The Experts below are selected from a list of 7080 Experts worldwide ranked by ideXlab platform
Hong Guo - One of the best experts on this subject based on the ideXlab platform.
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high efficiency Postprocessing for continuous variable quantum key distribution using all raw keys for parameter estimation and key extraction
Quantum Information Processing, 2019Co-Authors: Xiangyu Wang, Yichen Zhang, Hong GuoAbstract:High efficiency Postprocessing of continuous-variable quantum key distribution (CV-QKD) system has a significant impact on the secret key rate and transmission distance of the system. For a quantum channel with unknown prior characteristics, we have to sacrifice part (typically half) of the raw keys to estimate the channel parameters, which is used to assist in error correction and estimate the secret key rate. This introduces a trade-off between the secret key rate and the accuracy of parameter estimation when considering the finite-size effect. In this paper, we propose a high efficiency Postprocessing Method which uses all the raw keys for both parameter estimation and key extraction. The correcting party uses the extra data (used for phase compensation and synchronization etc.) to roughly estimate the quantum channel parameters, or she can use the results of the last block, then she selects a suitable code to correct the errors between them, finally she recovers the raw keys of the other side by a reverse mapping function after the success of error correction. Then, she uses all the raw keys of both sides for parameter estimation. We show that this Method improves the accuracy of parameter estimation and the secret key rate of CV-QKD system.
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high efficiency Postprocessing for continuous variable quantum key distribution using all raw keys for parameter estimation and key extraction
arXiv: Quantum Physics, 2018Co-Authors: Xiangyu Wang, Yichen Zhang, Hong GuoAbstract:High efficiency Postprocessing of continuous-variable quantum key distribution system has a significant impact on the secret key rate and transmission distance of the system. Currently, the Postprocessing mainly contains four steps in the following order: sifting, parameter estimation, information reconciliation, and privacy amplification. For a quantum channel with unknown prior characteristics, part of the raw keys (typically half) have to be sacrificed to estimate the channel parameters, which is used to assist in error correction (part of information reconciliation) and estimate the secret key rate. This introduces a tradeoff between the secret key rate and the accuracy of parameter estimation when considering the finite-size effect. In this paper, we propose a high efficiency Postprocessing Method which uses all the raw keys for both parameter estimation and key extraction. It is realized by exchanging the order of parameter estimation and information reconciliation, while the other steps remain unchanged. After the sifting step, the extra data (used for phase compensation and synchronization etc) can be used to roughly estimate the quantum channel parameters, or using the estimated results of last block, thus the error correction can be realized normally. After the success of error correction, the reconciler recovers the raw keys of the other side by a reverse mapping function. Then she uses all the raw keys of both sides for parameter estimation to estimate the quantum channel parameters and calculate the secret key rate of the system. Finally, they perform the privacy amplification step to obtain the unconditional security keys. We show that this Method improves the accuracy of parameter estimation and the secret key rate of continuous-variable quantum key distribution system.
William L Jorgensen - One of the best experts on this subject based on the ideXlab platform.
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metadynamics as a Postprocessing Method for virtual screening with application to the pseudokinase domain of jak2
Journal of Chemical Information and Modeling, 2020Co-Authors: Kara J Cutrona, Ana S Newton, S G Krimmer, Julian Tiradorives, William L JorgensenAbstract:With standard scoring Methods, top-ranked compounds from virtual screening by docking often turn out to be inactive. For this reason, Metadynamics, a Method used for sampling rare events, was studi...
