The Experts below are selected from a list of 2184 Experts worldwide ranked by ideXlab platform
William R Walsh - One of the best experts on this subject based on the ideXlab platform.
-
Cross-Sectional Area and Strength Differences of Fiberwire, Prolene, and Ticron Sutures
The Journal of hand surgery, 2010Co-Authors: Peter Scherman, Roger Haddad, Peter Scougall, William R WalshAbstract:PURPOSE: Flexor tendons should be repaired with suture material strong enough to permit early motion and small enough for the resulting knot to allow unimpeded tendon glide and healing. This study sought to define differences in cross-sectional area and knotted tensile strength among Fiberwire, Prolene, and Ticron sutures. METHODS: Five strands, each of 3-0 and 4-0 Prolene, Ticron, and Fiberwire sutures, were embedded in polymethylmethacrylate and sectioned in a linear precision saw to obtain 10 cross-sections of each material and size. These were examined by scanning electron microscopy and digitally analyzed for cross-sectional areas. Ten strands of each suture material and size had a single throw knot placed, and they were loaded to failure in a micromechanical tester. RESULTS: Prolene and Ticron cross-sections were circular. Fiberwire was noncircular. The 3-0 Fiberwire sutures had greater cross-sectional area than the 3-0 Ticron sutures (p < .001), which in turn were larger than 3-0 Prolene (p < .05). The 4-0 Fiberwire cross-sectional area was also greater than that of 3-0 Ticron and Prolene (p < .05). After relating knotted tensile strength to cross-sectional area, Fiberwire was 10% stronger than Prolene, and 25% stronger than Ticron. CONCLUSIONS: Fiberwire is not only stronger, but also larger than other sutures in the same or even higher suture size category. Failure to meet the United States Pharmacopeia standards for suture diameter is declared in the product information sheet, although surgeons may not be aware of these size variations. Suture size definitions are currently based on diameter, a consistent measure for circular monofilament sutures, but not for braided or noncircular sutures.
-
stress relaxation and creep viscoelastic properties of common suture materials used for flexor tendon repair
Journal of Hand Surgery (European Volume), 2008Co-Authors: Frank Vizesi, Christopher W Jones, Nick Lotz, Mark P Gianoutsos, William R WalshAbstract:Purpose The time-dependent mechanical behavior of common suture materials may have a pronounced influence on the quality of flexor tendon repairs with respect to gap formation. Methods Sutures commonly used in plastic surgery, particularly for hand tendon repair, were tested in tension for analysis of stress relaxation and creep properties. The three materials tested were (1) Prolene, a monofilament polypropylene(Ethicon, Somerville, NJ); (2) Ethilon, a monofilament nylon(Ethicon, Somerville, NJ); and (3) Ticron, a braided polyester fiber (Sherwood, Davis & Geck, St. Louis, MO). All measurements were made with 1.5-mm (4-0) varieties of the sutures, in physiological buffered solution (0.9% phosphate-buffered saline [PBS]) at both room (22°C) and body temperature (37°C) conditions. Results Ticron was the stiffest suture at both room and body temperature, followed by Prolene and Ethilon. Both Prolene and Ethilon showed statistically (p Conclusions Based on static and viscoelastic mechanical properties, Ticron is the most suitable suture for flexor tendon repairs when compared to Prolene and Ethilon.
-
effect of suture material on gap formation and failure in type 1 fdp avulsion repairs in a cadaver model
Clinical Biomechanics, 2006Co-Authors: F B Schreuder, Frank Vizesi, Peter Scougall, E Puchert, William R WalshAbstract:Abstract Background An in vitro cyclical testing simulating a passive mobilisation protocol was used to compare repair of flexor digitorum profundus tendon with modified-Bunnell two-strand pullout technique using a monofilament (Prolene), braided polyester (Ethibond) and a synthetic polyfilament ensheathed by caprolactan (Supramid) sutures. Methods Eighteen fresh-frozen cadaveric fingers were randomly divided into three repair groups (n = 6); modified-Bunnell technique with 3/0 Prolene, Ethibond or Supramid. After repair, specimens were cyclically loaded from 2 to 15 N at 5 N/s, for a total of 500 cycles. Gap formation at the tendon–bone interface was assessed every 100 cycles. Samples were tested to failure at the completion of 500 cycles. Findings All sutures held in all specimens during cyclic testing. The gap formation after 500 cycles was greatest with Prolene suture (6.8 mm, SD 1.2) followed by Supramid suture (4.0 mm, SD 1.1) and Ethibond suture (1.7 mm, SD 1.7) (P Interpretation Gap formation with Ethibond was significantly lower compared to Supramid and Prolene. The four strand nature of the Supramid repair was superior to Prolene but did not differ compared to Ethibond with respect to failure load. Prolene is the least favourable suture when considering gap formation and failure load, while Ethibond is the most favourable.
