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Anne Kjersti Daltveit - One of the best experts on this subject based on the ideXlab platform.
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Hypertensive Pregnancy Disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors.
International journal of cardiology, 2019Co-Authors: Hilde Kristin Refvik Riise, Gerhard Sulo, Grethe S. Tell, Jannicke Igland, Ottar Nygård, Ann-charlotte Iversen, Grace M. Egeland, Randi Selmer, Anne Kjersti DaltveitAbstract:Abstract Background and aim Hypertensive Pregnancy Disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate whether hypertensive Pregnancy Disorder in first Pregnancy is associated with increased subsequent risk of maternal CVD after adjustment for established CVD risk factors measured after Pregnancy. Methods and results A total of 20,075 women with a first delivery registered in the Medical Birth Registry of Norway (1980–2003) participated in Cohort of Norway (CONOR) health surveys a mean (standard deviation) of 10.7 (5.5) years after delivery. They were then followed (median 11.4 years) for an incident fatal or non-fatal CVD event through linkage to the Cardiovascular Disease in Norway (CVDNOR) database and the Norwegian Cause of Death Registry. Hypertensive Pregnancy Disorders were associated with an increased risk of CVD [Hazard ratio (HR) 2.3; 95% confidence interval (CI) 1.9–2.8], which remained significant after adjustment for established CVD risk factors including body mass index, smoking, hypertension, diabetes, serum glucose and lipid levels (HR 1.5; 95% CI 1.2–1.8). The population attributable fraction of CVD due to hypertensive Pregnancy Disorder was 4.3% (95% CI 1.9–6.6) after multivariable adjustment. Conclusion The association between hypertensive Pregnancy Disorders and CVD risk was mediated in part by related CVD risk factors measured 10 years following delivery. These results underline the importance of post-Pregnancy follow-up of women with hypertensive Pregnancy Disorders focusing on modifiable, lifestyle related risk factors to prevent future CVD.
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Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity
Journal of the American Heart Association, 2017Co-Authors: Hilde Kristin Refvik Riise, Gerhard Sulo, Grethe S. Tell, Jannicke Igland, Ottar Nygård, Stein Emil Vollset, Ann-charlotte Iversen, Rigmor Austgulen, Anne Kjersti DaltveitAbstract:BackgroundPreeclampsia is a severe Pregnancy Disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to as...
Eva Sverremark-ekström - One of the best experts on this subject based on the ideXlab platform.
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Enhanced Th1 and inflammatory mRNA responses upregulate NK cell cytotoxicity and NKG2D ligand expression in human pre-eclamptic placenta and target it for NK cell attack.
American journal of reproductive immunology (New York N.Y. : 1989), 2018Co-Authors: Marie-therese Vinnars, Emma Björk, Ivan Nagaev, Ulrika Ottander, Katarina Bremme, Ulrika Holmlund, Eva Sverremark-ekström, Lucia Mincheva-nilssonAbstract:Problem: Pre-eclampsia (PE), a severe human Pregnancy Disorder, is associated with exaggerated systemic inflammation, enhanced cytokine production, and increased shedding of microvesicles leading t ...
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Women with pre-eclampsia have an altered NKG2A and NKG2C receptor expression on peripheral blood natural killer cells.
American journal of reproductive immunology (New York N.Y. : 1989), 2009Co-Authors: Nora Bachmayer, Katarina Bremme, Ebba Sohlberg, Yvonne Sundström, Rangeen Rafik Hamad, Louise Berg, Eva Sverremark-ekströmAbstract:PROBLEM: Preeclampsia, a Pregnancy Disorder, is associated with exaggerated inflammation and increased serum monokines. Uterine natural killer (NK) cells are implicated in preeclampsia pathology, b ...
Dag Moster - One of the best experts on this subject based on the ideXlab platform.
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Risk of cerebral palsy in relation to Pregnancy Disorders and preterm birth: a national cohort study.
Developmental medicine and child neurology, 2014Co-Authors: Håvard Trønnes, Allen J. Wilcox, Rolv T. Lie, Trond Markestad, Dag MosterAbstract:Aim To assess the risk of developing cerebral palsy in relation to Pregnancy Disorders and preterm birth. Method By linking the Medical Birth Registry of Norway to other national registries, we identified all live births in Norway from 1967 through to 2001. Risks of cerebral palsy (CP) after preterm delivery and Pregnancy Disorders were estimated in different gestational age groups. Result In total, 1 764 509 children delivered at 23 to 43 weeks' gestation were included. The prevalence of CP was 1.8 per 1000 births. Absolute risk of CP was 8.5% among children born at 23 to 27 weeks' gestation, 5.6% at 28 to 30 weeks, 2.0% at 31 to 33 weeks, 0.4% at 34 to 36 weeks, and 0.1% thereafter. Placental abruption, chorioamnionitis, prolonged rupture of membranes, intrauterine growth restriction, pre-eclampsia, multiple births, placenta previa, bleeding, cervical conization, and congenital malformation were all associated with CP. Before 32 weeks' gestation, absolute risk of CP was highest with chorioamnionitis (9.1%) and lowest with pre-eclampsia (3.1%). Among those born after 31 weeks, the absolute risk of CP was more consistently (but also more slightly) increased with a recorded Pregnancy Disorder. Interpretation Early delivery and Pregnancy Disorders were both strong risk factors for CP. The added risks with recorded Pregnancy Disorders varied within categories of gestational age.
