The Experts below are selected from a list of 198 Experts worldwide ranked by ideXlab platform
F. Milliat - One of the best experts on this subject based on the ideXlab platform.
-
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis
American Journal of Pathology, 2015Co-Authors: E. Mintet, E. Rannou, V. Buard, G. West, O. Guipaud, G. Tarlet, J.-c. Sabourin, M. Benderitter, C. Fiocchi, F. MilliatAbstract:The endothelial-to-mesenchymal transition (EndoMT) is a crucial cellular process during heart development necessary to the formation of cardiac valves. This embryonic process reappears in several pathological situations, such as vascular injury or organ fibrosis of various etiologies, as a mediator of extracellular matrix-producing cells. Because radiation induces both vascular damage and fibrosis, we investigated whether radiation exposure induces EndoMT in primary human intestinal microvascular endothelial cells (HIMECs) and whether EndoMT contributes to radiation-induced rectal damage in humans and in a preclinical model of radiation proctitis in mice. Irradiated HIMECs show phenotypic hallmarks of radiation-induced endothelial cell activation in vitro. Moreover, HIMECs undergo changes in molecular expression pattern compatible with EndoMT, with up-regulation of mesenchymal markers and down-regulation of endothelial markers via transforming growth factor/Smad pathway activation. In vivo, EndoMT readily occurs in the human rectum after radiation therapy for rectal adenocarcinoma. Finally, EndoMT was observed in rectal mucosal and submucosal microvessels in a preclinical model of radiation proctitis in Tie2-green fluorescent protein reporter-expressing mice all along radiation proctitis development, also associated with transforming growth factor/Smad pathway activation. In conclusion, radiation-induced cell activation and tissue inflammation constitute a setting that fosters the phenotypic conversion of endothelial cells into mesenchymal cells. Therefore, EndoMT is identified as a Potential Participant in radiation-induced gut damage and may represent an interesting therapeutic target in cases of radiation-induced pelvic disease. © 2015 American Society for Investigative Pathology.
-
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis
The American journal of pathology, 2015Co-Authors: E. Mintet, E. Rannou, V. Buard, G. West, O. Guipaud, G. Tarlet, J.-c. Sabourin, M. Benderitter, C. Fiocchi, F. MilliatAbstract:The endothelial-to-mesenchymal transition (EndoMT) is a crucial cellular process during heart development necessary to the formation of cardiac valves. This embryonic process reappears in several pathological situations, such as vascular injury or organ fibrosis of various etiologies, as a mediator of extracellular matrix-producing cells. Because radiation induces both vascular damage and fibrosis, we investigated whether radiation exposure induces EndoMT in primary human intestinal microvascular endothelial cells (HIMECs) and whether EndoMT contributes to radiation-induced rectal damage in humans and in a preclinical model of radiation proctitis in mice. Irradiated HIMECs show phenotypic hallmarks of radiation-induced endothelial cell activation in vitro . Moreover, HIMECs undergo changes in molecular expression pattern compatible with EndoMT, with up-regulation of mesenchymal markers and down-regulation of endothelial markers via transforming growth factor/Smad pathway activation. In vivo , EndoMT readily occurs in the human rectum after radiation therapy for rectal adenocarcinoma. Finally, EndoMT was observed in rectal mucosal and submucosal microvessels in a preclinical model of radiation proctitis in Tie2-green fluorescent protein reporter–expressing mice all along radiation proctitis development, also associated with transforming growth factor/Smad pathway activation. In conclusion, radiation-induced cell activation and tissue inflammation constitute a setting that fosters the phenotypic conversion of endothelial cells into mesenchymal cells. Therefore, EndoMT is identified as a Potential Participant in radiation-induced gut damage and may represent an interesting therapeutic target in cases of radiation-induced pelvic disease.
Guillaume Chelius - One of the best experts on this subject based on the ideXlab platform.
-
ADHOC-NOW - Mitigating Reply Implosions in Query-Based Service Discovery Protocols for Mobile Wireless Ad Hoc Networks
Lecture Notes in Computer Science, 2008Co-Authors: Antônio Tadeu A. Gomes, Artur Ziviani, Luciana Dos S. Lima, Markus Endler, Guillaume CheliusAbstract:Providing service discovery in an efficient and scalable way in ad hoc networks is a challenging problem, in particular for multihop scenarios, due to the large number of Potential Participant nodes and the scarce resources in these networks. In this paper, we propose and evaluate an approach to mitigate the reply implosion problem in query-based service discovery protocols for multihop mobile ad hoc networks. Our simulation results show the scalability and efficiency of the proposed solution. We demonstrate that the proposed scheme considerably reduces the number of transmissions without compromising the efficiency of the service discovery in scenarios of pedestrian mobility.
