The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
Vera M. A. Dias - One of the best experts on this subject based on the ideXlab platform.
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Congenital hypothyroidism: the clinical profile of affected newborns identified by the Newborn Screening Program of the State of Minas Gerais, Brazil Hipotireoidismo congênito: perfil clínico dos recém-nascidos identificados pelo Programa de Triagem
2009Co-Authors: Isabela Leite Pezzuti, Patrícia P. De Lima, Vera M. A. DiasAbstract:Objective: To evaluate the clinical profile of newborns with congenital hypothyroidism identified by the Newborn Screening Program of the State of Minas Gerais, Brazil, between 2000 and 2006. Methods: Analysis of factors involved in this profile, including: TSH and FT4 levels (determined by chemiluminescence, with limits of normality set at 0.3-5.0 µUI/mL and 0.8-1.8 ng/dL, respectively), age at diagnosis and age at treatment. The study sample consisted of 443 children, 55.8% were female and 95% were seen before completing 60 days of life. Results: The most prevalent clinical signals were: umbilical hernia (51%), enlarged anterior Fontanel (50.3%), and open Posterior Fontanel (47.2%). Hypotonia, macroglossia and feeding difficulties were the clinical signs most frequently associated with the biochemical severity of the disease. A delay in bone age was present in 32.1% of the children at diagnosis. The median of serum TSH and FT4 was 120 µUI/mL and 0.62 ng/dL, respectively. The median age at start of treatment was 28 days. Conclusion: There are some early clinical signs that suggest a diagnosis of congenital hypothyroidism. Therefore, when presented with a child exhibiting these signs, serum TSH and FT4 should be assayed in order to confirm or rule out the disease, irrespective of the result of screening. Age at start of treatment remains high, but strategies are being implemented to reduce it.
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Hipotireoidismo congênito: perfil clínico dos recém-nascidos identificados pelo Programa de Triagem Neonatal de Minas Gerais Congenital hypothyroidism: the clinical profile of affected newborns identified by the Newborn Screening Program of the State
Elsevier, 2009Co-Authors: Isabela Leite Pezzuti, Patrícia P. De Lima, Vera M. A. DiasAbstract:OBJETIVO: Avaliar o perfil clínico de recém-nascidos com hipotireoidismo congênito identificados pelo Programa Estadual de Triagem Neonatal de Minas Gerais entre 2000 e 2006. MÉTODOS: A frequência das manifestações clínicas de hipotireoidismo congênito foi analisada em relação aos níveis de hormônio estimulante da tireoide T4L (determinados por quimioluminescência, valores de referência de 0,3 a 5,0 µUI/mL e 0,8 a 1,8 ng/dL, respectivamente) e idades ao diagnóstico e tratamento. Estudou-se 443 crianças, sendo 55,8% do sexo feminino e 95% delas com menos 60 dias de vida. RESULTADOS: Os sinais clínicos mais prevalentes foram: hérnia umbilical (51%), Fontanela anterior ampla (50,3%) e Fontanela Posterior aberta (47,2%). Hipotonia, macroglossia e sucção débil foram os sinais mais associados com a gravidade bioquímica da doença. Em 32,1% das crianças houve atraso na idade óssea ao diagnóstico. As medianas de TSH e T4L séricos foram 120 µUI/mL e 0,62 ng/dL, respectivamente. A mediana da idade de início de tratamento foi de 28 dias. CONCLUSÃO: Existem sinais clínicos precoces que sugerem o diagnóstico de hipotireoidismo congênito. Portanto, diante de uma criança com esses sinais, devem ser avaliados TSH e T4L séricos para confirmar ou excluir a doença, independentemente do resultado do teste de triagem. A idade de início de tratamento ainda foi elevada, mas o programa vem adotando estratégias para redução da mesma.OBJECTIVE: To evaluate the clinical profile of newborns with congenital hypothyroidism identified by the Newborn Screening Program of the State of Minas Gerais, Brazil, between 2000 and 2006. METHODS: Analysis of factors involved in this profile, including: TSH and FT4 levels (determined by chemiluminescence, with limits of normality set at 0.3-5.0 µUI/mL and 0.8-1.8 ng/dL, respectively), age at diagnosis and age at treatment. The study sample consisted of 443 children, 55.8% were female and 95% were seen before completing 60 days of life. RESULTS: The most prevalent clinical signals were: umbilical hernia (51%), enlarged anterior Fontanel (50.3%), and open Posterior Fontanel (47.2%). Hypotonia, macroglossia and feeding difficulties were the clinical signs most frequently associated with the biochemical severity of the disease. A delay in bone age was present in 32.1% of the children at diagnosis. The median of serum TSH and FT4 was 120 µUI/mL and 0.62 ng/dL, respectively. The median age at start of treatment was 28 days. CONCLUSION: There are some early clinical signs that suggest a diagnosis of congenital hypothyroidism. Therefore, when presented with a child exhibiting these signs, serum TSH and FT4 should be assayed in order to confirm or rule out the disease, irrespective of the result of screening. Age at start of treatment remains high, but strategies are being implemented to reduce it
J. W. Wladimiroff - One of the best experts on this subject based on the ideXlab platform.
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The role of three-dimensional ultrasound in visualizing the fetal cranial sutures and Fontanels during the second half of pregnancy.
