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Vijay Veer - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetic and biodistribution study of eserine and Pralidoxime Chloride in rabbits following a single application of a transdermal patch
    European Journal of Drug Metabolism and Pharmacokinetics, 2016
    Co-Authors: Subham Banerjee, Aseem Bhatnagar, Animesh Ghosh, Pronobesh Chattopadhyay, Vijay Veer
    Abstract:

    In the present study, a simple reverse-phase high-performance liquid chromatography method with diode array detection has been developed and validated for the simultaneous determination and quantification of eserine and Pralidoxime Chloride in rabbit plasma and its application to pharmacokinetic study. The pharmacokinetic study was performed after transdermal application of single patch in rabbits. The plasma levels of both drugs following transdermal application of single patch were maintained for 72 h after removal of the patch. The maximal concentrations ( C _max) of both drugs were significantly reduced while the mean areas under the plasma concentration vs. time moment curve and mean residence times were evidently increased and extended, respectively. A sustained activity was observed over a period of 3 days. This sustained activity was due to the controlled release of drug into the systemic circulation following transdermal application. Linear correlation was also observed when fraction of drug permeated was correlated with the fraction of drug absorbed at the same time point. Gamma scintigraphy imaging on rabbit following transdermal patch application was performed to ascertain the localization of drugs in rabbit brain.

  • protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning in rats
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

  • accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against (±)-Anatoxin A poisoning in rats.
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

Subham Banerjee - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetic and biodistribution study of eserine and Pralidoxime Chloride in rabbits following a single application of a transdermal patch
    European Journal of Drug Metabolism and Pharmacokinetics, 2016
    Co-Authors: Subham Banerjee, Aseem Bhatnagar, Animesh Ghosh, Pronobesh Chattopadhyay, Vijay Veer
    Abstract:

    In the present study, a simple reverse-phase high-performance liquid chromatography method with diode array detection has been developed and validated for the simultaneous determination and quantification of eserine and Pralidoxime Chloride in rabbit plasma and its application to pharmacokinetic study. The pharmacokinetic study was performed after transdermal application of single patch in rabbits. The plasma levels of both drugs following transdermal application of single patch were maintained for 72 h after removal of the patch. The maximal concentrations ( C _max) of both drugs were significantly reduced while the mean areas under the plasma concentration vs. time moment curve and mean residence times were evidently increased and extended, respectively. A sustained activity was observed over a period of 3 days. This sustained activity was due to the controlled release of drug into the systemic circulation following transdermal application. Linear correlation was also observed when fraction of drug permeated was correlated with the fraction of drug absorbed at the same time point. Gamma scintigraphy imaging on rabbit following transdermal patch application was performed to ascertain the localization of drugs in rabbit brain.

  • protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning in rats
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

  • accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against (±)-Anatoxin A poisoning in rats.
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

Animesh Ghosh - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetic and biodistribution study of eserine and Pralidoxime Chloride in rabbits following a single application of a transdermal patch
    European Journal of Drug Metabolism and Pharmacokinetics, 2016
    Co-Authors: Subham Banerjee, Aseem Bhatnagar, Animesh Ghosh, Pronobesh Chattopadhyay, Vijay Veer
    Abstract:

    In the present study, a simple reverse-phase high-performance liquid chromatography method with diode array detection has been developed and validated for the simultaneous determination and quantification of eserine and Pralidoxime Chloride in rabbit plasma and its application to pharmacokinetic study. The pharmacokinetic study was performed after transdermal application of single patch in rabbits. The plasma levels of both drugs following transdermal application of single patch were maintained for 72 h after removal of the patch. The maximal concentrations ( C _max) of both drugs were significantly reduced while the mean areas under the plasma concentration vs. time moment curve and mean residence times were evidently increased and extended, respectively. A sustained activity was observed over a period of 3 days. This sustained activity was due to the controlled release of drug into the systemic circulation following transdermal application. Linear correlation was also observed when fraction of drug permeated was correlated with the fraction of drug absorbed at the same time point. Gamma scintigraphy imaging on rabbit following transdermal patch application was performed to ascertain the localization of drugs in rabbit brain.

  • protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning in rats
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

  • accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against (±)-Anatoxin A poisoning in rats.
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

Pronobesh Chattopadhyay - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetic and biodistribution study of eserine and Pralidoxime Chloride in rabbits following a single application of a transdermal patch
    European Journal of Drug Metabolism and Pharmacokinetics, 2016
    Co-Authors: Subham Banerjee, Aseem Bhatnagar, Animesh Ghosh, Pronobesh Chattopadhyay, Vijay Veer
    Abstract:

    In the present study, a simple reverse-phase high-performance liquid chromatography method with diode array detection has been developed and validated for the simultaneous determination and quantification of eserine and Pralidoxime Chloride in rabbit plasma and its application to pharmacokinetic study. The pharmacokinetic study was performed after transdermal application of single patch in rabbits. The plasma levels of both drugs following transdermal application of single patch were maintained for 72 h after removal of the patch. The maximal concentrations ( C _max) of both drugs were significantly reduced while the mean areas under the plasma concentration vs. time moment curve and mean residence times were evidently increased and extended, respectively. A sustained activity was observed over a period of 3 days. This sustained activity was due to the controlled release of drug into the systemic circulation following transdermal application. Linear correlation was also observed when fraction of drug permeated was correlated with the fraction of drug absorbed at the same time point. Gamma scintigraphy imaging on rabbit following transdermal patch application was performed to ascertain the localization of drugs in rabbit brain.

  • protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning in rats
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

  • accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against anatoxin a poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Accelerated stability testing of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning
    Journal of Food and Drug Analysis, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer
    Abstract:

    The current study evaluated the stability potential of a transdermal patch composed of eserine and Pralidoxime Chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  • Protection by a transdermal patch containing eserine and Pralidoxime Chloride for prophylaxis against (±)-Anatoxin A poisoning in rats.
    European Journal of Pharmaceutical Sciences, 2014
    Co-Authors: Subham Banerjee, Animesh Ghosh, Pronobesh Chattopadhyay, Manash Pratim Pathak, Jyotchna Gogoi, Vijay Veer
    Abstract:

    Abstract The prophylactic and neuroprotective impact of a transdermal patch containing eserine and Pralidoxime Chloride (2-PAM) against (±)-Anatoxin A poisoning was investigated using Wistar strain albino rats. Rats were smooth-shaved on the dorsal side, attached with a drug-in-adhesive matrix type prophylactic transdermal patch for 72 h and challenged with subcutaneous injection of three doses (1.0, 1.5 and 2.0 × LD 50 ) of (±)-Anatoxin A. The LD 50 value of (±)-Anatoxin A was determined to be 1.25 mg/kg, and at this particular dose (1.0 × LD 50 ) of toxin induced severe clinical symptom including extreme seizures in rats, resulting acute brain injuries in discrete brain regions, leading to 100% mortality within 5 min. The anticonvulsant effect, antiarrythmic effect, nerve conduction study, clinical observations and mortality, neuroprotective effect as well as skin histopathology of the prophylactic transdermal patch against (±)-Anatoxin A poisoning were investigated systematically. It was found that seizures, tachycardia, nerve damage, clinical symptoms, brain injuries and mortality induced by such lethal toxin were effectively prevented by the prophylactic patch treatment up to certain LD 50 level. Hence, it could be a choice of potential therapeutic regimen against such lethal poisoning.

M Li - One of the best experts on this subject based on the ideXlab platform.

  • comparison on effects between concentrated dose and non concentrated dose Pralidoxime Chloride on respiratory muscle paralysis in acute organophosphorus pesticide poisoning
    Chinese Journal of Internal Medicine, 2000
    Co-Authors: G Zheng, S Song, M Li
    Abstract:

    OBJECTIVE: To compare the effects between concentrated-dose and non-concentrated-dose Pralidoxime Chloride on respiratory muscle paralysis(RMP) in acute organophosphorus pesticide poisoning(AOPP). METHODS: 76 cases of RMP due to AOPP were involved in a retrospective study. All the patients were poisoned through ingestion. According to the administered dose of Pralidoxime Chloride within the first three days after the onset, the patients were divided into two groups: Group A consisted 30 patients; they were given Pralidoxime Chloride 10.0-25.8 grams (with an average of 11.4 grams) everyday in the first three days after the onset. Group B included 46 patients; the dose of Pralidoxime Chloride used daily in the first three days ranged from 3.3 to 8.6 grams (average 6.3). RESULTS: The curative rate and the death rate in group A were 73.3% and 26.7% respectively, while those in group B were 21.7% and 78.3% respectively. The curative rate in group A was significantly higher than that in group B (chi 2 = 19.83, P < 0.005). CONCLUSION: Concentrated-dose Pralidoxime Chloride was more effective than non-concentrated-dose for patients with RMP due to AOPP and this kind of administration could remarkably improve the prognosis in such patients.