The Experts below are selected from a list of 48057 Experts worldwide ranked by ideXlab platform
Caroline G.l. Lee - One of the best experts on this subject based on the ideXlab platform.
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MicroRNA-224 targets SMAD family member 4 to Promote Cell Proliferation and negatively influence patient survival.
PloS one, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p
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microrna 224 targets smad family member 4 to Promote Cell Proliferation and negatively influence patient survival
PLOS ONE, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p<0.001, r = −0.45, R2 = 0.122). Furthermore, miR-224 up-regulation and SMAD4 down-regulation is significantly associated with poorer patient survival (p<0.05). In summary, miR-224/SMAD4 pathway is a clinically relevant pathway to provide new insights in understanding HCC. (191 words).
Pierce K. H. Chow - One of the best experts on this subject based on the ideXlab platform.
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MicroRNA-224 targets SMAD family member 4 to Promote Cell Proliferation and negatively influence patient survival.
PloS one, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p
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microrna 224 targets smad family member 4 to Promote Cell Proliferation and negatively influence patient survival
PLOS ONE, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p<0.001, r = −0.45, R2 = 0.122). Furthermore, miR-224 up-regulation and SMAD4 down-regulation is significantly associated with poorer patient survival (p<0.05). In summary, miR-224/SMAD4 pathway is a clinically relevant pathway to provide new insights in understanding HCC. (191 words).
Yu Wang - One of the best experts on this subject based on the ideXlab platform.
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microcarriers with controllable size via electrified liquid jets and phase separation technique Promote Cell Proliferation and osteogenic differentiation
ACS Applied Bio Materials, 2019Co-Authors: Zixue Jiao, Yu Wang, Zongliang Wang, Xincui Shi, Peibiao ZhangAbstract:Differently sized poly(lactic-co-glycolic) microspheres were efficiently prepared with electrified liquid jets and a phase separation technique for a wide range of applications. Higher polymer conc...
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MicroRNA-224 targets SMAD family member 4 to Promote Cell Proliferation and negatively influence patient survival.
PloS one, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p
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microrna 224 targets smad family member 4 to Promote Cell Proliferation and negatively influence patient survival
PLOS ONE, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p<0.001, r = −0.45, R2 = 0.122). Furthermore, miR-224 up-regulation and SMAD4 down-regulation is significantly associated with poorer patient survival (p<0.05). In summary, miR-224/SMAD4 pathway is a clinically relevant pathway to provide new insights in understanding HCC. (191 words).
London L. P. J. Ooi - One of the best experts on this subject based on the ideXlab platform.
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MicroRNA-224 targets SMAD family member 4 to Promote Cell Proliferation and negatively influence patient survival.
PloS one, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p
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microrna 224 targets smad family member 4 to Promote Cell Proliferation and negatively influence patient survival
PLOS ONE, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p<0.001, r = −0.45, R2 = 0.122). Furthermore, miR-224 up-regulation and SMAD4 down-regulation is significantly associated with poorer patient survival (p<0.05). In summary, miR-224/SMAD4 pathway is a clinically relevant pathway to provide new insights in understanding HCC. (191 words).
Han Chong Toh - One of the best experts on this subject based on the ideXlab platform.
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MicroRNA-224 targets SMAD family member 4 to Promote Cell Proliferation and negatively influence patient survival.
PloS one, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p
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microrna 224 targets smad family member 4 to Promote Cell Proliferation and negatively influence patient survival
PLOS ONE, 2013Co-Authors: Yu Wang, Jianwei Ren, Yun Gao, Joel Z. I., Han Chong Toh, Pierce K. H. Chow, Alexander Y. F. Chung, London L. P. J. Ooi, Caroline G.l. LeeAbstract:MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in Cell Proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that miR-224 up-regulation Promotes Cell Proliferation using both in vitro assays and in vivo tumor growth models. We systematically screened for high confidence miR-224 targets by overlapping in silico predicted targets from multiple algorithms and significantly down-regulated genes in miR-224-expressing Cells from whole genome expression microarrays. A total of 72 high confidence miR-224 targets were identified and found to be enriched in various cancer-related processes. SMAD family member 4 (SMAD4) is experimentally validated as the direct Cellular target through which miR-224 Promotes Cell Proliferation. The clinical relevance of our experimental observations was supported by a statistically significant inverse correlation between miR-224 and SMAD4 transcript expression in tumor versus paired adjacent non-tumorous tissues from HCC patients (p<0.001, r = −0.45, R2 = 0.122). Furthermore, miR-224 up-regulation and SMAD4 down-regulation is significantly associated with poorer patient survival (p<0.05). In summary, miR-224/SMAD4 pathway is a clinically relevant pathway to provide new insights in understanding HCC. (191 words).
