The Experts below are selected from a list of 1158 Experts worldwide ranked by ideXlab platform
Panayiotis N Varelas - One of the best experts on this subject based on the ideXlab platform.
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vasopressors and Propofol Infusion Syndrome in severe head trauma
Neurocritical Care, 2009Co-Authors: Heidi Smith, Grant Sinson, Panayiotis N VarelasAbstract:Introduction Propofol Infusion Syndrome (PRIS) is a rare, but lethal complication of high-dose Propofol Infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors.
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Vasopressors and Propofol Infusion Syndrome in Severe Head Trauma
Neurocritical Care, 2008Co-Authors: Heidi Smith, Grant Sinson, Panayiotis N VarelasAbstract:Introduction Propofol Infusion Syndrome (PRIS) is a rare, but lethal complication of high-dose Propofol Infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors. Methods We reviewed all patients with severe head trauma admitted to our Neuro-Intensive Care Unit over a 4-year period for use of Propofol and vasopressors. Those patients who developed unexplained acidosis, creatine kinase elevation unrelated to trauma, and electrocardiographic changes were considered having PRIS. We investigated the concomitant use of vasopressors while Propofol was used and calculated odds ratios for developing PRIS. Results We report three adult patients who developed PRIS out of 50 (6%) admitted patients with severe head trauma on Propofol Infusions. Two of these patients survived and one expired after withdrawal of life support. Concomitant use of vasopressors was associated with development of PRIS in this cohort (odds ratio 29, 95% CI 1.5–581, P
Heidi Smith - One of the best experts on this subject based on the ideXlab platform.
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vasopressors and Propofol Infusion Syndrome in severe head trauma
Neurocritical Care, 2009Co-Authors: Heidi Smith, Grant Sinson, Panayiotis N VarelasAbstract:Introduction Propofol Infusion Syndrome (PRIS) is a rare, but lethal complication of high-dose Propofol Infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors.
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Vasopressors and Propofol Infusion Syndrome in Severe Head Trauma
Neurocritical Care, 2008Co-Authors: Heidi Smith, Grant Sinson, Panayiotis N VarelasAbstract:Introduction Propofol Infusion Syndrome (PRIS) is a rare, but lethal complication of high-dose Propofol Infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors. Methods We reviewed all patients with severe head trauma admitted to our Neuro-Intensive Care Unit over a 4-year period for use of Propofol and vasopressors. Those patients who developed unexplained acidosis, creatine kinase elevation unrelated to trauma, and electrocardiographic changes were considered having PRIS. We investigated the concomitant use of vasopressors while Propofol was used and calculated odds ratios for developing PRIS. Results We report three adult patients who developed PRIS out of 50 (6%) admitted patients with severe head trauma on Propofol Infusions. Two of these patients survived and one expired after withdrawal of life support. Concomitant use of vasopressors was associated with development of PRIS in this cohort (odds ratio 29, 95% CI 1.5–581, P
Grant Sinson - One of the best experts on this subject based on the ideXlab platform.
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vasopressors and Propofol Infusion Syndrome in severe head trauma
Neurocritical Care, 2009Co-Authors: Heidi Smith, Grant Sinson, Panayiotis N VarelasAbstract:Introduction Propofol Infusion Syndrome (PRIS) is a rare, but lethal complication of high-dose Propofol Infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors.
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Vasopressors and Propofol Infusion Syndrome in Severe Head Trauma
Neurocritical Care, 2008Co-Authors: Heidi Smith, Grant Sinson, Panayiotis N VarelasAbstract:Introduction Propofol Infusion Syndrome (PRIS) is a rare, but lethal complication of high-dose Propofol Infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors. Methods We reviewed all patients with severe head trauma admitted to our Neuro-Intensive Care Unit over a 4-year period for use of Propofol and vasopressors. Those patients who developed unexplained acidosis, creatine kinase elevation unrelated to trauma, and electrocardiographic changes were considered having PRIS. We investigated the concomitant use of vasopressors while Propofol was used and calculated odds ratios for developing PRIS. Results We report three adult patients who developed PRIS out of 50 (6%) admitted patients with severe head trauma on Propofol Infusions. Two of these patients survived and one expired after withdrawal of life support. Concomitant use of vasopressors was associated with development of PRIS in this cohort (odds ratio 29, 95% CI 1.5–581, P
Daniel Villers - One of the best experts on this subject based on the ideXlab platform.
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Propofol Infusion Syndrome during refractory status epilepticus in a young adult successful ecmo resuscitation
Neurocritical Care, 2011Co-Authors: Christophe Guitton, Laurence Gabillet, Patrick Latour, Jeanchristophe Rigal, D Boutoille, Ousama Al Habash, Pascal Derkinderen, Cedric Bretonniere, Daniel VillersAbstract:Background Propofol Infusion Syndrome (PRIS) is a rare but serious complication of Propofol administration consisting of metabolic disorder with acidosis, often leading to fatal cardiovascular collapse.
J Vandenbrande - One of the best experts on this subject based on the ideXlab platform.
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short term Propofol Infusion Syndrome pris fact or fiction a systematic review on early pris in intensive care and anesthesia
Critical Care, 2015Co-Authors: J VandenbrandeAbstract:Propofol Infusion Syndrome (PRIS) is a rare Propofol complication, leading to cardiac failure. It was first described in critically ill children and in adults with traumatic brain injury. Pathophysiology is unknown although common factors are the prolonged (>48 hours) use of high-dose (>5 mg/kg/hour) Propofol combined with elevated levels of catecholamines and corticosteroids. Recently, case reports of early-onset PRIS during anesthesia and in the early postoperative setting were published. In many of these, lactic acidosis is interpreted as onset of PRIS. Criticism offers that it might concern a poor differential diagnostic approach or an observational bias. Also, lactic acidosis is not an obligate PRIS symptom and incidence of lactic acidosis during Propofol sedation is unknown. To gain insight into the incidence and characteristics of early PRIS, we performed a systematic review on early PRIS cases.
