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Danielle Jin Kwang Kim - One of the best experts on this subject based on the ideXlab platform.
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patients with peripheral arterial disease with exaggerated Pressor Response have greater ambulatory dysfunction than patients with lower Pressor Response
Angiology, 2020Co-Authors: Danielle Jin Kwang Kim, Polly S Montgomery, Ming Wang, Biyi Shen, Marcos Kuroki, Andrew W GardnerAbstract:We determined whether patients with peripheral arterial disease (PAD) who have either an exaggerated or a negative Pressor Response during treadmill walking have shorter peak walking time (PWT) and claudication onset time (COT) than patients with a normal Pressor Response, independent of comorbid conditions. A total of 249 patients were categorized to 1 of 3 groups based on systolic blood pressure (SBP) Responses at 2 minutes of treadmill walking (speed = 2 mph, grade = 0%): group 1 (negative Pressor Response, SBP 18 mm Hg). After adjusting for comorbid conditions, group 3 (exaggerated) had significantly reduced COT (P = .011) and PWT (P = .002) compared to group 2 (normal), while group 1 (negative) and group 2 (normal) were not different. Patients with symptomatic PAD with an increase in SBP > 18 mm Hg after 2 minutes of treadmill walking experience claudication earlier and thus have greater ambulatory dysfunction, compared to patients with PAD with a normal Pressor Response, whereas patients with PAD with negative Pressor Response had a similar walking performance. The implication is that the magnitude of Pressor Response to only 2 minutes of treadmill walking can partially explain the degree of ambulatory dysfunction in patients with PAD.
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vascular inflammation calf muscle oxygen saturation and blood glucose are associated with exercise Pressor Response in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether calf muscle oxygen saturation (StO2) and vascular biomarkers of inflammation and oxidative stress were associated with an exercise Pressor Response during treadmill walking in 179 patients with symptomatic peripheral artery disease (PAD). The exercise Pressor Response was measured as the change in blood pressure from rest to the end of the first 2-minute treadmill stage (2 mph, 0% grade). There was a wide range in the change in systolic blood pressure (-46 to 50 mm Hg) and in diastolic blood pressure (-23 to 38 mm Hg), with mean increases of 4.3 and 1.4 mm Hg, respectively. In multiple regression analyses, significant predictors of systolic pressure included glucose (P < .001) and insulin (P = .039). Significant predictors of diastolic pressure included cultured endothelial cell apoptosis (P = .019), the percentage drop in exercise calf muscle (StO2; P = .023), high-sensitivity C-reactive protein (P = .032), and glucose (P = .033). Higher levels in pro-inflammatory vascular biomarkers, impaired calf muscle StO2 during exercise, and elevated blood glucose were independently associated with greater exercise Pressor Response in patients with symptomatic PAD. The clinical implication is that exercise and nutritional interventions designed to improve inflammation, microcirculation, and glucose metabolism may also lower blood pressure during exercise in patients with symptomatic PAD.
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greater exercise Pressor Response is associated with impaired claudication outcomes in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether a greater exercise Pressor Response during a constant-load treadmill test was associated with lower peak walking time (PWT) and claudication onset time (COT) measured during a...
Andrew W Gardner - One of the best experts on this subject based on the ideXlab platform.
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patients with peripheral arterial disease with exaggerated Pressor Response have greater ambulatory dysfunction than patients with lower Pressor Response
Angiology, 2020Co-Authors: Danielle Jin Kwang Kim, Polly S Montgomery, Ming Wang, Biyi Shen, Marcos Kuroki, Andrew W GardnerAbstract:We determined whether patients with peripheral arterial disease (PAD) who have either an exaggerated or a negative Pressor Response during treadmill walking have shorter peak walking time (PWT) and claudication onset time (COT) than patients with a normal Pressor Response, independent of comorbid conditions. A total of 249 patients were categorized to 1 of 3 groups based on systolic blood pressure (SBP) Responses at 2 minutes of treadmill walking (speed = 2 mph, grade = 0%): group 1 (negative Pressor Response, SBP 18 mm Hg). After adjusting for comorbid conditions, group 3 (exaggerated) had significantly reduced COT (P = .011) and PWT (P = .002) compared to group 2 (normal), while group 1 (negative) and group 2 (normal) were not different. Patients with symptomatic PAD with an increase in SBP > 18 mm Hg after 2 minutes of treadmill walking experience claudication earlier and thus have greater ambulatory dysfunction, compared to patients with PAD with a normal Pressor Response, whereas patients with PAD with negative Pressor Response had a similar walking performance. The implication is that the magnitude of Pressor Response to only 2 minutes of treadmill walking can partially explain the degree of ambulatory dysfunction in patients with PAD.