S Van Steensel - One of the best experts on this subject based on the ideXlab platform.
-
prevention of incisional hernia using different suture materials for closing the abdominal wall a comparison of pds vicryl and Prolene in a rat model
Hernia, 2020Co-Authors: S Van Steensel, L C L Van Den Hil, A Bloemen, Marion J J Gijbels, Stephanie O Breukink, J Melenhorst, Kaatje LenaertsAbstract:An incisional hernia occurs frequently after a midline incision with an incidence of 12.8%. The choice in suture material used for abdominal wall closure is not straightforward and the conflicting literature focuses on clinical outcomes. This study compares a non-absorbable, slow-absorbable and fast-absorbable suture in a rat model, focusing on histological outcomes predicting better fascia healing. 33 male Wistar rats, divided over three groups, each received two separate 1 cm incisions closed with either Prolene 4/0, PDS 4/0 or Vicryl 4/0. At 7 days and 21 days, one of the incisions was explanted. Tissue was semi-quantitatively scored regarding inflammatory cells and collagen fibres present. Using qPCR macrophage polarisation, fibroblast activity and vascularisation were evaluated. Data were analysed by Kruskal–Wallis test with Mann–Whitney U post hoc test. A p value of 0.017 was considered significant after Bonferroni correction. All animals recovered without complications and completed the 21 days of follow-up. The Vicryl group showed a higher presence of macrophages after 21 days in comparison with Prolene (p = 0.003) and PDS (p = 0.006) and more foreign body giant cells compared to Prolene at 7 days (p = 0.010) and PDS at 21 days (p < 0.001). qPCR showed 2.5-fold higher expression of clec10A in PDS compared to Prolene after 7 days (p = 0.007). The results of this study carefully support the use of PDS suture, compared to Prolene and Vicryl, in abdominal wall closure based on a favourable macrophage response. The heterogeneity and variability in the data might be explained by the spectrum of the macrophage subtype paradigm.
Marilyn Schuman Jorns - One of the best experts on this subject based on the ideXlab platform.
-
monomeric sarcosine oxidase evidence for an ionizable group in the e s complex
Biochemistry, 2002Co-Authors: Gouhua Zhao, Marilyn Schuman JornsAbstract:Monomeric sarcosine oxidase (MSOX) contains covalently bound FAD and catalyzes the oxidation of sarcosine (N-methylglycine) and other secondary amino acids, including l-proline. The reductive half-reaction with l-proline proceeds via a rapidly attained equilibrium (Kd) between free Eox and the Eox·S complex, followed by a practically irreversible reduction step (Eox·S → Ered·P) associated with a rate constant, klim. The effect of pH on the reductive half-reaction shows that the Kd for l-proline binding is pH-independent (pH 6.46−9.0). This indicates that MSOX binds the zwitterionic form of l-proline, the predominant species in solution at neutral pH (pKa = 10.6). Values for the limiting rate of reduction (klim) are, however, strongly pH-dependent and indicate that an ionizable group in the Eox·l-proline complex (pKa = 8.02) must be unprotonated for conversion to Ered·P. Charge-transfer interaction with l-proline as the donor and FAD as acceptor is possible only with the anionic form of l-proline. The ioni...
-
monomeric sarcosine oxidase evidence for an ionizable group in the e s complex
Biochemistry, 2002Co-Authors: Gouhua Zhao, Marilyn Schuman JornsAbstract:Monomeric sarcosine oxidase (MSOX) contains covalently bound FAD and catalyzes the oxidation of sarcosine (N-methylglycine) and other secondary amino acids, including l-proline. The reductive half-reaction with l-proline proceeds via a rapidly attained equilibrium (Kd) between free Eox and the Eox·S complex, followed by a practically irreversible reduction step (Eox·S → Ered·P) associated with a rate constant, klim. The effect of pH on the reductive half-reaction shows that the Kd for l-proline binding is pH-independent (pH 6.46−9.0). This indicates that MSOX binds the zwitterionic form of l-proline, the predominant species in solution at neutral pH (pKa = 10.6). Values for the limiting rate of reduction (klim) are, however, strongly pH-dependent and indicate that an ionizable group in the Eox·l-proline complex (pKa = 8.02) must be unprotonated for conversion to Ered·P. Charge-transfer interaction with l-proline as the donor and FAD as acceptor is possible only with the anionic form of l-proline. The ioni...
A Bloemen - One of the best experts on this subject based on the ideXlab platform.
