The Experts below are selected from a list of 18333 Experts worldwide ranked by ideXlab platform

William S Dynan - One of the best experts on this subject based on the ideXlab platform.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

Shuyi Li - One of the best experts on this subject based on the ideXlab platform.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

G.g. Wicks - One of the best experts on this subject based on the ideXlab platform.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

Hairong Xiong - One of the best experts on this subject based on the ideXlab platform.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

Meiyao Wang - One of the best experts on this subject based on the ideXlab platform.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

  • Porous-Wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
    Nanomedicine: Nanotechnology Biology and Medicine, 2009
    Co-Authors: Shuyi Li, Lynsa Nguyen, Tom C.-c. Hu, Jin-xiong She, Steven M. Serkiz, Meiyao Wang, G.g. Wicks, Hairong Xiong, William S Dynan
    Abstract:

    Abstract Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the Porous Walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoPorous Walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor Porous-Wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.