The Experts below are selected from a list of 852 Experts worldwide ranked by ideXlab platform

Yogesh K. Vohra - One of the best experts on this subject based on the ideXlab platform.

  • Two ply tubular scaffolds comprised of proteins/Poliglecaprone/polycaprolactone fibers
    Journal of Materials Science: Materials in Medicine, 2010
    Co-Authors: Xing Zhang, Vinoy Thomas, Yogesh K. Vohra
    Abstract:

    Electrospun bi-layer tubular hybrid scaffolds composed of Poliglecaprone (PGC), polycaprolactone (PCL), elastin (E), and gelatin (G) were prepared and thereafter crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Scanning electron microscopic (SEM) images revealed a highly porous micro-structure comprising randomly distributed non-woven fibers with the majority of fibers in submicron diameters. The EDC-crosslinking yielded an average crosslinking degree of 40%. Uni-axial tensile test of hydrated scaffolds in both longitudinal and circumferential directions revealed tensile properties, comparable to those of native arteries. The graft (PGC:PCL = 1:3) did not demonstrate significant difference before and after EDC-crosslinking in tensile strength or % strain in either longitudinal or circumferential directions. However, crosslinking increased the Young’s modulus of the graft along the longitudinal direction (from 5.84 to 8.67 MPa). On the contrary, the graft (3:1) demonstrated a significant decrease in maximum strain in both directions. Cyto-assay using human umbilical vein endothelial cells (HUVECs) showed excellent cell viability.

  • two ply tubular scaffolds comprised of proteins Poliglecaprone polycaprolactone fibers
    Journal of Materials Science: Materials in Medicine, 2010
    Co-Authors: Xing Zhang, Vinoy Thomas, Yogesh K. Vohra
    Abstract:

    Electrospun bi-layer tubular hybrid scaffolds composed of Poliglecaprone (PGC), polycaprolactone (PCL), elastin (E), and gelatin (G) were prepared and thereafter crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Scanning electron microscopic (SEM) images revealed a highly porous micro-structure comprising randomly distributed non-woven fibers with the majority of fibers in submicron diameters. The EDC-crosslinking yielded an average crosslinking degree of 40%. Uni-axial tensile test of hydrated scaffolds in both longitudinal and circumferential directions revealed tensile properties, comparable to those of native arteries. The graft (PGC:PCL = 1:3) did not demonstrate significant difference before and after EDC-crosslinking in tensile strength or % strain in either longitudinal or circumferential directions. However, crosslinking increased the Young’s modulus of the graft along the longitudinal direction (from 5.84 to 8.67 MPa). On the contrary, the graft (3:1) demonstrated a significant decrease in maximum strain in both directions. Cyto-assay using human umbilical vein endothelial cells (HUVECs) showed excellent cell viability.

James O. Peabody - One of the best experts on this subject based on the ideXlab platform.

  • anastomosis during robot assisted radical prostatectomy randomized controlled trial comparing barbed and standard monofilament suture
    Urology, 2011
    Co-Authors: Jesse D. Sammon, Quoc-dien Trinh, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Craig G. Rogers, James O. Peabody
    Abstract:

    Objective To compare perioperative and functional outcomes after urethrovesical anastomosis (UVA) with barbed polyglyconate and monofilament Poliglecaprone in robot-assisted radical prostatectomy (RARP). Barbed polyglyconate suture was first used for the UVA during RARP beginning in January 2010; safety and feasibility were previously demonstrated in 51 patients. Methods From May to September 2010, 64 patients meeting all the inclusion criteria participated in the present multisurgeon prospective, randomized, controlled trial and underwent posterior repair and UVA during RARP with either barbed polyglyconate (n = 33) or monofilament Poliglecaprone (n = 31) suture. The primary outcomes were the anastomotic (UVA) and posterior reconstruction times. Secondary outcomes included cystogram leak, bladder neck reconstruction rate, and 6-week functional outcomes assessed by a self-administered validated patient questionnaire. Results Posterior reconstruction was performed within 3.3 minutes with the barbed suture versus 4.3 minutes with the monofilament Poliglecaprone suture (23.3% reduction) and UVA within 10.1 versus 13.8 minutes, respectively (26.8% reduction). The absolute time difference for the 2-layer anastomosis was 4.7 minutes (a 26.0% reduction in the total anastomosis time). All other perioperative outcomes were equivalent between the 2 groups. Urinary functional outcomes, including the pad use and leakage rates, were equivalent at 6 weeks. Conclusion Anastomosis during RARP with the V-Loc barbed suture can be performed safely and more efficiently than with standard monofilament suture. We demonstrated a 26% decrease in the anastomotic time with no increase in the adverse events, no instances of urinary retention and equivalent functional outcomes were measured with the self-administered patient questionnaire.

