The Experts below are selected from a list of 150 Experts worldwide ranked by ideXlab platform
Xinggang Yang - One of the best experts on this subject based on the ideXlab platform.
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in vitro and in vivo evaluation of controlled release matrix tablets of highly water soluble drug applying different mw Polyethylene Oxides peo as retardants
Drug Development and Industrial Pharmacy, 2018Co-Authors: Haoyang Wen, Weisan Pan, Haiying Wang, Yanyan Wang, Tuanjie Wang, Xinggang YangAbstract:The aim of the work presented is to prepare a controlled-release hydrophilic matrix tablet (CMT) controlling release of highly water-soluble drug applying pure combination of high- and low-Mw PEO as matrix materials, to avoid the lag time of drug release, and to overcome incomplete release in later stages. The influences of types and amounts of different Mw PEOs used, drug loading, pH of release medium and agitation rate on drug release were evaluated. The study of uptake and erosion of matrix was conducted and mechanism of improving drug release was discussed. In vivo pharmacokinetics of the CMT and reference preparation self-made controlled-release osmotic pump tablets (COPT) were performed in beagle dogs. The optimized formulation containing 43% PEO WSR 303 and 32% PEO N750 showed a zero order release from 1 h to 12 h. In vivo results demonstrated that the CMT had similar AUC0-48 h and Cmax with the COPT but smaller Tmax than the COPT and provided a more stable therapeutic concentration compare...
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zero order controlled delivery of gliclazide from Polyethylene Oxides matrix tables in vitro and in vivo evaluation
Current Drug Delivery, 2017Co-Authors: Lijie Wang, Xinggang Yang, Kai Chen, Haoyang Wen, Weisan PanAbstract:Background: In recent years, controlled and sustained release drug delivery system has become the focus of pharmaceutical researchers. Some technologies aimed to develop the controlled and sustained release of the drug, which used to be administered several times a day and generate plasma concentration fluctuation. As all, a controlled drug release rate has always been a goal pursued by researchers. This paper introduced a controlled delivery hydrophilic matrix system, and evaluated their relevance between in vitro and in vivo behaviors. Methods: The matrix tablets were fabricated by direct powder compression method. Single-factor test and the orthogonal experimental design were used to find out the optimal formulation. And the in vivo pharmacokinetics study was also evaluated in this paper. Results: The amount of WSR N301 and low viscosity materials significantly affect the drug release. Compared with commercially available sustained-release tablets Diamicron ® , the pharmacokinetics parameters of these matrix tablets exhibited similar blood profiles, and other parameters such as prolonged T max , C max , MRT and similar bioavailability. However, this matrix system showed unstable blood profiles in comparison with two-layer-core osmotic pump tablet. The IVIVC study suggested that there was a good correlation between absorption in vivo and drug release in vitro. Conclusion: Zero-order controlled drug release of hydrophilic matrix system has the simpler manufacture process. And it will be a promising system to control drug release. Due to the disadvantage of hydrophilic matrix tablets in vivo release, for further research the zero-order delivery of PEO matrix tablets system, some pharmaceutical technology are needed to decrease the influence of gastrointestinal peristalsis. Therefore, the study of Polyethylene oxide hydrophilic matrix tablets provides a promising formulation for promoting the development of a drug delivery system.
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design and evaluation of hydrophilic matrix system containing Polyethylene Oxides for the zero order controlled delivery of water insoluble drugs
Aaps Pharmscitech, 2017Co-Authors: Lijie Wang, Kai Chen, Haoyang Wen, Weisan Pan, Defang Ouyang, Yunyun Gao, Xinggang YangAbstract:The aim of this study was to design a Polyethylene oxide (PEO) binary hydrophilic matrix controlled system and investigate the most important influence(s) on the in vitro water-insoluble drug release behavior of this controlled system. Direct-compressed PEO binary matrix tablets were obtained from a variety of low viscosity hydrophilic materials as a sustained agent, using anhydrous drugs as a model drug. Water uptake rate, swelling rate, and erosion rate of matrices were investigated for the evaluation of the PEO hydrophilic matrix systems. The effect of the dose, the solubility of water-insoluble drug, and the rheology of polymers on in vitro release were also discussed. Based on the in vitro release kinetics study, three optimized PEO binary matrices were selected for further research. And, these PEO binary matrices had shown the similar release behavior that had been evaluated by the similarity factor f 2. Further study indicated that they had identical hydration, swelling, and erosion rate. Moreover, rheology study exhibited the similar rheological equation of Herschel-Bulkley and their viscosity was also within the same magnitude. Therefore, viscosity plays the most important role to control drug release compared to other factors in PEO binary matrix system. This research provides fundamental understanding of in vitro drug release of PEO binary hydrophilic matrix tablets and helps pharmaceutical workers to develop a hydrophilic controlled system, which will effectively shorten the process of formulation development by reducing trial-and-error.
