The Experts below are selected from a list of 105915 Experts worldwide ranked by ideXlab platform
G Alkhazov - One of the best experts on this subject based on the ideXlab platform.
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Precise Measurement of the top quark mass in the dilepton channel at d0
Physical Review Letters, 2011Co-Authors: V M Abazov, T Adams, A Alton, B Abbott, B S Acharya, M R Adams, G D Alexeev, G Alkhazov, G AlversonAbstract:We measure the top quark mass (m(t)) in p (p) over bar collisions at a center of mass energy root s = 1.96 TeV using dilepton t (t) over bar -> W(+)bW(-)b(-) -> l(+)nu(l)bl(-)(nu) over bar (l ...
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Precise Measurement of the top quark mass from lepton jets events
Physical Review Letters, 2011Co-Authors: V M Abazov, T Adams, B Abbott, M Abolins, B S Acharya, M R Adams, E Aguilo, M Ahsan, G D Alexeev, G AlkhazovAbstract:We report a Measurement of the mass of the top quark in lepton+jets final states of ppbar->ttbar data corresponding to 2.6 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Using a matrix element method, we combine an insitu jet energy calibration with our standard jet energy scale derived in studies of {\gamma}+jet and dijet events and employ a novel flavor-dependent jet response correction to measure a top-quark mass of mt = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of mt = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb-1 .
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Precise Measurement of the top quark mass from lepton jets events at d0
Physical Review D, 2011Co-Authors: V M Abazov, T Adams, B Abbott, M Abolins, B S Acharya, E Aguilo, M Ahsan, G D Alexeev, M Adams, G AlkhazovAbstract:We report a Measurement of the mass of the top quark in lepton+jets final states of ppbar->ttbar data corresponding to 2.6 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Using a matrix element method, we combine an insitu jet energy calibration with our standard jet energy scale derived in studies of {\gamma}+jet and dijet events and employ a novel flavor-dependent jet response correction to measure a top-quark mass of mt = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of mt = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb-1 .
V M Abazov - One of the best experts on this subject based on the ideXlab platform.
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Precise Measurement of the top quark mass in the dilepton channel at d0
Physical Review Letters, 2011Co-Authors: V M Abazov, T Adams, A Alton, B Abbott, B S Acharya, M R Adams, G D Alexeev, G Alkhazov, G AlversonAbstract:We measure the top quark mass (m(t)) in p (p) over bar collisions at a center of mass energy root s = 1.96 TeV using dilepton t (t) over bar -> W(+)bW(-)b(-) -> l(+)nu(l)bl(-)(nu) over bar (l ...
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Precise Measurement of the top quark mass from lepton jets events
Physical Review Letters, 2011Co-Authors: V M Abazov, T Adams, B Abbott, M Abolins, B S Acharya, M R Adams, E Aguilo, M Ahsan, G D Alexeev, G AlkhazovAbstract:We report a Measurement of the mass of the top quark in lepton+jets final states of ppbar->ttbar data corresponding to 2.6 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Using a matrix element method, we combine an insitu jet energy calibration with our standard jet energy scale derived in studies of {\gamma}+jet and dijet events and employ a novel flavor-dependent jet response correction to measure a top-quark mass of mt = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of mt = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb-1 .
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Precise Measurement of the top quark mass from lepton jets events at d0
Physical Review D, 2011Co-Authors: V M Abazov, T Adams, B Abbott, M Abolins, B S Acharya, E Aguilo, M Ahsan, G D Alexeev, M Adams, G AlkhazovAbstract:We report a Measurement of the mass of the top quark in lepton+jets final states of ppbar->ttbar data corresponding to 2.6 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Using a matrix element method, we combine an insitu jet energy calibration with our standard jet energy scale derived in studies of {\gamma}+jet and dijet events and employ a novel flavor-dependent jet response correction to measure a top-quark mass of mt = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of mt = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb-1 .
Yuting Huang - One of the best experts on this subject based on the ideXlab platform.
