The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Tarja Porkka-heiskanen - One of the best experts on this subject based on the ideXlab platform.
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Physiological and autonomic stress responses after Prolonged Sleep restriction and subsequent recovery Sleep in healthy young men
Sleep and biological rhythms, 2017Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Jussi Virkkala, Harri Lindholm, Ari Hirvonen, Christer Hublin, Tarja Porkka-heiskanen, Mikko HärmäAbstract:PurposeSleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to Prolonged Sleep restriction ...
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Prolonged Sleep Restriction Affects Glucose Metabolism in Healthy Young Men
International journal of endocrinology, 2010Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Ari Hirvonen, Christer Hublin, Mikko Härmä, Tarja Porkka-heiskanenAbstract:This study identifies the effects of Sleep restriction and subsequent recovery Sleep on glucose homeostasis, serum leptin levels, and feelings of subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experimental (EXP) group. After two nights of 8 h in bed (baseline, BL), EXP spent 4 h in bed for five days (Sleep restriction, SR), followed by two nights of 8 h (recovery, REC). CON spent 8 h in bed throughout the study. Blood samples were taken after the BL, SR, and REC period. In EXP, insulin and insulin-to-glucose ratio increased after SR. IGF-1 levels increased after REC. Leptin levels were elevated after both SR and REC; subjective satiety remained unaffected. No changes were observed in CON. The observed increase of serum IGF-1 and insulin-to-glucose ratio indicates that Sleep restriction may result in an increased risk to develop type 2 diabetes.
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Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
PloS one, 2009Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Harri Lindholm, Tarja Porkka-heiskanen, Mikko Härmä, Maili Lehto, Piia Karisola, Ritva Luukkonen, Harri AleniusAbstract:Background Sleep restriction, leading to deprivation of Sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects of Prolonged Sleep restriction and subsequent recovery Sleep, by simulating a working week and following recovery weekend in a laboratory environment.
Wessel M. A. Van Leeuwen - One of the best experts on this subject based on the ideXlab platform.
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Physiological and autonomic stress responses after Prolonged Sleep restriction and subsequent recovery Sleep in healthy young men
Sleep and biological rhythms, 2017Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Jussi Virkkala, Harri Lindholm, Ari Hirvonen, Christer Hublin, Tarja Porkka-heiskanen, Mikko HärmäAbstract:PurposeSleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to Prolonged Sleep restriction ...
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Prolonged Sleep Restriction Affects Glucose Metabolism in Healthy Young Men
International journal of endocrinology, 2010Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Ari Hirvonen, Christer Hublin, Mikko Härmä, Tarja Porkka-heiskanenAbstract:This study identifies the effects of Sleep restriction and subsequent recovery Sleep on glucose homeostasis, serum leptin levels, and feelings of subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experimental (EXP) group. After two nights of 8 h in bed (baseline, BL), EXP spent 4 h in bed for five days (Sleep restriction, SR), followed by two nights of 8 h (recovery, REC). CON spent 8 h in bed throughout the study. Blood samples were taken after the BL, SR, and REC period. In EXP, insulin and insulin-to-glucose ratio increased after SR. IGF-1 levels increased after REC. Leptin levels were elevated after both SR and REC; subjective satiety remained unaffected. No changes were observed in CON. The observed increase of serum IGF-1 and insulin-to-glucose ratio indicates that Sleep restriction may result in an increased risk to develop type 2 diabetes.
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Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
PloS one, 2009Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Harri Lindholm, Tarja Porkka-heiskanen, Mikko Härmä, Maili Lehto, Piia Karisola, Ritva Luukkonen, Harri AleniusAbstract:Background Sleep restriction, leading to deprivation of Sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects of Prolonged Sleep restriction and subsequent recovery Sleep, by simulating a working week and following recovery weekend in a laboratory environment.
Mikko Härmä - One of the best experts on this subject based on the ideXlab platform.
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Physiological and autonomic stress responses after Prolonged Sleep restriction and subsequent recovery Sleep in healthy young men
Sleep and biological rhythms, 2017Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Jussi Virkkala, Harri Lindholm, Ari Hirvonen, Christer Hublin, Tarja Porkka-heiskanen, Mikko HärmäAbstract:PurposeSleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to Prolonged Sleep restriction ...
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Prolonged Sleep Restriction Affects Glucose Metabolism in Healthy Young Men
International journal of endocrinology, 2010Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Ari Hirvonen, Christer Hublin, Mikko Härmä, Tarja Porkka-heiskanenAbstract:This study identifies the effects of Sleep restriction and subsequent recovery Sleep on glucose homeostasis, serum leptin levels, and feelings of subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experimental (EXP) group. After two nights of 8 h in bed (baseline, BL), EXP spent 4 h in bed for five days (Sleep restriction, SR), followed by two nights of 8 h (recovery, REC). CON spent 8 h in bed throughout the study. Blood samples were taken after the BL, SR, and REC period. In EXP, insulin and insulin-to-glucose ratio increased after SR. IGF-1 levels increased after REC. Leptin levels were elevated after both SR and REC; subjective satiety remained unaffected. No changes were observed in CON. The observed increase of serum IGF-1 and insulin-to-glucose ratio indicates that Sleep restriction may result in an increased risk to develop type 2 diabetes.
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Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
PloS one, 2009Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Harri Lindholm, Tarja Porkka-heiskanen, Mikko Härmä, Maili Lehto, Piia Karisola, Ritva Luukkonen, Harri AleniusAbstract:Background Sleep restriction, leading to deprivation of Sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects of Prolonged Sleep restriction and subsequent recovery Sleep, by simulating a working week and following recovery weekend in a laboratory environment.
Mikael Sallinen - One of the best experts on this subject based on the ideXlab platform.