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metadynamics as a Postprocessing Method for virtual screening with application to the pseudokinase domain of jak2
Journal of Chemical Information and Modeling, 2020Co-Authors: Kara J Cutrona, Ana S Newton, S G Krimmer, Julian Tiradorives, William L JorgensenAbstract:With standard scoring Methods, top-ranked compounds from virtual screening by docking often turn out to be inactive. For this reason, metadynamics, a Method used to sample rare events, was studied to further evaluate docking poses with the aim of reducing false positives. Specifically, virtual screening was performed with Glide SP to seek potential molecules to bind to the ATP site in the pseudokinase domain of JAK2 kinase, and promising compounds were selected from the top-ranked 1000 based on visualization. Rescoring with Glide XP, GOLD, and MM/GBSA was unable to differentiate well between active and inactive compounds. Metadynamics was then used to gauge the relative binding affinity from the required time or the potential of mean force needed to dissociate the ligand from the bound complex. With consideration of previously known binders of varying affinities, metadynamics was able to differentiate between the most active compounds and inactive or weakly active ones, and it could identify correctly most of the selected virtual screening compounds as false positives. Thus, metadynamics has the potential to be a viable Postprocessing Method for virtual screening, minimizing the expense of buying or synthesizing inactive compounds.
Xiangyu Wang - One of the best experts on this subject based on the ideXlab platform.
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high efficiency Postprocessing for continuous variable quantum key distribution using all raw keys for parameter estimation and key extraction
Quantum Information Processing, 2019Co-Authors: Xiangyu Wang, Yichen Zhang, Hong GuoAbstract:High efficiency Postprocessing of continuous-variable quantum key distribution (CV-QKD) system has a significant impact on the secret key rate and transmission distance of the system. For a quantum channel with unknown prior characteristics, we have to sacrifice part (typically half) of the raw keys to estimate the channel parameters, which is used to assist in error correction and estimate the secret key rate. This introduces a trade-off between the secret key rate and the accuracy of parameter estimation when considering the finite-size effect. In this paper, we propose a high efficiency Postprocessing Method which uses all the raw keys for both parameter estimation and key extraction. The correcting party uses the extra data (used for phase compensation and synchronization etc.) to roughly estimate the quantum channel parameters, or she can use the results of the last block, then she selects a suitable code to correct the errors between them, finally she recovers the raw keys of the other side by a reverse mapping function after the success of error correction. Then, she uses all the raw keys of both sides for parameter estimation. We show that this Method improves the accuracy of parameter estimation and the secret key rate of CV-QKD system.
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high efficiency Postprocessing for continuous variable quantum key distribution using all raw keys for parameter estimation and key extraction
arXiv: Quantum Physics, 2018Co-Authors: Xiangyu Wang, Yichen Zhang, Hong GuoAbstract:High efficiency Postprocessing of continuous-variable quantum key distribution system has a significant impact on the secret key rate and transmission distance of the system. Currently, the Postprocessing mainly contains four steps in the following order: sifting, parameter estimation, information reconciliation, and privacy amplification. For a quantum channel with unknown prior characteristics, part of the raw keys (typically half) have to be sacrificed to estimate the channel parameters, which is used to assist in error correction (part of information reconciliation) and estimate the secret key rate. This introduces a tradeoff between the secret key rate and the accuracy of parameter estimation when considering the finite-size effect. In this paper, we propose a high efficiency Postprocessing Method which uses all the raw keys for both parameter estimation and key extraction. It is realized by exchanging the order of parameter estimation and information reconciliation, while the other steps remain unchanged. After the sifting step, the extra data (used for phase compensation and synchronization etc) can be used to roughly estimate the quantum channel parameters, or using the estimated results of last block, thus the error correction can be realized normally. After the success of error correction, the reconciler recovers the raw keys of the other side by a reverse mapping function. Then she uses all the raw keys of both sides for parameter estimation to estimate the quantum channel parameters and calculate the secret key rate of the system. Finally, they perform the privacy amplification step to obtain the unconditional security keys. We show that this Method improves the accuracy of parameter estimation and the secret key rate of continuous-variable quantum key distribution system.
Kara J Cutrona - One of the best experts on this subject based on the ideXlab platform.
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metadynamics as a Postprocessing Method for virtual screening with application to the pseudokinase domain of jak2
Journal of Chemical Information and Modeling, 2020Co-Authors: Kara J Cutrona, Ana S Newton, S G Krimmer, Julian Tiradorives, William L JorgensenAbstract:With standard scoring Methods, top-ranked compounds from virtual screening by docking often turn out to be inactive. For this reason, Metadynamics, a Method used for sampling rare events, was studi...