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the changing 50 inhibitory concentration ic 50 of cisplatin a pilot study on the artifacts of the mtt assay and the Precise Measurement of density dependent chemoresistance in ovarian cancer
Oncotarget, 2016Co-Authors: Qiujing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Yuting HuangAbstract:// Yifeng He 1, 2, 5, * , Qiujing Zhu 1, 2, 3, * , Mo Chen 4, * , Qihong Huang 5 , Wenjing Wang 1, 2, 3 , Qing Li 1, 2, 3 , Yuting Huang 6 , Wen Di 1, 2, 3 1 Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 2 Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 3 State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 4 Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China 5 Tumor Microenvironment and Metastasis Program, The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 6 Children’s Research Institute, Children’s National Medical Center, Washington DC 20010, USA * These authors have contributed equally to this work Correspondence to: Wen Di, email: diwen163@163.com Yifeng He, email: he_yifeng@hotmail.com Keywords: inconsistency, cisplatin, 50% inhibitory concentration, ovarian cancer, density Received: April 28, 2016 Accepted: September 14, 2016 Published: September 23, 2016 ABSTRACT Inconsistencies in the half-maximal (50%) inhibitory concentration (IC 50 ) data for anticancer chemotherapeutic agents have yielded irreproducible experimental results and thus reciprocally contradictory theories in modern cancer research. The MTT assay is currently the most extensively used method for IC 50 Measurements. Here, we dissected the critical reasons behind MTT-dependent IC 50 inconsistencies. We showed that IC 50 errors caused by the technical deficiencies of the MTT assay are large and not adjustable (range: 300–11,000%). To overcome severe MTT artifacts, we developed an unbiased direct IC 50 Measurement method, the limiting dilution assay. This detection technique led us to the discovery of the inherent density-dependent chemoresistance variation of cancer cells, which is manifold and unpredictable in its forms. The subsequent intracellular signaling pathway analysis indicated that pAkt and p62 expression levels correlated with alterations in the IC 50 values for cisplatin in ovarian cancer, providing an explainable mechanism for this property. An in situ pAkt-and-p62-based immunohistochemical (IHC pAkt+p62 ) scoring system was thereby established. Both the limiting dilution assay and the IHC pAkt+p62 scoring system accurately predicted the primary chemoresistance against cisplatin in ovarian cancer patients. Furthermore, two distinct chemoresistant recurrence patterns were uncovered using these novel detection tools, which were linked to two different forms of density-chemoresistance relationships (positively vs. negatively correlated), respectively. An interpretation was given based on the cancer evolution theory. We concluded that the density-related IC 50 uncertainty is a natural property of the cancer cells and that the Precise Measurement of the density-dependent IC 50 spectrum can benefit both basic and clinical cancer research fields.
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the changing 50 inhibitory concentration ic50 of cisplatin a pilot study on the artifacts of the mtt assay and the Precise Measurement of density dependent chemoresistance in ovarian cancer
Oncotarget, 2016Co-Authors: Qiujing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Yuting HuangAbstract:// Yifeng He 1, 2, 5, * , Qiujing Zhu 1, 2, 3, * , Mo Chen 4, * , Qihong Huang 5 , Wenjing Wang 1, 2, 3 , Qing Li 1, 2, 3 , Yuting Huang 6 , Wen Di 1, 2, 3 1 Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 2 Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 3 State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 4 Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China 5 Tumor Microenvironment and Metastasis Program, The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 6 Children’s Research Institute, Children’s National Medical Center, Washington DC 20010, USA * These authors have contributed equally to this work Correspondence to: Wen Di, email: diwen163@163.com Yifeng He, email: he_yifeng@hotmail.com Keywords: inconsistency, cisplatin, 50% inhibitory concentration, ovarian cancer, density Received: April 28, 2016 Accepted: September 14, 2016 Published: September 23, 2016 ABSTRACT Inconsistencies in the half-maximal (50%) inhibitory concentration (IC 50 ) data for anticancer chemotherapeutic agents have yielded irreproducible experimental results and thus reciprocally contradictory theories in modern cancer research. The MTT assay is currently the most extensively used method for IC 50 Measurements. Here, we dissected the critical reasons behind MTT-dependent IC 50 inconsistencies. We showed that IC 50 errors caused by the technical deficiencies of the MTT assay are large and not adjustable (range: 300–11,000%). To overcome severe MTT artifacts, we developed an unbiased direct IC 50 Measurement method, the limiting dilution assay. This detection technique led us to the discovery of the inherent density-dependent chemoresistance variation of cancer cells, which is manifold and unpredictable in its forms. The subsequent intracellular signaling pathway analysis indicated that pAkt and p62 expression levels correlated with alterations in the IC 50 values for cisplatin in ovarian cancer, providing an explainable mechanism for this property. An in situ pAkt-and-p62-based immunohistochemical (IHC pAkt+p62 ) scoring system was thereby established. Both the limiting dilution assay and the IHC pAkt+p62 scoring system accurately predicted the primary chemoresistance against cisplatin in ovarian cancer patients. Furthermore, two distinct chemoresistant recurrence patterns were uncovered using these novel detection tools, which were linked to two different forms of density-chemoresistance relationships (positively vs. negatively correlated), respectively. An interpretation was given based on the cancer evolution theory. We concluded that the density-related IC 50 uncertainty is a natural property of the cancer cells and that the Precise Measurement of the density-dependent IC 50 spectrum can benefit both basic and clinical cancer research fields.
T Adams - One of the best experts on this subject based on the ideXlab platform.
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Precise Measurement of the top quark mass in the dilepton channel at d0
Physical Review Letters, 2011Co-Authors: V M Abazov, T Adams, A Alton, B Abbott, B S Acharya, M R Adams, G D Alexeev, G Alkhazov, G AlversonAbstract:We measure the top quark mass (m(t)) in p (p) over bar collisions at a center of mass energy root s = 1.96 TeV using dilepton t (t) over bar -> W(+)bW(-)b(-) -> l(+)nu(l)bl(-)(nu) over bar (l ...
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Precise Measurement of the top quark mass from lepton jets events at d0
Physical Review D, 2011Co-Authors: V M Abazov, T Adams, B Abbott, M Abolins, B S Acharya, E Aguilo, M Ahsan, G D Alexeev, M Adams, G AlkhazovAbstract:We report a Measurement of the mass of the top quark in lepton+jets final states of ppbar->ttbar data corresponding to 2.6 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Using a matrix element method, we combine an insitu jet energy calibration with our standard jet energy scale derived in studies of {\gamma}+jet and dijet events and employ a novel flavor-dependent jet response correction to measure a top-quark mass of mt = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of mt = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb-1 .
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Precise Measurement of the top quark mass from lepton jets events
Physical Review Letters, 2011Co-Authors: V M Abazov, T Adams, B Abbott, M Abolins, B S Acharya, M R Adams, E Aguilo, M Ahsan, G D Alexeev, G AlkhazovAbstract:We report a Measurement of the mass of the top quark in lepton+jets final states of ppbar->ttbar data corresponding to 2.6 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Using a matrix element method, we combine an insitu jet energy calibration with our standard jet energy scale derived in studies of {\gamma}+jet and dijet events and employ a novel flavor-dependent jet response correction to measure a top-quark mass of mt = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of mt = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb-1 .
