The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Ignacio E. Tapia - One of the best experts on this subject based on the ideXlab platform.
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Positive Airway Pressure for the treatment of the childhood obstructive sleep apnea syndrome.
Pediatric pulmonology, 2021Co-Authors: Melissa S. Xanthopoulos, Ariel A. Williamson, Ignacio E. TapiaAbstract:In this review, we have summarized the benefits of treatment with Positive Airway Pressure for the childhood obstructive sleep apnea syndrome and presented a socio-ecological framework to enhance our understanding of Positive Airway Pressure adherence predictors and important targets of comprehensive Positive Airway Pressure treatment models across different pediatric populations. Although Positive Airway Pressure is clearly a beneficial treatment for pediatric obstructive sleep apnea syndrome, additional research is needed to evaluate how socio-ecological factors may interact to predict Positive Airway Pressure adherence, with more attention to the impact of the broader healthcare setting and on treatment approaches and outcomes in special pediatric populations.
Frédéric Sériès - One of the best experts on this subject based on the ideXlab platform.
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Impact of continuous Positive Airway Pressure mode on adherence to treatment in obstructive sleep apnea patients awaiting bariatric surgery.
Journal of sleep research, 2021Co-Authors: Sophie B. Kermelly, Annie C. Lajoie, Marie-eve Boucher, Frédéric SérièsAbstract:Obstructive sleep apnea is prevalent in the bariatric population, and is associated with various complications. Despite increasing popularity, automatic Positive Airway Pressure has not yet been studied in this population. The objective was to compare treatment adherence between automatic Positive Airway Pressure and fixed Positive Airway Pressure (continuous Positive Airway Pressure) in obstructive sleep apnea patients awaiting bariatric surgery. This randomized controlled trial involved obese patients newly diagnosed with severe obstructive sleep apnea and awaiting bariatric surgery. The primary outcome was the difference in adherence between automatic Positive Airway Pressure and continuous Positive Airway Pressure pre-operatively. Secondary outcomes included Positive Airway Pressure efficacy, adherence at 1 month, adverse effects, quality of life and peri-operative complications. Analyses were conducted using a modified intention-to-treat methodology. Fifty patients were randomized. Baseline characteristics and duration of Positive Airway Pressure therapy were comparable between groups. At the time of surgery, the percentage of overall nights Positive Airway Pressure used was 96.9% [95% confidence interval: 93.5-100] and 86.0% [95% confidence interval: 66.9-100] in the automatic Positive Airway Pressure and continuous Positive Airway Pressure groups, respectively (p = .047). Average use was 6.3 hr per night [95% confidence interval: 5.1-7.2] and 5.9 hr per night [95% confidence interval: 3.0-8.8], with a difference of 0.4 hr favouring automatic Positive Airway Pressure (p = .75). Nightly use ≥ 4 hr per night was 86.4% and 74.0% in the automatic Positive Airway Pressure and fixed continuous Positive Airway Pressure groups, respectively (p = .22). There were no statistically significant differences regarding adherence at 1 month, efficacy parameters, adverse effects, quality of life and peri-operative complications. With no difference on the safety profile and efficiency parameters, treatment adherence is not improved with automatic Positive Airway Pressure compared with fixed continuous Positive Airway Pressure in obstructive sleep apnea patients awaiting bariatric surgery.
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Continuous Positive Airway Pressure for central sleep apnea and heart failure.
The New England journal of medicine, 2005Co-Authors: T. Douglas Bradley, Alexander G. Logan, R. John Kimoff, Frédéric Sériès, Debra Morrison, Kathleen A. Ferguson, Israel Belenkie, Michael Pfeifer, John A. Fleetham, Patrick J. HanlyAbstract:Background The Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial tested the hypothesis that continuous Positive Airway Pressure (CPAP) would...
Patrick Levy - One of the best experts on this subject based on the ideXlab platform.
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residual sleepiness in sleep apnea patients treated by continuous Positive Airway Pressure
Journal of Sleep Research, 2013Co-Authors: Merce Gasa, Renaud Tamisier, Sandrine Launois, Marc Sapene, Francis Martin, Bruno Stach, Yves Grillet, Patrick LevyAbstract:Summary Hypoxic brain damage might explain persistent sleepiness in some continuous Positive Airway Pressure-compliant obstructive sleep apnea called residual excessive sleepiness. Although continuous Positive Airway Pressure may not be fully efficient in treating this symptom, wake-promoting drug prescription in residual excessive sleepiness is no longer allowed by the European Medicines Agency. The aim of this study is to describe residual excessive sleepiness phenotypes in a large prospective sample of patients with obstructive sleep apnea. Residual excessive sleepiness was defined by an Epworth Sleepiness Scale score ≥ 11. Eligible patients from the French National Sleep Registry attending follow-up continuous Positive Airway Pressure visits numbered 1047. Patients using continuous Positive Airway Pressure 15 h−1 (n = 31) or with major depression were excluded (n = 150). Residual excessive sleepiness prevalence in continuous Positive Airway Pressure-treated obstructive sleep apnea was 13% (18% for those with an initial Epworth Sleepiness Scale score > 11), and significantly decreased with continuous Positive Airway Pressure use (9% in ≥ 6 h night−1 continuous Positive Airway Pressure users, P 30 h−1 versus 18% when AHI 15–30, P < 0.005). There was no relationship between residual excessive sleepiness and body mass index, cardiovascular co-morbidities or diabetes. Continuous Positive Airway Pressure improved symptoms in the whole population, but to a lower extent in patients with residual excessive sleepiness (fatigue scale: −5.2 versus −2.7 in residual excessive sleepiness− and residual excessive sleepiness+ patients, respectively, P < 0.001). Residual excessive sleepiness prevalence decreased with continuous Positive Airway Pressure compliance. Hypoxic insult is unlikely to explain residual excessive sleepiness as obstructive sleep apnea severity does not seem to be critical. Residual symptoms are not limited to sleepiness, suggesting a true ‘continuous Positive Airway Pressure-resistant syndrome’, which may justify treatment by wake-promoting drugs.
