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Zhiqiang Liu - One of the best experts on this subject based on the ideXlab platform.

  • study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the uplc esi qtof ms metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

  • Study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the UPLC-ESI-QTOF/MS metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

Weijia Chen - One of the best experts on this subject based on the ideXlab platform.

  • study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the uplc esi qtof ms metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

  • Study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the UPLC-ESI-QTOF/MS metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

Shu Liu - One of the best experts on this subject based on the ideXlab platform.

  • study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the uplc esi qtof ms metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

  • Study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the UPLC-ESI-QTOF/MS metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

Fengrui Song - One of the best experts on this subject based on the ideXlab platform.

  • study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the uplc esi qtof ms metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

  • Study on the treatment effect of Polygonum Cuspidatum for hyperuricemia in rats using the UPLC-ESI-QTOF/MS metabolomics approach
    Analytical Methods, 2015
    Co-Authors: Weijia Chen, Shu Liu, Fengrui Song, Zhiqiang Liu
    Abstract:

    A urinary metabolomics study based on ultra-performance liquid chromatography-electrospray ionization quadruple time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS) coupled with a pattern recognition approach was conducted to study the mechanism of Polygonum Cuspidatum, a traditional Chinese medicine, in treating hyperuricemic rats. Moreover, serum samples for biochemical measurements and kidney samples for histopathology were collected and measured. The results showed that a clear separation among healthy control rats, hyperuricemic rats and Polygonum Cuspidatum-treated rats was achieved by using pattern recognition approaches including principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). It revealed that Polygonum Cuspidatum could prevent the pathological process of hyperuricemia by regulating eighteen potential biomarkers associated with purine metabolism, tryptophan metabolism, tricarboxylic acid (TCA) cycle, phenylalanine metabolism, fatty acid metabolism, arginine and proline metabolism, valine metabolism and tyrosine metabolism. The biochemical assay and histopathological assay confirmed that Polygonum Cuspidatum could significantly reduce uric acid and showed a protective effect on kidneys of hyperuricemic rats.

Hong Zhou - One of the best experts on this subject based on the ideXlab platform.

  • botany phytochemistry pharmacology and potential application of Polygonum Cuspidatum sieb et zucc a review
    Journal of Ethnopharmacology, 2013
    Co-Authors: Wei Peng, Rongxin Qin, Hong Zhou
    Abstract:

    Abstract Ethnopharmacological relevance Polygonum Cuspidatum Sieb. et Zucc. (Polygonum Cuspidatum), also known as Reynoutria japonica Houtt and Huzhang in China, is a traditional and popular Chinese medicinal herb. Polygonum Cuspidatum with a wide spectrum of pharmacological effects has been used for treatment of inflammation, favus, jaundice, scald, and hyperlipemia, etc. Aim of the review The present paper reviews the traditional applications as well as advances in botany, phytochemistry, pharmacodynamics, pharmacokinetics and toxicology of this plant. Finally, the tendency and perspective for future investigation of this plant are discussed, too. Materials and methods A systematic review of literature about Polygonum Cuspidatum is carried out using resources including classic books about Chinese herbal medicine, and scientific databases including Pubmed, SciFinder, Scopus, the Web of Science and others. Results Polygonum Cuspidatum is widely distributed in the world and has been used as a traditional medicine for a long history in China. Over 67 compounds including quinones, stilbenes, flavonoids, counmarins and ligans have been isolated and identified from this plant. The root of this plant is used as the effective agent in pre-clinical and clinical practice for regulating lipids, anti-endotoxic shock, anti-infection and anti-inflammation, anti-cancer and other diseases in China and Japan. Conclusion As an important traditional Chinese medicine, Polygonum Cuspidatum has been used for treatment of hyperlipemia, inflammation, infection and cancer, etc. Because there is no enough systemic data about the chemical constituents and their pharmacological effects or toxicities, it is important to investigate the pharmacological effects and molecular mechanisms of this plant based on modern realization of diseases’ pathophysiology. Drug target-guided and bioactivity-guided isolation and purification of the chemical constituents from this plant and subsequent evaluation of their pharmacologic effects will promote the development of new drug and make sure which chemical constituent or multiple ingredients contributes its pharmacological effects. Additionally, chemicals and their pharmacological effects of the other parts such as the aerial part of this plant should be exploited in order to avoid resource waste and find new chemical constituents.