The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform
Weilung Tseng - One of the best experts on this subject based on the ideXlab platform.
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using Polysorbate 40 stabilized gold nanoparticles in colorimetric assays of hydrogen cyanide in cyanogenic glycoside containing plants
Analytical Methods, 2012Co-Authors: Weilung TsengAbstract:This study presents a convenient and homogeneous method for the selective detection of hydrogen cyanide in cyanogenic glycoside-containing plants using Polysorbate 40-stabilized gold nanoparticles (PS 40-AuNPs). Neutral PS 40 molecules stabilized citrate-capped AuNPs in a high-salinity solution. When the plant tissue is damaged, β-glucosidase rapidly hydrolyzes cyanogenic glycosides to produce hydrogen cyanide. The addition of the released hydrogen cyanide to a solution of PS 40-AuNPs resulted in the formation of AuCN(s) on the NP surface and Au(CN)2− in an aqueous solution. The removal of PS 40 molecules from the NP surface rendered the AuNPs unstable in a high-salinity solution, leading to NP aggregation. We used surface-assisted laser desorption/ionization time-of-flight mass spectrometry to detect the formation of AuCN(s). This probe was also successfully used to determine the total cyanide in cassava roots, peach kernels, and loquat kernels. When the three cyanogenic glycoside-containing plants were separately heated, this probe was capable of monitoring the removal of hydrogen cyanide during heating. In addition, the use of thiosulfate to detoxify the three cyanogenic glycoside-containing plants was evaluated using PS 40-AuNPs.
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colorimetric assay for cyanide and cyanogenic glycoside using Polysorbate 40 stabilized gold nanoparticles
Chemical Communications, 2011Co-Authors: Weilung TsengAbstract:This study describes a simple method for the selective and sensitive detection of cyanide and endogenous biological cyanide using Polysorbate 40-stabilized gold nanoparticles.
Jasjeet K. Sahni - One of the best experts on this subject based on the ideXlab platform.
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Mechanistic approach for the development of ultrafine oil-water emulsions using monoglyceride and blends of medium and long chain triglycerides: enhancement of the solubility and bioavailability of Perphenazine.
2020Co-Authors: Sanjula Baboota, Gulam Mustafa, Jasjeet K. SahniAbstract:A kinetically stable ultra-fine oil-water (o/w) emulsion containing Perphenazine and blends of long and medium chain triglycerides was prepared. The purpose of the ultra-fine emulsion was to increase the oral bioavailability of Perphenazine. The formulations were prepared using a low energy emulsification phase titration method. The optimized formulations consisted of blends of linseed oil and Sefsol 218 (1:1) (oil phase), Polysorbate 40 (surfactant), polyethylene glycol 400 (cosurfactant) and distilled water (dispersion medium). Characterization of viscosity, refractive index, particle size distribution, spectral transmittance and surface morphology of the formulations was performed. The release rate of Perphenazine from the formulations was quantified using the everted gut sac of rat intestinal mucosa. The ex vivo release data demonstrated that the formulated nanoemulsions increased significantly the permeation rate of Perphenazine when compared with a suspension. Following oral administration of selected nanoemulsions in Wistar rats, the AUC and C max of Perphenazine increased by 2.9 and 2.54-fold respectively compared with the Perphenazine suspension. The observed increase in bioavailability may be due to the increase in the dissolution rate from the molecularly dissolved drug in the oil phase and an increased rate of dispersion of the drug in the gastrointestinal (GI) tract which leads to greater absorption into the blood.
