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Kristine Marceau - One of the best experts on this subject based on the ideXlab platform.
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The Prenatal Environment in Twin Studies: A Review on Chorionicity
Behavior Genetics, 2016Co-Authors: Kristine Marceau, C. E. M. Beijsterveldt, M. T. B. Mcmaster, D. I. Boomsma, Taylor F. Smith, Joost G. Daams, Valerie S. KnopikAbstract:A literature search was conducted to identify articles examining the association of chorionicity (e.g., whether twins share a single chorion and thus placenta or have separate chorions/placentas) and genetics, psychiatry/behavior, and neurological manifestations in humans twins and higher-order multiples. The main aim was to assess how frequently chorionicity has been examined in relation to heritability estimates, and to assess which phenotypes may be most sensitive to, or affected by, bias in heritability estimates because of chorionicity. Consistent with the theory that some chorionicity effects could lead to overestimation and others to underestimation of heritability, there were instances of each across the many phenotypes reviewed. However, firm conclusions should not be drawn since some of the outcomes were only examined in one or few studies and often sample sizes were small. While the evidence for bias due to chorionicity was mixed or null for many outcomes, results do, however, consistently suggest that heritability estimates are underestimated for measures of birth weight and early growth when chorionicity is not taken into account.
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missouri mothers and their children a family study of the effects of genetics and the Prenatal Environment
Twin Research and Human Genetics, 2015Co-Authors: Valerie S. Knopik, Kristine Marceau, Andrew C Heath, Rohan H C Palmer, John E Mcgeary, Alexandre A Todorov, Allison Schettini EvansAbstract:The Missouri Mothers and Their Children Study was specifically designed to critically investigate Prenatal Environmental influences on child attention problems and associated learning and cognitive deficits. The project began as a pilot study in 2004 and was formally launched in 2008. Participants in the study were initially identified via the Department of Vital Statistics birth record database. Interview and lab-based data were obtained from (1) mothers of Missouri-born children (born 1998–2005), who smoked during one pregnancy but not during another pregnancy, (2) biological fathers when available, and (3) the children [i.e., full sibling pairs discordant for exposure to maternal smoking during pregnancy (SDP)]. This within-mother, between-pregnancy contrast provides the best possible methodological control for many stable maternal and familial confounding factors (e.g., heritable and socio-demographic characteristics of the mother that predict increased probability of SDP). It also controls for differences between mothers who do and do not smoke during pregnancy, and their partners, that might otherwise artifactually create, or alternatively mask, associations between SDP and child outcomes. Such a design will therefore provide opportunities to determine less biased effect sizes while also allowing us to investigate (on a preliminary basis) the possible contribution of paternal or other second-hand smoke exposure during the pre-, peri- and postnatal periods to offspring outcome. This protocol has developed a cohort that can be followed longitudinally through periods typically associated with increased externalizing symptoms and substance use initiation.
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Combined Influences of Genes, Prenatal Environment, Cortisol, and Parenting on the Development of Children’s Internalizing Versus Externalizing Problems
Behavior Genetics, 2015Co-Authors: Kristine Marceau, Jenae M. Neiderhiser, Heidemarie K. Laurent, David Reiss, Daniel S. Shaw, Misaki N. Natsuaki, Philip A. Fisher, Leslie D. LeveAbstract:Research suggests that genetic, Prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, Prenatal Environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased Prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that Prenatal maternal drug use/symptoms and children’s morning cortisol levels are mechanisms of genetic and Environmental influences on internalizing problems, but not externalizing problems, in childhood.
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combined influences of genes Prenatal Environment cortisol and parenting on the development of children s internalizing versus externalizing problems
Behavior Genetics, 2015Co-Authors: Jenae M. Neiderhiser, Kristine Marceau, Heidemarie K. Laurent, David Reiss, Daniel S. Shaw, Misaki N. Natsuaki, Philip A. Fisher, Leslie D. LeveAbstract:Research suggests that genetic, Prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, Prenatal Environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased Prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that Prenatal maternal drug use/symptoms and children’s morning cortisol levels are mechanisms of genetic and Environmental influences on internalizing problems, but not externalizing problems, in childhood.
Valerie S. Knopik - One of the best experts on this subject based on the ideXlab platform.
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The Importance of the Prenatal Environment in Behavioral Genetics: Introduction to Special Issue
Behavior Genetics, 2016Co-Authors: Valerie S. Knopik, Jenae M. Neiderhiser, Eco Geus, Dorret BoomsmaAbstract:We introduce and discuss a special issue on Prenatal factors in genetics research, that includes 14 papers ranging from studies on chorionicity, smoking during pregnancy, and more general Prenatal risks to papers about theory, methods and measurement. There are two review papers, one focused on chorioncity and the second on pre- and perinatal ischemia-hypoxia, that help to frame the state of research in these areas with a focus on the relevance across multiple fields of study. Taken together, these papers clearly demonstrate the importance of considering Prenatal Environment influences on functioning in offspring across the lifespan while also underscoring the importance of using genetically informed designs as a means to clarify causality.
