The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Seung Sik Hwang - One of the best experts on this subject based on the ideXlab platform.
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comparison of localized retinal nerve fiber layer defects between a low teen intraocular Pressure Group and a high teen intraocular Pressure Group in normal tension glaucoma patients
Journal of Glaucoma, 2007Co-Authors: Seung Sik HwangAbstract:PurposeTo compare the features of localized retinal nerve fiber layer (RNFL) defects between a low-teen intraocular Pressure (IOP) Group and a high-teen IOP Group in normal-tension glaucoma (NTG) patients.MethodsSeventy-seven eyes of 77 NTG patients showing localized RNFL defects on RNFL photographs
Ayse Filiz Gokmen Karasu - One of the best experts on this subject based on the ideXlab platform.
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the usual suspect cross sectional study of fundal Pressure at second stage of delivery and the association with pelvic floor damage
International Urogynecology Journal, 2020Co-Authors: Taha Takmaz, Serdar Aydin, Irana Gorchiyeva, Ayse Filiz Gokmen KarasuAbstract:INTRODUCTION AND HYPOTHESIS Uterine fundal Pressure is applied to accelerate birth by increasing the expulsive force of the uterus in the second stage of delivery. The aim of the study was to evaluate the effect of using uterine fundal Pressure during the second stage of delivery on the rate of pelvic floor damage among primiparous women using three-dimensional transperineal ultrasonography. METHODS The women were divided into two Groups: the fundal Pressure Group included women where the fundal Pressure maneuver was applied (n = 39); the control Group included women who delivered spontaneously without fundal Pressure (n = 47). 3D-TPU was performed within 48 h of delivery, and LAM biometry, LAM defect and loss of tenting were determined. RESULTS Anteroposterior hiatal dimensions on resting, maximal Valsalva and maximal PFMC were found to be higher in the fundal Pressure Group (p < 0.0001, p = 0.008, p = 0.007, respectively). The mean hiatal area at rest was larger in the fundal Pressure Group than in the control Group (p = 0.04). The rate of LAM defect was significantly higher in the fundal Pressure Group (p = 0.001). The rate of loss of tenting was significantly higher in the fundal Pressure Group (p < 0.0001). According to multivariate regression models, the fundal Pressure was the only independent factor associated with LAM defect (OR = 5.63; 95% CI = 12.01-15.74) and loss of tenting (OR = 8.74; 95% CI = 2.89-26.43). CONCLUSIONS Fundal Pressure during the second stage of delivery is associated with a higher risk of LAM defect and loss of anterior vaginal wall support. CLINICAL TRIAL REGISTRATION NCT03752879.
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The usual suspect: cross-sectional study of fundal Pressure at second stage of delivery and the association with pelvic floor damage
International Urogynecology Journal, 2020Co-Authors: Taha Takmaz, Serdar Aydin, Irana Gorchiyeva, Ayse Filiz Gokmen KarasuAbstract:Introduction and hypothesis Uterine fundal Pressure is applied to accelerate birth by increasing the expulsive force of the uterus in the second stage of delivery. The aim of the study was to evaluate the effect of using uterine fundal Pressure during the second stage of delivery on the rate of pelvic floor damage among primiparous women using three-dimensional transperineal ultrasonography. Methods The women were divided into two Groups: the fundal Pressure Group included women where the fundal Pressure maneuver was applied ( n = 39); the control Group included women who delivered spontaneously without fundal Pressure ( n = 47). 3D-TPU was performed within 48 h of delivery, and LAM biometry, LAM defect and loss of tenting were determined. Results Anteroposterior hiatal dimensions on resting, maximal Valsalva and maximal PFMC were found to be higher in the fundal Pressure Group ( p
William J. Kostis - One of the best experts on this subject based on the ideXlab platform.
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HIGHER MORTALITY AMONG PATIENTS WHO REQUIRED ONE OR MORE DRUGS TO ACHIEVE THE SAME SYSTOLIC BLOOD Pressure REGARDLESS OF THE RANDOMIZATION Group IN THE SYSTOLIC BLOOD Pressure INTERVENTION TRIAL
Journal of the American College of Cardiology, 2019Co-Authors: John B. Kostis, Chun Pang Lin, Javier Cabrera, Daniel Blickstein, William J. KostisAbstract:In the Systolic Blood Pressure Intervention Trial (SPRINT) patients were randomized to the intensive blood Pressure Group targeting systolic blood Pressure (SBP) less than 120 mm Hg or to the standard Group targeting SBP less than 140 mm Hg. Here we present data on 2907 patients initially randomized
Cynthia M. Trim - One of the best experts on this subject based on the ideXlab platform.
