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Luiz Carlos Schenberg - One of the best experts on this subject based on the ideXlab platform.
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on the verge of a respiratory type panic attack selective activations of rostrolateral and caudoventrolateral periaqueductal gray matter following short lasting escape to a low dose of Potassium Cyanide
2017Co-Authors: Claudia Janaina Torres Muller, Jeyce Willig Quintinodossantos, Fagna Giacomin Schimitel, Sergio Tufik, Vanessa Beijamini, Newton S Canteras, Luiz Carlos SchenbergAbstract:Abstract Intravenous injections of Potassium Cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60 µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior. Accordingly, here we compared the brainstem activations of saline-injected controls (air/saline) with those produced by a single intravenous injection of 40-µg KCN (air/KCN), a 2-min exposure to 13% CO2 (CO2/saline), or a combined stimulus (CO2/KCN). Behavioral effects of KCN microinjections into the PAG were assessed as well. Data showed that whereas the KCN microinjections were ineffective, KCN intravenous injections elicited escape in all tested rats. Moreover, whereas the CO2 alone was ineffective, it potentiated the KCN-evoked escape. Compared to controls, the nucleus tractus solitarius was significantly activated in both CO2/saline and CO2/KCN groups. Additionally, whereas the laterodorsal tegmental nucleus was activated by all treatments, the rostrolateral and caudoventrolateral PAG were activated by air/KCN only. Data suggest that the latter structures are key components of a hypoxia-sensitive suffocation alarm which activation may trigger a panic attack.
Anvarhusein A Isab - One of the best experts on this subject based on the ideXlab platform.
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nmr and kinetic studies of the interactions of au cis dach cl2 cl and au cis dach 2 cl3 with Potassium Cyanide in aqueous solution
2014Co-Authors: Adam A A Seliman, Muhammad Altaf, Abdelnasser Kawde, Mohammed I M Wazeer, Anvarhusein A IsabAbstract:The interactions of [Au(cis-DACH)Cl2]Cl and [Au(cis-DACH)2]Cl3 [where cis-DACH is cis-1,2-diaminocyclohexane] with enriched KCN were carried out in CD3OD and D2O, respectively. The reaction pathways of these complexes were studied by 1H, 13C, 15N NMR, UV spectrophotometry, and electrochemistry. The kinetic data for the reaction of Cyanide with [Au(cis-DACH)2]Cl3 are k = 18 M−1s−1, ∆H≠ = 11 kJ M−1, ∆S≠ = −185 JK−1 M−1, and Ea = 13 kJ M−1 with square wave voltammetric (SWV) peak +1.35 V, whereas the kinetic data for the reaction of Cyanide ion with [Au(cis-DACH)Cl2]Cl are k = 148 M−1s−1, ∆H≠ = 39 kJM−1, ∆S≠ = −80 JK-1 M−1, and Ea = 42 kJM−1 along with SWV peak +0.82 V, indicating much higher reactivity of [Au(cis-DACH)Cl2]Cl toward Cyanide than [Au(cis-DACH)2]Cl3. The interaction of these complexes with Potassium Cyanide resulted in an unstable [Au(13CN)4]− species which readily underwent reductive elimination reaction to generate [Au(13CN)2]− and cyanogen.
Claudia Janaina Torres Muller - One of the best experts on this subject based on the ideXlab platform.