  • Urethrovesical Anastomosis Using Barbed Suture During Robot-Assisted Radical Prostatectomy
    Journal of Endourology Part B Videourology, 2011
    Co-Authors: Quoc-dien Trinh, Jesse D. Sammon, Tae-kyung Kim, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Emil Kheterpal, Naveen Pokala, Craig G. Rogers, James O. Peabody
    Abstract:

    Abstract Introduction and Objectives: Barbed polyglyconate suture (V-Loc®; Covidien, Mansfield, Massachusetts) was first used for the urethrovesical anastomosis (UVA) during robot-assisted radical prostatectomy (RARP) beginning January 2010. Safety and feasibility were previously demonstrated in 51 patients.1 In this video, we demonstrate the technique of urethrovesical anastomosis with barbed suture and the results of a randomized, controlled trial assessing perioperative and functional outcomes after urethrovesical anastomosis with barbed polyglyconate versus monofilament Poliglecaprone in RARP. Methods: After institutional review board approval, 64 patients meeting all inclusion criteria participated in this multi-surgeon prospective, randomized, controlled trial between May and September 2010. Posterior repair and urethrovesical anastomosis during RARP were performed with barbed polyglyconate (n = 33) or monofilament Poliglecaprone (n = 31) suture. Primary outcomes were anastomotic (UVA) and posterior...

  • Laparoscopy and Robotics Anastomosis During Robot-assisted Radical Prostatectomy: Randomized Controlled Trial Comparing Barbed and Standard Monofilament Suture
    2011
    Co-Authors: Jesse D. Sammon, Quoc-dien Trinh, Tae-kyung Kim, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Craig G. Rogers, James O. Peabody
    Abstract:

    OBJECTIVE To compare perioperative and functional outcomes after urethrovesical anastomosis (UVA) with barbed polyglyconate and monofilament Poliglecaprone in robot-assisted radical prostatectomy (RARP). Barbed polyglyconate suture was first used for the UVA during RARP beginning in January 2010; safety and feasibility were previously demonstrated in 51 patients. METHODS From May to September 2010, 64 patients meeting all the inclusion criteria participated in the present multisurgeon prospective, randomized, controlled trial and underwent posterior repair and UVA during RARP with either barbed polyglyconate (n 33) or monofilament Poliglecaprone (n 31) suture. The primary outcomes were the anastomotic (UVA) and posterior reconstruction times. Secondary outcomes included cystogram leak, bladder neck reconstruction rate, and 6-week functional outcomes assessed by a self-administered validated patient questionnaire. RESULTS Posterior reconstruction was performed within 3.3 minutes with the barbed suture versus 4.3 minutes with the monofilament Poliglecaprone suture (23.3% reduction) and UVA within 10.1 versus 13.8 minutes, respectively (26.8% reduction). The absolute time difference for the 2-layer anastomosis was 4.7 minutes (a 26.0% reduction in the total anastomosis time). All other perioperative outcomes were equivalent between the 2 groups. Urinary functional outcomes, including the pad use and leakage rates, were equivalent at 6 weeks. CONCLUSION Anastomosis during RARP with the V-Loc barbed suture can be performed safely and more efficiently than with standard monofilament suture. We demonstrated a 26% decrease in the anastomotic time with no increase in the adverse events, no instances of urinary retention and equivalent functional outcomes were measured with the self-administered patient questionnaire. UROLOGY 78: 572‐580, 2011. © 2011 Elsevier Inc.

