The Experts below are selected from a list of 222492 Experts worldwide ranked by ideXlab platform
Claudio Tiberti - One of the best experts on this subject based on the ideXlab platform.
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tissue transglutaminase autoantibody detection in human saliva a Powerful Method for celiac disease screening
The Journal of Pediatrics, 2004Co-Authors: M Bonamico, M Ferri, Raffaella Nenna, Antonella Verrienti, Umberto Di Mario, Claudio TibertiAbstract:Abstract Objective To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA). Study design Paired saliva and serum samples from 39 patients with celiac disease (CD), at the first biopsy (Group 1: 28 females, mean age 11.5 ± 11.1 years); 32 controls with a normal duodenal mucosa (Group 2: 18 females, mean age 8.1 ± 3.6 years); and 32 healthy volunteers (Group 3: 21 females, mean age 31.7 ± 9.8 years) were studied for tTG-Ab presence. Limit of positivity for salivary assay was calculated according to the 99th percentiles of Group 2 control children and was expressed as an autoantibody (Ab) index. Results Salivary tTG-Abs were found in 97.4% of the patients with CD and in 100% of the corresponding serum samples. All Group 3 subjects were negative with both saliva and serum assays. A correlation between saliva and serum tTG-Ab titers was found (r = 0.826, P = .0014). Conclusions This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive Method.
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Tissue transglutaminase autoantibody detection in human saliva: a Powerful Method for celiac disease screening ☆
The Journal of pediatrics, 2004Co-Authors: M Bonamico, M Ferri, Raffaella Nenna, Antonella Verrienti, Umberto Di Mario, Claudio TibertiAbstract:Abstract Objective To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA). Study design Paired saliva and serum samples from 39 patients with celiac disease (CD), at the first biopsy (Group 1: 28 females, mean age 11.5 ± 11.1 years); 32 controls with a normal duodenal mucosa (Group 2: 18 females, mean age 8.1 ± 3.6 years); and 32 healthy volunteers (Group 3: 21 females, mean age 31.7 ± 9.8 years) were studied for tTG-Ab presence. Limit of positivity for salivary assay was calculated according to the 99th percentiles of Group 2 control children and was expressed as an autoantibody (Ab) index. Results Salivary tTG-Abs were found in 97.4% of the patients with CD and in 100% of the corresponding serum samples. All Group 3 subjects were negative with both saliva and serum assays. A correlation between saliva and serum tTG-Ab titers was found (r = 0.826, P = .0014). Conclusions This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive Method.
Shingo Ishikawa - One of the best experts on this subject based on the ideXlab platform.
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a Powerful Method for the direct arylation of furans at a sterically congested c h bond
Asian Journal of Organic Chemistry, 2016Co-Authors: Takashi Nishikata, Yu Yamane, Yousui Yamaguchi, Shingo IshikawaAbstract:The direct arylation of furans at a sterically congested C−H bond are accomplished. Although there are many Methods for catalytic C−H arylation, direct C−H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl2-1,2-bis(dicyclohexylphosphino)ethane (dcype) or PCy3 and silver salt system enables arylations at a sterically congested C−H bonds to produce “highly congested” and “very congested” triarylfurans.
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A Powerful Method for the Direct Arylation of Furans at a Sterically Congested C−H Bond
Asian Journal of Organic Chemistry, 2016Co-Authors: Takashi Nishikata, Yu Yamane, Yousui Yamaguchi, Shingo IshikawaAbstract:The direct arylation of furans at a sterically congested C−H bond are accomplished. Although there are many Methods for catalytic C−H arylation, direct C−H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl2-1,2-bis(dicyclohexylphosphino)ethane (dcype) or PCy3 and silver salt system enables arylations at a sterically congested C−H bonds to produce “highly congested” and “very congested” triarylfurans.
M Bonamico - One of the best experts on this subject based on the ideXlab platform.
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tissue transglutaminase autoantibody detection in human saliva a Powerful Method for celiac disease screening
The Journal of Pediatrics, 2004Co-Authors: M Bonamico, M Ferri, Raffaella Nenna, Antonella Verrienti, Umberto Di Mario, Claudio TibertiAbstract:Abstract Objective To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA). Study design Paired saliva and serum samples from 39 patients with celiac disease (CD), at the first biopsy (Group 1: 28 females, mean age 11.5 ± 11.1 years); 32 controls with a normal duodenal mucosa (Group 2: 18 females, mean age 8.1 ± 3.6 years); and 32 healthy volunteers (Group 3: 21 females, mean age 31.7 ± 9.8 years) were studied for tTG-Ab presence. Limit of positivity for salivary assay was calculated according to the 99th percentiles of Group 2 control children and was expressed as an autoantibody (Ab) index. Results Salivary tTG-Abs were found in 97.4% of the patients with CD and in 100% of the corresponding serum samples. All Group 3 subjects were negative with both saliva and serum assays. A correlation between saliva and serum tTG-Ab titers was found (r = 0.826, P = .0014). Conclusions This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive Method.
