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Henrik Toft Sørensen - One of the best experts on this subject based on the ideXlab platform.

  • a successful implementation of e epidemiology the danish Pregnancy Planning study snart gravid
    European Journal of Epidemiology, 2010
    Co-Authors: Krista F Huybrechts, Ellen M. Mikkelsen, Elizabeth E. Hatch, Lauren A. Wise, Anders H. Riis, Henrik Toft Sørensen, Tina Christensen, Kenneth J. Rothman
    Abstract:

    The attraction of being able to use the internet for the recruitment of an epidemiologic cohort stems mainly from cost efficiency and convenience. The Pregnancy Planning study (‘Snart-Gravid’)—a prospective cohort study of Danish women Planning a Pregnancy—was conducted to evaluate the feasibility and cost efficiency of using internet-based recruitment and follow-up. Feasibility was assessed by examining patient accrual data over time, questionnaire-specific response rates and losses to follow-up. The relative cost efficiency was examined by comparing the study costs with those of an alternative non internet-based study approach. The target recruitment of 2,500 participants over 6 months was achieved using advertisements on a health-related website, supported by a coordinated media strategy at study initiation. Questionnaire cycle-specific response rates ranged from 87 to 90% over the 12-month follow-up. At 6 months, 87% of women had a known outcome or were still under follow-up; at 12 months the figure was 82%. The study cost of $400,000 ($160 per enrolled subject) compared favorably with the estimated cost to conduct the same study using a conventional non-internet based approach ($322 per subject). The gain in efficiency with the internet-based approach appeared to be even more substantial with longer follow-up and larger study sizes. The successful conduct of this pilot study suggests that the internet may be a useful tool to recruit and follow subjects in prospective cohort studies.

  • cohort profile the danish web based Pregnancy Planning study snart gravid
    International Journal of Epidemiology, 2009
    Co-Authors: Ellen M. Mikkelsen, Elizabeth E. Hatch, Lauren A. Wise, Kenneth J. Rothman, Anders H. Riis, Henrik Toft Sørensen
    Abstract:

    The Danish Web-based Pregnancy Planning Studywas initiated in 2007 by researchers from AarhusUniversity Hospital, Denmark and Boston University,USA, primarily to evaluate the feasibility of Internet-based recruitment and follow-up of a cohort ofreproductive age women. In this report, we describethe study design and present descriptive data basedon the pilot phase of this ongoing study.Several large-scale cohort studies of reproductive agewomen have been conducted, including the DanishNational Birth Cohort

  • Cohort Profile: The Danish Web-based Pregnancy Planning Study—‘Snart-Gravid’
    International journal of epidemiology, 2008
    Co-Authors: Ellen M. Mikkelsen, Elizabeth E. Hatch, Lauren A. Wise, Kenneth J. Rothman, Anders H. Riis, Henrik Toft Sørensen
    Abstract:

    The Danish Web-based Pregnancy Planning Studywas initiated in 2007 by researchers from AarhusUniversity Hospital, Denmark and Boston University,USA, primarily to evaluate the feasibility of Internet-based recruitment and follow-up of a cohort ofreproductive age women. In this report, we describethe study design and present descriptive data basedon the pilot phase of this ongoing study.Several large-scale cohort studies of reproductive agewomen have been conducted, including the DanishNational Birth Cohort

Maciej T Malecki - One of the best experts on this subject based on the ideXlab platform.

  • Glycemic control and Pregnancy outcomes in women with type 2 diabetes from Poland. The impact of Pregnancy Planning and a comparison with type 1 diabetes subjects
    Endocrine, 2011
    Co-Authors: Katarzyna Cyganek, Barbara Katra, Jan Skupien, Tomasz Klupa, Izabela Janas, Irena Kaim, Alfred Reron, Alicja Hebda-szydło, Alicja Borodako, Maciej T Malecki
    Abstract:

