The Experts below are selected from a list of 25557 Experts worldwide ranked by ideXlab platform
Robert L. Hunter - One of the best experts on this subject based on the ideXlab platform.
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Pathology of post Primary Tuberculosis of the lung: an illustrated critical review.
Tuberculosis (Edinburgh Scotland), 2011Co-Authors: Robert L. HunterAbstract:Post Primary Tuberculosis occurs in immunocompetent adults, is restricted to the lungs and accounts for 80% of all clinical cases and nearly 100% of transmission of infection. The supply of human tissues with post Primary Tuberculosis plummeted with the introduction of antibiotics decades before the flowering of research using molecular methods in animal models. Unfortunately, the paucity of human tissues prevented validation of the models. As a result, it is a paradigm of contemporary research that caseating granulomas are the characteristic lesion of all Tuberculosis and that cavities form when they erode into bronchi. This differs from descriptions of the preantibiotic era when many investigators had access to thousands of cases. They reported that post Primary Tuberculosis begins as an exudative reaction: a tuberculous lipid pneumonia of foamy alveolar macrophages that undergoes caseation necrosis and fragmentation to produce cavities. Granulomas in post Primary disease arise only in response to old caseous pneumonia and produce fibrosis, not cavities. We confirmed and extended these observations with study of 104 cases of untreated Tuberculosis. In addition, studies of the lungs of infants and immunosuppressed adults revealed a second type of tuberculous pneumonia that seldom produces cavities. Since the concept that cavities arise from caseating granulomas was supported by studies of animals infected with Mycobacterium bovis, we investigated its pathology. We found that M. bovis does not produce post Primary Tuberculosis in any species. It only produces an aggressive Primary Tuberculosis that can develop small cavities by erosion of caseating granulomas. Consequently, a key unresolved question in the pathogenesis of Tuberculosis is identification of the mechanisms by which Mycobacterium Tuberculosis establish a localized safe haven in alveolar macrophages in an otherwise solidly immune host where it can develop conditions for formation of cavities and transmission to new hosts.
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On the pathogenesis of post Primary Tuberculosis: the role of bronchial obstruction in the pathogenesis of cavities.
Tuberculosis, 2011Co-Authors: Robert L. HunterAbstract:Mycobacterium Tuberculosis produces two distinct types of disease: Primary and post Primary Tuberculosis. We recently reported that post Primary Tuberculosis begins in immunocompetent adults as an endogenous lipid pneumonia that abruptly undergoes necrosis to produce cavities. Obstruction of bronchi by endobronchial Tuberculosis is a consistent finding in developing post Primary Tuberculosis. This paper reports a case of obstructive pneumonia caused by cancer that underwent rapid necrosis to produce a cavity that was similar to those produce by Tuberculosis. Analysis of this case with the relevant literature supports the hypothesis that bronchial obstruction is an essential contributor to the development of post Primary Tuberculosis and that it may help explain the localized suppression of host defense mechanisms in adult pulmonary Tuberculosis.
Pietro Cappugi - One of the best experts on this subject based on the ideXlab platform.
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Primary Tuberculosis of the penis.
Journal of the European Academy of Dermatology and Venereology : JEADV, 1999Co-Authors: Riccardo Rossi, Francesco Urbano, Enrico Tortoli, Michele Trotta, Giuliano Zuccati, Pietro CappugiAbstract:We present a case of Primary Tuberculosis of the inner lining of the prepuce in a 63-year-old man. The condition resembled carcinoma. The diagnosis was based on histopathology and on M. Tuberculosis culture. Successful treatment was by a combined medical and surgical approach. The rarity of the case is emphasized.
Janet A. Wilson - One of the best experts on this subject based on the ideXlab platform.
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Primary Tuberculosis of the posterior oropharyngeal wall.
The Journal of laryngology and otology, 1999Co-Authors: D. Hajioff, M. H. Snow, H. Thaker, Janet A. WilsonAbstract:We report a case of Primary Tuberculosis of the posterior oropharyngeal wall presenting with sore throat, fever and malaise. Pharyngeal Tuberculosis is rare and usually occurs with Primary pulmonary disease. Primary disease has been reported in small numbers in the nasopharynx and palatine tonsil but never before, to our knowledge, in the posterior oropharyngeal wall.
J K Sahni - One of the best experts on this subject based on the ideXlab platform.
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Primary Tuberculosis of tonsil and posterior oropharyngeal wall.
The Indian journal of tuberculosis, 2008Co-Authors: A Chakravarti, Swatilika Pal, J K SahniAbstract:Pharyngeal Tuberculosis is rare and usually occurs in association with Primary pulmonary disease. Primary Tuberculosis involving the palatine tonsils and the posterior oropharyngeal wall is still a rare clinical entity. We report one such case of Primary Tuberculosis involving both the palatine tonsils and the posterior oropharyngeal wall in a 22 year-old male. The patient responded to anti-tubercular treatment with complete disappearance of lesion and no sign of recurrence on one year follow-up. The final diagnosis was based upon histopathological report.
Riccardo Rossi - One of the best experts on this subject based on the ideXlab platform.
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Primary Tuberculosis of the penis.
Journal of the European Academy of Dermatology and Venereology : JEADV, 1999Co-Authors: Riccardo Rossi, Francesco Urbano, Enrico Tortoli, Michele Trotta, Giuliano Zuccati, Pietro CappugiAbstract:We present a case of Primary Tuberculosis of the inner lining of the prepuce in a 63-year-old man. The condition resembled carcinoma. The diagnosis was based on histopathology and on M. Tuberculosis culture. Successful treatment was by a combined medical and surgical approach. The rarity of the case is emphasized.