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The Prenatal Environment in Twin Studies: A Review on Chorionicity
Behavior Genetics, 2016Co-Authors: Kristine Marceau, C. E. M. Beijsterveldt, M. T. B. Mcmaster, D. I. Boomsma, Taylor F. Smith, Joost G. Daams, Valerie S. KnopikAbstract:A literature search was conducted to identify articles examining the association of chorionicity (e.g., whether twins share a single chorion and thus placenta or have separate chorions/placentas) and genetics, psychiatry/behavior, and neurological manifestations in humans twins and higher-order multiples. The main aim was to assess how frequently chorionicity has been examined in relation to heritability estimates, and to assess which phenotypes may be most sensitive to, or affected by, bias in heritability estimates because of chorionicity. Consistent with the theory that some chorionicity effects could lead to overestimation and others to underestimation of heritability, there were instances of each across the many phenotypes reviewed. However, firm conclusions should not be drawn since some of the outcomes were only examined in one or few studies and often sample sizes were small. While the evidence for bias due to chorionicity was mixed or null for many outcomes, results do, however, consistently suggest that heritability estimates are underestimated for measures of birth weight and early growth when chorionicity is not taken into account.
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missouri mothers and their children a family study of the effects of genetics and the Prenatal Environment
Twin Research and Human Genetics, 2015Co-Authors: Valerie S. Knopik, Kristine Marceau, Andrew C Heath, Rohan H C Palmer, John E Mcgeary, Alexandre A Todorov, Allison Schettini EvansAbstract:The Missouri Mothers and Their Children Study was specifically designed to critically investigate Prenatal Environmental influences on child attention problems and associated learning and cognitive deficits. The project began as a pilot study in 2004 and was formally launched in 2008. Participants in the study were initially identified via the Department of Vital Statistics birth record database. Interview and lab-based data were obtained from (1) mothers of Missouri-born children (born 1998–2005), who smoked during one pregnancy but not during another pregnancy, (2) biological fathers when available, and (3) the children [i.e., full sibling pairs discordant for exposure to maternal smoking during pregnancy (SDP)]. This within-mother, between-pregnancy contrast provides the best possible methodological control for many stable maternal and familial confounding factors (e.g., heritable and socio-demographic characteristics of the mother that predict increased probability of SDP). It also controls for differences between mothers who do and do not smoke during pregnancy, and their partners, that might otherwise artifactually create, or alternatively mask, associations between SDP and child outcomes. Such a design will therefore provide opportunities to determine less biased effect sizes while also allowing us to investigate (on a preliminary basis) the possible contribution of paternal or other second-hand smoke exposure during the pre-, peri- and postnatal periods to offspring outcome. This protocol has developed a cohort that can be followed longitudinally through periods typically associated with increased externalizing symptoms and substance use initiation.
Leslie D. Leve - One of the best experts on this subject based on the ideXlab platform.
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Combined Influences of Genes, Prenatal Environment, Cortisol, and Parenting on the Development of Children’s Internalizing Versus Externalizing Problems
Behavior Genetics, 2015Co-Authors: Kristine Marceau, Jenae M. Neiderhiser, Heidemarie K. Laurent, David Reiss, Daniel S. Shaw, Misaki N. Natsuaki, Philip A. Fisher, Leslie D. LeveAbstract:Research suggests that genetic, Prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, Prenatal Environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased Prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that Prenatal maternal drug use/symptoms and children’s morning cortisol levels are mechanisms of genetic and Environmental influences on internalizing problems, but not externalizing problems, in childhood.
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combined influences of genes Prenatal Environment cortisol and parenting on the development of children s internalizing versus externalizing problems
Behavior Genetics, 2015Co-Authors: Jenae M. Neiderhiser, Kristine Marceau, Heidemarie K. Laurent, David Reiss, Daniel S. Shaw, Misaki N. Natsuaki, Philip A. Fisher, Leslie D. LeveAbstract:Research suggests that genetic, Prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, Prenatal Environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased Prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that Prenatal maternal drug use/symptoms and children’s morning cortisol levels are mechanisms of genetic and Environmental influences on internalizing problems, but not externalizing problems, in childhood.