Xing Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Two ply tubular scaffolds comprised of proteins/Poliglecaprone/polycaprolactone fibers
    Journal of Materials Science: Materials in Medicine, 2010
    Co-Authors: Xing Zhang, Vinoy Thomas, Yogesh K. Vohra
    Abstract:

    Electrospun bi-layer tubular hybrid scaffolds composed of Poliglecaprone (PGC), polycaprolactone (PCL), elastin (E), and gelatin (G) were prepared and thereafter crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Scanning electron microscopic (SEM) images revealed a highly porous micro-structure comprising randomly distributed non-woven fibers with the majority of fibers in submicron diameters. The EDC-crosslinking yielded an average crosslinking degree of 40%. Uni-axial tensile test of hydrated scaffolds in both longitudinal and circumferential directions revealed tensile properties, comparable to those of native arteries. The graft (PGC:PCL = 1:3) did not demonstrate significant difference before and after EDC-crosslinking in tensile strength or % strain in either longitudinal or circumferential directions. However, crosslinking increased the Young’s modulus of the graft along the longitudinal direction (from 5.84 to 8.67 MPa). On the contrary, the graft (3:1) demonstrated a significant decrease in maximum strain in both directions. Cyto-assay using human umbilical vein endothelial cells (HUVECs) showed excellent cell viability.

  • two ply tubular scaffolds comprised of proteins Poliglecaprone polycaprolactone fibers
    Journal of Materials Science: Materials in Medicine, 2010
    Co-Authors: Xing Zhang, Vinoy Thomas, Yogesh K. Vohra
    Abstract:

    Electrospun bi-layer tubular hybrid scaffolds composed of Poliglecaprone (PGC), polycaprolactone (PCL), elastin (E), and gelatin (G) were prepared and thereafter crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Scanning electron microscopic (SEM) images revealed a highly porous micro-structure comprising randomly distributed non-woven fibers with the majority of fibers in submicron diameters. The EDC-crosslinking yielded an average crosslinking degree of 40%. Uni-axial tensile test of hydrated scaffolds in both longitudinal and circumferential directions revealed tensile properties, comparable to those of native arteries. The graft (PGC:PCL = 1:3) did not demonstrate significant difference before and after EDC-crosslinking in tensile strength or % strain in either longitudinal or circumferential directions. However, crosslinking increased the Young’s modulus of the graft along the longitudinal direction (from 5.84 to 8.67 MPa). On the contrary, the graft (3:1) demonstrated a significant decrease in maximum strain in both directions. Cyto-assay using human umbilical vein endothelial cells (HUVECs) showed excellent cell viability.

Jesse D. Sammon - One of the best experts on this subject based on the ideXlab platform.

  • anastomosis during robot assisted radical prostatectomy randomized controlled trial comparing barbed and standard monofilament suture
    Urology, 2011
    Co-Authors: Jesse D. Sammon, Quoc-dien Trinh, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Craig G. Rogers, James O. Peabody
    Abstract:

    Objective To compare perioperative and functional outcomes after urethrovesical anastomosis (UVA) with barbed polyglyconate and monofilament Poliglecaprone in robot-assisted radical prostatectomy (RARP). Barbed polyglyconate suture was first used for the UVA during RARP beginning in January 2010; safety and feasibility were previously demonstrated in 51 patients. Methods From May to September 2010, 64 patients meeting all the inclusion criteria participated in the present multisurgeon prospective, randomized, controlled trial and underwent posterior repair and UVA during RARP with either barbed polyglyconate (n = 33) or monofilament Poliglecaprone (n = 31) suture. The primary outcomes were the anastomotic (UVA) and posterior reconstruction times. Secondary outcomes included cystogram leak, bladder neck reconstruction rate, and 6-week functional outcomes assessed by a self-administered validated patient questionnaire. Results Posterior reconstruction was performed within 3.3 minutes with the barbed suture versus 4.3 minutes with the monofilament Poliglecaprone suture (23.3% reduction) and UVA within 10.1 versus 13.8 minutes, respectively (26.8% reduction). The absolute time difference for the 2-layer anastomosis was 4.7 minutes (a 26.0% reduction in the total anastomosis time). All other perioperative outcomes were equivalent between the 2 groups. Urinary functional outcomes, including the pad use and leakage rates, were equivalent at 6 weeks. Conclusion Anastomosis during RARP with the V-Loc barbed suture can be performed safely and more efficiently than with standard monofilament suture. We demonstrated a 26% decrease in the anastomotic time with no increase in the adverse events, no instances of urinary retention and equivalent functional outcomes were measured with the self-administered patient questionnaire.