Ultrasound in Obstetrics & Gynecology, 2004Co-Authors: C. M. Dikkeboom, N. M. Roelfsema, L.n.a. Van Adrichem, J. W. WladimiroffAbstract:Objectives The aim of this study was to evaluate the significance of three-dimensional (3D) ultrasound in visualizing fetal cranial sutures and Fontanels and to determine factors that could influence visualization and image quality. Methods Serial 3D ultrasound examinations were evaluated for visibility of fetal cranial sutures and Fontanels, image quality and possible influencing parameters in the second half of pregnancy. Thirty fetuses were scanned at four different gestational ages providing a data set of 120 cases. Results Most (82–100%) cranial sutures and Fontanels could be visualized with 3D ultrasound. However, the sagittal suture and Posterior Fontanel were visualized in only 47% and 42%, respectively. Gestational age significantly influenced the visibility of the sutures and Fontanels, image quality decreasing with advancing gestational age. Conclusions 3D ultrasound can be a reliable technique for visualizing most fetal cranial sutures and Fontanels. By performing a sagittal and a transverse scan, most of the sutures and Fontanels can be made visible during the second half of pregnancy. Visualization depends on gestational age. Copyright © 2004 ISUOG. Published by John Wiley & Sons, Ltd.
Sandra Horsch - One of the best experts on this subject based on the ideXlab platform.
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State-of-the-art neonatal cerebral ultrasound: technique and reporting
Pediatric Research, 2020Co-Authors: Jeroen Dudink, Sylke Jeanne Steggerda, Sandra HorschAbstract:In the past three decades, cerebral ultrasound (CUS) has become a trusted technique to study the neonatal brain. It is a relatively cheap, non-invasive, bedside neuroimaging method available in nearly every hospital. Traditionally, CUS was used to detect major abnormalities, such as intraventricular hemorrhage (IVH), periventricular hemorrhagic infarction, post-hemorrhagic ventricular dilatation, and (cystic) periventricular leukomalacia (cPVL). The use of different acoustic windows, such as the mastoid and Posterior Fontanel, and ongoing technological developments, allows for recognizing other lesion patterns (e.g., cerebellar hemorrhage, perforator stroke, developmental venous anomaly). The CUS technique is still being improved with the use of higher transducer frequencies (7.5–18 MHz), 3D applications, advances in vascular imaging (e.g. ultrafast plane wave imaging), and improved B-mode image processing. Nevertheless, the helpfulness of CUS still highly depends on observer skills, knowledge, and experience. In this special article, we discuss how to perform a dedicated state-of-the-art neonatal CUS, and we provide suggestions for structured reporting and quality assessment.
Isabela Leite Pezzuti - One of the best experts on this subject based on the ideXlab platform.
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Congenital hypothyroidism: the clinical profile of affected newborns identified by the Newborn Screening Program of the State of Minas Gerais, Brazil Hipotireoidismo congênito: perfil clínico dos recém-nascidos identificados pelo Programa de Triagem
2009Co-Authors: Isabela Leite Pezzuti, Patrícia P. De Lima, Vera M. A. DiasAbstract:Objective: To evaluate the clinical profile of newborns with congenital hypothyroidism identified by the Newborn Screening Program of the State of Minas Gerais, Brazil, between 2000 and 2006. Methods: Analysis of factors involved in this profile, including: TSH and FT4 levels (determined by chemiluminescence, with limits of normality set at 0.3-5.0 µUI/mL and 0.8-1.8 ng/dL, respectively), age at diagnosis and age at treatment. The study sample consisted of 443 children, 55.8% were female and 95% were seen before completing 60 days of life. Results: The most prevalent clinical signals were: umbilical hernia (51%), enlarged anterior Fontanel (50.3%), and open Posterior Fontanel (47.2%). Hypotonia, macroglossia and feeding difficulties were the clinical signs most frequently associated with the biochemical severity of the disease. A delay in bone age was present in 32.1% of the children at diagnosis. The median of serum TSH and FT4 was 120 µUI/mL and 0.62 ng/dL, respectively. The median age at start of treatment was 28 days. Conclusion: There are some early clinical signs that suggest a diagnosis of congenital hypothyroidism. Therefore, when presented with a child exhibiting these signs, serum TSH and FT4 should be assayed in order to confirm or rule out the disease, irrespective of the result of screening. Age at start of treatment remains high, but strategies are being implemented to reduce it.
