The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Caren C. Helbing - One of the best experts on this subject based on the ideXlab platform.
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Articles Exposure to the Herbicide Acetochlor Alters Thyroid Hormone-Dependent Gene Expression and Metamorphosis in Xenopus Laevis
2013Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrinedisrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3´-triiodothyronine (T 3)induced forelimb emergence and increase mRNA expression of thyroid hormone β receptors in ranid tadpoles. Here we show that T 3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor. Key words: acetochlor, cDNA array, endocrine disruptor, gene expression, Herbicides, metamorphosis, persistent organic pollutants, tadpoles, thyroid hormone, Xenopus laevis. Environ Health Perspect 110:1199–1205 (2002). [Online 7 October 2002
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Exposure to the Herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.
Environmental Health Perspectives, 2002Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrine-disrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3 -triiodothyronine (T3)-induced forelimb emergence and increase mRNA expression of thyroid hormone ss receptors in ranid tadpoles. Here we show that T3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor.
Doug Crump - One of the best experts on this subject based on the ideXlab platform.
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Articles Exposure to the Herbicide Acetochlor Alters Thyroid Hormone-Dependent Gene Expression and Metamorphosis in Xenopus Laevis
2013Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrinedisrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3´-triiodothyronine (T 3)induced forelimb emergence and increase mRNA expression of thyroid hormone β receptors in ranid tadpoles. Here we show that T 3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor. Key words: acetochlor, cDNA array, endocrine disruptor, gene expression, Herbicides, metamorphosis, persistent organic pollutants, tadpoles, thyroid hormone, Xenopus laevis. Environ Health Perspect 110:1199–1205 (2002). [Online 7 October 2002
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Exposure to the Herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.
Environmental Health Perspectives, 2002Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrine-disrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3 -triiodothyronine (T3)-induced forelimb emergence and increase mRNA expression of thyroid hormone ss receptors in ranid tadpoles. Here we show that T3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor.
Kate Werry - One of the best experts on this subject based on the ideXlab platform.
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Articles Exposure to the Herbicide Acetochlor Alters Thyroid Hormone-Dependent Gene Expression and Metamorphosis in Xenopus Laevis
2013Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrinedisrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3´-triiodothyronine (T 3)induced forelimb emergence and increase mRNA expression of thyroid hormone β receptors in ranid tadpoles. Here we show that T 3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor. Key words: acetochlor, cDNA array, endocrine disruptor, gene expression, Herbicides, metamorphosis, persistent organic pollutants, tadpoles, thyroid hormone, Xenopus laevis. Environ Health Perspect 110:1199–1205 (2002). [Online 7 October 2002
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Exposure to the Herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.
Environmental Health Perspectives, 2002Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrine-disrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3 -triiodothyronine (T3)-induced forelimb emergence and increase mRNA expression of thyroid hormone ss receptors in ranid tadpoles. Here we show that T3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor.
Nik Veldhoen - One of the best experts on this subject based on the ideXlab platform.
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Articles Exposure to the Herbicide Acetochlor Alters Thyroid Hormone-Dependent Gene Expression and Metamorphosis in Xenopus Laevis
2013Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrinedisrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3´-triiodothyronine (T 3)induced forelimb emergence and increase mRNA expression of thyroid hormone β receptors in ranid tadpoles. Here we show that T 3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor. Key words: acetochlor, cDNA array, endocrine disruptor, gene expression, Herbicides, metamorphosis, persistent organic pollutants, tadpoles, thyroid hormone, Xenopus laevis. Environ Health Perspect 110:1199–1205 (2002). [Online 7 October 2002
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Exposure to the Herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.
Environmental Health Perspectives, 2002Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrine-disrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3 -triiodothyronine (T3)-induced forelimb emergence and increase mRNA expression of thyroid hormone ss receptors in ranid tadpoles. Here we show that T3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor.
Graham Van Aggelen - One of the best experts on this subject based on the ideXlab platform.
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Articles Exposure to the Herbicide Acetochlor Alters Thyroid Hormone-Dependent Gene Expression and Metamorphosis in Xenopus Laevis
2013Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrinedisrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3´-triiodothyronine (T 3)induced forelimb emergence and increase mRNA expression of thyroid hormone β receptors in ranid tadpoles. Here we show that T 3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor. Key words: acetochlor, cDNA array, endocrine disruptor, gene expression, Herbicides, metamorphosis, persistent organic pollutants, tadpoles, thyroid hormone, Xenopus laevis. Environ Health Perspect 110:1199–1205 (2002). [Online 7 October 2002
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Exposure to the Herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.
Environmental Health Perspectives, 2002Co-Authors: Doug Crump, Kate Werry, Nik Veldhoen, Graham Van Aggelen, Caren C. HelbingAbstract:A growing number of substances released into the environment disrupt normal endocrine mechanisms in a wide range of vertebrates. Little is known about the effects and identities of endocrine-disrupting chemicals (EDCs) that target thyroid hormone (TH) action, particularly at the cellular level. Frog tadpole metamorphosis depends completely on TH, which has led to the suggestion of a metamorphosis-based assay for screening potential EDCs. A major mechanism of TH action is the alteration of gene expression via hormone-bound nuclear receptors. To assess the gene expression profiles in the frog model, we designed a novel multispecies frog cDNA microarray. Recently, the Preemergent Herbicide acetochlor was shown to accelerate 3,5,3 -triiodothyronine (T3)-induced forelimb emergence and increase mRNA expression of thyroid hormone ss receptors in ranid tadpoles. Here we show that T3-induced metamorphosis of Xenopus laevis, a species commonly used in the laboratory, is accelerated upon acute exposure to an environmentally relevant level of acetochlor. The morphologic changes observed are preceded by alterations in gene expression profiles detected in the tadpole tail, and the nature of these profiles suggest a novel mechanism of action for acetochlor.