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Mechanistic approach for the development of ultrafine o/w emulsions using blends medium and long chain triglycerides: solubility and bioavailability enhancement of perphenazine
Journal of Excipients and Food Chemicals, 2013Co-Authors: Sanjula Baboota, Abdullah Abdullah, Gulam Mustafa, Jasjeet K. SahniAbstract:A thermodynamically stable ultrafine (o/w) emulsion containing perphenazine for solubility and oral bioavailability enhancement using blends of long and medium chain triglyceride was developed. Formulation was prepared using low energy emulsification phase titration method. The optimized formulations consisted of blend of linseed and sefsol 218 (1:1), Polysorbate 40, polyethylene glycol 400 and distilled water as an oil, surfactant, cosurfactant and dispersion phase respectively. The formulations were characterized on the basis of viscosity, refractive index, particle size distribution, spectral transmittance and surface morphology. Formulations were evaluated for release study by everted gut sac using intestinal mucosa. The ex vivo release data showed that nanoemulsions significantly increased the permeation rate of perphenazine over the simple suspension. Following oral administration of nanoemulsion in wistar rats, both AUC and C max of perphenazine increased by 2.9 fold and 2.54-fold respectively compared with the perphenazine suspension. The resultant bioavailability might be due to increased solubility, bypassing the first-pass metabolism through lymphatic absorption and enhanced permeation potential of perphenazine.
Sanjula Baboota - One of the best experts on this subject based on the ideXlab platform.
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Mechanistic approach for the development of ultrafine oil-water emulsions using monoglyceride and blends of medium and long chain triglycerides: enhancement of the solubility and bioavailability of Perphenazine.
2020Co-Authors: Sanjula Baboota, Gulam Mustafa, Jasjeet K. SahniAbstract:A kinetically stable ultra-fine oil-water (o/w) emulsion containing Perphenazine and blends of long and medium chain triglycerides was prepared. The purpose of the ultra-fine emulsion was to increase the oral bioavailability of Perphenazine. The formulations were prepared using a low energy emulsification phase titration method. The optimized formulations consisted of blends of linseed oil and Sefsol 218 (1:1) (oil phase), Polysorbate 40 (surfactant), polyethylene glycol 400 (cosurfactant) and distilled water (dispersion medium). Characterization of viscosity, refractive index, particle size distribution, spectral transmittance and surface morphology of the formulations was performed. The release rate of Perphenazine from the formulations was quantified using the everted gut sac of rat intestinal mucosa. The ex vivo release data demonstrated that the formulated nanoemulsions increased significantly the permeation rate of Perphenazine when compared with a suspension. Following oral administration of selected nanoemulsions in Wistar rats, the AUC and C max of Perphenazine increased by 2.9 and 2.54-fold respectively compared with the Perphenazine suspension. The observed increase in bioavailability may be due to the increase in the dissolution rate from the molecularly dissolved drug in the oil phase and an increased rate of dispersion of the drug in the gastrointestinal (GI) tract which leads to greater absorption into the blood.
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Mechanistic approach for the development of ultrafine o/w emulsions using blends medium and long chain triglycerides: solubility and bioavailability enhancement of perphenazine
Journal of Excipients and Food Chemicals, 2013Co-Authors: Sanjula Baboota, Abdullah Abdullah, Gulam Mustafa, Jasjeet K. SahniAbstract:A thermodynamically stable ultrafine (o/w) emulsion containing perphenazine for solubility and oral bioavailability enhancement using blends of long and medium chain triglyceride was developed. Formulation was prepared using low energy emulsification phase titration method. The optimized formulations consisted of blend of linseed and sefsol 218 (1:1), Polysorbate 40, polyethylene glycol 400 and distilled water as an oil, surfactant, cosurfactant and dispersion phase respectively. The formulations were characterized on the basis of viscosity, refractive index, particle size distribution, spectral transmittance and surface morphology. Formulations were evaluated for release study by everted gut sac using intestinal mucosa. The ex vivo release data showed that nanoemulsions significantly increased the permeation rate of perphenazine over the simple suspension. Following oral administration of nanoemulsion in wistar rats, both AUC and C max of perphenazine increased by 2.9 fold and 2.54-fold respectively compared with the perphenazine suspension. The resultant bioavailability might be due to increased solubility, bypassing the first-pass metabolism through lymphatic absorption and enhanced permeation potential of perphenazine.
Navideh Anarjan - One of the best experts on this subject based on the ideXlab platform.
