The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform
Kifayat Ullah Shah - One of the best experts on this subject based on the ideXlab platform.
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once daily controlled release matrix tablet of Prochlorperazine Maleate influence of ethocel and or methocel on in vitro drug release and bioavailability
Drug Development and Industrial Pharmacy, 2012Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
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Once daily controlled release matrix tablet of Prochlorperazine Maleate: influence of Ethocel® and/or Methocel® on in vitro drug release and bioavailability.
Drug development and industrial pharmacy, 2011Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
Amir Badshah - One of the best experts on this subject based on the ideXlab platform.
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once daily controlled release matrix tablet of Prochlorperazine Maleate influence of ethocel and or methocel on in vitro drug release and bioavailability
Drug Development and Industrial Pharmacy, 2012Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
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Once daily controlled release matrix tablet of Prochlorperazine Maleate: influence of Ethocel® and/or Methocel® on in vitro drug release and bioavailability.
Drug development and industrial pharmacy, 2011Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
Islam Ullah Khan - One of the best experts on this subject based on the ideXlab platform.
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Spectrophotometric Determination of Prochlorperazine Maleate in Pure and Pharmaceutical Preparations
Microchimica Acta, 2002Co-Authors: Tehseen Aman, Zeeshan Majeed, Asrar Ahmad Kazi, Islam Ullah KhanAbstract:Prochlorperazine Maleate reacts with 1-naphthylamine and sodium nitrite, after heating for 110 s at 80 °C to give an orange red colour having maximum absorbance at 460 nm. The reaction is selective for Prochlorperazine Maleate with 0.01 mg/mL as visual limit of quantitation and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.01 mg/10 mL to 0.33 mg/10 mL of Prochlorperazine Maleate and the relative standard deviation is 0.68%. The quantitative assessment of tolerable amounts of other drugs is also studied.
Nisar Hussain Shah - One of the best experts on this subject based on the ideXlab platform.
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once daily controlled release matrix tablet of Prochlorperazine Maleate influence of ethocel and or methocel on in vitro drug release and bioavailability
Drug Development and Industrial Pharmacy, 2012Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
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Once daily controlled release matrix tablet of Prochlorperazine Maleate: influence of Ethocel® and/or Methocel® on in vitro drug release and bioavailability.
Drug development and industrial pharmacy, 2011Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
Nadeem Irfan Bukhari - One of the best experts on this subject based on the ideXlab platform.
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once daily controlled release matrix tablet of Prochlorperazine Maleate influence of ethocel and or methocel on in vitro drug release and bioavailability
Drug Development and Industrial Pharmacy, 2012Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...
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Once daily controlled release matrix tablet of Prochlorperazine Maleate: influence of Ethocel® and/or Methocel® on in vitro drug release and bioavailability.
Drug development and industrial pharmacy, 2011Co-Authors: Amir Badshah, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, Kifayat Ullah ShahAbstract:Context: Controlled release (CR) matrix tablet of Prochlorperazine Maleate was developed to improve its patient compliance.Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel® K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel® K100 LV-CR Premium and Ethocel® Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil® tablet was conducted on rabbits, using HPLC-UV system at λmax 254 nm.Results: The test tablet, containing 28% Methocel® and 58% Ethocel® (F6) exhibited desired zero order kinetics for 24 h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel® content in the blend was increased, perha...