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Yasunori Morimoto - One of the best experts on this subject based on the ideXlab platform.
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potential usefulness of solubility index for prediction of the skin permeation rate of 5 ismn from Pressure Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Abstract Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick’s second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape.
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Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from Pressure-Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick's second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape. © 2001 Elsevier Science B.V.
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A protective effect against undesirable increase of dihydroetorphine permeation through damaged skin by using Pressure-Sensitive Adhesive tape with an ethylene-vinyl acetate co-polymer membrane
Biol.Pharm.Bull., 2001Co-Authors: SHINYA OHMORI, Y Sugiyama, Yasunori MorimotoAbstract:The release kinetics of dihydroetorphine (DHE) from Pressure-Sensitive Adhesive (PSA) tape with an ethylene-vinyl acetate co-polymer (EVA) membrane as a diffusion-controlling membrane and its protective effect from an unpredictable increase in skin permeation of DHE caused by stratum corneum damage were investigated. The DHE flux through the EVA membrane was enhanced with the increase of vinyl acetate content. Although the DHE release from the PSA tape was proportional to the square root of the time, the release from the PSA tape covered with the EVA membrane was dominated by zero-order rate. The release rate increased by the addition of isopropyl myristate to the PSA layer, due to the increase of solubility and diffusivity of DHE in the PSA layer, and not a decrease of permeation resistance in the EVA membrane. When using the PSA tape with the EVA membrane, the steady-state flux of DHE through hairless rat skin with stratum corneum damage was not 2-fold more than that through non-damaged skin. Plasma DHE concentration rose promptly above 5 ng/ml after the application of the PSA tape onto the damaged skin in hairless rat. In contrast, when the PSA tape with the EVA membrane was applied onto the damaged or non-damaged skin, plasma concentrations in the both cases were maintained in the therapeutic range (0.2-1.2 ng/ml). These results suggest that the PSA tape with the EVA membrane can be used to protect from the unpredictable increase in skin permeation of DHE due to stratum corneum damage
Kimihiro Sato - One of the best experts on this subject based on the ideXlab platform.
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potential usefulness of solubility index for prediction of the skin permeation rate of 5 ismn from Pressure Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Abstract Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick’s second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape.
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Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from Pressure-Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick's second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape. © 2001 Elsevier Science B.V.
Naomi Mitsui - One of the best experts on this subject based on the ideXlab platform.
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potential usefulness of solubility index for prediction of the skin permeation rate of 5 ismn from Pressure Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Abstract Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick’s second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape.
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Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from Pressure-Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick's second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape. © 2001 Elsevier Science B.V.
Kenji Sugibayashi - One of the best experts on this subject based on the ideXlab platform.
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potential usefulness of solubility index for prediction of the skin permeation rate of 5 ismn from Pressure Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Abstract Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick’s second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape.
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Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from Pressure-Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick's second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape. © 2001 Elsevier Science B.V.
Tetsuya Hasegawa - One of the best experts on this subject based on the ideXlab platform.
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potential usefulness of solubility index for prediction of the skin permeation rate of 5 ismn from Pressure Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Abstract Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick’s second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape.
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Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from Pressure-Sensitive Adhesive tape
Journal of Controlled Release, 2001Co-Authors: Kimihiro Sato, Naomi Mitsui, Kenji Sugibayashi, Tetsuya Hasegawa, Yasunori MorimotoAbstract:Skin permeation of 5-ISMN from Pressure Sensitive Adhesive (PSA) tape was evaluated using thermodynamic activity of the drug in PSA. Three acrylic Adhesives (Gelva 737, Gelva 1430 and Gelva 1753) were used as PSA. Since the drug activity in PSA is difficult to determine, however, a solubility index was defined. Several PSA tapes containing different amounts of 5-ISMN were prepared, and heat of fusion at the dissolution of 5-ISMN in each PSA was determined by DSC. No exothermic peak was found when the drug concentration was less than the solubility in PSA, whereas the heat of fusion increased proportionally with amount of solid drug in the PSA when the drug concentration was above the solubility. The bending point in the profile of heat of fusion versus 5-ISMN content in PSA was defined as the solubility index. In vitro skin permeation was determined using excised hairless rat skin from 5-ISMN-saturated PSA tapes. The obtained skin permeation of the drug decreased with increases in the solubility index. These profiles were confirmed by a theoretical approach using the differential equation corresponding to Fick's second law of diffusion. These results suggested that the solubility index can be utilized for prediction of the skin permeability of drugs from PSA tape. © 2001 Elsevier Science B.V.
