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Loic Guillevin - One of the best experts on this subject based on the ideXlab platform.

  • Polyarteritis nodosa neurologic manifestations
    Neurologic Clinics, 2019
    Co-Authors: Hubert De Boysson, Loic Guillevin
    Abstract:

    Polyarteritis nodosa (PAN) is a necrotizing vasculitis affecting medium-sized vessels whose main manifestations are weight loss, fever, peripheral neuropathy, renal, musculoskeletal, gastrointestinal tract and/or cutaneous involvement(s), hypertension and/or cardiac failure. Peripheral neuropathy is one of the most frequent and earliest symptoms, affecting 50% to 75% of PAN patients. Central nervous system involvement affects only 2% to 10% of PAN patients, often late during the disease course. Treatment relies on combining corticosteroids and an immunosuppressant (mainly cyclophosphamide) in patients with poor prognoses. In patients with hepatitis B virus-related PAN, plasma exchanges and antiviral drugs should be combined with corticosteroids.

  • hepatitis b virus associated Polyarteritis nodosa clinical characteristics outcome and impact of treatment in 115 patients
    Medicine, 2005
    Co-Authors: Loic Guillevin, Christian Pagnoux, Alfred Mahr, Patrice Callard, Pascal Godmer, Emmanuelle Leray, Pascal Cohen
    Abstract:

    Abstract:Hepatitis B virus-associated Polyarteritis nodosa (HBV-PAN) is a typical form of classic PAN whose pathogenesis has been attributed to immune-complex deposition with antigen excess. We conducted the current study to 1) analyze the frequency of HBV infection in patients with PAN, in light of

  • microscopic polyangiitis and Polyarteritis nodosa how and when do they start
    Arthritis & Rheumatism, 2003
    Co-Authors: C Agard, Alfred Mahr, Luc Mouthon, Loic Guillevin
    Abstract:

    Objective To describe initial clinical symptoms attributable to microscopic polyangiitis (MPA) or Polyarteritis nodosa (PAN). Methods We retrospectively reviewed the medical files of 72 patients (mean followup 6.7 years) with biopsy-proven MPA (n = 36) or PAN (n = 36). Results Initial manifestations were similar in both entities except for peripheral neuropathy (P = 0.02) and gastrointestinal tract involvement (P = 0.006), which were significantly more frequent in PAN, and general signs alone in MPA (8%; P = 0.02). The mean time to diagnosis was 9.8 ± 19.4 months; 35% of the patients died and 26% relapsed; significantly more MPA than PAN patients relapsed (P = 0.03). Time to diagnosis ≥90 days was associated with a trend toward more patients relapsing (P = 0.12), but not with an increased risk of mortality. Conclusion Initial symptoms of MPA and PAN are usually nonspecific and last for several months before the diagnosis is made. A longer time to diagnosis is associated with a tendency to a higher relapse rate.

  • Polyarteritis nodosa microscopic polyangiitis and churg strauss syndrome
    Lupus, 1998
    Co-Authors: F Lhote, Pascal Cohen, Loic Guillevin
    Abstract:

    Polyarteritis nodosa (PAN), first described by Kussmaul and Maier, is a well-known form of necrotizing angiitis whose manifestations are weight loss, fever, asthenia, peripheral neuropathy, renal involvement, musculoskeletal and cutaneous manifestations, hypertension, gastrointestinal tract involvement, and cardiac failure. Recently individualized from PAN, microscopic polyangiitis (MPA) is a systemic vasculitis of small-size vessels whose clinical manifestations are very similar to those of PAN, but it is characterized by the presence of rapidly progressive glomerulonephritis (RPGN), which is nearly constant, and pulmonary involvement usually absent in PAN. Churg Strauss syndrome (CSS) is a disorder characterized by hypereosinophilia and systemic vasculitis similar to that of PAN and occurring in individuals with asthma and allergic rhinitis. Considering the etiologies of PAN, primary and secondary vasculitides can also be distinguished because PAN can be the consequence of hepatitis B virus (HBV) infection and sometimes of other etiologic agents. The prognosis of systemic vasculitides has been transformed by corticosteroids that are, except in HBV-related PAN, the basic treatment. Immunosuppressive drugs, especially cyclophophamide, have also contributed to improving the prognosis, but their precise role in the management of these vasculitides is still being elucidated.