  • Urethrovesical Anastomosis Using Barbed Suture During Robot-Assisted Radical Prostatectomy
    Journal of Endourology Part B Videourology, 2011
    Co-Authors: Quoc-dien Trinh, Jesse D. Sammon, Tae-kyung Kim, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Emil Kheterpal, Naveen Pokala, Craig G. Rogers, James O. Peabody
    Abstract:

    Abstract Introduction and Objectives: Barbed polyglyconate suture (V-Loc®; Covidien, Mansfield, Massachusetts) was first used for the urethrovesical anastomosis (UVA) during robot-assisted radical prostatectomy (RARP) beginning January 2010. Safety and feasibility were previously demonstrated in 51 patients.1 In this video, we demonstrate the technique of urethrovesical anastomosis with barbed suture and the results of a randomized, controlled trial assessing perioperative and functional outcomes after urethrovesical anastomosis with barbed polyglyconate versus monofilament Poliglecaprone in RARP. Methods: After institutional review board approval, 64 patients meeting all inclusion criteria participated in this multi-surgeon prospective, randomized, controlled trial between May and September 2010. Posterior repair and urethrovesical anastomosis during RARP were performed with barbed polyglyconate (n = 33) or monofilament Poliglecaprone (n = 31) suture. Primary outcomes were anastomotic (UVA) and posterior...

  • Laparoscopy and Robotics Anastomosis During Robot-assisted Radical Prostatectomy: Randomized Controlled Trial Comparing Barbed and Standard Monofilament Suture
    2011
    Co-Authors: Jesse D. Sammon, Quoc-dien Trinh, Tae-kyung Kim, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Craig G. Rogers, James O. Peabody
    Abstract:

    OBJECTIVE To compare perioperative and functional outcomes after urethrovesical anastomosis (UVA) with barbed polyglyconate and monofilament Poliglecaprone in robot-assisted radical prostatectomy (RARP). Barbed polyglyconate suture was first used for the UVA during RARP beginning in January 2010; safety and feasibility were previously demonstrated in 51 patients. METHODS From May to September 2010, 64 patients meeting all the inclusion criteria participated in the present multisurgeon prospective, randomized, controlled trial and underwent posterior repair and UVA during RARP with either barbed polyglyconate (n 33) or monofilament Poliglecaprone (n 31) suture. The primary outcomes were the anastomotic (UVA) and posterior reconstruction times. Secondary outcomes included cystogram leak, bladder neck reconstruction rate, and 6-week functional outcomes assessed by a self-administered validated patient questionnaire. RESULTS Posterior reconstruction was performed within 3.3 minutes with the barbed suture versus 4.3 minutes with the monofilament Poliglecaprone suture (23.3% reduction) and UVA within 10.1 versus 13.8 minutes, respectively (26.8% reduction). The absolute time difference for the 2-layer anastomosis was 4.7 minutes (a 26.0% reduction in the total anastomosis time). All other perioperative outcomes were equivalent between the 2 groups. Urinary functional outcomes, including the pad use and leakage rates, were equivalent at 6 weeks. CONCLUSION Anastomosis during RARP with the V-Loc barbed suture can be performed safely and more efficiently than with standard monofilament suture. We demonstrated a 26% decrease in the anastomotic time with no increase in the adverse events, no instances of urinary retention and equivalent functional outcomes were measured with the self-administered patient questionnaire. UROLOGY 78: 572‐580, 2011. © 2011 Elsevier Inc.

Quoc-dien Trinh - One of the best experts on this subject based on the ideXlab platform.

  • anastomosis during robot assisted radical prostatectomy randomized controlled trial comparing barbed and standard monofilament suture
    Urology, 2011
    Co-Authors: Jesse D. Sammon, Quoc-dien Trinh, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Craig G. Rogers, James O. Peabody
    Abstract:

