The Experts below are selected from a list of 123 Experts worldwide ranked by ideXlab platform
L. Hendel - One of the best experts on this subject based on the ideXlab platform.
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hydroxyproline in the oesophageal mucosa of patients with Progressive Systemic Sclerosis during omeprazole induced healing of reflux oesophagitis
Alimentary Pharmacology & Therapeutics, 2007Co-Authors: L. HendelAbstract:SUMMARY Hydroxyproline concentration in oesophageal mucosal biopsies was used as an index of collagen in an attempt to evaluate the potential for stricture formation in patients with Progressive Systemic Sclerosis. Eight patients suffering from Progressive Systemic Sclerosis with complicating gastro-oesophageal reflux, 8 patients with idiopathic gastro-oesophageal reflux, and 7 normal controls were compared. Acid gastro-oesophageal reflux was assessed with 24-h pH-metry; degree of oesophagitis was evaluated both endoscopically and histopathologically. The patients with Progressive Systemic Sclerosis were investigated at the start of the study and later when healing of oesophagitis was accomplished with omeprazole therapy. The hydroxyproline concentration was significantly increased (P < 0.01) in the oesophageal mucosa from patients with Progressive Systemic Sclerosis (median 21.8 nmol/mg) as compared to patients with idiopathic gastro-oesophageal reflux (median 6.4 nmol/mg) and normal controls (median 8.1 nmol/mg). Hydroxyproline concentration in oesophageal mucosa from patients with Progressive Systemic Sclerosis decreased significantly and to a normal level (median 6.5 nmol/pg; P= 0.014) when healing of oesophagitis was achieved.
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Hydroxyproline in the oesophageal mucosa of patients with Progressive Systemic Sclerosis during omeprazole‐induced healing of reflux oesophagitis
Alimentary Pharmacology & Therapeutics, 2007Co-Authors: L. HendelAbstract:SUMMARY Hydroxyproline concentration in oesophageal mucosal biopsies was used as an index of collagen in an attempt to evaluate the potential for stricture formation in patients with Progressive Systemic Sclerosis. Eight patients suffering from Progressive Systemic Sclerosis with complicating gastro-oesophageal reflux, 8 patients with idiopathic gastro-oesophageal reflux, and 7 normal controls were compared. Acid gastro-oesophageal reflux was assessed with 24-h pH-metry; degree of oesophagitis was evaluated both endoscopically and histopathologically. The patients with Progressive Systemic Sclerosis were investigated at the start of the study and later when healing of oesophagitis was accomplished with omeprazole therapy. The hydroxyproline concentration was significantly increased (P < 0.01) in the oesophageal mucosa from patients with Progressive Systemic Sclerosis (median 21.8 nmol/mg) as compared to patients with idiopathic gastro-oesophageal reflux (median 6.4 nmol/mg) and normal controls (median 8.1 nmol/mg). Hydroxyproline concentration in oesophageal mucosa from patients with Progressive Systemic Sclerosis decreased significantly and to a normal level (median 6.5 nmol/pg; P= 0.014) when healing of oesophagitis was achieved.
Gerald P. Rodnan - One of the best experts on this subject based on the ideXlab platform.
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d penicillamine therapy in Progressive Systemic Sclerosis scleroderma
Annals of Internal Medicine, 2020Co-Authors: Virginia D Steen, Thomas A Medsger, Gerald P. RodnanAbstract:Abstract In a retrospective study on Progressive Systemic Sclerosis, we compared 73 patients who had receivedD-penicillamine therapy for a minimum of 6 consecutive months with 45 patients who had n...
Oded Abramsky - One of the best experts on this subject based on the ideXlab platform.
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neurologic manifestations of Progressive Systemic Sclerosis
JAMA Neurology, 1992Co-Authors: Lea Averbuchheller, Israel Steiner, Oded AbramskyAbstract:• Neurologic involvement in Progressive Systemic Sclerosis is considered uncommon. We retrospectively examined the prevalence and nature of neurologic complications in 50 patients with Progressive Systemic Sclerosis. In 20 (40%), neurologic abnormalities were detected, with a total of 28 neurologic manifestations. All levels of the central and peripheral nervous system were affected: muscle (22%), peripheral nerve (18%), spinal cord (8%), and brain (6%). Of note were the presence of myelopathy in four patients and inclusion-body myositis in two. In 10 patients (20%), no definable cause of the neurologic dysfunction could be identified, apart from Progressive Systemic Sclerosis. Thus, neurologic presentations of Progressive Systemic Sclerosis are much more common than previously reported and may be due to direct involvement of the nervous system by a primary pathologic process in a significant number of patients.
James C Steigerwald - One of the best experts on this subject based on the ideXlab platform.
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the kidney in Progressive Systemic Sclerosis
Annals of Internal Medicine, 2020Co-Authors: Michael T Kovalchik, Stephen J Guggenheim, Michael H Silverman, James S Robertson, James C SteigerwaldAbstract:Abstract Nine normotensive Progressive Systemic Sclerosis patients with normal renal function underwent renal biopsy. Four specimens had prominent vascular abnormalities, two mild vascular abnormal...
Virginia D Steen - One of the best experts on this subject based on the ideXlab platform.
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d penicillamine therapy in Progressive Systemic Sclerosis scleroderma
Annals of Internal Medicine, 2020Co-Authors: Virginia D Steen, Thomas A Medsger, Gerald P. RodnanAbstract:Abstract In a retrospective study on Progressive Systemic Sclerosis, we compared 73 patients who had receivedD-penicillamine therapy for a minimum of 6 consecutive months with 45 patients who had n...