Ning Zhao - One of the best experts on this subject based on the ideXlab platform.
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composite electrolytes of Polyethylene Oxides garnets interfacially wetted by ionic liquid for room temperature solid state lithium battery
Journal of Power Sources, 2017Co-Authors: Ning Zhao, Fuming Du, Yiqiu LiAbstract:Abstract Paramount attention has been paid on solid polymer electrolytes due to their potential in enhancement of energy density as well as improvement of safety. Herein, the composite electrolytes consisting of Li-salt-free Polyethylene Oxides and 200 nm-sized Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 particles interfacially wetted by [BMIM]TF 2 N of 1.8 μL cm −2 have been prepared. Such wetted ionic liquid remains the solid state of membrane electrolytes and decreases the interface impedance between the electrodes and the electrolytes. There is no release of the liquid phase from the PEO matrix when the pressure of 5.0 × 10 4 Pa being applied for 24 h. The interfacially wetted membrane electrolytes show the conductivity of 2.2 × 10 −4 S cm −1 at 20 °C, which is one order of magnitude greater than that of the membranes without the wetted ionic liquids. The conduction mechanism is related to a large number of lithium ions releasing from Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 particles and the improved conductive paths along the ion-liquid-wetted interfaces between the polymer matrix and ceramic grains. When the membranes being used in the solid-state LiFePO 4 /Li and LiFe 0.15 Mn 0.85 PO 4 /Li cells at 25 °C, the excellent rate capability and superior cycle stability has been shown. The results provide a new prospect for solid polymer electrolytes used for room-temperature solid-state lithium batteries.
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flexible and ion conducting membrane electrolytes for solid state lithium batteries dispersion of garnet nanoparticles in insulating Polyethylene oxide
Nano Energy, 2016Co-Authors: Jingxian Zhang, Ning Zhao, Miao Zhang, Paul K Chu, Xiangxin Guo, Xi WangAbstract:Abstract Solid-state electrolytes with high ionic conductivity, large electrochemical window, good mechanical properties, and easy processability are needed for high-energy solid-state lithium batteries. In this work, composite membranes consisting of lithium garnet (i.e. Li6.4La3Zr1.4Ta0.6O12, LLZTO) particles and Li-salt-free Polyethylene Oxides (PEOs) are produced as solid-state electrolytes. Li-ion-conducting particles in nano-scale are crucial for the enhancement of conductivity and the membranes containing ~40 nm LLZTO particles exhibit conductivities nearly two orders of magnitude larger than those with the micro-scale ones, which is attributed to the difference in specific surface area related to the percolation effect. Compared to the conventional PEO doped with lithium salt, the insulating PEO in PEO:LLZTO membrane electrolyte is conducive to the suppression of lithium dendrite growth owing to prohibition of current flow. With PEO:LLZTO membrane electrolytes in conductivity of 2.1×10−4 S cm−1 at 30 °C and 5.6×10−4 S cm−1 at 60 °C, the solid-state LiFePO4/PEO:LLZTO/Li and LiFe0.15Mn0.85PO4/PEO:LLZTO/Li cells deliver energy densities of 345 Wh kg−1 (662 Wh L−1) and 405 Wh kg−1 (700 Wh L−1) (without the package weight or volume) with good rate capability and cycling performance. This study suggests that the conjunction of nano-scale Li-ion-conducting particles and an insulating polymer provides a promising solution to produce powerful solid-state electrolytes for high-performance solid-state lithium batteries.
Yiqiu Li - One of the best experts on this subject based on the ideXlab platform.
