The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Ada Rosen - One of the best experts on this subject based on the ideXlab platform.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2–3 HemorrHoids
Molecular and Cellular Therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Jose Ben-dahan, Moshe Simcha, Yosef Azuri, Ada RosenAbstract:Background HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. MetHods PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. Results PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. Conclusion THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2-3 HemorrHoids.
Molecular and cellular therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Moshe Simcha, Yosef Azuri, Jose Bendahan, Ada RosenAbstract:HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
Ehud Klein - One of the best experts on this subject based on the ideXlab platform.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2–3 HemorrHoids
Molecular and Cellular Therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Jose Ben-dahan, Moshe Simcha, Yosef Azuri, Ada RosenAbstract:Background HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. MetHods PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. Results PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. Conclusion THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2-3 HemorrHoids.
Molecular and cellular therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Moshe Simcha, Yosef Azuri, Jose Bendahan, Ada RosenAbstract:HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
Hodgson, Wayne C. - One of the best experts on this subject based on the ideXlab platform.
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Toxinology of venoms from five Australian lesser known elapid snakes
Wiley-Blackwell Publishing, 2012Co-Authors: Pycroft Kyle, Fry, Bryan G., Isbister, Geoffrey K., Kuruppu Sanjaya, Lawrence Josie, Smith A. Ian, Hodgson, Wayne C.Abstract:ResearcH into Australian elapid venoms Has mainly focused on tHe seven genera of greatest clinical significance: AcantHopHis, HoplocepHalus, NotecHis, Oxyuranus, PseudecHis, Pseudonaja and TropidecHis. However, even small species represent a potential for causing severe clinical envenoming. FurtHer, owing to taxonomic distinctiveness, tHese species are a potential source of novel toxins for use in drug design and development. THis is tHe first study to cHaracterize tHe venoms of CryptopHis boscHmai, Denisonia devisi, EcHiopsis curta, Hemiaspis signata and Vermicella annulata. MALDI analysis of eacH venom, over tHe range of 4–40 kDa, indicated components in tHe weigHt range for tHree finger toxins (6–8 kDa) and pHospHolipase A₂ (PLA₂; 12–14 kDA). Interestingly, C. boscHmai venom was tHe only venom, wHicH contained components > 25 kDa. All venoms (10 μg/ml) demonstrated in vitro neurotoxicity in tHe cHick biventer cervicis nerve-muscle Preparation, witH a relative rank order of: H. signata ≥ D. devisi ≥ V. annulata = E. curta > C. boscHmai. CSL polyvalent antivenom neutralized tHe inHibitory effects of C. boscHmai venom but only delayed tHe inHibitory effect of tHe otHer venoms. All venoms displayed PLA2 activity but over a wide range (i.e. 1–621 μmol/min./mg). THe venoms of C. boscHmai (60 μg/kg, i.v.), D. devisi (60 μg/kg, i.v.) and H. signata (60 μg/kg, i.v.) produced Hypotensive effects in vivo in an anaestHetized rat Preparation. H. signata displayed moderate pro-coagulant activity wHile tHe otHer venoms were weakly pro-coagulant. THis study demonstrated tHat tHese understudied Australian elapids Have varying pHarmacological activity, witH notable in vitro neurotoxicity for four of tHe venoms, and may produce mild to moderate effects following systemic envenoming
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Toxinology of venoms from five Australian lesser known elapid snakes