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vascular inflammation calf muscle oxygen saturation and blood glucose are associated with exercise Pressor Response in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether calf muscle oxygen saturation (StO2) and vascular biomarkers of inflammation and oxidative stress were associated with an exercise Pressor Response during treadmill walking in 179 patients with symptomatic peripheral artery disease (PAD). The exercise Pressor Response was measured as the change in blood pressure from rest to the end of the first 2-minute treadmill stage (2 mph, 0% grade). There was a wide range in the change in systolic blood pressure (-46 to 50 mm Hg) and in diastolic blood pressure (-23 to 38 mm Hg), with mean increases of 4.3 and 1.4 mm Hg, respectively. In multiple regression analyses, significant predictors of systolic pressure included glucose (P < .001) and insulin (P = .039). Significant predictors of diastolic pressure included cultured endothelial cell apoptosis (P = .019), the percentage drop in exercise calf muscle (StO2; P = .023), high-sensitivity C-reactive protein (P = .032), and glucose (P = .033). Higher levels in pro-inflammatory vascular biomarkers, impaired calf muscle StO2 during exercise, and elevated blood glucose were independently associated with greater exercise Pressor Response in patients with symptomatic PAD. The clinical implication is that exercise and nutritional interventions designed to improve inflammation, microcirculation, and glucose metabolism may also lower blood pressure during exercise in patients with symptomatic PAD.
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greater exercise Pressor Response is associated with impaired claudication outcomes in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether a greater exercise Pressor Response during a constant-load treadmill test was associated with lower peak walking time (PWT) and claudication onset time (COT) measured during a...
Marcos Kuroki - One of the best experts on this subject based on the ideXlab platform.
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patients with peripheral arterial disease with exaggerated Pressor Response have greater ambulatory dysfunction than patients with lower Pressor Response
Angiology, 2020Co-Authors: Danielle Jin Kwang Kim, Polly S Montgomery, Ming Wang, Biyi Shen, Marcos Kuroki, Andrew W GardnerAbstract:We determined whether patients with peripheral arterial disease (PAD) who have either an exaggerated or a negative Pressor Response during treadmill walking have shorter peak walking time (PWT) and claudication onset time (COT) than patients with a normal Pressor Response, independent of comorbid conditions. A total of 249 patients were categorized to 1 of 3 groups based on systolic blood pressure (SBP) Responses at 2 minutes of treadmill walking (speed = 2 mph, grade = 0%): group 1 (negative Pressor Response, SBP 18 mm Hg). After adjusting for comorbid conditions, group 3 (exaggerated) had significantly reduced COT (P = .011) and PWT (P = .002) compared to group 2 (normal), while group 1 (negative) and group 2 (normal) were not different. Patients with symptomatic PAD with an increase in SBP > 18 mm Hg after 2 minutes of treadmill walking experience claudication earlier and thus have greater ambulatory dysfunction, compared to patients with PAD with a normal Pressor Response, whereas patients with PAD with negative Pressor Response had a similar walking performance. The implication is that the magnitude of Pressor Response to only 2 minutes of treadmill walking can partially explain the degree of ambulatory dysfunction in patients with PAD.