-
prevention of incisional hernia using different suture materials for closing the abdominal wall a comparison of pds vicryl and Prolene in a rat model
Hernia, 2020Co-Authors: S Van Steensel, L C L Van Den Hil, A Bloemen, Marion J J Gijbels, Stephanie O Breukink, J Melenhorst, Kaatje LenaertsAbstract:An incisional hernia occurs frequently after a midline incision with an incidence of 12.8%. The choice in suture material used for abdominal wall closure is not straightforward and the conflicting literature focuses on clinical outcomes. This study compares a non-absorbable, slow-absorbable and fast-absorbable suture in a rat model, focusing on histological outcomes predicting better fascia healing. 33 male Wistar rats, divided over three groups, each received two separate 1 cm incisions closed with either Prolene 4/0, PDS 4/0 or Vicryl 4/0. At 7 days and 21 days, one of the incisions was explanted. Tissue was semi-quantitatively scored regarding inflammatory cells and collagen fibres present. Using qPCR macrophage polarisation, fibroblast activity and vascularisation were evaluated. Data were analysed by Kruskal–Wallis test with Mann–Whitney U post hoc test. A p value of 0.017 was considered significant after Bonferroni correction. All animals recovered without complications and completed the 21 days of follow-up. The Vicryl group showed a higher presence of macrophages after 21 days in comparison with Prolene (p = 0.003) and PDS (p = 0.006) and more foreign body giant cells compared to Prolene at 7 days (p = 0.010) and PDS at 21 days (p < 0.001). qPCR showed 2.5-fold higher expression of clec10A in PDS compared to Prolene after 7 days (p = 0.007). The results of this study carefully support the use of PDS suture, compared to Prolene and Vicryl, in abdominal wall closure based on a favourable macrophage response. The heterogeneity and variability in the data might be explained by the spectrum of the macrophage subtype paradigm.
-
randomized clinical trial comparing polypropylene or polydioxanone for midline abdominal wall closure
British Journal of Surgery, 2011Co-Authors: A Bloemen, P Van Dooren, B F Huizinga, A G M HoofwijkAbstract:Background: Incisional hernia is a frequent complication of abdominal surgery, often requiring surgical intervention. This prospective randomized trial compared suture materials for closure of the fascia after abdominal surgery. Methods: In 456 patients the abdominal fascia was closed with either non-absorbable (polypropylene; Prolene®) or absorbable (polydioxanone; PDS®) suture material. Follow-up was by clinical examination and ultrasonography at 6-month intervals. Outcome measures were incisional hernia, surgical-site infection and suture sinus. Results: Some 223 patients were analysed after closure with Prolene® and 233 after PDS®. Median follow-up was 32 and 31 months respectively. There was no significant difference in the incidence of incisional hernia between the groups: 20·2 per cent (45 of 223) for Prolene® and 24·9 per cent (58 of 233) with PDS® (P = 0·229). Kaplan-Meier analysis showed a cumulative rate after 4 years of 23·7 and 30·2 per cent for Prolene® and PDS® respectively (P = 0·222). Secondary outcome measures showed no significant differences. Conclusion: The incidence of incisional hernia in both groups was higher than expected from previous literature. There were no significant differences between the two suture methods. Registration number: ISRCTN65599814 (http://www.clinical-trials.com). Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Kaatje Lenaerts - One of the best experts on this subject based on the ideXlab platform.
-
prevention of incisional hernia using different suture materials for closing the abdominal wall a comparison of pds vicryl and Prolene in a rat model
Hernia, 2020Co-Authors: S Van Steensel, L C L Van Den Hil, A Bloemen, Marion J J Gijbels, Stephanie O Breukink, J Melenhorst, Kaatje LenaertsAbstract:An incisional hernia occurs frequently after a midline incision with an incidence of 12.8%. The choice in suture material used for abdominal wall closure is not straightforward and the conflicting literature focuses on clinical outcomes. This study compares a non-absorbable, slow-absorbable and fast-absorbable suture in a rat model, focusing on histological outcomes predicting better fascia healing. 33 male Wistar rats, divided over three groups, each received two separate 1 cm incisions closed with either Prolene 4/0, PDS 4/0 or Vicryl 4/0. At 7 days and 21 days, one of the incisions was explanted. Tissue was semi-quantitatively scored regarding inflammatory cells and collagen fibres present. Using qPCR macrophage polarisation, fibroblast activity and vascularisation were evaluated. Data were analysed by Kruskal–Wallis test with Mann–Whitney U post hoc test. A p value of 0.017 was considered significant after Bonferroni correction. All animals recovered without complications and completed the 21 days of follow-up. The Vicryl group showed a higher presence of macrophages after 21 days in comparison with Prolene (p = 0.003) and PDS (p = 0.006) and more foreign body giant cells compared to Prolene at 7 days (p = 0.010) and PDS at 21 days (p < 0.001). qPCR showed 2.5-fold higher expression of clec10A in PDS compared to Prolene after 7 days (p = 0.007). The results of this study carefully support the use of PDS suture, compared to Prolene and Vicryl, in abdominal wall closure based on a favourable macrophage response. The heterogeneity and variability in the data might be explained by the spectrum of the macrophage subtype paradigm.