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effects of selected Polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions
Molecules, 2013Co-Authors: Navideh AnarjanAbstract:The effects of selected nonionic emulsifiers on the physicochemical characteristics of astaxanthin nanodispersions produced by an emulsification/evaporation technique were studied. The emulsifiers used were Polysorbates (Polysorbate 20, Polysorbate 40, Polysorbate 60 and Polysorbate 80) and sucrose esters of fatty acids (sucrose laurate, palmitate, stearate and oleate). The mean particle diameters of the nanodispersions ranged from 70 nm to 150 nm, depending on the emulsifier used. In the prepared nanodispersions, the astaxanthin particle diameter decreased with increasing emulsifier hydrophilicity and decreasing carbon number of the fatty acid in the emulsifier structure. Astaxanthin nanodispersions with the smallest particle diameters were produced with Polysorbate 20 and sucrose laurate among the Polysorbates and the sucrose esters, respectively. We also found that the Polysorbate 80- and sucrose oleate-stabilized nanodispersions had the highest astaxanthin losses (i.e., the lowest astaxanthin contents in the final products) among the nanodispersions. This work demonstrated the importance of emulsifier type in determining the physicochemical characteristics of astaxanthin nano-dispersions.
Gulam Mustafa - One of the best experts on this subject based on the ideXlab platform.
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Mechanistic approach for the development of ultrafine oil-water emulsions using monoglyceride and blends of medium and long chain triglycerides: enhancement of the solubility and bioavailability of Perphenazine.
2020Co-Authors: Sanjula Baboota, Gulam Mustafa, Jasjeet K. SahniAbstract:A kinetically stable ultra-fine oil-water (o/w) emulsion containing Perphenazine and blends of long and medium chain triglycerides was prepared. The purpose of the ultra-fine emulsion was to increase the oral bioavailability of Perphenazine. The formulations were prepared using a low energy emulsification phase titration method. The optimized formulations consisted of blends of linseed oil and Sefsol 218 (1:1) (oil phase), Polysorbate 40 (surfactant), polyethylene glycol 400 (cosurfactant) and distilled water (dispersion medium). Characterization of viscosity, refractive index, particle size distribution, spectral transmittance and surface morphology of the formulations was performed. The release rate of Perphenazine from the formulations was quantified using the everted gut sac of rat intestinal mucosa. The ex vivo release data demonstrated that the formulated nanoemulsions increased significantly the permeation rate of Perphenazine when compared with a suspension. Following oral administration of selected nanoemulsions in Wistar rats, the AUC and C max of Perphenazine increased by 2.9 and 2.54-fold respectively compared with the Perphenazine suspension. The observed increase in bioavailability may be due to the increase in the dissolution rate from the molecularly dissolved drug in the oil phase and an increased rate of dispersion of the drug in the gastrointestinal (GI) tract which leads to greater absorption into the blood.
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Mechanistic approach for the development of ultrafine o/w emulsions using blends medium and long chain triglycerides: solubility and bioavailability enhancement of perphenazine
Journal of Excipients and Food Chemicals, 2013Co-Authors: Sanjula Baboota, Abdullah Abdullah, Gulam Mustafa, Jasjeet K. SahniAbstract:A thermodynamically stable ultrafine (o/w) emulsion containing perphenazine for solubility and oral bioavailability enhancement using blends of long and medium chain triglyceride was developed. Formulation was prepared using low energy emulsification phase titration method. The optimized formulations consisted of blend of linseed and sefsol 218 (1:1), Polysorbate 40, polyethylene glycol 400 and distilled water as an oil, surfactant, cosurfactant and dispersion phase respectively. The formulations were characterized on the basis of viscosity, refractive index, particle size distribution, spectral transmittance and surface morphology. Formulations were evaluated for release study by everted gut sac using intestinal mucosa. The ex vivo release data showed that nanoemulsions significantly increased the permeation rate of perphenazine over the simple suspension. Following oral administration of nanoemulsion in wistar rats, both AUC and C max of perphenazine increased by 2.9 fold and 2.54-fold respectively compared with the perphenazine suspension. The resultant bioavailability might be due to increased solubility, bypassing the first-pass metabolism through lymphatic absorption and enhanced permeation potential of perphenazine.