The Experts below are selected from a list of 213 Experts worldwide ranked by ideXlab platform
H. W. Pfister - One of the best experts on this subject based on the ideXlab platform.
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Tick-borne encephalitis with Polyradiculitis documented by MRI.
Neurology, 2007Co-Authors: Thomas Pfefferkorn, Berend Feddersen, Schulte-altedorneburg G, Jennifer Linn, H. W. PfisterAbstract:Tick-borne encephalitis (TBE) is a flavivirus infection with an incidence of up to 1/100,000 or more in endemic areas. The typical clinical course of TBE is biphasic: after an incubation period of 3 to 21 days, prodromal flu-like symptoms appear. After an asymptomatic interval of a few days these unspecific symptoms are then followed by neurologic manifestations such as meningitis (49%), meningoencephalitis (41%), and meningoencephalomyelitis with or without radiculitis (10%).1,2 Positive MRI findings are present in only a minority of cases.1,3,4 We report here on a patient with tick-borne encephalitis and MRI-documented Polyradiculitis. ### Case. Ten days after receiving a tick bite in an endemic area, a previously healthy 50-year-old man had diarrhea for 4 days. Seven days later he developed severe headache and fever up to 40.2 °C, followed by dysarthria and confusion. On admission he was drowsy, confused, and disoriented. While meningeal signs were present, there were no …
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Zyktokin CXCL13
Der Nervenarzt, 2006Co-Authors: T. A. Rupprecht, Barbara Angele, Uwe Koedel, V. Fingerle, H. W. PfisterAbstract:The definitive diagnosis of acute neuroborreliosis (NB) is based upon the presence of lymphomonocytic CSF pleocytosis and intrathecal Borrelia burgdorferi (B.b.)-specific antibody production (expressed by an antibody index of >2). However, the latter might be absent in early stages of the disease. Now a recently discovered additional CSF marker—the cytokine CXCL13—was found to be positive in every initial CSF sample from patients with NB and therefore could be a valuable tool for early diagnosis and initiation of antibiotic therapy. We report an unusual case of NB in a patient with a history of metastatic carcinoma of the prostate and unilateral Polyradiculitis. While no intrathecal B.b.-specific antibody production could be demonstrated initially, the CSF CXCL13 level was high (>500 ng/g vs 500 ng/g — Kontrollpatienten hatten stets CXCL13-Werte
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Zyktokin CXCL13: Ein früher Liquormarker für die Neuroborreliose?
Der Nervenarzt, 2006Co-Authors: T Rupprecht, Uwe Koedel, Barbara Angele, V. Fingerle, H. W. PfisterAbstract:The definitive diagnosis of acute neuroborreliosis (NB) is based upon the presence of lymphomonocytic CSF pleocytosis and intrathecal Borrelia burgdorferi (B.b.)-specific antibody production (expressed by an antibody index of >2). However, the latter might be absent in early stages of the disease. Now a recently discovered additional CSF marker-the cytokine CXCL13-was found to be positive in every initial CSF sample from patients with NB and therefore could be a valuable tool for early diagnosis and initiation of antibiotic therapy. We report an unusual case of NB in a patient with a history of metastatic carcinoma of the prostate and unilateral Polyradiculitis. While no intrathecal B.b.-specific antibody production could be demonstrated initially, the CSF CXCL13 level was high (>500 ng/g vs
Franz Fazekas - One of the best experts on this subject based on the ideXlab platform.
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Polyradiculitis as a Predominant Symptom of Tick-Borne Encephalitis Virus Infection
Archives of neurology, 2009Co-Authors: Christian Enzinger, Barbara Melisch, Alexander Reischl, J. Simbrunner, Franz FazekasAbstract:A58-YEAR-OLD MAN hadrapidlyprogressive and painful paresis of the left leg. He described a tick bite3weekspriortoadmissionwithouthavingbeenvaccinatedfortickborne encephalitis virus (TBEv). Neurological examination showed pronounced diffuse paresis, hypesthesia, and diminished tendon reflexes of the left lower extremity. Analysisofcerebrospinalfluiddemonstrated lymphoplasmacellular moderate pleocytosis (cell count, 44/µL;protein[total],0.260g/dL[to convert to grams per liter, multiply by10.0];glucose,58mg/dL[toconvert to millimoles per liter, multiply by 0.0555]; lactate, 18.0 mg/dL [to convert to millimoles per liter, multiply by 0.111]) and detected IgMandIgGagainstTBEv.Inthecerebrospinal fluid, oligoclonal bands were present, but identical bands were identified in the blood. In the serum, IgM against TBEv were also detected, and the IgG titer was elevated (94 U/mL). Titers and polymerasechainreactionevaluationfor Lyme borreliosis were negative. Peripheral nerve electrophysiological studies were normal except for damage to the left peroneal nerve against the background of a past trauma. An electromyogram provided no evidence of florid damage in the gastrocnemius or tibialis anterior muscles. Motor evoked potentials to the left lower limb were abnormal, suggesting damage to the nerve root, plexus, or ischiadic nerve.Lumbarspinemagneticresonance imaging finally helped establish the diagnosis of TBEv Polyradiculitis (Figure 1 and Figure 2).
