The Experts below are selected from a list of 5442 Experts worldwide ranked by ideXlab platform
Russell S. Scott - One of the best experts on this subject based on the ideXlab platform.
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The Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, Brett Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p
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the Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, B I Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA 1 c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and Postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. Conclusions/interpretation. The Postprandial State does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with Type 2 diabetes, irrespective of glycaemic control.
Christopher H. Strey - One of the best experts on this subject based on the ideXlab platform.
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The Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, Brett Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p
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the Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, B I Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA 1 c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and Postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. Conclusions/interpretation. The Postprandial State does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with Type 2 diabetes, irrespective of glycaemic control.
Josef R. Patsch - One of the best experts on this subject based on the ideXlab platform.
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Postprandial State and atherosclerosis.
Current opinion in lipidology, 1995Co-Authors: Christoph Ebenbichler, Rudolf Kirchmair, C. Egger, Josef R. PatschAbstract:Accumulating evidence suggests that triglyceride-rich lipoproteins are an independent risk factor for atherosclerosis. This epidemiological evidence first emerged as a result of studying Postprandial lipaemia that characterized the metabolic capacity of triglycerides in the postabsorptive State, tha
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Relation of triglyceride metabolism and coronary artery disease. Studies in the Postprandial State.
Arteriosclerosis and thrombosis : a journal of vascular biology, 1992Co-Authors: Josef R. Patsch, Gero Miesenböck, T. Hopferwieser, V. Mühlberger, E. Knapp, J K Dunn, Antonio M. Gotto, W. PatschAbstract:The status of fasting triglycerides as a risk factor for coronary artery disease (CAD) has been considered weak because in multivariate analyses, triglycerides tend to be eliminated by high density lipoprotein (HDL) cholesterol. To further evaluate the role of triglycerides in CAD, we employed Postprandial lipemia as a more informative means of characterizing triglyceride metabolism. In 61 male subjects with severe CAD and 40 control subjects without CAD as verified by angiography, we measured cholesterol; triglycerides; HDL cholesterol; HDL2 cholesterol; and apolipoproteins A-I, A-II, and B in fasting plasma and triglycerides before and 2, 4, 6, and 8 hours after a standardized test meal. Both the maximal triglyceride increase and the magnitude of Postprandial lipemia (area under the triglyceride curve over 8 hours after the meal) were higher in cases than in control subjects. Single Postprandial triglyceride levels 6 and 8 hours after the meal were highly discriminatory (p < 0.001), and by logistic-regression analysis displayed an accuracy of 68% in predicting the presence or absence of CAD. In this respect, accuracy was higher than that of HDL2 cholesterol (64%) and equal to that of apolipoprotein B (68%), the most discriminatory fasting parameter. Multivariate logistic-regression analysis was performed to reduce the number of risk factors to those that were statistically independent. This statistical procedure selected Postprandial but not fasting triglycerides into the most accurate multivariate model, which also contained the accepted risk factors HDL2 cholesterol, apolipoprotein B, and age. This model classified 82% of subjects correctly. We conclude that triglycerides are independent predictors of CAD in multivariate analyses including HDL cholesterol, provided that a challenge test of triglyceride metabolism such as Postprandial lipemia is used. The study suggests that the metabolism of triglycerides is a critical determinant of cholesterol metabolic routing. The findings support the concept that the negative association between HDL cholesterol levels and CAD actually originates in part from a positive relation between CAD and plasma triglycerides, as ascertained in the Postprandial State.
M. Collier - One of the best experts on this subject based on the ideXlab platform.
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The Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, Brett Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p
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the Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, B I Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA 1 c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and Postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. Conclusions/interpretation. The Postprandial State does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with Type 2 diabetes, irrespective of glycaemic control.
Joanna M. Young - One of the best experts on this subject based on the ideXlab platform.
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The Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, Brett Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p
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the Postprandial State does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control
Diabetologia, 2004Co-Authors: Christopher H. Strey, Joanna M. Young, M. Collier, Christopher M. Florkowski, B I Shand, Russell S. ScottAbstract:Aims/hypothesis. The Postprandial State has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, Postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the Postprandial State. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting State, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA 1 c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and Postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. Conclusions/interpretation. The Postprandial State does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with Type 2 diabetes, irrespective of glycaemic control.