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1259 Gestational Age and Pregnancy Disorders as Risk Factors for Cerebral Palsy
Archives of Disease in Childhood, 2012Co-Authors: Håvard Trønnes, Rolv T. Lie, Trond Markestad, Dag MosterAbstract:Background Both Pregnancy Disorders and low gestational age (GA) are associated with an elevated risk of cerebral palsy (CP). As many Pregnancy Disorders are associated with preterm birth, it is unclear whether the increased risk of CP in preterm children can be attributed to the Pregnancy Disorder or the low GA. Aim To disentangle the risk of CP according to GA and Pregnancy Disorders in children born preterm. Method Norwegian, national cohort study with linkage of the Medical Birth Registry of Norway to the Statistics Norway and the National Insurance Scheme. All births from 1967 to 2001 were followed through 2005, and 1,499,705 individuals were included in the cohort. Results Placental abruption, chorioamnionitis, placenta previa, multiple birth, prolonged rupture of membranes, cervical conisation, unspecified bleeding and pre-eclampsia were associated with an increased risk of CP. The risk of CP increased with decreasing GA (23–27 wks RR 83.3 [95% CI, 69.8–99.4], 28–30 wks RR 49.5 [95% CI, 43.2–56.6], 31–33 wks RR 17.4 [95% CI, 15.3–19.7], 34–36 wks RR 3.3 [95% CI, 2.9–3.8]). The association between GA and CP was not substantially weakened after adjustment for Pregnancy Disorders. Conclusion Although several Pregnancy Disorders were associated with an increased risk of CP, low GA appeared to be a more important risk factor for CP in preterm children.
Hilde Kristin Refvik Riise - One of the best experts on this subject based on the ideXlab platform.
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Hypertensive Pregnancy Disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors.
International journal of cardiology, 2019Co-Authors: Hilde Kristin Refvik Riise, Gerhard Sulo, Grethe S. Tell, Jannicke Igland, Ottar Nygård, Ann-charlotte Iversen, Grace M. Egeland, Randi Selmer, Anne Kjersti DaltveitAbstract:Abstract Background and aim Hypertensive Pregnancy Disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate whether hypertensive Pregnancy Disorder in first Pregnancy is associated with increased subsequent risk of maternal CVD after adjustment for established CVD risk factors measured after Pregnancy. Methods and results A total of 20,075 women with a first delivery registered in the Medical Birth Registry of Norway (1980–2003) participated in Cohort of Norway (CONOR) health surveys a mean (standard deviation) of 10.7 (5.5) years after delivery. They were then followed (median 11.4 years) for an incident fatal or non-fatal CVD event through linkage to the Cardiovascular Disease in Norway (CVDNOR) database and the Norwegian Cause of Death Registry. Hypertensive Pregnancy Disorders were associated with an increased risk of CVD [Hazard ratio (HR) 2.3; 95% confidence interval (CI) 1.9–2.8], which remained significant after adjustment for established CVD risk factors including body mass index, smoking, hypertension, diabetes, serum glucose and lipid levels (HR 1.5; 95% CI 1.2–1.8). The population attributable fraction of CVD due to hypertensive Pregnancy Disorder was 4.3% (95% CI 1.9–6.6) after multivariable adjustment. Conclusion The association between hypertensive Pregnancy Disorders and CVD risk was mediated in part by related CVD risk factors measured 10 years following delivery. These results underline the importance of post-Pregnancy follow-up of women with hypertensive Pregnancy Disorders focusing on modifiable, lifestyle related risk factors to prevent future CVD.
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Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity
Journal of the American Heart Association, 2017Co-Authors: Hilde Kristin Refvik Riise, Gerhard Sulo, Grethe S. Tell, Jannicke Igland, Ottar Nygård, Stein Emil Vollset, Ann-charlotte Iversen, Rigmor Austgulen, Anne Kjersti DaltveitAbstract:BackgroundPreeclampsia is a severe Pregnancy Disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to as...
Katarina Bremme - One of the best experts on this subject based on the ideXlab platform.
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Enhanced Th1 and inflammatory mRNA responses upregulate NK cell cytotoxicity and NKG2D ligand expression in human pre-eclamptic placenta and target it for NK cell attack.
American journal of reproductive immunology (New York N.Y. : 1989), 2018Co-Authors: Marie-therese Vinnars, Emma Björk, Ivan Nagaev, Ulrika Ottander, Katarina Bremme, Ulrika Holmlund, Eva Sverremark-ekström, Lucia Mincheva-nilssonAbstract:Problem: Pre-eclampsia (PE), a severe human Pregnancy Disorder, is associated with exaggerated systemic inflammation, enhanced cytokine production, and increased shedding of microvesicles leading t ...
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Women with pre-eclampsia have an altered NKG2A and NKG2C receptor expression on peripheral blood natural killer cells.
American journal of reproductive immunology (New York N.Y. : 1989), 2009Co-Authors: Nora Bachmayer, Katarina Bremme, Ebba Sohlberg, Yvonne Sundström, Rangeen Rafik Hamad, Louise Berg, Eva Sverremark-ekströmAbstract:PROBLEM: Preeclampsia, a Pregnancy Disorder, is associated with exaggerated inflammation and increased serum monokines. Uterine natural killer (NK) cells are implicated in preeclampsia pathology, b ...