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metadynamics as a Postprocessing Method for virtual screening with application to the pseudokinase domain of jak2
Journal of Chemical Information and Modeling, 2020Co-Authors: Kara J Cutrona, Ana S Newton, S G Krimmer, Julian Tiradorives, William L JorgensenAbstract:With standard scoring Methods, top-ranked compounds from virtual screening by docking often turn out to be inactive. For this reason, metadynamics, a Method used to sample rare events, was studied to further evaluate docking poses with the aim of reducing false positives. Specifically, virtual screening was performed with Glide SP to seek potential molecules to bind to the ATP site in the pseudokinase domain of JAK2 kinase, and promising compounds were selected from the top-ranked 1000 based on visualization. Rescoring with Glide XP, GOLD, and MM/GBSA was unable to differentiate well between active and inactive compounds. Metadynamics was then used to gauge the relative binding affinity from the required time or the potential of mean force needed to dissociate the ligand from the bound complex. With consideration of previously known binders of varying affinities, metadynamics was able to differentiate between the most active compounds and inactive or weakly active ones, and it could identify correctly most of the selected virtual screening compounds as false positives. Thus, metadynamics has the potential to be a viable Postprocessing Method for virtual screening, minimizing the expense of buying or synthesizing inactive compounds.
Yichen Zhang - One of the best experts on this subject based on the ideXlab platform.
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high efficiency Postprocessing for continuous variable quantum key distribution using all raw keys for parameter estimation and key extraction
Quantum Information Processing, 2019Co-Authors: Xiangyu Wang, Yichen Zhang, Hong GuoAbstract:High efficiency Postprocessing of continuous-variable quantum key distribution (CV-QKD) system has a significant impact on the secret key rate and transmission distance of the system. For a quantum channel with unknown prior characteristics, we have to sacrifice part (typically half) of the raw keys to estimate the channel parameters, which is used to assist in error correction and estimate the secret key rate. This introduces a trade-off between the secret key rate and the accuracy of parameter estimation when considering the finite-size effect. In this paper, we propose a high efficiency Postprocessing Method which uses all the raw keys for both parameter estimation and key extraction. The correcting party uses the extra data (used for phase compensation and synchronization etc.) to roughly estimate the quantum channel parameters, or she can use the results of the last block, then she selects a suitable code to correct the errors between them, finally she recovers the raw keys of the other side by a reverse mapping function after the success of error correction. Then, she uses all the raw keys of both sides for parameter estimation. We show that this Method improves the accuracy of parameter estimation and the secret key rate of CV-QKD system.
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high efficiency Postprocessing for continuous variable quantum key distribution using all raw keys for parameter estimation and key extraction
arXiv: Quantum Physics, 2018Co-Authors: Xiangyu Wang, Yichen Zhang, Hong GuoAbstract:High efficiency Postprocessing of continuous-variable quantum key distribution system has a significant impact on the secret key rate and transmission distance of the system. Currently, the Postprocessing mainly contains four steps in the following order: sifting, parameter estimation, information reconciliation, and privacy amplification. For a quantum channel with unknown prior characteristics, part of the raw keys (typically half) have to be sacrificed to estimate the channel parameters, which is used to assist in error correction (part of information reconciliation) and estimate the secret key rate. This introduces a tradeoff between the secret key rate and the accuracy of parameter estimation when considering the finite-size effect. In this paper, we propose a high efficiency Postprocessing Method which uses all the raw keys for both parameter estimation and key extraction. It is realized by exchanging the order of parameter estimation and information reconciliation, while the other steps remain unchanged. After the sifting step, the extra data (used for phase compensation and synchronization etc) can be used to roughly estimate the quantum channel parameters, or using the estimated results of last block, thus the error correction can be realized normally. After the success of error correction, the reconciler recovers the raw keys of the other side by a reverse mapping function. Then she uses all the raw keys of both sides for parameter estimation to estimate the quantum channel parameters and calculate the secret key rate of the system. Finally, they perform the privacy amplification step to obtain the unconditional security keys. We show that this Method improves the accuracy of parameter estimation and the secret key rate of continuous-variable quantum key distribution system.