-
Mitigating Reply Implosions in Query-Based Service Discovery Protocols for Mobile Wireless Ad Hoc Networks
2008Co-Authors: Antônio Tadeu Gomez, Artur Ziviani, Markus Endler, Luciana Lima, Guillaume CheliusAbstract:Providing service discovery in an efficient and scalable way in ad hoc networks is a challenging problem, in particular for multihop scenarios, due to the large number of Potential Participant nodes and the scarce resources in these networks. In this paper, we propose and evaluate an approach to mitigate the reply implosion problem in query-based service discovery protocols for multihop mobile ad hoc networks. Our simulation results show the scalability and efficiency of the proposed solution. We demonstrate that the proposed scheme considerably reduces the number of transmissions without compromising the efficiency of the service discovery in scenarios of pedestrian mobility.
Allison Y Hsiang - One of the best experts on this subject based on the ideXlab platform.
-
a north american stem turaco and the complex biogeographic history of modern birds
BMC Evolutionary Biology, 2018Co-Authors: Daniel J Field, Allison Y HsiangAbstract:Earth’s lower latitudes boast the majority of extant avian species-level and higher-order diversity, with many deeply diverging clades restricted to vestiges of Gondwana. However, palaeontological analyses reveal that many avian crown clades with restricted extant distributions had stem group relatives in very different parts of the world. Our phylogenetic analyses support the enigmatic fossil bird Foro panarium Olson 1992 from the early Eocene (Wasatchian) of Wyoming as a stem turaco (Neornithes: Pan-Musophagidae), a clade that is presently endemic to sub-Saharan Africa. Our analyses offer the first well-supported evidence for a stem musophagid (and therefore a useful fossil calibration for avian molecular divergence analyses), and reveal surprising new information on the early morphology and biogeography of this clade. Total-clade Musophagidae is identified as a Potential Participant in dispersal via the recently proposed ‘North American Gateway’ during the Palaeogene, and new biogeographic analyses illustrate the importance of the fossil record in revealing the complex historical biogeography of crown birds across geological timescales. In the Palaeogene, total-clade Musophagidae was distributed well outside the range of crown Musophagidae in the present day. This observation is consistent with similar biogeographic observations for numerous other modern bird clades, illustrating shortcomings of historical biogeographic analyses that do not incorporate information from the avian fossil record.
-
A North American stem turaco, and the complex biogeographic history of modern birds
BMC Evolutionary Biology, 2018Co-Authors: Daniel J Field, Allison Y HsiangAbstract:Background Earth’s lower latitudes boast the majority of extant avian species-level and higher-order diversity, with many deeply diverging clades restricted to vestiges of Gondwana. However, palaeontological analyses reveal that many avian crown clades with restricted extant distributions had stem group relatives in very different parts of the world. Results Our phylogenetic analyses support the enigmatic fossil bird Foro panarium Olson 1992 from the early Eocene (Wasatchian) of Wyoming as a stem turaco (Neornithes: Pan-Musophagidae), a clade that is presently endemic to sub-Saharan Africa. Our analyses offer the first well-supported evidence for a stem musophagid (and therefore a useful fossil calibration for avian molecular divergence analyses), and reveal surprising new information on the early morphology and biogeography of this clade. Total-clade Musophagidae is identified as a Potential Participant in dispersal via the recently proposed ‘North American Gateway’ during the Palaeogene, and new biogeographic analyses illustrate the importance of the fossil record in revealing the complex historical biogeography of crown birds across geological timescales. Conclusions In the Palaeogene, total-clade Musophagidae was distributed well outside the range of crown Musophagidae in the present day. This observation is consistent with similar biogeographic observations for numerous other modern bird clades, illustrating shortcomings of historical biogeographic analyses that do not incorporate information from the avian fossil record.
E. Mintet - One of the best experts on this subject based on the ideXlab platform.
-
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis
American Journal of Pathology, 2015Co-Authors: E. Mintet, E. Rannou, V. Buard, G. West, O. Guipaud, G. Tarlet, J.-c. Sabourin, M. Benderitter, C. Fiocchi, F. MilliatAbstract:The endothelial-to-mesenchymal transition (EndoMT) is a crucial cellular process during heart development necessary to the formation of cardiac valves. This embryonic process reappears in several pathological situations, such as vascular injury or organ fibrosis of various etiologies, as a mediator of extracellular matrix-producing cells. Because radiation induces both vascular damage and fibrosis, we investigated whether radiation exposure induces EndoMT in primary human intestinal microvascular endothelial cells (HIMECs) and whether EndoMT contributes to radiation-induced rectal damage in humans and in a preclinical model of radiation proctitis in mice. Irradiated HIMECs show phenotypic hallmarks of radiation-induced endothelial cell activation in vitro. Moreover, HIMECs undergo changes in molecular expression pattern compatible with EndoMT, with up-regulation of mesenchymal markers and down-regulation of endothelial markers via transforming growth factor/Smad pathway activation. In vivo, EndoMT readily occurs in the human rectum after radiation therapy for rectal adenocarcinoma. Finally, EndoMT was observed in rectal mucosal and submucosal microvessels in a preclinical model of radiation proctitis in Tie2-green fluorescent protein reporter-expressing mice all along radiation proctitis development, also associated with transforming growth factor/Smad pathway activation. In conclusion, radiation-induced cell activation and tissue inflammation constitute a setting that fosters the phenotypic conversion of endothelial cells into mesenchymal cells. Therefore, EndoMT is identified as a Potential Participant in radiation-induced gut damage and may represent an interesting therapeutic target in cases of radiation-induced pelvic disease. © 2015 American Society for Investigative Pathology.