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Precise Measurement of dimuon production cross sections in muon neutrino fe and muon anti neutrino fe deep inelastic scattering at the tevatron
Physical Review D, 2001Co-Authors: M Goncharov, T Adams, A Alton, T Bolton, J Goldman, P Spentzouris, J M Conrad, B T Fleming, J A Formaggio, S KoutsoliotasAbstract:We present Measurements of the semi-inclusive cross sections for νμ- and ν¯μ-nucleon deep inelastic scattering interactions with two oppositely charged muons in the final state. These events dominantly arise from the production of a charm quark during the scattering process. The Measurement was obtained from the analysis of 5102 νμ-induced and 1458 ν¯μ-induced events collected with the NuTeV detector exposed to a sign-selected beam at the Fermilab Tevatron. We also extract a cross-section Measurement from a reanalysis of 5030 νμ-induced and 1060 ν¯μ-induced events collected from the exposure of the same detector to a quad-triplet beam by the Chicago Columbia Fermilab Rochester (CCFR) experiment. The results are combined to obtain the most statistically Precise Measurement of neutrino-induced dimuon production cross sections to date. These Measurements should be of broad use to phenomenologists interested in the dynamics of charm production, the strangeness content of the nucleon, and the Cabibbo-Kobayashi-Maskawa matrix element Vcd.
T Aaltonen - One of the best experts on this subject based on the ideXlab platform.
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Precise Measurement of the w boson mass with the collider detector at fermilab
Physical Review D, 2014Co-Authors: T Aaltonen, S Amerio, D Amidei, A Anastassov, A Annovi, J Antos, G Apollinari, J A AppelAbstract:We present a Measurement of the $W$-boson mass, ${M}_{W}$, using data corresponding to $2.2\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of integrated luminosity collected in $p\overline{p}$ collisions at $\sqrt{s}=1.96\text{ }\text{ }\mathrm{TeV}$ with the CDF II detector at the Fermilab Tevatron. The selected sample of 470 126 $W\ensuremath{\rightarrow}e\ensuremath{\nu}$ candidates and 624 708 $W\ensuremath{\rightarrow}\ensuremath{\mu}\ensuremath{\nu}$ candidates yields the Measurement ${M}_{W}=80387\ifmmode\pm\else\textpm\fi{}12(\text{stat})\ifmmode\pm\else\textpm\fi{}15(\text{syst})=80387\ifmmode\pm\else\textpm\fi{}19\text{ }\text{ }\mathrm{MeV}/{c}^{2}$. This is the most Precise single Measurement of the $W$-boson mass to date.
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Precise Measurement of the w boson mass with the cdf ii detector
Physical Review Letters, 2012Co-Authors: T Aaltonen, Alvarez B Gonzalez, S Amerio, D Amidei, A Anastassov, A Annovi, J AntosAbstract:We have measured the W-boson mass M{sub W} using data corresponding to 2.2 fb{sup -1} of integrated luminosity collected in p{bar p} collisions at {radical}s = 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470 126 W {yields} e{nu} candidates and 624 708 W {yields} {mu}{nu} candidates yield the Measurement M{sub W} = 80 387 {+-} 12{sub stat} {+-} 15{sub syst} = 80 387 {+-} 19 MeV/c{sup 2}. This is the most Precise Measurement of the W-boson mass to date and significantly exceeds the precision of all previous Measurements combined.
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Precise Measurement of the top quark mass in the lepton jets topology at cdf ii
Physical Review Letters, 2007Co-Authors: T Aaltonen, S Amerio, D Amidei, A Anastassov, A Abulencia, J Adelman, T Affolder, T Akimoto, M G Albrow, K AnikeevAbstract:The authors present a Measurement of the mass of the top quark from proton-antiproton collisions recorded at the CDF experiment in Run II of the Fermilab Tevatron. They analyze events from the single lepton plus jets final state (t{bar t} {yields} W{sup +}bW{sup -}{bar b} {yields} lvbq{bar q}{bar b}). The top quark mass is extracted using a direct calculation of the probability density that each event corresponds to the t{bar t} final state. The probability is a function of both the mass of the top quark and the energy scale of the calorimeter jets, which is constrained in situ by the hadronic W boson mass. Using 167 events observed in 955 pb{sup -1} of integrated luminosity, they achieve the single most Precise Measurement of the top quark mass, 170.8 {+-} 2.2(stat.) {+-} 1.4(syst.) GeV/c{sup 2}.