Thomas Pfefferkorn - One of the best experts on this subject based on the ideXlab platform.
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Tick-borne encephalitis with Polyradiculitis documented by MRI.
Neurology, 2007Co-Authors: Thomas Pfefferkorn, Berend Feddersen, Schulte-altedorneburg G, Jennifer Linn, H. W. PfisterAbstract:Tick-borne encephalitis (TBE) is a flavivirus infection with an incidence of up to 1/100,000 or more in endemic areas. The typical clinical course of TBE is biphasic: after an incubation period of 3 to 21 days, prodromal flu-like symptoms appear. After an asymptomatic interval of a few days these unspecific symptoms are then followed by neurologic manifestations such as meningitis (49%), meningoencephalitis (41%), and meningoencephalomyelitis with or without radiculitis (10%).1,2 Positive MRI findings are present in only a minority of cases.1,3,4 We report here on a patient with tick-borne encephalitis and MRI-documented Polyradiculitis. ### Case. Ten days after receiving a tick bite in an endemic area, a previously healthy 50-year-old man had diarrhea for 4 days. Seven days later he developed severe headache and fever up to 40.2 °C, followed by dysarthria and confusion. On admission he was drowsy, confused, and disoriented. While meningeal signs were present, there were no …
Christian Enzinger - One of the best experts on this subject based on the ideXlab platform.
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Polyradiculitis as a Predominant Symptom of Tick-Borne Encephalitis Virus Infection
Archives of neurology, 2009Co-Authors: Christian Enzinger, Barbara Melisch, Alexander Reischl, J. Simbrunner, Franz FazekasAbstract:A58-YEAR-OLD MAN hadrapidlyprogressive and painful paresis of the left leg. He described a tick bite3weekspriortoadmissionwithouthavingbeenvaccinatedfortickborne encephalitis virus (TBEv). Neurological examination showed pronounced diffuse paresis, hypesthesia, and diminished tendon reflexes of the left lower extremity. Analysisofcerebrospinalfluiddemonstrated lymphoplasmacellular moderate pleocytosis (cell count, 44/µL;protein[total],0.260g/dL[to convert to grams per liter, multiply by10.0];glucose,58mg/dL[toconvert to millimoles per liter, multiply by 0.0555]; lactate, 18.0 mg/dL [to convert to millimoles per liter, multiply by 0.111]) and detected IgMandIgGagainstTBEv.Inthecerebrospinal fluid, oligoclonal bands were present, but identical bands were identified in the blood. In the serum, IgM against TBEv were also detected, and the IgG titer was elevated (94 U/mL). Titers and polymerasechainreactionevaluationfor Lyme borreliosis were negative. Peripheral nerve electrophysiological studies were normal except for damage to the left peroneal nerve against the background of a past trauma. An electromyogram provided no evidence of florid damage in the gastrocnemius or tibialis anterior muscles. Motor evoked potentials to the left lower limb were abnormal, suggesting damage to the nerve root, plexus, or ischiadic nerve.Lumbarspinemagneticresonance imaging finally helped establish the diagnosis of TBEv Polyradiculitis (Figure 1 and Figure 2).
Berend Feddersen - One of the best experts on this subject based on the ideXlab platform.
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Tick-borne encephalitis with Polyradiculitis documented by MRI.
Neurology, 2007Co-Authors: Thomas Pfefferkorn, Berend Feddersen, Schulte-altedorneburg G, Jennifer Linn, H. W. PfisterAbstract:Tick-borne encephalitis (TBE) is a flavivirus infection with an incidence of up to 1/100,000 or more in endemic areas. The typical clinical course of TBE is biphasic: after an incubation period of 3 to 21 days, prodromal flu-like symptoms appear. After an asymptomatic interval of a few days these unspecific symptoms are then followed by neurologic manifestations such as meningitis (49%), meningoencephalitis (41%), and meningoencephalomyelitis with or without radiculitis (10%).1,2 Positive MRI findings are present in only a minority of cases.1,3,4 We report here on a patient with tick-borne encephalitis and MRI-documented Polyradiculitis. ### Case. Ten days after receiving a tick bite in an endemic area, a previously healthy 50-year-old man had diarrhea for 4 days. Seven days later he developed severe headache and fever up to 40.2 °C, followed by dysarthria and confusion. On admission he was drowsy, confused, and disoriented. While meningeal signs were present, there were no …