D. I. Boomsma - One of the best experts on this subject based on the ideXlab platform.
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Chorionicity and Heritability Estimates from Twin Studies: The Prenatal Environment of Twins and Their Resemblance Across a Large Number of Traits
Behavior Genetics, 2016Co-Authors: C. E. M. Beijsterveldt, L. I. H. Overbeek, L. Rozendaal, M. T. B. Mcmaster, T. J. Glasner, M. Bartels, J. M. Vink, N. G. Martin, C. V. Dolan, D. I. BoomsmaAbstract:There are three types of monozygotic (MZ) twins. MZ twins can either share one chorion and one amnion, each twin can have its own amnion, or MZ twins can—like dizygotic twins—each have their own chorion and amnion. Sharing the same chorion may create a more similar/dissimilar Prenatal Environment and bias heritability estimates, but most twin studies do not distinguish between these three types of MZ twin pairs. The aim of this paper is to investigate the effect of chorion sharing on the similarity within MZ twin pairs for a large number of traits. Information on chorion status was obtained for the Netherlands twin register (NTR) by linkage to the records from the database of the dutch pathological anatomy national automated archive (PALGA). Record linkage was successful for over 9000 pairs. Effect of chorion type was tested by comparing the within-pair similarity between monochorionic (MC) and dichorionic (DC) MZ twins on 66 traits including weight, height, motor milestones, child problem behaviors, cognitive function, wellbeing and personality. For only 10 traits, within-pair similarity differed between MCMZ and DCMZ pairs. For traits influenced by birth weight (e.g. weight and height in young children) we expected that MC twins would be more discordant. This was found for 5 out of 13 measures. When looking at traits where blood supply is important, we saw MCMZ twins to be more concordant than DCMZ’s for 3 traits. We conclude that the influence on the MZ twin correlation of the intra-uterine Prenatal Environment, as measured by sharing a chorion type, is small and limited to a few phenotypes. This implies that the assumption of equal Prenatal Environment of mono- and DC MZ twins, which characterizes the classical twin design, is largely tenable.
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The Prenatal Environment in Twin Studies: A Review on Chorionicity
Behavior Genetics, 2016Co-Authors: Kristine Marceau, C. E. M. Beijsterveldt, M. T. B. Mcmaster, D. I. Boomsma, Taylor F. Smith, Joost G. Daams, Valerie S. KnopikAbstract:A literature search was conducted to identify articles examining the association of chorionicity (e.g., whether twins share a single chorion and thus placenta or have separate chorions/placentas) and genetics, psychiatry/behavior, and neurological manifestations in humans twins and higher-order multiples. The main aim was to assess how frequently chorionicity has been examined in relation to heritability estimates, and to assess which phenotypes may be most sensitive to, or affected by, bias in heritability estimates because of chorionicity. Consistent with the theory that some chorionicity effects could lead to overestimation and others to underestimation of heritability, there were instances of each across the many phenotypes reviewed. However, firm conclusions should not be drawn since some of the outcomes were only examined in one or few studies and often sample sizes were small. While the evidence for bias due to chorionicity was mixed or null for many outcomes, results do, however, consistently suggest that heritability estimates are underestimated for measures of birth weight and early growth when chorionicity is not taken into account.
Jenae M. Neiderhiser - One of the best experts on this subject based on the ideXlab platform.
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The Importance of the Prenatal Environment in Behavioral Genetics: Introduction to Special Issue
Behavior Genetics, 2016Co-Authors: Valerie S. Knopik, Jenae M. Neiderhiser, Eco Geus, Dorret BoomsmaAbstract:We introduce and discuss a special issue on Prenatal factors in genetics research, that includes 14 papers ranging from studies on chorionicity, smoking during pregnancy, and more general Prenatal risks to papers about theory, methods and measurement. There are two review papers, one focused on chorioncity and the second on pre- and perinatal ischemia-hypoxia, that help to frame the state of research in these areas with a focus on the relevance across multiple fields of study. Taken together, these papers clearly demonstrate the importance of considering Prenatal Environment influences on functioning in offspring across the lifespan while also underscoring the importance of using genetically informed designs as a means to clarify causality.
-
Combined Influences of Genes, Prenatal Environment, Cortisol, and Parenting on the Development of Children’s Internalizing Versus Externalizing Problems
Behavior Genetics, 2015Co-Authors: Kristine Marceau, Jenae M. Neiderhiser, Heidemarie K. Laurent, David Reiss, Daniel S. Shaw, Misaki N. Natsuaki, Philip A. Fisher, Leslie D. LeveAbstract:Research suggests that genetic, Prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, Prenatal Environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased Prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that Prenatal maternal drug use/symptoms and children’s morning cortisol levels are mechanisms of genetic and Environmental influences on internalizing problems, but not externalizing problems, in childhood.
-
combined influences of genes Prenatal Environment cortisol and parenting on the development of children s internalizing versus externalizing problems
Behavior Genetics, 2015Co-Authors: Jenae M. Neiderhiser, Kristine Marceau, Heidemarie K. Laurent, David Reiss, Daniel S. Shaw, Misaki N. Natsuaki, Philip A. Fisher, Leslie D. LeveAbstract:Research suggests that genetic, Prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, Prenatal Environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased Prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that Prenatal maternal drug use/symptoms and children’s morning cortisol levels are mechanisms of genetic and Environmental influences on internalizing problems, but not externalizing problems, in childhood.