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Physiological and autonomic stress responses after Prolonged Sleep restriction and subsequent recovery Sleep in healthy young men
Sleep and biological rhythms, 2017Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Jussi Virkkala, Harri Lindholm, Ari Hirvonen, Christer Hublin, Tarja Porkka-heiskanen, Mikko HärmäAbstract:PurposeSleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to Prolonged Sleep restriction ...
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Prolonged Sleep Restriction Affects Glucose Metabolism in Healthy Young Men
International journal of endocrinology, 2010Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Ari Hirvonen, Christer Hublin, Mikko Härmä, Tarja Porkka-heiskanenAbstract:This study identifies the effects of Sleep restriction and subsequent recovery Sleep on glucose homeostasis, serum leptin levels, and feelings of subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experimental (EXP) group. After two nights of 8 h in bed (baseline, BL), EXP spent 4 h in bed for five days (Sleep restriction, SR), followed by two nights of 8 h (recovery, REC). CON spent 8 h in bed throughout the study. Blood samples were taken after the BL, SR, and REC period. In EXP, insulin and insulin-to-glucose ratio increased after SR. IGF-1 levels increased after REC. Leptin levels were elevated after both SR and REC; subjective satiety remained unaffected. No changes were observed in CON. The observed increase of serum IGF-1 and insulin-to-glucose ratio indicates that Sleep restriction may result in an increased risk to develop type 2 diabetes.
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Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
PloS one, 2009Co-Authors: Wessel M. A. Van Leeuwen, Mikael Sallinen, Harri Lindholm, Tarja Porkka-heiskanen, Mikko Härmä, Maili Lehto, Piia Karisola, Ritva Luukkonen, Harri AleniusAbstract:Background Sleep restriction, leading to deprivation of Sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects of Prolonged Sleep restriction and subsequent recovery Sleep, by simulating a working week and following recovery weekend in a laboratory environment.
Carol A. Everson - One of the best experts on this subject based on the ideXlab platform.
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Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to Sleep deprivation in laboratory rats
American journal of physiology. Regulatory integrative and comparative physiology, 2005Co-Authors: Carol A. EversonAbstract:The specific systems and mechanisms affected by Sleep deprivation that may perpetuate disease processes in humans still are speculative. In laboratory rats, Prolonged Sleep deprivation induces a st...
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Effects of Prolonged Sleep deprivation on local rates of cerebral energy metabolism in freely moving rats
The Journal of Neuroscience, 1994Co-Authors: Carol A. Everson, Carolyn Beebe Smith, L SokoloffAbstract:Although Sleep deprivation interferes with biological processes essential for performance, health, and longevity, previous studies have failed to reveal any structural or functional changes in brain. We have therefore measured local rates of cerebral glucose utilization (ICMRglc) with the quantitative autoradiographic 2–14C-deoxyglucose method in an effort to determine if and, if so, where Sleep deprivation might affect function in Sleep-deprived rats. Sleep deprivation was maintained for 11–12 d, long enough to increase whole body energy metabolism, thus confirming that pathophysiological processes that might involve brain functions were evolving. Deep brain temperature was also measured in similarly treated rats and found to be mildly elevated relative to core body temperature. Despite the increased deep brain temperature, systemic hypermetabolism, and sympathetic activation, ICMRglc was not elevated in any of the 60 brain structures examined. Average glucose utilization in the brain as a whole was unchanged in the Sleep-deprived rats, but regional decreases were found. The most marked decreases in ICMRglc were in regions of the hypothalamus, thalamus, and limbic system. Mesencephalic and pontine regions were relatively unaffected except for the central gray area. The medulla was entirely normal. The effects of Sleep deprivation on brain tended, therefore, to be unidirectional toward decreased energy metabolism, primarily in regions associated with mechanisms of thermoregulation, endocrine regulation, and Sleep. Correspondence was found between the hypometabolic brain regions and some aspects of peripheral symptoms.
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Nutritional and metabolic adaptations to Prolonged Sleep deprivation in the rat
American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 1993Co-Authors: Carol A. Everson, T. A. WehrAbstract:To understand how and why Sleep deprivation is physically harmful, we explored the possible causal relationship between its two main effects, 1) negative energy balance and 2) a composite of symptoms that resemble protein malnutrition, both of which occur despite increased food consumption. We provided balanced diets augmented with either protein or calories (by increased fat content) to freely moving rats. Interactions between Sleep deprivation symptoms and energy and protein supplies were assessed from measurements of body weight regulation, consumption of macronutrients, clinical chemistry and hematology profiles, and physical appearance. The results indicate that Sleep deprivation causes malnutrition, which is secondary to increased energy expenditure. Even though food consumption remained normal in Sleep-deprived rats fed a diet of high protein-to-calorie ratio, body weight loss was more than 16% of baseline, development of skin lesions was hastened, and longevity was shortened by 40% compared with Sleep-deprived rats fed the calorie-augmented diet. Food consumption of the calorie-fed rats was lower during baseline than that of the protein-fed group but during Sleep deprivation increased to amounts 250% of normal without net body weight gain. Despite a fat-laden diet the calorie-fed hyperphagic group did not have abnormal levels of plasma cholesterol, triglycerides, or glucose, indicating accelerated turnover of nutrients. As would be consistent with calorie malnutrition, pronounced clinical chemistry or hematological abnormalities were not found in any group. Beneficial effects of the calorie-augmented diet are attributed to 1) caloric density of fat, 2) induction of hyperphagia, and 3) efficiency of utilization of fat. We conclude that diet composition interacts strongly with Sleep deprivation, affecting the time course and development of pathologies, whereas it exerted negligible influence on body weight regulation under normal conditions.