-
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis
The American journal of pathology, 2015Co-Authors: E. Mintet, E. Rannou, V. Buard, G. West, O. Guipaud, G. Tarlet, J.-c. Sabourin, M. Benderitter, C. Fiocchi, F. MilliatAbstract:The endothelial-to-mesenchymal transition (EndoMT) is a crucial cellular process during heart development necessary to the formation of cardiac valves. This embryonic process reappears in several pathological situations, such as vascular injury or organ fibrosis of various etiologies, as a mediator of extracellular matrix-producing cells. Because radiation induces both vascular damage and fibrosis, we investigated whether radiation exposure induces EndoMT in primary human intestinal microvascular endothelial cells (HIMECs) and whether EndoMT contributes to radiation-induced rectal damage in humans and in a preclinical model of radiation proctitis in mice. Irradiated HIMECs show phenotypic hallmarks of radiation-induced endothelial cell activation in vitro . Moreover, HIMECs undergo changes in molecular expression pattern compatible with EndoMT, with up-regulation of mesenchymal markers and down-regulation of endothelial markers via transforming growth factor/Smad pathway activation. In vivo , EndoMT readily occurs in the human rectum after radiation therapy for rectal adenocarcinoma. Finally, EndoMT was observed in rectal mucosal and submucosal microvessels in a preclinical model of radiation proctitis in Tie2-green fluorescent protein reporter–expressing mice all along radiation proctitis development, also associated with transforming growth factor/Smad pathway activation. In conclusion, radiation-induced cell activation and tissue inflammation constitute a setting that fosters the phenotypic conversion of endothelial cells into mesenchymal cells. Therefore, EndoMT is identified as a Potential Participant in radiation-induced gut damage and may represent an interesting therapeutic target in cases of radiation-induced pelvic disease.
K. M. Dunn - One of the best experts on this subject based on the ideXlab platform.
-
Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial
BMC Family Practice, 2020Co-Authors: J. C. Hill, S. Garvin, Y. Chen, V. Cooper, S. Wathall, B. Saunders, M. Lewis, J. Protheroe, A. Chudyk, K. M. DunnAbstract:Background Musculoskeletal (MSK) pain from the five most common presentations to primary care (back, neck, shoulder, knee or multi-site pain), where the majority of patients are managed, is a costly global health challenge. At present, first-line decision-making is based on clinical reasoning and stratified models of care have only been tested in patients with low back pain. We therefore, examined the feasibility of; a) a future definitive cluster randomised controlled trial (RCT), and b) General Practitioners (GPs) providing stratified care at the point-of-consultation for these five most common MSK pain presentations. Methods The design was a pragmatic pilot, two parallel-arm (stratified versus non-stratified care), cluster RCT and the setting was 8 UK GP practices (4 intervention, 4 control) with randomisation (stratified by practice size) and blinding of trial statistician and outcome data-collectors. Participants were adult consulters with MSK pain without indicators of serious pathologies, urgent medical needs, or vulnerabilities. Potential Participant records were tagged and individuals sent postal invitations using a GP point-of-consultation electronic medical record (EMR) template. The intervention was supported by the EMR template housing the Keele STarT MSK Tool (to stratify into low, medium and high-risk prognostic subgroups of persistent pain and disability) and recommended matched treatment options. Feasibility outcomes included exploration of recruitment and follow-up rates, selection bias, and GP intervention fidelity. To capture recommended outcomes including pain and function, Participants completed an initial questionnaire, brief monthly questionnaire (postal or SMS), and 6-month follow-up questionnaire. An anonymised EMR audit described GP decision-making. Results GPs screened 3063 patients (intervention = 1591, control = 1472), completed the EMR template with 1237 eligible patients (interventio n = 513, control = 724) and 524 Participants (42%) consented to data collection (interventio n = 231, control = 293). Recruitment took 28 weeks (target 12 weeks) with > 90% follow-up retention (target > 75%). We detected no selection bias of concern and no harms identified. GP stratification tool fidelity failed to achieve a-priori success criteria, whilst fidelity to the matched treatments achieved “complete success”. Conclusions A future definitive cluster RCT of stratified care for MSK pain is feasible and is underway, following key amendments including a clinician-completed version of the stratification tool and refinements to recommended matched treatments. Trial registration Name of the registry: ISRCTN. Trial registration number: 15366334 . Date of registration: 06/04/2016.