  • Polyarteritis nodosa related to hepatitis b virus a prospective study with long term observation of 41 patients
    Medicine, 1995
    Co-Authors: Loic Guillevin, F Lhote, Pascal Cohen, Francoise Sauvaget, B Jarrousse, Olivier Lortholary, Laurehelene Noel, Christian Trepo
    Abstract:

    Polyarteritis nodosa Related to Hepatitis B Virus A Prospective Study with Long-Term Observation of 41 Patients Loic Guillevin;Francois Lhote;Pascal Cohen;Francoise Sauvaget;Bernard Jarrousse;Olivier Lortholary;Laure-Helene Noel;Christian Trepo; Medicine

F Lhote - One of the best experts on this subject based on the ideXlab platform.

  • Polyarteritis nodosa microscopic polyangiitis and churg strauss syndrome
    Lupus, 1998
    Co-Authors: F Lhote, Pascal Cohen, Loic Guillevin
    Abstract:

    Polyarteritis nodosa (PAN), first described by Kussmaul and Maier, is a well-known form of necrotizing angiitis whose manifestations are weight loss, fever, asthenia, peripheral neuropathy, renal involvement, musculoskeletal and cutaneous manifestations, hypertension, gastrointestinal tract involvement, and cardiac failure. Recently individualized from PAN, microscopic polyangiitis (MPA) is a systemic vasculitis of small-size vessels whose clinical manifestations are very similar to those of PAN, but it is characterized by the presence of rapidly progressive glomerulonephritis (RPGN), which is nearly constant, and pulmonary involvement usually absent in PAN. Churg Strauss syndrome (CSS) is a disorder characterized by hypereosinophilia and systemic vasculitis similar to that of PAN and occurring in individuals with asthma and allergic rhinitis. Considering the etiologies of PAN, primary and secondary vasculitides can also be distinguished because PAN can be the consequence of hepatitis B virus (HBV) infection and sometimes of other etiologic agents. The prognosis of systemic vasculitides has been transformed by corticosteroids that are, except in HBV-related PAN, the basic treatment. Immunosuppressive drugs, especially cyclophophamide, have also contributed to improving the prognosis, but their precise role in the management of these vasculitides is still being elucidated.

  • Polyarteritis nodosa related to hepatitis b virus a prospective study with long term observation of 41 patients
    Medicine, 1995
    Co-Authors: Loic Guillevin, F Lhote, Pascal Cohen, Francoise Sauvaget, B Jarrousse, Olivier Lortholary, Laurehelene Noel, Christian Trepo
    Abstract:

    Polyarteritis nodosa Related to Hepatitis B Virus A Prospective Study with Long-Term Observation of 41 Patients Loic Guillevin;Francois Lhote;Pascal Cohen;Francoise Sauvaget;Bernard Jarrousse;Olivier Lortholary;Laure-Helene Noel;Christian Trepo; Medicine

  • distinguishing Polyarteritis nodosa from microscopic polyangiitis and implications for treatment
    Current Opinion in Rheumatology, 1995
    Co-Authors: Loic Guillevin, F Lhote
    Abstract:

    The vasculitides are a heterogeneous group of disorders for which classification is needed to facilitate diagnosis and treatment. Recent studies based on a more comprehensive clinical analysis of symptoms and virologic investigations favor the recognition, in the Polyarteritis nodosa (PAN) group, of a distinct form of systemic vasculitis called microscopic polyangiitis (MPA). This distinction may be confusing, so the features of each condition need to be more precisely defined. Differentiation between PAN and MPA cannot be based on only histologic criteria. Clinical manifestations (especially lung and kidney involvement), biologic signs (antineutrophil cytoplasmic antibodies and hepatitis B and C infection), and angiographic data must be taken into consideration. Therapeutic strategy should differ dramatically, depending on whether primary or secondary MPA or PAN has been diagnosed, and treatment optimization is certainly the best reason for improving the classification of the systemic vasculitides.

