in Mediterranean region as well. This phenomenon is explained by migration of pufferFish across the Suez Channel (lessepsian migration) (Eisenman et al., 2008, Bentur et al., 2008). With lessepsian migration came the first reports of TTX poisoning in the Mediterranean region. We report a patient with a particularly severe and life-threatening TTX poisoning caused by consumption of Lagocephalus sceleratus and treated by cholinesterase inhibitor to a complete and uneventful recovery.
Nimal Senanayake - One of the best experts on this subject based on the ideXlab platform.
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Venomous snake bites, scorpions, and spiders.
Handbook of Clinical Neurology, 2013Co-Authors: Senanayake A. M. Kularatne, Nimal SenanayakeAbstract:Neurologic dysfunction due to natural neurotoxins is an important, but neglected, public health hazard in many parts of the world, particularly in the tropics. These toxins are produced by or found among a variety of live forms that include venomous snakes, arthropods such as scorpions, spiders, centipedes, stinging insects (Hymenoptera), ticks, certain Poisonous Fish, shellFish, crabs, cone shells, skin secretions of dart-poison frogs, and bacterial poisons such as botulinum toxin. These toxins commonly act on neuromuscular transmission at the neuromuscular junction where acetylcholine is the neurotransmitter, but in certain situations the toxins interfere with neurotransmitters such as GABA, noradrenaline, adrenaline, dopamine, and γ-aminobutyrate. Of the toxins, α-toxins and κ-toxins (e.g., Chinese krait, Bungarus multicinctus) act on the postsynaptic membrane, blocking the receptors, whilst β-toxin (e.g., common krait, B. caeruleus) acts on the presynaptic membrane, causing impairment of acetylcholine release. Conversely, dendrotoxins of the African mamba enhance acetylcholine release. The toxins of scorpions and spiders commonly interfere with voltage-gated ion channels. Clinically, the cardinal manifestation is muscle paralysis. In severe cases respiratory paralysis could be fatal. Effective antivenoms are the mainstay of treatment of envenoming, but their lack of availability is the major concern in the regions of the globe where they are desperately needed. Interestingly, some toxins have proved to be valuable pharmaceutical agents, while some others are widely exploited to study neuromuscular physiology and pathology.
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Disorders of neuromuscular transmission due to natural environmental toxins.
Journal of the Neurological Sciences, 2003Co-Authors: Nimal Senanayake, Gustavo C. RománAbstract:Abstract A variety of natural toxins of animal, plant, and bacterial origin are capable of causing disorders of neuromuscular transmission. Animal toxins include venomous snakes and arthropods, venoms of certain marine creatures, skin secretions of dart-poison frogs, and Poisonous Fish, shellFish, and crabs. There are plant poisons such as curare, and bacterial poisons such as botulinum toxin. These act at single or multiple sites of the neuromuscular apparatus interfering with voltage-gated ion channels, acetylcholine release, depolarization of the postsynaptic membrane, or generation and spread of the muscle action potential. The specific actions of these toxins are being widely exploited in the study of neuromuscular physiology and pathology. Some toxins have proved to be valuable pharmaceutical agents. Poisoning by natural neurotoxins is an important public health hazard in many parts of the world, particularly in the tropics. Poisoning may occur by a bite or a sting of a venomous animal, or by the ingestion of Poisonous Fish, shellFish or other marine delicacies. Contaminated food is a vehicle for poisons such as botulinum toxin. Clinically, a cardinal feature in the symptomatology is muscle paralysis with a distribution characteristic of myasthenia gravis, affecting muscles innervated by cranial nerves, neck flexors, proximal limb muscles, and respiratory muscles. Respiratory paralysis may end fatally. This paper reviews from the clinical and pathophysiologic viewpoints, naturally occurring environmental neurotoxins acting at the neuromuscular junction.
Daniel Golani - One of the best experts on this subject based on the ideXlab platform.
