The Experts below are selected from a list of 975 Experts worldwide ranked by ideXlab platform
Tsuyoshi Yokoi - One of the best experts on this subject based on the ideXlab platform.
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Fluoroquinolones and Propionic Acid Derivatives induce inflammatory responses in vitro.
Cell biology and toxicology, 2017Co-Authors: Akira Nakajima, Hiroki Sato, Shingo Oda, Tsuyoshi YokoiAbstract:Fluoroquinolones and Propionic Acid Derivatives are widely used antibacterials and non-steroidal anti-inflammatory drugs, respectively, which have been reported to frequently trigger drug hypersensitivity reactions. Such reactions are induced by inflammatory mediators such as cytokines and chemokines. The present study investigated whether levofloxacin, a fluoroquinolone, and loxoprofen, a Propionic Acid Derivative, have the potential to induce immune-related gene expression in dendritic cell-like cell lines such as HL-60, K562, and THP-1, and immortalized keratinocytes such as HaCaT. The expression of IL-8, MCP-1, and TNFα messenger RNA (mRNA) was found to increase following treatment with levofloxacin or loxoprofen in HL-60 cells. In addition, these drugs increased the mRNA content of annexin A1, a factor related to keratinocyte necroptosis in patients with severe cutaneous adverse reactions. Inhibition studies using specific inhibitors of mitogen-activated protein (MAP) kinases and NF-κB suggest that the extracellular signal-regulated kinase (ERK) pathway is the pathway principally involved in the induction of cytokines and annexin A1 by levofloxacin, whereas the involvement of MAP kinases and NF-κB in the loxoprofen-induced gene expression of these factors may be limited. Fluoroquinolones and Propionic Acid Derivatives that are structurally related to levofloxacin and loxoprofen, respectively, were also found to induce immune-related gene expression in HL-60 cells. Collectively, these results suggest that fluoroquinolones and Propionic Acid Derivatives have the potential to induce the expression of immune-related factors and that an in vitro cell-based assay system to detect the immune-stimulating potential of systemic drugs might be useful for assessing the risk of drug hypersensitivity reactions.
Rodrigo A.a. Munoz - One of the best experts on this subject based on the ideXlab platform.
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Size effects of multi-walled carbon nanotubes on the electrochemical oxidation of Propionic Acid Derivative drugs: Ibuprofen and naproxen
Journal of Electroanalytical Chemistry, 2016Co-Authors: Rodrigo H. O. Montes, Ana P. Lima, Rafael R. Cunha, Tiago J. Guedes, Wallans T. P. Dos Santos, Edson Nossol, Eduardo M. Richter, Rodrigo A.a. MunozAbstract:Abstract The superior electrochemical activity of multi-walled carbon nanotubes (MWCNTs) of shorter dimensions towards the oxidation of Propionic Acid Derivative drugs, namely ibuprofen (IBF) and naproxen (NPX), is presented. A glassy-carbon electrode was modified with MWCNTs of different sizes (diameter × length: 100–170 nm × 5–9 μm and 6–9 nm × 5 μm, corresponding to LD- and SD-MWCNTs, respectively, larger and shorter diameter). Cyclic voltammetry of the SD-MWCNT-modified electrode showed a 200–300 mV decrease in the overpotential of oxidation reactions of both drugs and an increase in current (2 to 3.5-fold) in comparison with the LD-MWCNT-modified and unmodified electrodes. Similarly, the amperometric determination of both drugs using the SD-MWCNT-modified electrode presented an increase in sensitivity in comparison with LD-MWCNT-modified electrode (2 to 2.8-fold). Improved performance of the SD-MWCNT-modified electrode was in agreement with electrochemical impedance spectroscopy measurements. These results indicate the higher electrocatalytic activity of SD-MWCNTs, which can be explained by the increased defect density revealed by Raman spectroscopic measurements. Additionally, we report the first amperometric method for IBF determination using the SD-MWCNT-modified electrode, with a linear range from 10 to 1000 μmol L − 1 , detection limit of 1.9 μmol L − 1 , precision of 4%, and accuracy attested by capillary electrophoresis analyses.
Sylvain Chemtob - One of the best experts on this subject based on the ideXlab platform.
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Alterations in the electroretinogram of newborn piglets by Propionic Acid-Derivative nonsteroidal antiinflammatory drugs but not by indomethacin and diclofenac.
Pediatric research, 1995Co-Authors: Nelly Hanna, Pierre Lachapelle, Marie-sylvie Roy, Jacqueline Orquin, Daya R. Varma, Sylvain ChemtobAbstract:ABSTRACT: Different nonsteroidal antiinflammatory drugs (NSAID), especially ibuprofen, are being considered as an alternative to indomethacin for use in the newborn and as antipyretics for infants. However, some of these NSAID have been shown to cause visual complications. We therefore studied the effects of different NSAID indomethacin 19.6 μ-mol/kg (7 mg/kg), diclofenac 15.7 μmol/kg (5 mg/kg), ibuprofen 48 and 194 μmol/kg (10 and 40 mg/kg), naproxen 79 μ,mol/kg (20 mg/kg), and flurbipro-fen 41 μmol/kg (10 mg/kg) on photopic and scotopic electroretinograms (ERG) and retinal prostaglandin E2, prostaglandin F2α, and 6-keto-prostaglandin F1α levels in piglets 1–5 d old. All NSAID decreased retinal prostaglandin levels, but their effects on the ERG were not identical. Indomethacin and diclofenac did not alter the ERG. In contrast, the Propionic Acid Derivatives ibuprofen (the two doses used), naproxen, and flurbiprofen affected the amplitude as well as the implicit time of the ERG under photopic and scotopic conditions. These changes are suggestive of generalized alterations in the function of rods and cones. Prior inhibition of prostaglandin synthesis by indomethacin did not modify the effects of ibuprofen on the ERG. These findings thus show a dissociation between the effects of NSAID on the ERG and prostaglandin synthesis. Because ERG changes are associated with visual alterations, these effects of Propionic Acid Derivatives should be taken into account before considering their use in infants.
Kazuo Shinozuka - One of the best experts on this subject based on the ideXlab platform.
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stabilizing effect of Propionic Acid Derivative of anthraquinone polyamine conjugate incorporated into α β chimeric oligonucleotides on the alternate stranded triple helix
Bioconjugate Chemistry, 2011Co-Authors: Tomohisa Moriguchi, A Zafrul T M Azam, Kazuo ShinozukaAbstract:Two types of anthraquinone conjugates were synthesized as non-nucleosidic oligonucleotide components. These include an anthraquinone Derivative conjugated with 2,2-bis(hydroxymethyl)Propionic Acid and an anthraquinone--polyamine Derivative conjugated with 2,2-bis(hydroxymethyl)Propionic Acid. The conjugates were successfully incorporated into the "linking-region" of the α-β chimeric oligonucleotides via phosphoramidite method as non-nucleosidic backbone units. The resultant novel α-β chimeric oligonucleotides possessed two diastereomers that were generated by the introduction of the anthraquinone conjugate with a stereogenic carbon atom. The isomers were successfully separated by a reversed-phase HPLC. UV-melting experiments revealed that both stereoisomers formed a substantially stable alternate-strand triple helix, irrespective of the stereochemistry of the incorporated non-nucleosidic backbone unit. However, the enhancing effect on thermal stability depended on the length of the alkyl linker connecting anthraquinone moiety and the Propionic Acid moiety. The sequence discrimination ability of the chimeric oligonucleotides toward mismatch target duplex was also examined. The T(m) values of the triplexes containing the mismatch target were substantially lower than the T(m) values of those containing the full-match target. The thermodynamic parameters (ΔH°, ΔS°, and ΔG°) required for the dissociation of the triplexes into the third strand and target duplex were also measured.
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Modified α–β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)Propionic Acid–anthraquinone–polyamine exhibited improved and stereo-nonspecific triplex-forming ability
Chemical communications (Cambridge England), 2005Co-Authors: A. T. M. Zafrul Azam, Tomohisa Moriguchi, Kazuo ShinozukaAbstract:Novel α–β chimeric oligonucleotides bearing a Propionic Acid Derivative of an anthraquinone–polyamine conjugate in the “linker” region sequence-specifically formed a substantially stable alternate-stranded triplex with dsDNA almost regardless of the stereochemistry of the Derivative.
Akira Nakajima - One of the best experts on this subject based on the ideXlab platform.
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Fluoroquinolones and Propionic Acid Derivatives induce inflammatory responses in vitro.
Cell biology and toxicology, 2017Co-Authors: Akira Nakajima, Hiroki Sato, Shingo Oda, Tsuyoshi YokoiAbstract:Fluoroquinolones and Propionic Acid Derivatives are widely used antibacterials and non-steroidal anti-inflammatory drugs, respectively, which have been reported to frequently trigger drug hypersensitivity reactions. Such reactions are induced by inflammatory mediators such as cytokines and chemokines. The present study investigated whether levofloxacin, a fluoroquinolone, and loxoprofen, a Propionic Acid Derivative, have the potential to induce immune-related gene expression in dendritic cell-like cell lines such as HL-60, K562, and THP-1, and immortalized keratinocytes such as HaCaT. The expression of IL-8, MCP-1, and TNFα messenger RNA (mRNA) was found to increase following treatment with levofloxacin or loxoprofen in HL-60 cells. In addition, these drugs increased the mRNA content of annexin A1, a factor related to keratinocyte necroptosis in patients with severe cutaneous adverse reactions. Inhibition studies using specific inhibitors of mitogen-activated protein (MAP) kinases and NF-κB suggest that the extracellular signal-regulated kinase (ERK) pathway is the pathway principally involved in the induction of cytokines and annexin A1 by levofloxacin, whereas the involvement of MAP kinases and NF-κB in the loxoprofen-induced gene expression of these factors may be limited. Fluoroquinolones and Propionic Acid Derivatives that are structurally related to levofloxacin and loxoprofen, respectively, were also found to induce immune-related gene expression in HL-60 cells. Collectively, these results suggest that fluoroquinolones and Propionic Acid Derivatives have the potential to induce the expression of immune-related factors and that an in vitro cell-based assay system to detect the immune-stimulating potential of systemic drugs might be useful for assessing the risk of drug hypersensitivity reactions.
