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Souleymane Méité - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE Open Access Laxative activities of Mareya micrantha (Benth.)
2013Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N’guessanAbstract:Background: Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d’Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino’s Wistar rats. Methods: Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results: Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extrac
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laxative activities of mareya micrantha benth mull arg euphorbiaceae leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Jacques Y Datté, Joseph A Djaman, David Jean NguessanAbstract:Mareya micrantha (Benth.) Mull. Arg. (Euphorbiaceae) is a shrub that is commonly used in Cote d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl-, Na+, K+ and Ca2+ in the intestinal fluid (p < 0.01). The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
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Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N'guessanAbstract:Background Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Methods Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o .), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg ( p.o .) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o ). The same doses of the extract (200 and 400 mg/kg, p.o .) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl^-, Na^+, K^+ and Ca^2+ in the intestinal fluid (p < 0.01). Conclusions The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
Ipou Ipou Joseph - One of the best experts on this subject based on the ideXlab platform.
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Ethnobotanique et analyse phytochimique qualitative de Pteridium aquilinum (L.) Kühn (Dennstaedtiaceae), une Ptéridophyte utilisée comme plante médicinale en Côte d’Ivoire
'African Journals Online (AJOL)', 2017Co-Authors: Adou, Lydie Marie Dominique, Kone, Mamidou Withabouna, Ipou Ipou Joseph, N’guessan, Edouard KouakouAbstract:En Côte d’Ivoire, les études ethnobotaniques ont longtemps été réservées aux spermaphytes. Très rarement, ces études ont concerné les Ptéridophytes. Il est donc nécessaire de connaître les différentes utilisations de ces taxons. La présente étude vise à valoriser Pteridium aquilinum, une Ptéridophyte communément appelé fougère aigle. Cette valorisation consiste à montrer les différents usages de la plante et à déterminer les différents groupes de composés chimiques contenus dans cette dernière pour tenter d’expliquer les effets thérapeutiques potentiels de la plante. La démarche méthodologique a consisté à réaliser une enquête ethnobotanique auprès des populations de la zone d’étude. Le type de méthode est une interview directe, qui consiste à interroger les populations. Leurs réponses sont transcrites sur une fiche d’enquête adaptée, conçue à cet effet. Ainsi une étude phytochimique a été réalisée avec les extraits de Pteridium aquilinum. Il ressort de ces investigations que sur 99 personnes interrogées, 29 soit 29% connaissent la plante ou en savent l’utilité. La plante entière est utilisée pour la préparation des recettes médicamenteuses dans (66%) des cas. La préparationdes recettes médicamenteuses fait intervenir majoritairement la décoction 66%. On note également divers modes d’administration de ces médicaments : boisson, bain de vapeur et onguent utilisé chacun à 33%. Les investigations phytochimiques menées sur des extraits de la plante suivant la méthode de la caractérisation en tube, ont révélé que Pteridium aquilinum renferme des stérols, des polyterpènes, des polyphénols, des flavonoïdes, des tanins catéchiques et des substances quinoniques. Ce sont ces substances qui confèrent à la plante son aptitude à traiter certaines maladies. En conclusion, Pteridium aquilinum est utilisée comme plante médicinale sous diverses formes de préparations médicamenteuses dans la lutte contre le rhumatisme et les convulsions des nouveau-nés.© 2016 International Formulae Group. All rights reserved.Mots clés: Composés chimiques, Fougère, Phytochimie, Ptéridophyte, Sud-Est de la Côte d’IvoireEnglish Title: Ethnobotanical and qualitative phytochemical analysis of Pteridium aquilinum. (L.) Kühn (Dennstaedtiaceae), a Pteridophyte used as medicinal plant in Côte d'IvoireEnglish AbstractIn Côte d’Ivoire, ethnobotanical studies have concerned seed plants or spermatophytes for a long time. They very rarely dealt with Pteridophytes. That is why it is necessary to know the different uses of these taxa. The present study aims to increase the value of Pteridium aquilinum, a Pteridophyte commonly called bracken. This valuation is to show the different uses of the plant and determine the different chemical components it contains in order to explain its therapeutic potentials. The methodological approach was to carry out an ethnobotanical survey among people in the study area. The type of method is a live interview which involves interviewing people. Their responses were transcribed on an adapted survey sheet, designed for this purpose. A phytochemical study was also conducted with the extracts of Pteridium aquilinum. From these investigations on 99 respondents, 29 or 29% know the plant or know the utility. The whole plant is used for the preparation of drug recipes in (66%) of cases. The preparation of medicinal recipes mostly involve decoction (66%). There are also various modes of administration of these drugs: drink, steam bath and ointment, used each at 33%. Phytochemical investigations on extracts of the plant following the method of characterization tube revealed that Pteridium aquilinum contains sterols, Polyterpenes, polyphenols, flavonoids, catechin tannins and quinone substances. These are the substances that give the plant its ability to treat certain diseases. In conclusion, Pteridium aquilinum is used as a medicinal plant in various forms of pharmaceutical preparations in the fight against rheumatism and convulsions of new-borns.© 2016 International Formulae Group. All rights reserved.Keywords: Chemical components, Ferns, Phytochemistry, Pteridophytes, South East Côte d’Ivoir
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nephrolepis biserrata une pteridophyte utilisee comme plante medicinale en cote d ivoire