Sandrine Launois - One of the best experts on this subject based on the ideXlab platform.
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residual sleepiness in sleep apnea patients treated by continuous Positive Airway Pressure
Journal of Sleep Research, 2013Co-Authors: Merce Gasa, Renaud Tamisier, Sandrine Launois, Marc Sapene, Francis Martin, Bruno Stach, Yves Grillet, Patrick LevyAbstract:Summary Hypoxic brain damage might explain persistent sleepiness in some continuous Positive Airway Pressure-compliant obstructive sleep apnea called residual excessive sleepiness. Although continuous Positive Airway Pressure may not be fully efficient in treating this symptom, wake-promoting drug prescription in residual excessive sleepiness is no longer allowed by the European Medicines Agency. The aim of this study is to describe residual excessive sleepiness phenotypes in a large prospective sample of patients with obstructive sleep apnea. Residual excessive sleepiness was defined by an Epworth Sleepiness Scale score ≥ 11. Eligible patients from the French National Sleep Registry attending follow-up continuous Positive Airway Pressure visits numbered 1047. Patients using continuous Positive Airway Pressure 15 h−1 (n = 31) or with major depression were excluded (n = 150). Residual excessive sleepiness prevalence in continuous Positive Airway Pressure-treated obstructive sleep apnea was 13% (18% for those with an initial Epworth Sleepiness Scale score > 11), and significantly decreased with continuous Positive Airway Pressure use (9% in ≥ 6 h night−1 continuous Positive Airway Pressure users, P 30 h−1 versus 18% when AHI 15–30, P < 0.005). There was no relationship between residual excessive sleepiness and body mass index, cardiovascular co-morbidities or diabetes. Continuous Positive Airway Pressure improved symptoms in the whole population, but to a lower extent in patients with residual excessive sleepiness (fatigue scale: −5.2 versus −2.7 in residual excessive sleepiness− and residual excessive sleepiness+ patients, respectively, P < 0.001). Residual excessive sleepiness prevalence decreased with continuous Positive Airway Pressure compliance. Hypoxic insult is unlikely to explain residual excessive sleepiness as obstructive sleep apnea severity does not seem to be critical. Residual symptoms are not limited to sleepiness, suggesting a true ‘continuous Positive Airway Pressure-resistant syndrome’, which may justify treatment by wake-promoting drugs.
Renaud Tamisier - One of the best experts on this subject based on the ideXlab platform.
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residual sleepiness in sleep apnea patients treated by continuous Positive Airway Pressure
Journal of Sleep Research, 2013Co-Authors: Merce Gasa, Renaud Tamisier, Sandrine Launois, Marc Sapene, Francis Martin, Bruno Stach, Yves Grillet, Patrick LevyAbstract:Summary Hypoxic brain damage might explain persistent sleepiness in some continuous Positive Airway Pressure-compliant obstructive sleep apnea called residual excessive sleepiness. Although continuous Positive Airway Pressure may not be fully efficient in treating this symptom, wake-promoting drug prescription in residual excessive sleepiness is no longer allowed by the European Medicines Agency. The aim of this study is to describe residual excessive sleepiness phenotypes in a large prospective sample of patients with obstructive sleep apnea. Residual excessive sleepiness was defined by an Epworth Sleepiness Scale score ≥ 11. Eligible patients from the French National Sleep Registry attending follow-up continuous Positive Airway Pressure visits numbered 1047. Patients using continuous Positive Airway Pressure 15 h−1 (n = 31) or with major depression were excluded (n = 150). Residual excessive sleepiness prevalence in continuous Positive Airway Pressure-treated obstructive sleep apnea was 13% (18% for those with an initial Epworth Sleepiness Scale score > 11), and significantly decreased with continuous Positive Airway Pressure use (9% in ≥ 6 h night−1 continuous Positive Airway Pressure users, P 30 h−1 versus 18% when AHI 15–30, P < 0.005). There was no relationship between residual excessive sleepiness and body mass index, cardiovascular co-morbidities or diabetes. Continuous Positive Airway Pressure improved symptoms in the whole population, but to a lower extent in patients with residual excessive sleepiness (fatigue scale: −5.2 versus −2.7 in residual excessive sleepiness− and residual excessive sleepiness+ patients, respectively, P < 0.001). Residual excessive sleepiness prevalence decreased with continuous Positive Airway Pressure compliance. Hypoxic insult is unlikely to explain residual excessive sleepiness as obstructive sleep apnea severity does not seem to be critical. Residual symptoms are not limited to sleepiness, suggesting a true ‘continuous Positive Airway Pressure-resistant syndrome’, which may justify treatment by wake-promoting drugs.