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vascular inflammation calf muscle oxygen saturation and blood glucose are associated with exercise Pressor Response in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether calf muscle oxygen saturation (StO2) and vascular biomarkers of inflammation and oxidative stress were associated with an exercise Pressor Response during treadmill walking in 179 patients with symptomatic peripheral artery disease (PAD). The exercise Pressor Response was measured as the change in blood pressure from rest to the end of the first 2-minute treadmill stage (2 mph, 0% grade). There was a wide range in the change in systolic blood pressure (-46 to 50 mm Hg) and in diastolic blood pressure (-23 to 38 mm Hg), with mean increases of 4.3 and 1.4 mm Hg, respectively. In multiple regression analyses, significant predictors of systolic pressure included glucose (P < .001) and insulin (P = .039). Significant predictors of diastolic pressure included cultured endothelial cell apoptosis (P = .019), the percentage drop in exercise calf muscle (StO2; P = .023), high-sensitivity C-reactive protein (P = .032), and glucose (P = .033). Higher levels in pro-inflammatory vascular biomarkers, impaired calf muscle StO2 during exercise, and elevated blood glucose were independently associated with greater exercise Pressor Response in patients with symptomatic PAD. The clinical implication is that exercise and nutritional interventions designed to improve inflammation, microcirculation, and glucose metabolism may also lower blood pressure during exercise in patients with symptomatic PAD.
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greater exercise Pressor Response is associated with impaired claudication outcomes in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether a greater exercise Pressor Response during a constant-load treadmill test was associated with lower peak walking time (PWT) and claudication onset time (COT) measured during a...
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abstract 721 the exercise Pressor Response to lower extremity dynamic exercise is accompanied by an abnormal change in total peripheral resistance in peripheral arterial disease subjects
Arteriosclerosis Thrombosis and Vascular Biology, 2018Co-Authors: Marcos Kuroki, Zhaohui Gao, Danielle J Kim, Jian Cui, Cheryl Blaha, Urs A Leuenberger, Lawrence I. SinowayAbstract:Patients with peripheral arterial disease (PAD) have an exaggerated Pressor Response to dynamic exercise of the affected limb. We tested the hypothesis that this Response is mediated by an increase...
Antonio Rusca - One of the best experts on this subject based on the ideXlab platform.
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Pressor Response to Oral Tyramine and Monoamine Oxidase Inhibition During Treatment with Ralfinamide (NW-1029)
Neurotoxicity Research, 2013Co-Authors: Andrea F. D. Stefano, Milko Massimiliano Radicioni, Antonio RuscaAbstract:Ralfinamide, an original Na^+ channel blocker developed for the treatment of chronic pain, inhibits monoamineoxidase-B with no apparent effect on monoamineoxidase-A. To evaluate the Pressor Response to oral tyramine under fasting conditions during treatment with ralfinamide in healthy normotensive subjects. Ten women and 10 men aged 52.9 ± 5.5, sensitive to the oral tyramine Pressor effect in the dose range 200–400 mg, received ralfinamide 320 mg daily during 7 days of confinement. Starting on day 5, ascending doses of tyramine 50, 100 and 200 mg were daily administered to subjects, who had responded to 200 mg at screening, and 100, 200 and 400 mg to the 400 mg responders. Vital parameters were monitored. The systolic blood pressure peak (ΔSBP), the time to achieve the peak (Δ t ) and the area under the pressure curve (over baseline) were calculated. ΔSBP ≥ 30 mmHg were measured for one subject with tyramine 200 mg and for 11 subjects with 400 mg, whilst ΔSBP was
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Pressor Response to oral tyramine during co-administration with safinamide in healthy volunteers
Naunyn-Schmiedeberg's Archives of Pharmacology, 2011Co-Authors: Andrea Francesco Daniele Stefano, Antonio RuscaAbstract:The aim of this study was to evaluate the Pressor Response to oral tyramine during repeated administration of oral safinamide in healthy volunteers. Twelve females and eight males aged 52.7 ± 4.9 years entered the study. An oral tyramine screening test was conducted to select subjects sensitive to the tyramine Pressor effect on systolic blood pressure (SBP) in the dose range of 200–400 mg. Safinamide 300 mg was then administered once daily under fasting conditions. Starting on day 5 (safinamide pharmacokinetic steady state), single ascending doses of tyramine were co-administered daily: 50, 100 and 200 mg were administered on days 5, 6 and 7, respectively. Vital parameters were monitored by telemetry. No SBP increase ≥30 mmHg over baseline was observed when tyramine was co-administered with safinamide. Less than one third of the 400 mg responders reported SBP increases between 22 and 27 mmHg, which were below the threshold of 30 mmHg over baseline. SBP increases, as well as time interval to Pressor Response measured after co-treatment with safinamide and tyramine 200 mg, were not significantly different from those measured after administration of oral tyramine 200 mg alone. Safinamide 300 mg, administered o.d. under fasting conditions, does not change the tyramine Pressor Response as evaluated at steady state after 6–7 days of treatment as compared with the effect of tyramine administered alone. Safinamide, which inhibits monoamine oxidase (MAO)-B, does not affect oral tyramine metabolism mediated mostly by the intestinal MAO-A.
