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Litao Jia - One of the best experts on this subject based on the ideXlab platform.

  • two stripper flash distillation column system design operation and control for separating 2 pentanone 4 heptanone water azeotropic mixture via navigating residue curve maps and balancing total annual cost and Product Loss
    Industrial & Engineering Chemistry Research, 2018
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigor...

  • Two-Stripper/Flash/Distillation Column System Design, Operation, and Control for Separating 2‑Pentanone/4-Heptanone/Water Azeotropic Mixture via Navigating Residue Curve Maps and Balancing Total Annual Cost and Product Loss
    2017
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigorous economic design and optimum operation of the flow sheet are further investigated in detail. Moreover, several control structures (TCS1, TCS2, and DTCS, CTCS, C&TCS) are successively explored with consideration of ordinary-purity and high-purity separations. Dynamic control shows that whereas the flow sheet can be controlled by controlling one tray temperature in each stripper/column for ordinary-purity separation, an expensive and high-maintenance online composition control should be considered for high-purity separation

Ming Xia - One of the best experts on this subject based on the ideXlab platform.

  • two stripper flash distillation column system design operation and control for separating 2 pentanone 4 heptanone water azeotropic mixture via navigating residue curve maps and balancing total annual cost and Product Loss
    Industrial & Engineering Chemistry Research, 2018
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigor...

  • Two-Stripper/Flash/Distillation Column System Design, Operation, and Control for Separating 2‑Pentanone/4-Heptanone/Water Azeotropic Mixture via Navigating Residue Curve Maps and Balancing Total Annual Cost and Product Loss
    2017
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigorous economic design and optimum operation of the flow sheet are further investigated in detail. Moreover, several control structures (TCS1, TCS2, and DTCS, CTCS, C&TCS) are successively explored with consideration of ordinary-purity and high-purity separations. Dynamic control shows that whereas the flow sheet can be controlled by controlling one tray temperature in each stripper/column for ordinary-purity separation, an expensive and high-maintenance online composition control should be considered for high-purity separation

Erwin Freund - One of the best experts on this subject based on the ideXlab platform.

  • mechanistic studies of glass vial breakage for frozen formulations i vial breakage caused by crystallizable excipient mannitol
    Pda Journal of Pharmaceutical Science and Technology, 2007
    Co-Authors: Ge Jiang, Mike Akers, Manish Jain, Adrian Distler, Rob Swift, Manpreetvick S Wadhwa, Feroz Jameel, Sugu Patro, Erwin Freund
    Abstract:

    The process of freeze-thaw not only subjects bioProducts to potentially destabilizing stress, but also imposes challenges to retain container integrity. Shipment and storage of frozen Products in glass vials and thawing of the vials prior to use at clinics is a common situation. Vial integrity failure during freeze-thaw results in Product Loss and safety issues. Formulations of biomolecules often include crystallizable excipients, which can cause glass vial breakage during freeze-thaw operations. In this study, mannitol formulations served as models for mechanistic investigation of root causes for vial breakage. Several parameters and their impacts on vial breakage were investigated, including mannitol concentration (5% and 15%), different freeze-thaw conditions (fast, slow, and staging), fill configurations (varying fill volume/vial size ratio), and vial tray materials (plastic, stainless steel, corrugated cardboard, aluminum, and polyurethane foam). The results in this study were subjected to a statistical proportion test. The data showed that large fill volumes strongly correlated with higher percentage of vial cracks. Furthermore, the 15% mannitol was found to cause more breakage than 5% mannitol, especially with fast temperature gradient. Significantly more thawing vial breakage occurred in the fast compared to slow freeze-thaw with all types of vial trays. The freezing breakage was substantially lower than the thawing breakage using the fast temperature gradient, and the trend was reversed with the slow temperature gradient. An intermediate hold at −30 °C prior to further decrease in temperature proved to be a practical approach to minimize mannitol-induced vial breakage. Thermal mechanical analysis (TMA) and strain gage techniques were employed to gain mechanistic insights, and it was found that the primary causes for mannitol-induced vial breakage were partial crystallization during freezing and “secondary” crystallization of non-crystallized fraction during thawing. The strain on the vial9s axial direction was significantly higher than the hoop direction, typically resulting in bottom lens of the vial coming off. Without a −30 °C hold, rapid volume expansions due to initial crystallization and secondary crystallization of mannitol were observed in TMA profiles, and these expansions were more apparent in 15% mannitol compared to 5% mannitol. With the introduction of a −30 °C hold step, abrupt expansions diminished in TMA profiles, suggesting that most of the mannitol crystallization occurred concurrently with ice solidification during the −30 °C holding step and, thus, secondary crystallization during thawing was minimal and the sudden expansion event was eliminated. Therefore, vial breakage during both freezing and thawing was reduced.