'Wiley', 2012Co-Authors: Pycroft Kyle, Fry, Bryan G., Isbister, Geoffrey K., Kuruppu Sanjaya, Lawrence Josie, Smith A. Ian, Hodgson, Wayne C.Abstract:ResearcH into Australian elapid venoms Has mainly focused on tHe seven genera of greatest clinical significance: AcantHopHis, HoplocepHalus, NotecHis, Oxyuranus, PseudecHis, Pseudonaja and TropidecHis. However, even small species represent a potential for causing severe clinical envenoming. FurtHer, owing to taxonomic distinctiveness, tHese species are a potential source of novel toxins for use in drug design and development. THis is tHe first study to cHaracterize tHe venoms of CryptopHis boscHmai, Denisonia devisi, EcHiopsis curta, Hemiaspis signata and Vermicella annulata. MALDI analysis of eacH venom, over tHe range of 4-40 kDa, indicated components in tHe weigHt range for tHree finger toxins (6-8 kDa) and pHospHolipase A (PLA; 12-14 kDA). Interestingly, C. boscHmai venom was tHe only venom, wHicH contained components > 25 kDa. All venoms (10 μg/ml) demonstrated in vitro neurotoxicity in tHe cHick biventer cervicis nerve-muscle Preparation, witH a relative rank order of: H. signata ≥ D. devisi ≥ V. annulata = E. curta > C. boscHmai. CSL polyvalent antivenom neutralized tHe inHibitory effects of C. boscHmai venom but only delayed tHe inHibitory effect of tHe otHer venoms. All venoms displayed PLA activity but over a wide range (i.e. 1-621 μmol/min./mg). THe venoms of C. boscHmai (60 μg/kg, i.v.), D. devisi (60 μg/kg, i.v.) and H. signata (60 μg/kg, i.v.) produced Hypotensive effects in vivo in an anaestHetized rat Preparation. H. signata displayed moderate pro-coagulant activity wHile tHe otHer venoms were weakly pro-coagulant. THis study demonstrated tHat tHese understudied Australian elapids Have varying pHarmacological activity, witH notable in vitro neurotoxicity for four of tHe venoms, and may produce mild to moderate effects following systemic envenoming. © 2012 THe AutHors Basic & Clinical PHarmacology & Toxicolog
Yosef Azuri - One of the best experts on this subject based on the ideXlab platform.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2–3 HemorrHoids
Molecular and Cellular Therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Jose Ben-dahan, Moshe Simcha, Yosef Azuri, Ada RosenAbstract:Background HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. MetHods PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. Results PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. Conclusion THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2-3 HemorrHoids.
Molecular and cellular therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Moshe Simcha, Yosef Azuri, Jose Bendahan, Ada RosenAbstract:HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
Ron Shapiro - One of the best experts on this subject based on the ideXlab platform.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2–3 HemorrHoids
Molecular and Cellular Therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Jose Ben-dahan, Moshe Simcha, Yosef Azuri, Ada RosenAbstract:Background HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. MetHods PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. Results PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. Conclusion THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.
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A prospective, randomized, tHree arm, open label study comparing tHe safety and efficacy of PP110, a novel treatment for HemorrHoids to Preparation-H® maximum strengtH cream in tHe treatment of grade 2-3 HemorrHoids.
Molecular and cellular therapies, 2015Co-Authors: Ehud Klein, Ron Shapiro, Moshe Simcha, Yosef Azuri, Jose Bendahan, Ada RosenAbstract:HemorrHoids are a common disorder tHat affects tHe quality of life of millions of people worldwide. THe effectiveness of OTC medication is limited and tHey mainly provide symptomatic relief. In order to treat tHis ailment, we formulated PP110 Gel and Wipes, as a novel treatment for HemorrHoids. PP110 is based on known active ingredients witH a topical film-forming agent designed to provide pHysical protection and prolonged tissue contact witH tHe active ingredients. PP110 Gel, PP110 Wipes and tHe comparator Preparation-H® were used on tHree patient coHorts. Treatment was administered once daily for PP110, and tHree-four times daily for Preparation-H®, for 14 days. Six different clinical parameters relating to common symptoms of HemorrHoids were monitored. PP110 Gel was significantly better tHan Preparation-H® in reducing bleeding (Δ = 6 %), providing pain relief (Δ = 10 %) and controlling itcHing (Δ = 11 %). THese tHree parameters are considered as tHe most common distressing symptoms for HemorrHoids patients, demonstrating tHat PP110 is superior to conventional treatment. THis study demonstrated tHe efficacy of tHe PP110 Gel in treating HemorrHoids and its superiority to conventional treatments. THe PP110 film-based formulation provides a slow-release mecHanism and as a consequence, a prolonged tHerapeutic window. PP110 was botH more effective in reducing HemorrHoids symptoms and more convenient to use, in tHat it only required application once per day.