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on the verge of a respiratory type panic attack selective activations of rostrolateral and caudoventrolateral periaqueductal gray matter following short lasting escape to a low dose of Potassium Cyanide
2017Co-Authors: Claudia Janaina Torres Muller, Jeyce Willig Quintinodossantos, Fagna Giacomin Schimitel, Sergio Tufik, Vanessa Beijamini, Newton S Canteras, Luiz Carlos SchenbergAbstract:Abstract Intravenous injections of Potassium Cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60 µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior. Accordingly, here we compared the brainstem activations of saline-injected controls (air/saline) with those produced by a single intravenous injection of 40-µg KCN (air/KCN), a 2-min exposure to 13% CO2 (CO2/saline), or a combined stimulus (CO2/KCN). Behavioral effects of KCN microinjections into the PAG were assessed as well. Data showed that whereas the KCN microinjections were ineffective, KCN intravenous injections elicited escape in all tested rats. Moreover, whereas the CO2 alone was ineffective, it potentiated the KCN-evoked escape. Compared to controls, the nucleus tractus solitarius was significantly activated in both CO2/saline and CO2/KCN groups. Additionally, whereas the laterodorsal tegmental nucleus was activated by all treatments, the rostrolateral and caudoventrolateral PAG were activated by air/KCN only. Data suggest that the latter structures are key components of a hypoxia-sensitive suffocation alarm which activation may trigger a panic attack.
Mohsiung Yang - One of the best experts on this subject based on the ideXlab platform.
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cholestatic hepatitis caused by acute gold Potassium Cyanide poisoning
2001Co-Authors: Weijen Tsai, Jiin Ger, Joufang Deng, Shyhhaw Tsay, Mohsiung YangAbstract:Introduction: Poisoning after oral ingestion of gold Potassium Cyanide is rarely reported. A case of suicidal ingestion of gold Potassium Cyanide (Potassium dicyanoaurate; CAS# 13967-50-5) is described. Case Report: A 27-year-old man attempted suicide by ingesting 5 mL gold Potassium Cyanide solution. He developed vomiting, hyperamylasemia, and hepatic dysfunction. Cyanide poisoning was not detected but acute gold toxicity was noted. Pathologic findings of the liver showed centrilobular cholestasis with eosinophilic degeneration. The whole blood and serum gold were 4361 and 6011 μg/L, respectively, and the 24-hour urine gold was 429 μg/d in samples obtained on day 4. Conclusion: Gold-induced hepatotoxicity has been seen infrequently in patients receiving gold therapy. Reported agents include sodium aurothiomalate, sodium aurothiopropranol sulfonate, aurothioglucose, aurothiopolypeptide (Auro-detoxin), auric sulfide, and gold thiosulfate, our report adds gold Potassium Cyanide.
Adam A A Seliman - One of the best experts on this subject based on the ideXlab platform.
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nmr and kinetic studies of the interactions of au cis dach cl2 cl and au cis dach 2 cl3 with Potassium Cyanide in aqueous solution
2014Co-Authors: Adam A A Seliman, Muhammad Altaf, Abdelnasser Kawde, Mohammed I M Wazeer, Anvarhusein A IsabAbstract:The interactions of [Au(cis-DACH)Cl2]Cl and [Au(cis-DACH)2]Cl3 [where cis-DACH is cis-1,2-diaminocyclohexane] with enriched KCN were carried out in CD3OD and D2O, respectively. The reaction pathways of these complexes were studied by 1H, 13C, 15N NMR, UV spectrophotometry, and electrochemistry. The kinetic data for the reaction of Cyanide with [Au(cis-DACH)2]Cl3 are k = 18 M−1s−1, ∆H≠ = 11 kJ M−1, ∆S≠ = −185 JK−1 M−1, and Ea = 13 kJ M−1 with square wave voltammetric (SWV) peak +1.35 V, whereas the kinetic data for the reaction of Cyanide ion with [Au(cis-DACH)Cl2]Cl are k = 148 M−1s−1, ∆H≠ = 39 kJM−1, ∆S≠ = −80 JK-1 M−1, and Ea = 42 kJM−1 along with SWV peak +0.82 V, indicating much higher reactivity of [Au(cis-DACH)Cl2]Cl toward Cyanide than [Au(cis-DACH)2]Cl3. The interaction of these complexes with Potassium Cyanide resulted in an unstable [Au(13CN)4]− species which readily underwent reductive elimination reaction to generate [Au(13CN)2]− and cyanogen.