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Aleš Mrhar - One of the best experts on this subject based on the ideXlab platform.

  • mucoadhesion on pig vesical mucosa influence of Polycarbophil Calcium interactions
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

  • Mucoadhesion on pig vesical mucosa: influence of Polycarbophil/Calcium interactions.
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

Mojca Kerec - One of the best experts on this subject based on the ideXlab platform.

  • mucoadhesion on pig vesical mucosa influence of Polycarbophil Calcium interactions
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

  • Mucoadhesion on pig vesical mucosa: influence of Polycarbophil/Calcium interactions.
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

B Mugerle - One of the best experts on this subject based on the ideXlab platform.

  • mucoadhesion on pig vesical mucosa influence of Polycarbophil Calcium interactions
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

  • Mucoadhesion on pig vesical mucosa: influence of Polycarbophil/Calcium interactions.
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

Mirjana Gašperlin - One of the best experts on this subject based on the ideXlab platform.

  • mucoadhesion on pig vesical mucosa influence of Polycarbophil Calcium interactions
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

  • Mucoadhesion on pig vesical mucosa: influence of Polycarbophil/Calcium interactions.
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

Marija Bogataj - One of the best experts on this subject based on the ideXlab platform.

  • mucoadhesion on pig vesical mucosa influence of Polycarbophil Calcium interactions
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.

  • Mucoadhesion on pig vesical mucosa: influence of Polycarbophil/Calcium interactions.
    International Journal of Pharmaceutics, 2002
    Co-Authors: Mojca Kerec, Marija Bogataj, B Mugerle, Mirjana Gašperlin, Aleš Mrhar
    Abstract:

    The influence of Polycarbophil/Calcium interactions on the mucoadhesive properties of Polycarbophil has been examined. Polycarbophil dispersions and films with different concentrations of Calcium or sodium ions were prepared and the following parameters were measured: detachment force on pig vesical mucosa, zeta potential, pH and viscosity. Polycarbophil detachment force decreased significantly in the presence of Calcium but not sodium. Both ions decrease the pH of Polycarbophil dispersions. On the other hand, altering the pH of hydrated Polycarbophil films in the absence of added ions had an insignificant effect on detachment force. Both ions reduce the absolute values of Polycarbophil zeta potential, Calcium more efficiently than sodium. We could conclude that decreased mucoadhesion strength of Polycarbophil in the presence of Calcium is due to the chelation of Polycarbophil carboxylic groups by Calcium and crosslinking of polymer. The crosslinked polymer chains would be expected to be less flexible, and therefore, interpenetrate to a lesser extent with the glycosaminoglycans of mucus. Additionally, the interactions between functional groups of Polycarbophil and mucus glycosaminoglycans are lowered due to the Calcium, blocking the carboxylic groups. The mechanism of Calcium influence on viscosity of Polycarbophil dispersions appears to be different: repulsion between ionised carboxylic groups of Polycarbophil prevails over the crosslinking of Polycarbophil by Calcium.