    Objective To compare perioperative and functional outcomes after urethrovesical anastomosis (UVA) with barbed polyglyconate and monofilament Poliglecaprone in robot-assisted radical prostatectomy (RARP). Barbed polyglyconate suture was first used for the UVA during RARP beginning in January 2010; safety and feasibility were previously demonstrated in 51 patients. Methods From May to September 2010, 64 patients meeting all the inclusion criteria participated in the present multisurgeon prospective, randomized, controlled trial and underwent posterior repair and UVA during RARP with either barbed polyglyconate (n = 33) or monofilament Poliglecaprone (n = 31) suture. The primary outcomes were the anastomotic (UVA) and posterior reconstruction times. Secondary outcomes included cystogram leak, bladder neck reconstruction rate, and 6-week functional outcomes assessed by a self-administered validated patient questionnaire. Results Posterior reconstruction was performed within 3.3 minutes with the barbed suture versus 4.3 minutes with the monofilament Poliglecaprone suture (23.3% reduction) and UVA within 10.1 versus 13.8 minutes, respectively (26.8% reduction). The absolute time difference for the 2-layer anastomosis was 4.7 minutes (a 26.0% reduction in the total anastomosis time). All other perioperative outcomes were equivalent between the 2 groups. Urinary functional outcomes, including the pad use and leakage rates, were equivalent at 6 weeks. Conclusion Anastomosis during RARP with the V-Loc barbed suture can be performed safely and more efficiently than with standard monofilament suture. We demonstrated a 26% decrease in the anastomotic time with no increase in the adverse events, no instances of urinary retention and equivalent functional outcomes were measured with the self-administered patient questionnaire.

  • Urethrovesical Anastomosis Using Barbed Suture During Robot-Assisted Radical Prostatectomy
    Journal of Endourology Part B Videourology, 2011
    Co-Authors: Quoc-dien Trinh, Jesse D. Sammon, Tae-kyung Kim, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Emil Kheterpal, Naveen Pokala, Craig G. Rogers, James O. Peabody
    Abstract:

    Abstract Introduction and Objectives: Barbed polyglyconate suture (V-Loc®; Covidien, Mansfield, Massachusetts) was first used for the urethrovesical anastomosis (UVA) during robot-assisted radical prostatectomy (RARP) beginning January 2010. Safety and feasibility were previously demonstrated in 51 patients.1 In this video, we demonstrate the technique of urethrovesical anastomosis with barbed suture and the results of a randomized, controlled trial assessing perioperative and functional outcomes after urethrovesical anastomosis with barbed polyglyconate versus monofilament Poliglecaprone in RARP. Methods: After institutional review board approval, 64 patients meeting all inclusion criteria participated in this multi-surgeon prospective, randomized, controlled trial between May and September 2010. Posterior repair and urethrovesical anastomosis during RARP were performed with barbed polyglyconate (n = 33) or monofilament Poliglecaprone (n = 31) suture. Primary outcomes were anastomotic (UVA) and posterior...

  • Laparoscopy and Robotics Anastomosis During Robot-assisted Radical Prostatectomy: Randomized Controlled Trial Comparing Barbed and Standard Monofilament Suture
    2011
    Co-Authors: Jesse D. Sammon, Quoc-dien Trinh, Tae-kyung Kim, Akshay Bhandari, Sanjeev Kaul, Shyam Sukumar, Craig G. Rogers, James O. Peabody
    Abstract:

    OBJECTIVE To compare perioperative and functional outcomes after urethrovesical anastomosis (UVA) with barbed polyglyconate and monofilament Poliglecaprone in robot-assisted radical prostatectomy (RARP). Barbed polyglyconate suture was first used for the UVA during RARP beginning in January 2010; safety and feasibility were previously demonstrated in 51 patients. METHODS From May to September 2010, 64 patients meeting all the inclusion criteria participated in the present multisurgeon prospective, randomized, controlled trial and underwent posterior repair and UVA during RARP with either barbed polyglyconate (n 33) or monofilament Poliglecaprone (n 31) suture. The primary outcomes were the anastomotic (UVA) and posterior reconstruction times. Secondary outcomes included cystogram leak, bladder neck reconstruction rate, and 6-week functional outcomes assessed by a self-administered validated patient questionnaire. RESULTS Posterior reconstruction was performed within 3.3 minutes with the barbed suture versus 4.3 minutes with the monofilament Poliglecaprone suture (23.3% reduction) and UVA within 10.1 versus 13.8 minutes, respectively (26.8% reduction). The absolute time difference for the 2-layer anastomosis was 4.7 minutes (a 26.0% reduction in the total anastomosis time). All other perioperative outcomes were equivalent between the 2 groups. Urinary functional outcomes, including the pad use and leakage rates, were equivalent at 6 weeks. CONCLUSION Anastomosis during RARP with the V-Loc barbed suture can be performed safely and more efficiently than with standard monofilament suture. We demonstrated a 26% decrease in the anastomotic time with no increase in the adverse events, no instances of urinary retention and equivalent functional outcomes were measured with the self-administered patient questionnaire. UROLOGY 78: 572‐580, 2011. © 2011 Elsevier Inc.