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Tissue transglutaminase autoantibody detection in human saliva: a Powerful Method for celiac disease screening ☆
The Journal of pediatrics, 2004Co-Authors: M Bonamico, M Ferri, Raffaella Nenna, Antonella Verrienti, Umberto Di Mario, Claudio TibertiAbstract:Abstract Objective To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA). Study design Paired saliva and serum samples from 39 patients with celiac disease (CD), at the first biopsy (Group 1: 28 females, mean age 11.5 ± 11.1 years); 32 controls with a normal duodenal mucosa (Group 2: 18 females, mean age 8.1 ± 3.6 years); and 32 healthy volunteers (Group 3: 21 females, mean age 31.7 ± 9.8 years) were studied for tTG-Ab presence. Limit of positivity for salivary assay was calculated according to the 99th percentiles of Group 2 control children and was expressed as an autoantibody (Ab) index. Results Salivary tTG-Abs were found in 97.4% of the patients with CD and in 100% of the corresponding serum samples. All Group 3 subjects were negative with both saliva and serum assays. A correlation between saliva and serum tTG-Ab titers was found (r = 0.826, P = .0014). Conclusions This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive Method.
Takashi Nishikata - One of the best experts on this subject based on the ideXlab platform.
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a Powerful Method for the direct arylation of furans at a sterically congested c h bond
Asian Journal of Organic Chemistry, 2016Co-Authors: Takashi Nishikata, Yu Yamane, Yousui Yamaguchi, Shingo IshikawaAbstract:The direct arylation of furans at a sterically congested C−H bond are accomplished. Although there are many Methods for catalytic C−H arylation, direct C−H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl2-1,2-bis(dicyclohexylphosphino)ethane (dcype) or PCy3 and silver salt system enables arylations at a sterically congested C−H bonds to produce “highly congested” and “very congested” triarylfurans.
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A Powerful Method for the Direct Arylation of Furans at a Sterically Congested C−H Bond
Asian Journal of Organic Chemistry, 2016Co-Authors: Takashi Nishikata, Yu Yamane, Yousui Yamaguchi, Shingo IshikawaAbstract:The direct arylation of furans at a sterically congested C−H bond are accomplished. Although there are many Methods for catalytic C−H arylation, direct C−H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl2-1,2-bis(dicyclohexylphosphino)ethane (dcype) or PCy3 and silver salt system enables arylations at a sterically congested C−H bonds to produce “highly congested” and “very congested” triarylfurans.
Umberto Di Mario - One of the best experts on this subject based on the ideXlab platform.
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tissue transglutaminase autoantibody detection in human saliva a Powerful Method for celiac disease screening
The Journal of Pediatrics, 2004Co-Authors: M Bonamico, M Ferri, Raffaella Nenna, Antonella Verrienti, Umberto Di Mario, Claudio TibertiAbstract:Abstract Objective To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA). Study design Paired saliva and serum samples from 39 patients with celiac disease (CD), at the first biopsy (Group 1: 28 females, mean age 11.5 ± 11.1 years); 32 controls with a normal duodenal mucosa (Group 2: 18 females, mean age 8.1 ± 3.6 years); and 32 healthy volunteers (Group 3: 21 females, mean age 31.7 ± 9.8 years) were studied for tTG-Ab presence. Limit of positivity for salivary assay was calculated according to the 99th percentiles of Group 2 control children and was expressed as an autoantibody (Ab) index. Results Salivary tTG-Abs were found in 97.4% of the patients with CD and in 100% of the corresponding serum samples. All Group 3 subjects were negative with both saliva and serum assays. A correlation between saliva and serum tTG-Ab titers was found (r = 0.826, P = .0014). Conclusions This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive Method.
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Tissue transglutaminase autoantibody detection in human saliva: a Powerful Method for celiac disease screening ☆
The Journal of pediatrics, 2004Co-Authors: M Bonamico, M Ferri, Raffaella Nenna, Antonella Verrienti, Umberto Di Mario, Claudio TibertiAbstract:Abstract Objective To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA). Study design Paired saliva and serum samples from 39 patients with celiac disease (CD), at the first biopsy (Group 1: 28 females, mean age 11.5 ± 11.1 years); 32 controls with a normal duodenal mucosa (Group 2: 18 females, mean age 8.1 ± 3.6 years); and 32 healthy volunteers (Group 3: 21 females, mean age 31.7 ± 9.8 years) were studied for tTG-Ab presence. Limit of positivity for salivary assay was calculated according to the 99th percentiles of Group 2 control children and was expressed as an autoantibody (Ab) index. Results Salivary tTG-Abs were found in 97.4% of the patients with CD and in 100% of the corresponding serum samples. All Group 3 subjects were negative with both saliva and serum assays. A correlation between saliva and serum tTG-Ab titers was found (r = 0.826, P = .0014). Conclusions This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive Method.