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composite electrolytes of Polyethylene Oxides garnets interfacially wetted by ionic liquid for room temperature solid state lithium battery
Journal of Power Sources, 2017Co-Authors: Ning Zhao, Fuming Du, Yiqiu LiAbstract:Abstract Paramount attention has been paid on solid polymer electrolytes due to their potential in enhancement of energy density as well as improvement of safety. Herein, the composite electrolytes consisting of Li-salt-free Polyethylene Oxides and 200 nm-sized Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 particles interfacially wetted by [BMIM]TF 2 N of 1.8 μL cm −2 have been prepared. Such wetted ionic liquid remains the solid state of membrane electrolytes and decreases the interface impedance between the electrodes and the electrolytes. There is no release of the liquid phase from the PEO matrix when the pressure of 5.0 × 10 4 Pa being applied for 24 h. The interfacially wetted membrane electrolytes show the conductivity of 2.2 × 10 −4 S cm −1 at 20 °C, which is one order of magnitude greater than that of the membranes without the wetted ionic liquids. The conduction mechanism is related to a large number of lithium ions releasing from Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 particles and the improved conductive paths along the ion-liquid-wetted interfaces between the polymer matrix and ceramic grains. When the membranes being used in the solid-state LiFePO 4 /Li and LiFe 0.15 Mn 0.85 PO 4 /Li cells at 25 °C, the excellent rate capability and superior cycle stability has been shown. The results provide a new prospect for solid polymer electrolytes used for room-temperature solid-state lithium batteries.
Haoyang Wen - One of the best experts on this subject based on the ideXlab platform.
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in vitro and in vivo evaluation of controlled release matrix tablets of highly water soluble drug applying different mw Polyethylene Oxides peo as retardants
Drug Development and Industrial Pharmacy, 2018Co-Authors: Haoyang Wen, Weisan Pan, Haiying Wang, Yanyan Wang, Tuanjie Wang, Xinggang YangAbstract:The aim of the work presented is to prepare a controlled-release hydrophilic matrix tablet (CMT) controlling release of highly water-soluble drug applying pure combination of high- and low-Mw PEO as matrix materials, to avoid the lag time of drug release, and to overcome incomplete release in later stages. The influences of types and amounts of different Mw PEOs used, drug loading, pH of release medium and agitation rate on drug release were evaluated. The study of uptake and erosion of matrix was conducted and mechanism of improving drug release was discussed. In vivo pharmacokinetics of the CMT and reference preparation self-made controlled-release osmotic pump tablets (COPT) were performed in beagle dogs. The optimized formulation containing 43% PEO WSR 303 and 32% PEO N750 showed a zero order release from 1 h to 12 h. In vivo results demonstrated that the CMT had similar AUC0-48 h and Cmax with the COPT but smaller Tmax than the COPT and provided a more stable therapeutic concentration compare...
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zero order controlled delivery of gliclazide from Polyethylene Oxides matrix tables in vitro and in vivo evaluation
Current Drug Delivery, 2017Co-Authors: Lijie Wang, Xinggang Yang, Kai Chen, Haoyang Wen, Weisan PanAbstract:Background: In recent years, controlled and sustained release drug delivery system has become the focus of pharmaceutical researchers. Some technologies aimed to develop the controlled and sustained release of the drug, which used to be administered several times a day and generate plasma concentration fluctuation. As all, a controlled drug release rate has always been a goal pursued by researchers. This paper introduced a controlled delivery hydrophilic matrix system, and evaluated their relevance between in vitro and in vivo behaviors. Methods: The matrix tablets were fabricated by direct powder compression method. Single-factor test and the orthogonal experimental design were used to find out the optimal formulation. And the in vivo pharmacokinetics study was also evaluated in this paper. Results: The amount of WSR N301 and low viscosity materials significantly affect the drug release. Compared with commercially available sustained-release tablets Diamicron ® , the pharmacokinetics parameters of these matrix tablets exhibited similar blood profiles, and other parameters such as prolonged T max , C max , MRT and similar bioavailability. However, this matrix system showed unstable blood profiles in comparison with two-layer-core osmotic pump tablet. The IVIVC study suggested that there was a good correlation between absorption in vivo and drug release in vitro. Conclusion: Zero-order controlled drug release of hydrophilic matrix system has the simpler manufacture process. And it will be a promising system to control drug release. Due to the disadvantage of hydrophilic matrix tablets in vivo release, for further research the zero-order delivery of PEO matrix tablets system, some pharmaceutical technology are needed to decrease the influence of gastrointestinal peristalsis. Therefore, the study of Polyethylene oxide hydrophilic matrix tablets provides a promising formulation for promoting the development of a drug delivery system.