    The number of pregnancies complicated by type 2 diabetes mellitus (T2DM) is growing; however, their clinical characteristics remain incomplete. We aimed to assess clinical characteristics, glycemic control, and selected Pregnancy outcomes in pregestational T2DM from Poland and to compare them with those of T1DM. We analyzed 415 consecutive singleton pregnancies; among them, there were 70 women with T2DM and 345 with T1DM. As compared to T1DM patients, women with T2DM were older (mean age 33.1 years vs. 27.8, respectively), heavier before Pregnancy (mean BMI 30.8 kg/m² vs. 23.9), and had a shorter duration of diabetes (mean 3.3 years vs. 11.4); ( P < 0.0001 for all comparisons). The gestational age at the first visit was higher in T2DM (mean 11.4 weeks vs. 8.6; P = 0.0004). Nevertheless, they had better glycemic control in the first trimester (mean HbA1c 6.2% vs. 7.0; P = 0.003); in subsequent months, the differences in HbA1c were no longer significant. T2DM women gained less weight during Pregnancy (mean 9.9 kgs vs. 14.1; P < 0.0001). The proportion of miscarriages (10.0 vs. 7.3%; P = 0.32), preterm deliveries (12.7 vs. 17.8%; P = 0.32), combined infant deaths, and congenital malformations were similar in both groups (9.5 vs. 8.8%; P = 0.4) as was the frequency of caesarean sections (58.7 vs. 64.1%; P = 0.30). Macrosomic babies were more than twice less frequent in T2DM and the difference reached borderline significance (7.9 vs. 17.5%, P = 0.07). Pregnancy Planning in T2DM had a significant impact on HbA1c in the first trimester (5.7 vs. 6.4% in the Planning vs. the not Planning group, P = 0.02); the difference was not significant in the second and third trimester. T2DM women had better glycemic control in the first trimester than T1DM subjects and gained less weight during Pregnancy. This could have been the reason for the slightly lower number of macrosomic babies but did not affect other outcomes. In T2DM, Pregnancy Planning had a beneficial glycemic effect in the first trimester.

  • glycemic control and selected Pregnancy outcomes in type 1 diabetes women on continuous subcutaneous insulin infusion and multiple daily injections the significance of Pregnancy Planning
    Diabetes Technology & Therapeutics, 2010
    Co-Authors: Katarzyna Cyganek, Alicja Hebdaszydlo, Barbara Katra, Jan Skupien, Tomasz Klupa, Izabela Janas, Irena Kaim, Jacek Sieradzki, Alfred Reron, Maciej T Malecki
    Abstract:

    Abstract Background: Two regimens are used to achieve excellent glycemic control during Pregnancy in type 1 diabetes mellitus (T1DM): continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI). We assessed their efficacy and safety and the effect of Pregnancy Planning. Methods: We examined 269 pregnant T1DM women: 157 treated with MDI (MDI group), 42 with CSII (CSII group), and 70 who switched from MDI to CSII in the first trimester (MDI/CSII group). There were 116 women who planned Pregnancy: 58 in the MDI group, 38 in the CSII group, and 20 in the MDI/CSII group. The estimated differences in glycemic control and maternal and fetal outcomes were adjusted for baseline characteristics. Results: Mean glycated A1c (HbA1c) in the first trimester in the whole group was 6.9%, and the women differed depending on whether they planned Pregnancy or not (P < 0.0001). A multiple regression model showed an average difference of about 0.9% in favor of Pregnancy Planning, with no interaction bet...

  • Glycemic control and selected Pregnancy outcomes in type 1 diabetes women on continuous subcutaneous insulin infusion and multiple daily injections: the significance of Pregnancy Planning.
    Diabetes technology & therapeutics, 2010
    Co-Authors: Katarzyna Cyganek, Barbara Katra, Jan Skupien, Tomasz Klupa, Izabela Janas, Irena Kaim, Jacek Sieradzki, Alfred Reron, Alicja Hebda-szydło, Maciej T Malecki
    Abstract:

    Abstract Background: Two regimens are used to achieve excellent glycemic control during Pregnancy in type 1 diabetes mellitus (T1DM): continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI). We assessed their efficacy and safety and the effect of Pregnancy Planning. Methods: We examined 269 pregnant T1DM women: 157 treated with MDI (MDI group), 42 with CSII (CSII group), and 70 who switched from MDI to CSII in the first trimester (MDI/CSII group). There were 116 women who planned Pregnancy: 58 in the MDI group, 38 in the CSII group, and 20 in the MDI/CSII group. The estimated differences in glycemic control and maternal and fetal outcomes were adjusted for baseline characteristics. Results: Mean glycated A1c (HbA1c) in the first trimester in the whole group was 6.9%, and the women differed depending on whether they planned Pregnancy or not (P 

Kenneth J. Rothman - One of the best experts on this subject based on the ideXlab platform.