  • mechanistic studies of glass vial breakage for frozen formulations i vial breakage caused by crystallizable excipient mannitol
    Pda Journal of Pharmaceutical Science and Technology, 2007
    Co-Authors: Ge Jiang, Mike Akers, Manish Jain, Adrian Distler, Rob Swift, Manpreetvick S Wadhwa, Feroz Jameel, Sugu Patro, Jeremy Guo, Erwin Freund
    Abstract:

    The process of freeze-thaw not only subjects bioProducts to potentially destabilizing stress, but also imposes challenges to retain container integrity. Shipment and storage of frozen Products in glass vials and thawing of the vials prior to use at clinics is a common situation. Vial integrity failure during freeze-thaw results in Product Loss and safety issues. Formulations of biomolecules often include crystallizable excipients, which can cause glass vial breakage during freeze-thaw operations. In this study, mannitol formulations served as models for mechanistic investigation of root causes for vial breakage. Several parameters and their impacts on vial breakage were investigated, including mannitol concentration (5% and 15%), different freeze-thaw conditions (fast, slow, and staging), fill configurations (varying fill volume/vial size ratio), and vial tray materials (plastic, stainless steel, corrugated cardboard, aluminum, and polyurethane foam). The results in this study were subjected to a statistical proportion test. The data showed that large fill volumes strongly correlated with higher percentage of vial cracks. Furthermore, the 15% mannitol was found to cause more breakage than 5% mannitol, especially with fast temperature gradient. Significantly more thawing vial breakage occurred in the fast compared to slow freeze-thaw with all types of vial trays. The freezing breakage was substantially lower than the thawing breakage using the fast temperature gradient, and the trend was reversed with the slow temperature gradient. An intermediate hold at -30 degrees C prior to further decrease in temperature proved to be a practical approach to minimize mannitol-induced vial breakage. Thermal mechanical analysis (TMA) and strain gage techniques were employed to gain mechanistic insights, and it was found that the primary causes for mannitol-induced vial breakage were partial crystallization during freezing and "secondary" crystallization of non-crystallized fraction during thawing. The strain on the vial's axial direction was significantly higher than the hoop direction, typically resulting in bottom lens of the vial coming off. Without a -30 degrees C hold, rapid volume expansions due to initial crystallization and secondary crystallization of mannitol were observed in TMA profiles, and these expansions were more apparent in 15% mannitol compared to 5% mannitol. With the introduction of a -30 degrees C hold step, abrupt expansions diminished in TMA profiles, suggesting that most of the mannitol crystallization occurred concurrently with ice solidification during the -30 degrees C holding step and, thus, secondary crystallization during thawing was minimal and the sudden expansion event was eliminated. Therefore, vial breakage during both freezing and thawing was reduced.

Bo Hou - One of the best experts on this subject based on the ideXlab platform.

  • two stripper flash distillation column system design operation and control for separating 2 pentanone 4 heptanone water azeotropic mixture via navigating residue curve maps and balancing total annual cost and Product Loss
    Industrial & Engineering Chemistry Research, 2018
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigor...

  • Two-Stripper/Flash/Distillation Column System Design, Operation, and Control for Separating 2‑Pentanone/4-Heptanone/Water Azeotropic Mixture via Navigating Residue Curve Maps and Balancing Total Annual Cost and Product Loss
    2017
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigorous economic design and optimum operation of the flow sheet are further investigated in detail. Moreover, several control structures (TCS1, TCS2, and DTCS, CTCS, C&TCS) are successively explored with consideration of ordinary-purity and high-purity separations. Dynamic control shows that whereas the flow sheet can be controlled by controlling one tray temperature in each stripper/column for ordinary-purity separation, an expensive and high-maintenance online composition control should be considered for high-purity separation

Congbiao Chen - One of the best experts on this subject based on the ideXlab platform.

  • two stripper flash distillation column system design operation and control for separating 2 pentanone 4 heptanone water azeotropic mixture via navigating residue curve maps and balancing total annual cost and Product Loss
    Industrial & Engineering Chemistry Research, 2018
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigor...

  • Two-Stripper/Flash/Distillation Column System Design, Operation, and Control for Separating 2‑Pentanone/4-Heptanone/Water Azeotropic Mixture via Navigating Residue Curve Maps and Balancing Total Annual Cost and Product Loss
    2017
    Co-Authors: Ming Xia, Hui Shi, Congbiao Chen, Yong Xiao, Bo Hou, Litao Jia
    Abstract:

    A novel method for the synergetic Production of 2-pentanone and 4-heptanone has been explored recently at the Institute of Coal Chemistry, Chinese Academy of Sciences (ICC, CAS). The collected mixture, containing mainly 2-pentanone/4-heptanone/water/carbon dioxide, presents heterogeneous azeotropes. The separation of this quaternary mixture is the main problem urgently to be effectively solved. In this work, a two-stripper/flash/column flow sheet is proposed to achieve the separation, in which the heterogeneity of the system is fully utilized by using an overhead vapor–liquid–liquid (VLL) flash. A general total annual cost (GTAC) for balancing total annual cost (TAC) and Product Loss (PL) is proposed as an optimization function, and several optimization sequences are presented to facilitate the optimization. Four candidate sequences (S1, S2, S3, and S4) are derived from navigating the ternary and residue curve maps, of which the S4 cuts the GTAC with a marked margin (83.9%) compared with the S1. The rigorous economic design and optimum operation of the flow sheet are further investigated in detail. Moreover, several control structures (TCS1, TCS2, and DTCS, CTCS, C&TCS) are successively explored with consideration of ordinary-purity and high-purity separations. Dynamic control shows that whereas the flow sheet can be controlled by controlling one tray temperature in each stripper/column for ordinary-purity separation, an expensive and high-maintenance online composition control should be considered for high-purity separation