The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform

Ghosh S. - One of the best experts on this subject based on the ideXlab platform.

  • Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
    'EMBO', 2020
    Co-Authors: Ghosh S., Guimaraes J. C), Lanzafame M., Schmidt A., Syed A. Pasha), Dimitriades B., Börsch A., Mittal N., Montavon T.
    Abstract:

    Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis. In contrast to other mammalian Argonaute protein family members with primarily cytoplasmic functions, AGO1x exhibits nuclear localization in the vicinity of nucleoli. We identify AGO1x interaction with the Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) and show that the depletion of this protein further augments dsRNA accumulation. Our study thus uncovers a novel function of an Argonaute protein in buffering the endogenous dsRNA-induced interferon responses, different than the canonical function of AGO proteins in the miRNA effector pathway. As AGO1x expression is tightly linked to breast cancer cell proliferation, our study thus suggests a new direction for limiting tumor growth.journal article2020 Aug 192020 08 19importe

Montavon T. - One of the best experts on this subject based on the ideXlab platform.

  • Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
    'EMBO', 2020
    Co-Authors: Ghosh S., Guimaraes J. C), Lanzafame M., Schmidt A., Syed A. Pasha), Dimitriades B., Börsch A., Mittal N., Montavon T.
    Abstract:

    Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis. In contrast to other mammalian Argonaute protein family members with primarily cytoplasmic functions, AGO1x exhibits nuclear localization in the vicinity of nucleoli. We identify AGO1x interaction with the Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) and show that the depletion of this protein further augments dsRNA accumulation. Our study thus uncovers a novel function of an Argonaute protein in buffering the endogenous dsRNA-induced interferon responses, different than the canonical function of AGO proteins in the miRNA effector pathway. As AGO1x expression is tightly linked to breast cancer cell proliferation, our study thus suggests a new direction for limiting tumor growth.journal article2020 Aug 192020 08 19importe

Montavon Thomas - One of the best experts on this subject based on the ideXlab platform.

  • Prevention of dsRNA‐induced interferon signaling by AGO1x is linked to breast cancer cell proliferation
    'EMBO', 2020
    Co-Authors: Ghosh Souvik, Guimaraes J. C), Syed A. Pasha), Lanzafame Manuela, Schmidt Alexander, Dimitriades Beatrice, Börsch Anastasiya, Ghosh Shreemoyee, Mittal Nitish, Montavon Thomas
    Abstract:

    Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis. In contrast to other mammalian Argonaute protein family members with primarily cytoplasmic functions, AGO1x exhibits nuclear localization in the vicinity of nucleoli. We identify AGO1x interaction with the Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) and show that the depletion of this protein further augments dsRNA accumulation. Our study thus uncovers a novel function of an Argonaute protein in buffering the endogenous dsRNA-induced interferon responses, different than the canonical function of AGO proteins in the miRNA effector pathway. As AGO1x expression is tightly linked to breast cancer cell proliferation, our study thus suggests a new direction for limiting tumor growth

Thomas Montavon - One of the best experts on this subject based on the ideXlab platform.

  • Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation
    EMBO Journal, 2020
    Co-Authors: Souvik Ghosh, Joao C Guimaraes, Manuela Lanzafame, Alexander Schmidt, Afzal Pasha Syed, Beatrice Dimitriades, Anastasiya Börsch, Shreemoyee Ghosh, Nitish Mittal, Thomas Montavon
    Abstract:

    Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis. In contrast to other mammalian Argonaute protein family members with primarily cytoplasmic functions, AGO1x exhibits nuclear localization in the vicinity of nucleoli. We identify AGO1x interaction with the Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) and show that the depletion of this protein further augments dsRNA accumulation. Our study thus uncovers a novel function of an Argonaute protein in buffering the endogenous dsRNA-induced interferon responses, different than the canonical function of AGO proteins in the miRNA effector pathway. As AGO1x expression is tightly linked to breast cancer cell proliferation, our study thus suggests a new direction for limiting tumor growth.

Syed A. Pasha) - One of the best experts on this subject based on the ideXlab platform.

  • Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
    'EMBO', 2020
    Co-Authors: Ghosh S., Guimaraes J. C), Lanzafame M., Schmidt A., Syed A. Pasha), Dimitriades B., Börsch A., Mittal N., Montavon T.
    Abstract:

    Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis. In contrast to other mammalian Argonaute protein family members with primarily cytoplasmic functions, AGO1x exhibits nuclear localization in the vicinity of nucleoli. We identify AGO1x interaction with the Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) and show that the depletion of this protein further augments dsRNA accumulation. Our study thus uncovers a novel function of an Argonaute protein in buffering the endogenous dsRNA-induced interferon responses, different than the canonical function of AGO proteins in the miRNA effector pathway. As AGO1x expression is tightly linked to breast cancer cell proliferation, our study thus suggests a new direction for limiting tumor growth.journal article2020 Aug 192020 08 19importe

  • Prevention of dsRNA‐induced interferon signaling by AGO1x is linked to breast cancer cell proliferation
    'EMBO', 2020
    Co-Authors: Ghosh Souvik, Guimaraes J. C), Syed A. Pasha), Lanzafame Manuela, Schmidt Alexander, Dimitriades Beatrice, Börsch Anastasiya, Ghosh Shreemoyee, Mittal Nitish, Montavon Thomas
    Abstract:

    Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis. In contrast to other mammalian Argonaute protein family members with primarily cytoplasmic functions, AGO1x exhibits nuclear localization in the vicinity of nucleoli. We identify AGO1x interaction with the Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) and show that the depletion of this protein further augments dsRNA accumulation. Our study thus uncovers a novel function of an Argonaute protein in buffering the endogenous dsRNA-induced interferon responses, different than the canonical function of AGO proteins in the miRNA effector pathway. As AGO1x expression is tightly linked to breast cancer cell proliferation, our study thus suggests a new direction for limiting tumor growth