E C Keystone - One of the best experts on this subject based on the ideXlab platform.

  • outcome of Polyarteritis nodosa and churg strauss syndrome
    Arthritis & Rheumatism, 1994
    Co-Authors: Mahmoud Abushakra, H A Smythe, Jody Lewtas, Elizabeth M Badley, Deborah Weber, E C Keystone
    Abstract:

    Objective. To compare outcome in patients with Polyarteritis nodosa (PAN) and patients with Churg-Strauss syndrome (CSS) followed up at a single center. Methods. A retrospective data review of 13 patients with PAN and 12 patients with CSS who were followed up at a vasculitis clinic. Outcome measures included a global damage index, disability and pain dimensions of the Health Assessment Questionnaire, and mortality rate. Results. Compared with patients with CSS, patients with PAN had a significantly higher mean damage index score (5.15 versus 2.42; P = 0.011), a higher disability score (1.09 versus 0.16; P = 0.007), and a higher pain score (1.04 versus 0.01; P = 0.017). Patients with PAN had more relapses (relative risk = 5.07; P < 0.000) and a higher mortality rate (31%) compared with patients with CSS (8%). Conclusion. PAN and CSS differ in their morbidity and mortality; therefore, they should be considered as distinct clinical entities.

Guillevin L - One of the best experts on this subject based on the ideXlab platform.

Pascal Cohen - One of the best experts on this subject based on the ideXlab platform.

  • hepatitis b virus associated Polyarteritis nodosa clinical characteristics outcome and impact of treatment in 115 patients
    Medicine, 2005
    Co-Authors: Loic Guillevin, Christian Pagnoux, Alfred Mahr, Patrice Callard, Pascal Godmer, Emmanuelle Leray, Pascal Cohen
    Abstract:

    Abstract:Hepatitis B virus-associated Polyarteritis nodosa (HBV-PAN) is a typical form of classic PAN whose pathogenesis has been attributed to immune-complex deposition with antigen excess. We conducted the current study to 1) analyze the frequency of HBV infection in patients with PAN, in light of

  • Polyarteritis nodosa microscopic polyangiitis and churg strauss syndrome
    Lupus, 1998
    Co-Authors: F Lhote, Pascal Cohen, Loic Guillevin
    Abstract:

    Polyarteritis nodosa (PAN), first described by Kussmaul and Maier, is a well-known form of necrotizing angiitis whose manifestations are weight loss, fever, asthenia, peripheral neuropathy, renal involvement, musculoskeletal and cutaneous manifestations, hypertension, gastrointestinal tract involvement, and cardiac failure. Recently individualized from PAN, microscopic polyangiitis (MPA) is a systemic vasculitis of small-size vessels whose clinical manifestations are very similar to those of PAN, but it is characterized by the presence of rapidly progressive glomerulonephritis (RPGN), which is nearly constant, and pulmonary involvement usually absent in PAN. Churg Strauss syndrome (CSS) is a disorder characterized by hypereosinophilia and systemic vasculitis similar to that of PAN and occurring in individuals with asthma and allergic rhinitis. Considering the etiologies of PAN, primary and secondary vasculitides can also be distinguished because PAN can be the consequence of hepatitis B virus (HBV) infection and sometimes of other etiologic agents. The prognosis of systemic vasculitides has been transformed by corticosteroids that are, except in HBV-related PAN, the basic treatment. Immunosuppressive drugs, especially cyclophophamide, have also contributed to improving the prognosis, but their precise role in the management of these vasculitides is still being elucidated.

  • Polyarteritis nodosa related to hepatitis b virus a prospective study with long term observation of 41 patients
    Medicine, 1995
    Co-Authors: Loic Guillevin, F Lhote, Pascal Cohen, Francoise Sauvaget, B Jarrousse, Olivier Lortholary, Laurehelene Noel, Christian Trepo
    Abstract:

    Polyarteritis nodosa Related to Hepatitis B Virus A Prospective Study with Long-Term Observation of 41 Patients Loic Guillevin;Francois Lhote;Pascal Cohen;Francoise Sauvaget;Bernard Jarrousse;Olivier Lortholary;Laure-Helene Noel;Christian Trepo; Medicine