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Hipotireoidismo congênito: perfil clínico dos recém-nascidos identificados pelo Programa de Triagem Neonatal de Minas Gerais Congenital hypothyroidism: the clinical profile of affected newborns identified by the Newborn Screening Program of the State
Elsevier, 2009Co-Authors: Isabela Leite Pezzuti, Patrícia P. De Lima, Vera M. A. DiasAbstract:OBJETIVO: Avaliar o perfil clínico de recém-nascidos com hipotireoidismo congênito identificados pelo Programa Estadual de Triagem Neonatal de Minas Gerais entre 2000 e 2006. MÉTODOS: A frequência das manifestações clínicas de hipotireoidismo congênito foi analisada em relação aos níveis de hormônio estimulante da tireoide T4L (determinados por quimioluminescência, valores de referência de 0,3 a 5,0 µUI/mL e 0,8 a 1,8 ng/dL, respectivamente) e idades ao diagnóstico e tratamento. Estudou-se 443 crianças, sendo 55,8% do sexo feminino e 95% delas com menos 60 dias de vida. RESULTADOS: Os sinais clínicos mais prevalentes foram: hérnia umbilical (51%), Fontanela anterior ampla (50,3%) e Fontanela Posterior aberta (47,2%). Hipotonia, macroglossia e sucção débil foram os sinais mais associados com a gravidade bioquímica da doença. Em 32,1% das crianças houve atraso na idade óssea ao diagnóstico. As medianas de TSH e T4L séricos foram 120 µUI/mL e 0,62 ng/dL, respectivamente. A mediana da idade de início de tratamento foi de 28 dias. CONCLUSÃO: Existem sinais clínicos precoces que sugerem o diagnóstico de hipotireoidismo congênito. Portanto, diante de uma criança com esses sinais, devem ser avaliados TSH e T4L séricos para confirmar ou excluir a doença, independentemente do resultado do teste de triagem. A idade de início de tratamento ainda foi elevada, mas o programa vem adotando estratégias para redução da mesma.OBJECTIVE: To evaluate the clinical profile of newborns with congenital hypothyroidism identified by the Newborn Screening Program of the State of Minas Gerais, Brazil, between 2000 and 2006. METHODS: Analysis of factors involved in this profile, including: TSH and FT4 levels (determined by chemiluminescence, with limits of normality set at 0.3-5.0 µUI/mL and 0.8-1.8 ng/dL, respectively), age at diagnosis and age at treatment. The study sample consisted of 443 children, 55.8% were female and 95% were seen before completing 60 days of life. RESULTS: The most prevalent clinical signals were: umbilical hernia (51%), enlarged anterior Fontanel (50.3%), and open Posterior Fontanel (47.2%). Hypotonia, macroglossia and feeding difficulties were the clinical signs most frequently associated with the biochemical severity of the disease. A delay in bone age was present in 32.1% of the children at diagnosis. The median of serum TSH and FT4 was 120 µUI/mL and 0.62 ng/dL, respectively. The median age at start of treatment was 28 days. CONCLUSION: There are some early clinical signs that suggest a diagnosis of congenital hypothyroidism. Therefore, when presented with a child exhibiting these signs, serum TSH and FT4 should be assayed in order to confirm or rule out the disease, irrespective of the result of screening. Age at start of treatment remains high, but strategies are being implemented to reduce it
C. M. Dikkeboom - One of the best experts on this subject based on the ideXlab platform.
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The role of three-dimensional ultrasound in visualizing the fetal cranial sutures and Fontanels during the second half of pregnancy.
Ultrasound in Obstetrics & Gynecology, 2004Co-Authors: C. M. Dikkeboom, N. M. Roelfsema, L.n.a. Van Adrichem, J. W. WladimiroffAbstract:Objectives The aim of this study was to evaluate the significance of three-dimensional (3D) ultrasound in visualizing fetal cranial sutures and Fontanels and to determine factors that could influence visualization and image quality. Methods Serial 3D ultrasound examinations were evaluated for visibility of fetal cranial sutures and Fontanels, image quality and possible influencing parameters in the second half of pregnancy. Thirty fetuses were scanned at four different gestational ages providing a data set of 120 cases. Results Most (82–100%) cranial sutures and Fontanels could be visualized with 3D ultrasound. However, the sagittal suture and Posterior Fontanel were visualized in only 47% and 42%, respectively. Gestational age significantly influenced the visibility of the sutures and Fontanels, image quality decreasing with advancing gestational age. Conclusions 3D ultrasound can be a reliable technique for visualizing most fetal cranial sutures and Fontanels. By performing a sagittal and a transverse scan, most of the sutures and Fontanels can be made visible during the second half of pregnancy. Visualization depends on gestational age. Copyright © 2004 ISUOG. Published by John Wiley & Sons, Ltd.
