The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform

Dietmar W Hutmacher - One of the best experts on this subject based on the ideXlab platform.

  • initial design and physical characterization of a Polymeric Device for osmosis driven delayed burst delivery of vaccines
    Biotechnology and Bioengineering, 2015
    Co-Authors: Ferry P W Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville, Dietmar W Hutmacher
    Abstract:

    Achieving the combination of delayed and immediate release of a vaccine from a delivery Device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(e-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131.t + 3.4 (R2 = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic e -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico–chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound. Biotechnol. Bioeng. 2015;112: 1927–1935. © 2015 Wiley Periodicals, Inc.

  • initial design and physical characterization of a Polymeric Device for osmosis driven delayed burst delivery of vaccines
    Faculty of Health; Institute of Health and Biomedical Innovation; Science & Engineering Faculty, 2015
    Co-Authors: Ferry P W Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville, Dietmar W Hutmacher
    Abstract:

    Achieving the combination of delayed and immediate release of a vaccine from a delivery Device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131.t + 3.4 (R2 = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic  -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico-chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound.

Ferry P W Melchels - One of the best experts on this subject based on the ideXlab platform.

  • initial design and physical characterization of a Polymeric Device for osmosis driven delayed burst delivery of vaccines
    Biotechnology and Bioengineering, 2015
    Co-Authors: Ferry P W Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville, Dietmar W Hutmacher
    Abstract:

    Achieving the combination of delayed and immediate release of a vaccine from a delivery Device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(e-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131.t + 3.4 (R2 = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic e -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico–chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound. Biotechnol. Bioeng. 2015;112: 1927–1935. © 2015 Wiley Periodicals, Inc.

  • initial design and physical characterization of a Polymeric Device for osmosis driven delayed burst delivery of vaccines
    Faculty of Health; Institute of Health and Biomedical Innovation; Science & Engineering Faculty, 2015
    Co-Authors: Ferry P W Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville, Dietmar W Hutmacher
    Abstract:

    Achieving the combination of delayed and immediate release of a vaccine from a delivery Device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131.t + 3.4 (R2 = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic  -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico-chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound.

S Offenbacher - One of the best experts on this subject based on the ideXlab platform.

  • a Polymeric Device for delivery of anti microbial and anti fungal drugs in the oral environment effect of temperature and medium on the rate of drug release
    Dental Materials, 2003
    Co-Authors: S Kalachandra, J Valiyaparambil, S Offenbacher
    Abstract:

    OBJECTIVES: The use of drug delivery systems in dentistry is a relatively new area of research with the exception of fluoride ion release from polyalkenoate cements and their predecessor silicate cements. The present study is based on the use of a bio-compatible material ethylene vinyl acetate copolymer (EVA) that enables constant release of drugs of therapeutic levels over extended periods of time at doses suitable for the treatment of oral conditions. METHODS: Polymer casting solutions were made by dissolving EVA and the drug in the ratio of 40:1 in 70 ml of dichloromethane at 38 degrees C for 6 h. Thin square films of 3 x 3 cm2 with a thickness of 1 mm were cut from the dry sheet obtained by solvent evaporation technique. Drug loaded samples were extracted for a minimum of 14 days in 10 ml medium (double distilled water or water/ethanol (4:1)) which was replaced daily. Spectral measurements were made to follow changes in optical densities (OD) during release kinetics. Effect of temperature (24 and 37 degrees C) on the rate of drug release was studied and the energies of activation (DeltaE not equal ) were calculated using Arrehenius equation for the diffusion (translocation) of molecules of tetracycline hydrochloride (TTH), doxycycline hydrochloride (DOH), and chlorhexidine diacetate (CDA) in water as extracting medium. Effect of extracting medium (water and water/ethanol (4:1)) was also investigated on the rate of drug release measurements at 24 degrees C. RESULTS: Analysis of variance of the data revealed that significantly enhanced rates were observed at the higher temperature (37 degrees C) and when extracting medium was changed to water/ethanol (4:1) for TTH, DOH and CDA (p<0.0015). The enhanced rate values seem to be due to the formation of channels in the polymer. The largest activation energy (21.83 kcal mol(-1)) observed for CDA was interpreted as due to the highest average molecular weight (626) compared to TTH (481) and DOH (481).Significance. These in vitro rate of drug release measurements will provide a basis for establishing a novel approach (treatment modality) for sustained intra-oral drug delivery over extended time periods using laboratory methods and materials that are readily available to dentists.

N.a. Peppas - One of the best experts on this subject based on the ideXlab platform.

  • Control and modeling of drug delivery Devices for the treatment of diabetes
    Proceedings of 1995 American Control Conference - ACC'95, 1995
    Co-Authors: F.j. Doyle, C. Dorski, J.e. Harting, N.a. Peppas
    Abstract:

    The complications of diabetes are thought to arise from poor control of blood glucose concentration because of inadequate secretion of insulin by the pancreas. This has motivated the undertaking of novel therapeutic approaches to improve insulin delivery. In this paper, two approaches are presented: model-based control algorithms for use in implantable insulin pumps, and a novel Polymeric Device which releases insulin at desirable levels.

Urip Dunker - One of the best experts on this subject based on the ideXlab platform.

  • initial design and physical characterization of a Polymeric Device for osmosis driven delayed burst delivery of vaccines
    Biotechnology and Bioengineering, 2015
    Co-Authors: Ferry P W Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville, Dietmar W Hutmacher
    Abstract:

    Achieving the combination of delayed and immediate release of a vaccine from a delivery Device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(e-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131.t + 3.4 (R2 = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic e -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico–chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound. Biotechnol. Bioeng. 2015;112: 1927–1935. © 2015 Wiley Periodicals, Inc.

  • initial design and physical characterization of a Polymeric Device for osmosis driven delayed burst delivery of vaccines
    Faculty of Health; Institute of Health and Biomedical Innovation; Science & Engineering Faculty, 2015
    Co-Authors: Ferry P W Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville, Dietmar W Hutmacher
    Abstract:

    Achieving the combination of delayed and immediate release of a vaccine from a delivery Device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131.t + 3.4 (R2 = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic  -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico-chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound.