The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
토쿠타로우 야스에 - One of the best experts on this subject based on the ideXlab platform.
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therapeutic agent for liver disease containing 2 amino 1 3 Propanediol Derivative as active ingredient and therapeutic method for liver disease
2006Co-Authors: 타카시 카네코, 에이지 코바야시, 토쿠타로우 야스에Abstract:The present invention provides novel therapeutic agents for organ disease, particularly hepatic diseases. In general formula (1) [Formula 1] Diarylsulfide or diarylether Derivatives having a 2-amino-1,3-Propanediol structure, which is a sphingosine-1-phosphate receptor agonist represented by the present invention, and pharmaceutically acceptable salts and hydrates thereof are particularly useful for treating long-term diseases, It has been found to be useful as a treatment for liver disease. Hepatic disease treatment agent, Hepatic disease treatment method, Diaryl sulfide, Diaryl ether Derivatives.
Tetsuo Suami - One of the best experts on this subject based on the ideXlab platform.
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Oxidation of 3-C-(2-amino-2-deoxy-D-glucopyranosyl)-1-propene compounds and the structure of 3-C-(2-amino-2-deoxy-D-glucopyranosyl)-1,2-Propanediol Derivatives for a synthesis of 2,3-didehydro-2,7-dideoxy-N-acetylneuraminic acid.
Carbohydrate research, 2002Co-Authors: Tomoya Machinami, Yasuyuki Itaba, Ayumi Kayama, Takashi Fujimoto, Tetsuo SuamiAbstract:Oxidation of 5-acetamido-4,8-anhydro-1,2,3,5-tetradeoxy-D-glycero-D-ido-non-1-enitol [3-C-(2-amino-2-deoxy-beta-D-glucopyranosyl)-1-propene] was studied to search for preparative routes to aminodeoxy didehydro nonulosonic acid Derivatives. Since only moderate chiral induction was observed with osmium tetroxide dihydroxylation as well as with peracid epoxidation, the catalytic asymmetric dihydroxylation conditions were applied to give the stereocontrolled formation of 1,2-Propanediol Derivatives. The structures of these diastereoisomeric 1,2-Propanediol Derivatives were determined by X-ray crystallographic analyses. The formation of diastereoisomeric 1,2-Propanediols also varied with the nature of 2-substituent on the aminodoexy glycosyl moiety. Thus 5-acetamido-4,8-anhydro-3,5-dideoxy-D-erythro-L-ido-nonitol [(2S)-3-C-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-1,2-Propanediol] was obtained predominantly up to 70% from 3-C-(2-acetamido-2-deoxyglycosyl)-1-propene by the use of ADmixbeta reagent. The (2S)-Propanediol Derivative was transformed in a five-step reaction sequence to 2,3-didehydro-2,7-dideoxy-N-acetylneuraminic acid.
타카시 카네코 - One of the best experts on this subject based on the ideXlab platform.
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therapeutic agent for liver disease containing 2 amino 1 3 Propanediol Derivative as active ingredient and therapeutic method for liver disease
2006Co-Authors: 타카시 카네코, 에이지 코바야시, 토쿠타로우 야스에Abstract:The present invention provides novel therapeutic agents for organ disease, particularly hepatic diseases. In general formula (1) [Formula 1] Diarylsulfide or diarylether Derivatives having a 2-amino-1,3-Propanediol structure, which is a sphingosine-1-phosphate receptor agonist represented by the present invention, and pharmaceutically acceptable salts and hydrates thereof are particularly useful for treating long-term diseases, It has been found to be useful as a treatment for liver disease. Hepatic disease treatment agent, Hepatic disease treatment method, Diaryl sulfide, Diaryl ether Derivatives.
Tomoya Machinami - One of the best experts on this subject based on the ideXlab platform.
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Oxidation of 3-C-(2-amino-2-deoxy-D-glucopyranosyl)-1-propene compounds and the structure of 3-C-(2-amino-2-deoxy-D-glucopyranosyl)-1,2-Propanediol Derivatives for a synthesis of 2,3-didehydro-2,7-dideoxy-N-acetylneuraminic acid.
Carbohydrate research, 2002Co-Authors: Tomoya Machinami, Yasuyuki Itaba, Ayumi Kayama, Takashi Fujimoto, Tetsuo SuamiAbstract:Oxidation of 5-acetamido-4,8-anhydro-1,2,3,5-tetradeoxy-D-glycero-D-ido-non-1-enitol [3-C-(2-amino-2-deoxy-beta-D-glucopyranosyl)-1-propene] was studied to search for preparative routes to aminodeoxy didehydro nonulosonic acid Derivatives. Since only moderate chiral induction was observed with osmium tetroxide dihydroxylation as well as with peracid epoxidation, the catalytic asymmetric dihydroxylation conditions were applied to give the stereocontrolled formation of 1,2-Propanediol Derivatives. The structures of these diastereoisomeric 1,2-Propanediol Derivatives were determined by X-ray crystallographic analyses. The formation of diastereoisomeric 1,2-Propanediols also varied with the nature of 2-substituent on the aminodoexy glycosyl moiety. Thus 5-acetamido-4,8-anhydro-3,5-dideoxy-D-erythro-L-ido-nonitol [(2S)-3-C-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-1,2-Propanediol] was obtained predominantly up to 70% from 3-C-(2-acetamido-2-deoxyglycosyl)-1-propene by the use of ADmixbeta reagent. The (2S)-Propanediol Derivative was transformed in a five-step reaction sequence to 2,3-didehydro-2,7-dideoxy-N-acetylneuraminic acid.
스코트더블유 웜블 - One of the best experts on this subject based on the ideXlab platform.
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2 2 amino 1 6 dihydro 6 oxo purin 9 yl methoxy 1 3 Propanediol Derivative
1995Co-Authors: 존제이 네스터, 스코트더블유 웜블Abstract:L- derived from 2- (2-amino-1, 6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-Propanediol, useful as an antiviral drug with improved absorption Monovaline esters and their pharmaceutically acceptable salts are disclosed.