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Marvin Bergsneider - One of the best experts on this subject based on the ideXlab platform.

  • opposing csf hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    Fluids and Barriers of the CNS, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Paul Vespa, Amber Y Dorn, Marvin Bergsneider
    Abstract:

    This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction.

  • Opposing CSF hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    BMC, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Amber Dorn, Paul Vespa, Marvin Bergsneider
    Abstract:

    Abstract Background This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Methods Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Results Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Conclusions Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction

  • subpeak regional analysis of intracranial pressure waveform morphology based on cerebrospinal fluid hydrodynamics in the cerebral aqueduct and Prepontine Cistern
    International Conference of the IEEE Engineering in Medicine and Biology Society, 2012
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Paul Vespa, Marvin Bergsneider
    Abstract:

    The objective of this study is to investigate the relationship between intracranial pressure (ICP) pulse waveform morphology and selected hydrodynamic metrics of cerebrospinal fluid (CSF) movement using a novel method for ICP pulse pressure regional analysis based on the Morphological Clustering and Analysis of Continuous Intracranial Pulse (MOCAIP) algorithm.

  • Quantification of Pulsatile Cerebrospinal Fluid Flow within the Prepontine Cistern
    Acta neurochirurgica. Supplement, 2012
    Co-Authors: Robert Hamilton, Justin Dye, Andrew Frew, Kevin Baldwin, Marvin Bergsneider
    Abstract:

    Background: Phase-contrast MRI (PC-MRI) has previously been used for the quantification of CSF and blood flow throughout the body. We propose a new method of semi-automated segmentation for the Prepontine Cistern based on anatomical and pulsatility information.

Robert B. Hamilton - One of the best experts on this subject based on the ideXlab platform.

  • opposing csf hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    Fluids and Barriers of the CNS, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Paul Vespa, Amber Y Dorn, Marvin Bergsneider
    Abstract:

    This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction.

  • Opposing CSF hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    BMC, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Amber Dorn, Paul Vespa, Marvin Bergsneider
    Abstract:

    Abstract Background This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Methods Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Results Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Conclusions Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction

  • subpeak regional analysis of intracranial pressure waveform morphology based on cerebrospinal fluid hydrodynamics in the cerebral aqueduct and Prepontine Cistern
    International Conference of the IEEE Engineering in Medicine and Biology Society, 2012
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Paul Vespa, Marvin Bergsneider
    Abstract:

    The objective of this study is to investigate the relationship between intracranial pressure (ICP) pulse waveform morphology and selected hydrodynamic metrics of cerebrospinal fluid (CSF) movement using a novel method for ICP pulse pressure regional analysis based on the Morphological Clustering and Analysis of Continuous Intracranial Pulse (MOCAIP) algorithm.

Olivier Baledent - One of the best experts on this subject based on the ideXlab platform.

Kevin Baldwin - One of the best experts on this subject based on the ideXlab platform.

  • opposing csf hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    Fluids and Barriers of the CNS, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Paul Vespa, Amber Y Dorn, Marvin Bergsneider
    Abstract:

    This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction.

  • Opposing CSF hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    BMC, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Amber Dorn, Paul Vespa, Marvin Bergsneider
    Abstract:

    Abstract Background This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Methods Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Results Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Conclusions Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction

  • subpeak regional analysis of intracranial pressure waveform morphology based on cerebrospinal fluid hydrodynamics in the cerebral aqueduct and Prepontine Cistern
    International Conference of the IEEE Engineering in Medicine and Biology Society, 2012
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Paul Vespa, Marvin Bergsneider
    Abstract:

    The objective of this study is to investigate the relationship between intracranial pressure (ICP) pulse waveform morphology and selected hydrodynamic metrics of cerebrospinal fluid (CSF) movement using a novel method for ICP pulse pressure regional analysis based on the Morphological Clustering and Analysis of Continuous Intracranial Pulse (MOCAIP) algorithm.

  • Quantification of Pulsatile Cerebrospinal Fluid Flow within the Prepontine Cistern
    Acta neurochirurgica. Supplement, 2012
    Co-Authors: Robert Hamilton, Justin Dye, Andrew Frew, Kevin Baldwin, Marvin Bergsneider
    Abstract:

    Background: Phase-contrast MRI (PC-MRI) has previously been used for the quantification of CSF and blood flow throughout the body. We propose a new method of semi-automated segmentation for the Prepontine Cistern based on anatomical and pulsatility information.

Paul Vespa - One of the best experts on this subject based on the ideXlab platform.

  • opposing csf hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    Fluids and Barriers of the CNS, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Paul Vespa, Amber Y Dorn, Marvin Bergsneider
    Abstract:

    This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction.

  • Opposing CSF hydrodynamic trends found in the cerebral aqueduct and Prepontine Cistern following shunt treatment in patients with normal pressure hydrocephalus
    BMC, 2019
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Fabien Scalzo, Amber Dorn, Paul Vespa, Marvin Bergsneider
    Abstract:

    Abstract Background This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the Prepontine Cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in Cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Methods Scans were conducted on 30 pre-treatment patients ranging in age from 58 to 88 years along with an additional 12 controls. Twelve patients also received scans following either ventriculoatrial (VA) or ventriculoperitoneal (VP) shunt treatment (9 VP, 3 VA), ranging in age from 74 to 89 years with a mean follow up time of 6 months. Results Significant differences in area, velocity, flow, and stroke volume for the cerebral aqueduct were found between the pre-treatment NPH group and the healthy controls. Shunting caused a significant decrease in both caudal and cranial mean flow and stroke volume in the cerebral aqueduct. No significant changes were found in the Prepontine Cistern between the pre-treatment group and healthy controls. For the PFL, no significant differences were seen in the cerebral aqueduct between any of the three groups; however, the Prepontine Cistern PFL was significantly decreased in the pre-treatment NPH group when compared to the control group. Conclusions Although several studies have quantified the changes in aqueductal flow between hydrocephalic groups and controls, few studies have investigated Prepontine Cistern flow. Our study was the first to investigate both regions in the same patients for NPH pre- and post- treatment. Following shunt treatment, the aqueductal CSF metrics decreased toward control values, while the Prepontine Cistern metrics trended up (not significantly) from the normal values established in this study. The opposing trend of the two locations suggests a redistribution of CSF pulsatility in NPH patients. Furthermore, the significantly decreased latency of the Prepontine Cisternal CSF flow suggests additional evidence for CSF pulsatility dysfunction

  • subpeak regional analysis of intracranial pressure waveform morphology based on cerebrospinal fluid hydrodynamics in the cerebral aqueduct and Prepontine Cistern
    International Conference of the IEEE Engineering in Medicine and Biology Society, 2012
    Co-Authors: Robert B. Hamilton, Kevin Baldwin, Paul Vespa, Marvin Bergsneider
    Abstract:

    The objective of this study is to investigate the relationship between intracranial pressure (ICP) pulse waveform morphology and selected hydrodynamic metrics of cerebrospinal fluid (CSF) movement using a novel method for ICP pulse pressure regional analysis based on the Morphological Clustering and Analysis of Continuous Intracranial Pulse (MOCAIP) algorithm.