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The effects of two endotracheal tube cuff inflation Pressures on liquid aspiration and tracheal wall damage in horses
Veterinary anaesthesia and analgesia, 2005Co-Authors: Gwenola Touzot-jourde, Nancy L. Stedman, Cynthia M. TrimAbstract:To investigate the effect of endotracheal tube cuff inflation Pressure on the occurrence of liquid aspiration and tracheal wall damage. Prospective, randomized experimental study. Ten healthy horses, weighing 535 +/- 55 kg. Horses were anesthetized, orotracheally intubated, placed in dorsal recumbency, and maintained on isoflurane in oxygen with controlled ventilation for 175 +/- 15 minutes. The horses were randomly assigned to an endotracheal cuff Pressure of 80-100 or 120 cm H2O. The cuff Pressure was continuously monitored and maintained at a constant Pressure. Methylene blue in saline was instilled proximal to the cuff. After euthanasia, the trachea was opened distal to the endotracheal tube tip to check for evidence of dye leaking past the cuff. The cervical trachea was then resected and opened longitudinally for gross and histologic examinations. No blue staining was found distal to the cuff in any horse. Visual examination of the tracheal mucosa revealed hyperemic and hemorrhagic lesions at the site of the cuff contact. Histologic changes included epithelium attenuation or erosion, submucosal neutrophilic infiltration, and submucosal hemorrhages. Lesions were absent or less extensive in the lower cuff Pressure Group as compared to the high cuff Pressure Group. The endotracheal tube cuff produced a seal sufficient to prevent leakage in both Groups. Tracheal wall damage was more severe and occurred more frequently in the higher cuff Pressure Group. Tracheal mucosal damage induced by cuff inflation is Pressure-dependent. Cuff Pressure monitoring is recommended.
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the effects of two endotracheal tube cuff inflation Pressures on liquid aspiration and tracheal wall damage in horses
Veterinary Anaesthesia and Analgesia, 2005Co-Authors: Gwenola Touzotjourde, Nancy L. Stedman, Cynthia M. TrimAbstract:Objective To investigate the effect of endotracheal tube cuff inflation Pressure on the occurrence of liquid aspiration and tracheal wall damage. Study design Prospective, randomized experimental study. Animals Ten healthy horses, weighing 535 ± 55 kg. Methods Horses were anesthetized, orotracheally intubated, placed in dorsal recumbency, and maintained on isoflurane in oxygen with controlled ventilation for 175 ± 15 minutes. The horses were randomly assigned to an endotracheal cuff Pressure of 80–100 or 120 cm H2O. The cuff Pressure was continuously monitored and maintained at a constant Pressure. Methylene blue in saline was instilled proximal to the cuff. After euthanasia, the trachea was opened distal to the endotracheal tube tip to check for evidence of dye leaking past the cuff. The cervical trachea was then resected and opened longitudinally for gross and histologic examinations. Results No blue staining was found distal to the cuff in any horse. Visual examination of the tracheal mucosa revealed hyperemic and hemorrhagic lesions at the site of the cuff contact. Histologic changes included epithelium attenuation or erosion, submucosal neutrophilic infiltration, and submucosal hemorrhages. Lesions were absent or less extensive in the lower cuff Pressure Group as compared to the high cuff Pressure Group. Conclusions The endotracheal tube cuff produced a seal sufficient to prevent leakage in both Groups. Tracheal wall damage was more severe and occurred more frequently in the higher cuff Pressure Group. Clinical relevance Tracheal mucosal damage induced by cuff inflation is Pressure-dependent. Cuff Pressure monitoring is recommended.
Nandor Marczin - One of the best experts on this subject based on the ideXlab platform.
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inflation Pressures are associated with outcomes in ventilated patients after lung transplantation
European Respiratory Journal, 2014Co-Authors: Louit Thakuria, Rosada Davey, Rosalba Romano, Martin Carby, Sundeep Kaul, Mark J D Griffiths, A R Simon, A Reed, Nandor MarczinAbstract:Introduction The injurious effects of large tidal volumes during mechanical ventilation in ARDS are well established, but the impact and determinants of injurious ventilation in lung transplantation are unknown. Methods 124 bilateral lung transplants between June 2010 and April 2013 were reviewed. Patients were retrospectively assigned to high (≥25cm H 2 O) and low Pressure ( 2 O) Groups based on the average inflation Pressures used in the first 6 hours after surgery. Average tidal volumes and lung compliance were also recorded. The median values [with interquartile ranges] for ICU length of stay (LOS) and lung function (% predicted FEV 1 at 3 months) were documented for each Group. The 6 month survival rate was also recorded. Results The low-Pressure Group (n=76) had a LOS of 5 days [4-19], FEV 1 of 79.2% [62.7-92.6] and 6 month survival rate of 95%. The high-Pressure Group (n=48) had a prolonged LOS of 12 days ([4-36], p=0.012), a lower FEV 1 at 61.4% ([51.3-67.0], p 2 O, [28-39]) than the high Pressure Group (24ml/cmH 2 O, [20-27], p Discussion Reduced lung compliance and mechanical ventilation with high inflation Pressures in the first hours following lung transplantation are significantly associated with poorer outcomes for months after surgery. This may reflect early lung injury necessitating the use of higher inflation Pressures. Alternatively, ventilation with higher inflation Pressures might have inflicted lung injury that adversely affected clinical outcomes.