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design and evaluation of hydrophilic matrix system containing Polyethylene Oxides for the zero order controlled delivery of water insoluble drugs
Aaps Pharmscitech, 2017Co-Authors: Lijie Wang, Kai Chen, Haoyang Wen, Weisan Pan, Defang Ouyang, Yunyun Gao, Xinggang YangAbstract:The aim of this study was to design a Polyethylene oxide (PEO) binary hydrophilic matrix controlled system and investigate the most important influence(s) on the in vitro water-insoluble drug release behavior of this controlled system. Direct-compressed PEO binary matrix tablets were obtained from a variety of low viscosity hydrophilic materials as a sustained agent, using anhydrous drugs as a model drug. Water uptake rate, swelling rate, and erosion rate of matrices were investigated for the evaluation of the PEO hydrophilic matrix systems. The effect of the dose, the solubility of water-insoluble drug, and the rheology of polymers on in vitro release were also discussed. Based on the in vitro release kinetics study, three optimized PEO binary matrices were selected for further research. And, these PEO binary matrices had shown the similar release behavior that had been evaluated by the similarity factor f 2. Further study indicated that they had identical hydration, swelling, and erosion rate. Moreover, rheology study exhibited the similar rheological equation of Herschel-Bulkley and their viscosity was also within the same magnitude. Therefore, viscosity plays the most important role to control drug release compared to other factors in PEO binary matrix system. This research provides fundamental understanding of in vitro drug release of PEO binary hydrophilic matrix tablets and helps pharmaceutical workers to develop a hydrophilic controlled system, which will effectively shorten the process of formulation development by reducing trial-and-error.
U Conte - One of the best experts on this subject based on the ideXlab platform.
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dissolution behaviour of hydrophilic matrix tablets containing two different Polyethylene Oxides peos for the controlled release of a water soluble drug dimensionality study
Biomaterials, 2002Co-Authors: L Maggi, L Segale, Maria Luisa Torre, Ochoa E Machiste, U ConteAbstract:Abstract Hydrophilic matrix tablets containing Polyethylene Oxides as the retarding polymer have been successfully employed in the controlled release of drugs. To evaluate the relative influence of drug diffusion and polymer erosion mechanisms in the drug delivery process, we studied the hydration behaviour of matrix tablets containing a water-soluble drug and PEOs of two different molecular weights: Polyox WSRN 1105 (Mw=0.9×106) and Polyox WSRN 301 (Mw=4×106). The hydration rate, the extent of swelling, and the erosion rate of matrices containing the polymer, the drug and tableting excipients were evaluated in comparison to tablets made of pure polymer. The results of these studies on function of the release behaviour were then discussed. The results show that the higher molecular weight PEO swells to a greater extent and tends to form, upon hydration, a stronger gel, which is therefore less liable to erosion, if compared to the lower molecular weight PEO. This difference in the erosion behaviour can explain the different efficiencies of the two polymeric products in modulating the delivery rate of the water-soluble drug. Moreover, the presence of other soluble components (drug and excipients) in the dosage form enhances the erosion trend of the tablets with a consequent reduction of the efficiency of the polymer in drug release control.
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high molecular weight Polyethylene Oxides peos as an alternative to hpmc in controlled release dosage forms
International Journal of Pharmaceutics, 2000Co-Authors: L Maggi, R Bruni, U ConteAbstract:Abstract High molecular weight Polyethylene Oxides (PEOs) have recently been proposed as an alternative to hydroxypropylmethylcellulose (HPMC) in controlled release matrix tablets. In this study, we compared the performance of PEO and HPMC polymers when employed in the Geomatrix® 1 technology, a versatile, well-known method to achieve extended release of drugs at a constant rate. Four core formulations were prepared, containing a soluble drug (diltiazem) and, alternatively, PEO or HPMC of two different viscosity grades. These formulations have the same composition except for the polymer employed. Similarly, four barrier formulations were also prepared, which only differ in the kind of polymer employed. Three-layer Geomatrix® systems were then prepared using these core and barrier formulations. The release profiles of the different three-layer systems obtained were compared, to verify if PEO could efficiently replace HPMC in this type of dosage form. The results show that slower release rates can be obtained from the plain matrices containing HPMC compared to PEO, moreover HPMC, used in the barrier formulations, is generally more efficient in controlling drug release rate in three-layer Geomatrix systems.