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Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean
Toxicon, 2008Co-Authors: Yedidia Bentur, Daniel Golani, Jalal Ashkar, Yael Lurie, Yishai Levy, Zaher S. Azzam, Moni Litmanovich, Marina Golik, Bella Gurevych, Arie EisenmanAbstract:Abstract Background The Suez Canal permits migration of Fish from the Indo-Pacific Ocean to the Mediterranean Sea. This phenomenon (Lessepsian migration) has enabled Poisonous Fish species to colonize the Mediterranean Sea. Objective To report clinical tetrodotoxin poisoning after consumption of the Lessepsian immigrant Fish Lagocephalus sceleratus caught on the Israeli coast of the eastern Mediterranean. Case series Thirteen patients aged 26–70 years were admitted after consuming L. sceleratus . Signs of toxicity appeared within 1 h. The main manifestations included vomiting, diarrhea, headache, paraesthesias, slurred speech, muscle weakness, dyspnea, hypertension, tachycardia, respiratory arrest, seizures and coma. Treatment was supportive, including mechanical ventilation (two patients). Patients recovered within 4 days. All Fish were identified as L. sceleratus , a species known to contain tetrodotoxin. Discussion The diagnosis of tetrodotoxin poisoning was suggested by typical clinical manifestations together with temporal proximity to consumption of tetrodotoxin-containing Fish. To the best of our knowledge, this is the first case series of tetrodotoxin poisoning reported from the eastern Mediterranean and due to L. sceleratus . Man made disruption of the ecological balance has resulted in the spread of tetrodotoxin-containing Fish from the Indo-Pacific region to the Mediterranean Sea. Increased awareness is required to identify tetrodotoxin poisoning in an atypical fauna.
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An odd pilgrim in the Holy Land
American Journal of Emergency Medicine, 2008Co-Authors: Arie Eisenman, Victoria Rusetski, Diana Sharivker, Zehava Yona, Daniel GolaniAbstract:Abstract Fugu is a delicate dish prepared from Lagocephalus scleratus , a Poisonous Fish that contains tetrodotoxin—a very potent neurotoxin. It is usually confined to the Indo-Pacific Ocean where it is responsible for many accidental deaths each year. This very weird case report is about an Israeli couple that was poisoned by this Fish caught for the first time in the eastern Mediterranean Sea. The prompt identification of the yet unrecognized Fish by professional zoologists enabled an immediate effective treatment. This case represents another interesting manifestation of the globalization process our world undergoes and emphasizes, once again, the need of present emergency physicians to be aware of remote overseas medical problems. The article discusses the possible presumptions of the ways the Fish arrived to the Mediterranean Sea and elaborates a review on tetrodotoxin from historical, structural, biologic activity as well as the diagnostic and treatment means available today.
Yedidia Bentur - One of the best experts on this subject based on the ideXlab platform.
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Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean
Toxicon, 2008Co-Authors: Yedidia Bentur, Daniel Golani, Jalal Ashkar, Yael Lurie, Yishai Levy, Zaher S. Azzam, Moni Litmanovich, Marina Golik, Bella Gurevych, Arie EisenmanAbstract:Abstract Background The Suez Canal permits migration of Fish from the Indo-Pacific Ocean to the Mediterranean Sea. This phenomenon (Lessepsian migration) has enabled Poisonous Fish species to colonize the Mediterranean Sea. Objective To report clinical tetrodotoxin poisoning after consumption of the Lessepsian immigrant Fish Lagocephalus sceleratus caught on the Israeli coast of the eastern Mediterranean. Case series Thirteen patients aged 26–70 years were admitted after consuming L. sceleratus . Signs of toxicity appeared within 1 h. The main manifestations included vomiting, diarrhea, headache, paraesthesias, slurred speech, muscle weakness, dyspnea, hypertension, tachycardia, respiratory arrest, seizures and coma. Treatment was supportive, including mechanical ventilation (two patients). Patients recovered within 4 days. All Fish were identified as L. sceleratus , a species known to contain tetrodotoxin. Discussion The diagnosis of tetrodotoxin poisoning was suggested by typical clinical manifestations together with temporal proximity to consumption of tetrodotoxin-containing Fish. To the best of our knowledge, this is the first case series of tetrodotoxin poisoning reported from the eastern Mediterranean and due to L. sceleratus . Man made disruption of the ecological balance has resulted in the spread of tetrodotoxin-containing Fish from the Indo-Pacific region to the Mediterranean Sea. Increased awareness is required to identify tetrodotoxin poisoning in an atypical fauna.