Ming Wang - One of the best experts on this subject based on the ideXlab platform.
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patients with peripheral arterial disease with exaggerated Pressor Response have greater ambulatory dysfunction than patients with lower Pressor Response
Angiology, 2020Co-Authors: Danielle Jin Kwang Kim, Polly S Montgomery, Ming Wang, Biyi Shen, Marcos Kuroki, Andrew W GardnerAbstract:We determined whether patients with peripheral arterial disease (PAD) who have either an exaggerated or a negative Pressor Response during treadmill walking have shorter peak walking time (PWT) and claudication onset time (COT) than patients with a normal Pressor Response, independent of comorbid conditions. A total of 249 patients were categorized to 1 of 3 groups based on systolic blood pressure (SBP) Responses at 2 minutes of treadmill walking (speed = 2 mph, grade = 0%): group 1 (negative Pressor Response, SBP 18 mm Hg). After adjusting for comorbid conditions, group 3 (exaggerated) had significantly reduced COT (P = .011) and PWT (P = .002) compared to group 2 (normal), while group 1 (negative) and group 2 (normal) were not different. Patients with symptomatic PAD with an increase in SBP > 18 mm Hg after 2 minutes of treadmill walking experience claudication earlier and thus have greater ambulatory dysfunction, compared to patients with PAD with a normal Pressor Response, whereas patients with PAD with negative Pressor Response had a similar walking performance. The implication is that the magnitude of Pressor Response to only 2 minutes of treadmill walking can partially explain the degree of ambulatory dysfunction in patients with PAD.
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vascular inflammation calf muscle oxygen saturation and blood glucose are associated with exercise Pressor Response in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether calf muscle oxygen saturation (StO2) and vascular biomarkers of inflammation and oxidative stress were associated with an exercise Pressor Response during treadmill walking in 179 patients with symptomatic peripheral artery disease (PAD). The exercise Pressor Response was measured as the change in blood pressure from rest to the end of the first 2-minute treadmill stage (2 mph, 0% grade). There was a wide range in the change in systolic blood pressure (-46 to 50 mm Hg) and in diastolic blood pressure (-23 to 38 mm Hg), with mean increases of 4.3 and 1.4 mm Hg, respectively. In multiple regression analyses, significant predictors of systolic pressure included glucose (P < .001) and insulin (P = .039). Significant predictors of diastolic pressure included cultured endothelial cell apoptosis (P = .019), the percentage drop in exercise calf muscle (StO2; P = .023), high-sensitivity C-reactive protein (P = .032), and glucose (P = .033). Higher levels in pro-inflammatory vascular biomarkers, impaired calf muscle StO2 during exercise, and elevated blood glucose were independently associated with greater exercise Pressor Response in patients with symptomatic PAD. The clinical implication is that exercise and nutritional interventions designed to improve inflammation, microcirculation, and glucose metabolism may also lower blood pressure during exercise in patients with symptomatic PAD.
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greater exercise Pressor Response is associated with impaired claudication outcomes in symptomatic peripheral artery disease
Angiology, 2019Co-Authors: Andrew W Gardner, Polly S Montgomery, Ming Wang, Marcos Kuroki, Chixiang Chen, Danielle Jin Kwang KimAbstract:We determined whether a greater exercise Pressor Response during a constant-load treadmill test was associated with lower peak walking time (PWT) and claudication onset time (COT) measured during a...
