The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
G Guillet - One of the best experts on this subject based on the ideXlab platform.
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a 3 year causative study of Pompholyx in 120 patients
Archives of Dermatology, 2007Co-Authors: Marie Helene Guillet, Ewa Wierzbicka, Stephanie Guillet, Guy Dagregorio, G GuilletAbstract:Objective To assess the relative frequency of the different causes of Pompholyx evoked in the literature. Design Prospective survey. Setting Clinical outpatient setting. Patients A total of 120 consecutive patients with Pompholyx referred to our department from 2000 through 2003. Main Outcome Measures Systematic investigation of different causes of Pompholyx: fungal intertrigo, hyperhidrosis, atopy, contact eczema, and internal reactions with systematic provocation tests to metals, balsam of Peru, and food allergen when suspected. Results The present study found the following causes of Pompholyx in the 120 patients: mycosis (10.0%); allergic contact Pompholyx (67.5%), with cosmetic and hygiene products as the main factor (31.7%), followed by metals (16.7%); and internal reactivation from drug, food, or haptenic (nickel) origin (6.7%). The remaining 15.0% of patients were classified as idiopathic patients, but all were atopic. (Percentages do not total 100 because of rounding.) Conclusions Our data confirm the existence of reactional Pompholyx to interdigital-plantar intertrigos and endogenous reactions to metals or other allergens, but they mainly point at the unexpected importance of a so-called contact Pompholyx in which cosmetic and hygiene products play a preponderant role compared with metals. The great frequency of atopic conditions, even if idiopathic Pompholyx is not inferred as an equivalent of atopy, should lead to further causative investigations before undertaking more expensive or extensive treatments of refractory Pompholyx.
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a 3 year causative study of Pompholyx in 120 patients commentary
Archives of Dermatology, 2007Co-Authors: Marie Helene Guillet, Ewa Wierzbicka, Stephanie Guillet, Guy Dagregorio, G Guillet, Frances J StorrsAbstract:Objective: To assess the relative frequency of the different causes of Pompholyx evoked in the literature. Design: Prospective survey. Setting: Clinical outpatient setting. Patients: A total of 120 consecutive patients with Pompholyx referred to our department from 2000 through 2003. Main Outcome Measures: Systematic investigation of different causes of Pompholyx: fungal intertrigo, hyperhidrosis, atopy, contact eczema, and internal reactions with systematic provocation tests to metals, balsam of Peru, and food allergen when suspected. Results: The present study found the following causes of Pompholyx in the 120 patients: mycosis (10.0%); allergic contact Pompholyx (67.5%), with cosmetic and hygiene products as the main factor (31.7%), followed by metals (16.7%); and internal reactivation from drug, food, or haptenic (nickel) origin (6.7%). The remaining 15.0% of patients were classified as idiopathic patients, but all were atopic. (Percentages do not total 100 because of rounding.) Conclusions: Our data confirm the existence of reactional Pompholyx to interdigital-plantar intertrigos and endogenous reactions to metals or other allergens, but they mainly point at the unexpected importance of a so-called contact Pompholyx in which cosmetic and hygiene products play a preponderant role compared with metals. The great frequency of atopic conditions, even if idiopathic Pompholyx is not inferred as an equivalent of atopy, should lead to further causative investigations before undertaking more expensive or extensive treatments of refractory Pompholyx.
Uwe Wollina - One of the best experts on this subject based on the ideXlab platform.
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Pompholyx a review of clinical features differential diagnosis and management
American Journal of Clinical Dermatology, 2010Co-Authors: Uwe WollinaAbstract:Pompholyx is a vesicobullous disorder of the palms and soles. The condition is hard to treat because of the peculiarities of the affected skin, namely the thick horny layer and richness of the sweat glands. In this article, we review the available therapies, and score the treatments according to the level of evidence. The cornerstones of topical therapy are corticosteroids, although calcineurin inhibitors also seem to be effective. Topical photochemotherapy with methoxsalen (8-methoxypsoralen) is as effective as systemic photochemotherapy or high-dose UVA-1 irradiation. Systemic therapy is often necessary in bullous Pompholyx. Corticosteroids are commonly used although no controlled study has been published to date. For recalcitrant cases, corticosteroids are combined with immunosuppressants. Alitretinoin has efficacy in chronic hand dermatitis including Pompholyx. Another evolving treatment seems to be the intradermal injection of botulinum toxin. Radiotherapy might be an option for selected patients not responding to conventional treatment. In practice, patients benefit most from a combination of treatments.