  • a successful implementation of e epidemiology the danish Pregnancy Planning study snart gravid
    European Journal of Epidemiology, 2010
    Co-Authors: Krista F Huybrechts, Ellen M. Mikkelsen, Elizabeth E. Hatch, Lauren A. Wise, Anders H. Riis, Henrik Toft Sørensen, Tina Christensen, Kenneth J. Rothman
    Abstract:

    The attraction of being able to use the internet for the recruitment of an epidemiologic cohort stems mainly from cost efficiency and convenience. The Pregnancy Planning study (‘Snart-Gravid’)—a prospective cohort study of Danish women Planning a Pregnancy—was conducted to evaluate the feasibility and cost efficiency of using internet-based recruitment and follow-up. Feasibility was assessed by examining patient accrual data over time, questionnaire-specific response rates and losses to follow-up. The relative cost efficiency was examined by comparing the study costs with those of an alternative non internet-based study approach. The target recruitment of 2,500 participants over 6 months was achieved using advertisements on a health-related website, supported by a coordinated media strategy at study initiation. Questionnaire cycle-specific response rates ranged from 87 to 90% over the 12-month follow-up. At 6 months, 87% of women had a known outcome or were still under follow-up; at 12 months the figure was 82%. The study cost of $400,000 ($160 per enrolled subject) compared favorably with the estimated cost to conduct the same study using a conventional non-internet based approach ($322 per subject). The gain in efficiency with the internet-based approach appeared to be even more substantial with longer follow-up and larger study sizes. The successful conduct of this pilot study suggests that the internet may be a useful tool to recruit and follow subjects in prospective cohort studies.

  • cohort profile the danish web based Pregnancy Planning study snart gravid
    International Journal of Epidemiology, 2009
    Co-Authors: Ellen M. Mikkelsen, Elizabeth E. Hatch, Lauren A. Wise, Kenneth J. Rothman, Anders H. Riis, Henrik Toft Sørensen
    Abstract:

    The Danish Web-based Pregnancy Planning Studywas initiated in 2007 by researchers from AarhusUniversity Hospital, Denmark and Boston University,USA, primarily to evaluate the feasibility of Internet-based recruitment and follow-up of a cohort ofreproductive age women. In this report, we describethe study design and present descriptive data basedon the pilot phase of this ongoing study.Several large-scale cohort studies of reproductive agewomen have been conducted, including the DanishNational Birth Cohort

  • Cohort Profile: The Danish Web-based Pregnancy Planning Study—‘Snart-Gravid’
    International journal of epidemiology, 2008
    Co-Authors: Ellen M. Mikkelsen, Elizabeth E. Hatch, Lauren A. Wise, Kenneth J. Rothman, Anders H. Riis, Henrik Toft Sørensen
    Abstract:

    The Danish Web-based Pregnancy Planning Studywas initiated in 2007 by researchers from AarhusUniversity Hospital, Denmark and Boston University,USA, primarily to evaluate the feasibility of Internet-based recruitment and follow-up of a cohort ofreproductive age women. In this report, we describethe study design and present descriptive data basedon the pilot phase of this ongoing study.Several large-scale cohort studies of reproductive agewomen have been conducted, including the DanishNational Birth Cohort

Eric Renard - One of the best experts on this subject based on the ideXlab platform.