Journal of Applied Biosciences, 2014Co-Authors: Alm Dominique, T Awa, C Koffi, Ipou Ipou JosephAbstract:Objectif : La presente etude vise a valoriser Nephrolepis biserrata , une Pteridophyte de la classe des fougeres, communement appelee fougere du palmier. Cette valorisation consiste a montrer les differentes utilisations de la plante par les populations du Sud-est de la cote d’Ivoire. Methodologie et resultats : la methode d’approche est une enquete ethnobotanique realisee aupres des populations de la zone d’etude. Le type de methode est une interview directe, qui consiste a interroger les populations. Leurs reponses sont transcrites sur une fiche d’enquete adaptee, concue a cet effet. Aussi avec les extraits de Nephrolepis biserrata , nous avons realises des tests biologiques et des investigations phytochimiques. Les resultats ont montres que sur 91 personnes interrogees, 44 soit 48 % connaissent la plante ou en savent l’utilite. Les feuilles et la plante entiere sont utilisees pour la preparation des recettes medicamenteuses par les herboristes et les villageois. Ces recettes necessitent divers modes de preparation qui sont la decoction, le ramollissement et le petrissage des medicaments. On note egalement divers modes d’administration de ces medicaments : bain, boisson et pansement. En plus d’etre utilisee comme plante medicinale, elle est utilisee dans d’autres domaines. Les investigations phytochimiques menees sur des extraits de la plante obtenus suivant la methode de la caracterisation en tube, ont revele que Nephrolepis biserrata renferme des sterols, des Polyterpenes, des polyphenols, des flavonoides, des tanins catechiques et des substances quinoniques. Ce sont ces substances qui conferent a la plante son aptitude a traiter certaines maladies. Conclusion et application des resultats : Nephrolepis biserrata est utilisee comme plante medicinale sous diverses formes de preparations medicamenteuses dans la lutte contre diverses pathologies (panaris, plaies, furoncles, extraire les epines, fontanelle, paludisme, bebe maladif et nonchalant et la reduction des gros nombrils des enfants). Mots cles : Pteridophyte, Fougere, Cote d’Ivoire, Ethnobotanique, Sud-est, Phytochimie.
Jacques Y Datté - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE Open Access Laxative activities of Mareya micrantha (Benth.)
2013Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N’guessanAbstract:Background: Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d’Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino’s Wistar rats. Methods: Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results: Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extrac
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laxative activities of mareya micrantha benth mull arg euphorbiaceae leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Jacques Y Datté, Joseph A Djaman, David Jean NguessanAbstract:Mareya micrantha (Benth.) Mull. Arg. (Euphorbiaceae) is a shrub that is commonly used in Cote d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl-, Na+, K+ and Ca2+ in the intestinal fluid (p < 0.01). The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
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Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N'guessanAbstract:Background Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Methods Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o .), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg ( p.o .) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o ). The same doses of the extract (200 and 400 mg/kg, p.o .) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl^-, Na^+, K^+ and Ca^2+ in the intestinal fluid (p < 0.01). Conclusions The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
Calixte Bahi - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE Open Access Laxative activities of Mareya micrantha (Benth.)
2013Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N’guessanAbstract:Background: Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d’Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino’s Wistar rats. Methods: Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results: Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extrac
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laxative activities of mareya micrantha benth mull arg euphorbiaceae leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Jacques Y Datté, Joseph A Djaman, David Jean NguessanAbstract:Mareya micrantha (Benth.) Mull. Arg. (Euphorbiaceae) is a shrub that is commonly used in Cote d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl-, Na+, K+ and Ca2+ in the intestinal fluid (p < 0.01). The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
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Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N'guessanAbstract:Background Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Methods Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o .), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg ( p.o .) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o ). The same doses of the extract (200 and 400 mg/kg, p.o .) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl^-, Na^+, K^+ and Ca^2+ in the intestinal fluid (p < 0.01). Conclusions The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
Joseph A Djaman - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE Open Access Laxative activities of Mareya micrantha (Benth.)
2013Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N’guessanAbstract:Background: Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d’Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino’s Wistar rats. Methods: Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results: Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extrac
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laxative activities of mareya micrantha benth mull arg euphorbiaceae leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Jacques Y Datté, Joseph A Djaman, David Jean NguessanAbstract:Mareya micrantha (Benth.) Mull. Arg. (Euphorbiaceae) is a shrub that is commonly used in Cote d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (200 and 400 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl-, Na+, K+ and Ca2+ in the intestinal fluid (p < 0.01). The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.
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Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats
BMC Complementary and Alternative Medicine, 2010Co-Authors: Souleymane Méité, Calixte Bahi, Dodéhé Yéo, Jacques Y Datté, Joseph A Djaman, David J N'guessanAbstract:Background Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) is a shrub that is commonly used in Côte d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Methods Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and Polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o .), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg ( p.o .) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o ). The same doses of the extract (200 and 400 mg/kg, p.o .) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl^-, Na^+, K^+ and Ca^2+ in the intestinal fluid (p < 0.01). Conclusions The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.