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Pompholyx or dyshidrosis
Expert Review of Dermatology, 2009Co-Authors: Uwe WollinaAbstract:Pompholyx is an inflammatory vesicobullous disorder of the palms and soles. Although originally thought to be related to eccrine gland pathology, the condition is now considered to be part of the eczema spectrum. Pompholyx has a number of differential diagnoses and the etiopathology of this disease is not uniform. It can develop on the basis of atopy, contact irritation and contact sensitization, mycid reaction and as a side effect of drug treatment. Pompholyx treatment is challenging: topical therapy is based on corticosteroids and calcineurin inhibitors. Topical and systemic photochemotherapy and high-dose UVA-1 irradiation have been successfully used. Systemic therapy is often necessary in advanced cases of Pompholyx. Corticosteroids are commonly used, sometimes combined with immunosuppressants. Alitretinoin has efficacy in chronic hand eczema including Pompholyx. Another evolving treatment seems to be the intradermal injection of botulinum toxin. In practice, patients benefit most from a combination o...
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Pompholyx what s new
Expert Opinion on Investigational Drugs, 2008Co-Authors: Uwe WollinaAbstract:Background: Pompholyx is a chronic relapsing inflammatory vesicobullous skin disease of the hands and feet belonging to the spectrum of eczema. Established treatments, both topical and systemic, are limited in efficacy, risk:benefit ratio and prevention of further relapses. New treatment options are needed. Objective: The article will discuss new treatment options, in particular for cheiroPompholyx. Methods: A MEDLINE® and ClinicalTrials.gov® research has been conducted and publications about new and emerging treatments for Pompholyx have been analysed. Results/conclusions: Among the recent developments, topical calcineurin inhibitors (TCI) and botulinum toxin A (BTXA) seem to be effective against Pompholyx. The major disadvantage of BTXA is the need for injections, but efforts are being made to develop a topical form of application. Bexaroten gel has been used for chronic hand dermatitis, with good efficacy in the hyperkeratotic type. Further studies on Pompholyx are needed. There is currently widespread...
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pharmacotherapy of Pompholyx
Expert Opinion on Pharmacotherapy, 2004Co-Authors: Uwe Wollina, Mohamed Badawy Abdel NaserAbstract:Pompholyx is an inflammatory vesicobullous disorder of the palms and soles. The condition is difficult to treat because of the peculiarities of the affected skin, namely, the thick horny layer and richness of sweat glands. The cornerstones of topical therapy are corticosteroids, although calcineurin inhibitors seem to be effective as well. Topical photochemotherapy with 8-methoxypsoralen is as effective as systemic photochemotherapy or high-dose ultra violet Type A-1 irradiation. Systemic therapy is often necessary in bullous Pompholyx. Corticosteroids are used commonly, although no controlled studies have been published. For recalcitrant cases corticosteroids are combined with immunosuppressants. A new evolving treatment seems to be the intradermal injection of botulinum toxin.
Marie Helene Guillet - One of the best experts on this subject based on the ideXlab platform.
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a 3 year causative study of Pompholyx in 120 patients
Archives of Dermatology, 2007Co-Authors: Marie Helene Guillet, Ewa Wierzbicka, Stephanie Guillet, Guy Dagregorio, G GuilletAbstract:Objective To assess the relative frequency of the different causes of Pompholyx evoked in the literature. Design Prospective survey. Setting Clinical outpatient setting. Patients A total of 120 consecutive patients with Pompholyx referred to our department from 2000 through 2003. Main Outcome Measures Systematic investigation of different causes of Pompholyx: fungal intertrigo, hyperhidrosis, atopy, contact eczema, and internal reactions with systematic provocation tests to metals, balsam of Peru, and food allergen when suspected. Results The present study found the following causes of Pompholyx in the 120 patients: mycosis (10.0%); allergic contact Pompholyx (67.5%), with cosmetic and hygiene products as the main factor (31.7%), followed by metals (16.7%); and internal reactivation from drug, food, or haptenic (nickel) origin (6.7%). The remaining 15.0% of patients were classified as idiopathic patients, but all were atopic. (Percentages do not total 100 because of rounding.) Conclusions Our data confirm the existence of reactional Pompholyx to interdigital-plantar intertrigos and endogenous reactions to metals or other allergens, but they mainly point at the unexpected importance of a so-called contact Pompholyx in which cosmetic and hygiene products play a preponderant role compared with metals. The great frequency of atopic conditions, even if idiopathic Pompholyx is not inferred as an equivalent of atopy, should lead to further causative investigations before undertaking more expensive or extensive treatments of refractory Pompholyx.