  • Assessment of the effect of Pregnancy Planning in women with type 1 diabetes treated by insulin pump
    Acta Diabetologica, 2020
    Co-Authors: Lucie Mourou, Valeria Vallone, Eleonora Vania, Silvia Galasso, Cécile Brunet, Florent Fuchs, Federico Boscari, Francesco Cavallin, Daniela Bruttomesso, Eric Renard
    Abstract:

    Background Pregnant women with type 1 diabetes (T1D) have high risk of complications despite improved care based on technology advancements. Objective To assess the effects of Pregnancy Planning on fetal and maternal outcomes in T1D women treated with continuous subcutaneous insulin infusion (CSII). Study design We retrospectively assessed maternal and neonatal outcomes in T1D women using CSII who had planned or unplanned pregnancies between 2002 and 2018. The study was done in two European countries with similar sustained programs for Pregnancy Planning over the study period. Results Data from 107 pregnancies and newborn babies were collected. Seventy-nine pregnancies (73.8%) had been planned. HbA1c was lower in planned versus unplanned Pregnancy before and during all three trimesters of Pregnancy ( p  

  • Assessment of the effect of Pregnancy Planning in women with type 1 diabetes treated by insulin pump
    Acta Diabetologica, 2020
    Co-Authors: Lucie Mourou, Valeria Vallone, Eleonora Vania, Silvia Galasso, Cécile Brunet, Florent Fuchs, Federico Boscari, Francesco Cavallin, Daniela Bruttomesso, Eric Renard
    Abstract:

    Background: Pregnant women with type 1 diabetes (T1D) have high risk of complications despite improved care based on technology advancements. Objective: To assess the effects of Pregnancy Planning on fetal and maternal outcomes in T1D women treated with continuous subcutaneous insulin infusion (CSII). Study design: We retrospectively assessed maternal and neonatal outcomes in T1D women using CSII who had planned or unplanned pregnancies between 2002 and 2018. The study was done in two European countries with similar sustained programs for Pregnancy Planning over the study period. Results: Data from 107 pregnancies and newborn babies were collected. Seventy-nine pregnancies (73.8%) had been planned. HbA1c was lower in planned versus unplanned Pregnancy before and during all three trimesters of Pregnancy (p < 0.0001). Pregnancy Planning was associated with a reduction in the occurrence of iatrogenic preterm delivery (RR 0.44, 95% CI 0.23-0.95; p = 0.01). Risk reduction persisted after adjustments for mother's age above 40 years and preeclampsia. High HbA1c before or during Pregnancy was associated with an increased risk of iatrogenic preterm delivery (RR 3.05, 95% CI 1.78-5.22, p < 0.0001). Premature newborns needed intensive care more often than those at term (RR 3.10, 95% CI 1.53-4.31; p = 0.002). Conclusions: Pregnancy Planning in T1D women using CSII was associated with better glucose control and decreased risk of iatrogenic preterm delivery. Hence preconception care also improves Pregnancy outcome in patients using an advanced mode of insulin delivery. Planned pregnancies could further benefit from the use of new metrics of glucose control.

Katarzyna Cyganek - One of the best experts on this subject based on the ideXlab platform.

  • Glycemic control and Pregnancy outcomes in women with type 2 diabetes from Poland. The impact of Pregnancy Planning and a comparison with type 1 diabetes subjects
    Endocrine, 2011
    Co-Authors: Katarzyna Cyganek, Barbara Katra, Jan Skupien, Tomasz Klupa, Izabela Janas, Irena Kaim, Alfred Reron, Alicja Hebda-szydło, Alicja Borodako, Maciej T Malecki
    Abstract:

    The number of pregnancies complicated by type 2 diabetes mellitus (T2DM) is growing; however, their clinical characteristics remain incomplete. We aimed to assess clinical characteristics, glycemic control, and selected Pregnancy outcomes in pregestational T2DM from Poland and to compare them with those of T1DM. We analyzed 415 consecutive singleton pregnancies; among them, there were 70 women with T2DM and 345 with T1DM. As compared to T1DM patients, women with T2DM were older (mean age 33.1 years vs. 27.8, respectively), heavier before Pregnancy (mean BMI 30.8 kg/m² vs. 23.9), and had a shorter duration of diabetes (mean 3.3 years vs. 11.4); ( P < 0.0001 for all comparisons). The gestational age at the first visit was higher in T2DM (mean 11.4 weeks vs. 8.6; P = 0.0004). Nevertheless, they had better glycemic control in the first trimester (mean HbA1c 6.2% vs. 7.0; P = 0.003); in subsequent months, the differences in HbA1c were no longer significant. T2DM women gained less weight during Pregnancy (mean 9.9 kgs vs. 14.1; P < 0.0001). The proportion of miscarriages (10.0 vs. 7.3%; P = 0.32), preterm deliveries (12.7 vs. 17.8%; P = 0.32), combined infant deaths, and congenital malformations were similar in both groups (9.5 vs. 8.8%; P = 0.4) as was the frequency of caesarean sections (58.7 vs. 64.1%; P = 0.30). Macrosomic babies were more than twice less frequent in T2DM and the difference reached borderline significance (7.9 vs. 17.5%, P = 0.07). Pregnancy Planning in T2DM had a significant impact on HbA1c in the first trimester (5.7 vs. 6.4% in the Planning vs. the not Planning group, P = 0.02); the difference was not significant in the second and third trimester. T2DM women had better glycemic control in the first trimester than T1DM subjects and gained less weight during Pregnancy. This could have been the reason for the slightly lower number of macrosomic babies but did not affect other outcomes. In T2DM, Pregnancy Planning had a beneficial glycemic effect in the first trimester.

  • glycemic control and selected Pregnancy outcomes in type 1 diabetes women on continuous subcutaneous insulin infusion and multiple daily injections the significance of Pregnancy Planning
    Diabetes Technology & Therapeutics, 2010
    Co-Authors: Katarzyna Cyganek, Alicja Hebdaszydlo, Barbara Katra, Jan Skupien, Tomasz Klupa, Izabela Janas, Irena Kaim, Jacek Sieradzki, Alfred Reron, Maciej T Malecki
    Abstract:

    Abstract Background: Two regimens are used to achieve excellent glycemic control during Pregnancy in type 1 diabetes mellitus (T1DM): continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI). We assessed their efficacy and safety and the effect of Pregnancy Planning. Methods: We examined 269 pregnant T1DM women: 157 treated with MDI (MDI group), 42 with CSII (CSII group), and 70 who switched from MDI to CSII in the first trimester (MDI/CSII group). There were 116 women who planned Pregnancy: 58 in the MDI group, 38 in the CSII group, and 20 in the MDI/CSII group. The estimated differences in glycemic control and maternal and fetal outcomes were adjusted for baseline characteristics. Results: Mean glycated A1c (HbA1c) in the first trimester in the whole group was 6.9%, and the women differed depending on whether they planned Pregnancy or not (P < 0.0001). A multiple regression model showed an average difference of about 0.9% in favor of Pregnancy Planning, with no interaction bet...

  • Glycemic control and selected Pregnancy outcomes in type 1 diabetes women on continuous subcutaneous insulin infusion and multiple daily injections: the significance of Pregnancy Planning.
    Diabetes technology & therapeutics, 2010
    Co-Authors: Katarzyna Cyganek, Barbara Katra, Jan Skupien, Tomasz Klupa, Izabela Janas, Irena Kaim, Jacek Sieradzki, Alfred Reron, Alicja Hebda-szydło, Maciej T Malecki
    Abstract:

    Abstract Background: Two regimens are used to achieve excellent glycemic control during Pregnancy in type 1 diabetes mellitus (T1DM): continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI). We assessed their efficacy and safety and the effect of Pregnancy Planning. Methods: We examined 269 pregnant T1DM women: 157 treated with MDI (MDI group), 42 with CSII (CSII group), and 70 who switched from MDI to CSII in the first trimester (MDI/CSII group). There were 116 women who planned Pregnancy: 58 in the MDI group, 38 in the CSII group, and 20 in the MDI/CSII group. The estimated differences in glycemic control and maternal and fetal outcomes were adjusted for baseline characteristics. Results: Mean glycated A1c (HbA1c) in the first trimester in the whole group was 6.9%, and the women differed depending on whether they planned Pregnancy or not (P