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a 3 year causative study of Pompholyx in 120 patients commentary
Archives of Dermatology, 2007Co-Authors: Marie Helene Guillet, Ewa Wierzbicka, Stephanie Guillet, Guy Dagregorio, G Guillet, Frances J StorrsAbstract:Objective: To assess the relative frequency of the different causes of Pompholyx evoked in the literature. Design: Prospective survey. Setting: Clinical outpatient setting. Patients: A total of 120 consecutive patients with Pompholyx referred to our department from 2000 through 2003. Main Outcome Measures: Systematic investigation of different causes of Pompholyx: fungal intertrigo, hyperhidrosis, atopy, contact eczema, and internal reactions with systematic provocation tests to metals, balsam of Peru, and food allergen when suspected. Results: The present study found the following causes of Pompholyx in the 120 patients: mycosis (10.0%); allergic contact Pompholyx (67.5%), with cosmetic and hygiene products as the main factor (31.7%), followed by metals (16.7%); and internal reactivation from drug, food, or haptenic (nickel) origin (6.7%). The remaining 15.0% of patients were classified as idiopathic patients, but all were atopic. (Percentages do not total 100 because of rounding.) Conclusions: Our data confirm the existence of reactional Pompholyx to interdigital-plantar intertrigos and endogenous reactions to metals or other allergens, but they mainly point at the unexpected importance of a so-called contact Pompholyx in which cosmetic and hygiene products play a preponderant role compared with metals. The great frequency of atopic conditions, even if idiopathic Pompholyx is not inferred as an equivalent of atopy, should lead to further causative investigations before undertaking more expensive or extensive treatments of refractory Pompholyx.
R. Charles-holmes - One of the best experts on this subject based on the ideXlab platform.
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Linear IgA disease with haemorrhagic Pompholyx and dapsone-induced neutropenia.
The British journal of dermatology, 1991Co-Authors: P. Duhra, R. Charles-holmesAbstract:Summary A case of haemorrhagic Pompholyx occurring in a 29-year-old man with linear IgA disease is described. There were several features in our patient that are usually seen in chronic bullous disease of childhood. Treatment with dapsone cleared the eruption but induced a progressive yet reversible neutropenia.
Charpentier Claudia - One of the best experts on this subject based on the ideXlab platform.
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Variación estacional en el Lago de Río Cuarto, provincia de Alajuela, Costa Rica. II Distribución estacional del zooplancton
Universidad Nacional de Costa Rica, 2016Co-Authors: Ramírez Elizabeth, Tabash Farid, Charpentier ClaudiaAbstract:Several limnological studies were carried out between February 1984 and March 1985 in Río Cuarto Lake. Composition of the zooplanktonic community seasonal changes and vertical distribution of the most abundant zooplankton species were determined, and correlated with the results of chemicals, physical and biological data. The rotifers were the most important group in the zooplanktonic community. The rotifers identified were Keratella americana, Polyarthra vulgaris, Pompholix complanata, Hexarthra intermedia, Euchlanis diladata and Lecane sp. In addition the cladocerans Diaphanosoma spinulossum and Bosmina longirostris and a copepod Microcyclops varicans were found.The greatest zooplanktonic diversity was found during the rain seasons, which were characterized by higher oxygen concentrations in the water column.On the other hand the dry season favored population increments during which period the density of the zooplanktonic community was the highest. The most important food sources for zooplankton were phytoplankton, bacteria and detritus.En el lago de Río Cuarto, provincia de Alajuela, Costa Rica, durante los meses comprendidos entre febrero de 1984 y marzo de 1985, se realizaron estudios sobre la composición de la comunidad zooplanctónica, las variaciones estacionales y la distribución vertical de las especies más abundantes, en relación con los análisis químicos, físicos y biológicos.La comunidad zooplanctónica estuvo constituida principalmente por rotíferos Keratella americana, Polyarthra vulgaris, Pompholix complanata, Hexarthra intermedia, Euchlanis diladata y Lecane sp. Además, se identificaron las especies de Cladóceros Diaphanosoma spinulossum y Bosmina longirostris y un copépodo Microcyclops varicans.La mayor diversidad de los organismos zooplanctónicos se presentó durante la época lluviosa, la cual se caracteriza por una mayor concentración de oxígeno disuelto en la columna de agua. La época seca, por el contrario, favoreció el crecimiento poblacional, observándose durante este periodo las máximas densidades de la comunidad zooplanctónica. Las principales fuentes de alimentación de los organismos zooplanctónicos fueron, además, del fitoplancton, las bacterias y detritus.
