The Experts below are selected from a list of 33636 Experts worldwide ranked by ideXlab platform
Meir J Stampfer - One of the best experts on this subject based on the ideXlab platform.
-
dairy intake after Prostate Cancer Diagnosis in relation to disease specific and total mortality
International Journal of Cancer, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Meir J StampferAbstract:Information regarding postdiagnostic dairy intake and Prostate Cancer survival is limited. We evaluated intake of total, high-fat and low-fat dairy after Prostate Cancer Diagnosis in relation to disease-specific and total mortality. We included 926 men from the Physicians' Health Study diagnosed with non-metastatic Prostate Cancer between 1982 and 2000 who completed a diet questionnaire a median of 5 years after Diagnosis and were followed thereafter for a median of 10 years to assess mortality. Cox proportional hazards regression was used to estimate associations between dairy intake and Prostate Cancer specific and all-cause mortality. During 8,903 person-years of follow-up, 333 men died, 56 due to Prostate Cancer. Men consuming ≥3 servings/day of total dairy products had a 76% higher risk of total mortality and a 141% higher risk of Prostate Cancer-specific mortality compared to men who consumed less than 1 dairy product/day (hazard ratio (HR) = 1.76, 95% confidence interval (CI): 1.21, 2.55, ptrend < 0.001 for total mortality; HR = 2.41, 95% CI: 0.96, 6.02, ptrend = 0.04 for Prostate Cancer-specific mortality). The association between high-fat dairy and mortality risk appeared to be stronger than that of low-fat dairy, but the difference between them was not statistically significant (p for difference = 0.57 for Prostate Cancer-specific mortality and 0.56 for total mortality). Among men without metastases when diagnosed, higher intake of dairy foods after Prostate Cancer Diagnosis may be associated with increased Prostate Cancer-specific and all-cause mortality.
-
abstract a32 dairy intake in relation to disease specific and total mortality after Prostate Cancer Diagnosis
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Jorge E ChavarroAbstract:Introduction: Literature is limited regarding post-diagnostic dairy intake and Prostate Cancer survival. We evaluated dietary intake of total, high-fat, and low-fat dairy in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. Methods: We included 926 men from the Physicians9 Health Study diagnosed with non-metastatic Prostate Cancer from 1982 to 2012, who completed a food frequency questionnaire a median of 5.1 years after Diagnosis and were followed thereafter to assess mortality for a median of 9.9 years. Cox proportional hazards regression estimated the association between frequency categories of dairy intake and Prostate Cancer-specific and all-cause mortality. Person-years of follow-up were counted from the date of FFQ completion until death or end of follow-up, whichever came first. Models were adjusted for age at Diagnosis, total energy intake, vigorous exercise, body mass index, smoking status, clinical stage, Gleason score, Prostate specific antigen levels at Diagnosis, indicators for prudent dietary pattern and western dietary pattern, and time interval between Diagnosis and FFQ completion. Results: A total of 333 men died during follow-up, including 56 due to Prostate Cancer. Post-diagnosed dairy consumption was relatively limited, with medians of 1.7 servings/day for total dairy intake, 0.64 servings/day for high-fat dairy intake, and 1 serving/day for low-fat dairy intake. Men consuming dairy foods more than 3 times per day had a 76% higher risk of total mortality and a 144% increased risk of Prostate Cancer specific mortality than those consuming less than one dairy product per day (relative risk (RR)=1.76, 95% confidence interval (CI): 1.21, 2.55, Plinear-trend=0.001 for total mortality; RR=2.44, 95%CI: 0.99, 6.03, Plinear-trend=0.03 for disease-specific mortality). For total mortality, high-fat dairy intake (RR≥2 times/day vs Conclusions: Among men diagnosed with non-metastatic Prostate Cancer, post-diagnostic dairy food intake was associated with greater Prostate Cancer-specific and all-cause mortality. The associations of low-fat and high-fat dairy were comparable for Prostate Cancer-specific mortality, while intake of high-fat dairy products may be particularly detrimental for total mortality. Citation Format: Meng Yang, Stacey A. Kenfield, Erin L. Van Blarigan, Kathryn M. Wilson, Julie L. Batista, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Dairy intake in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A32.
-
abstract 1871 circulating cis and trans palmitoleic acid in relation to Prostate Cancer specific mortality among Prostate Cancer patients
Cancer Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Hannia Campos, Jorge E ChavarroAbstract:Background: Palmitoleic acid (16:1n-7c), a lipokine, and its trans isomer (16:1n-7t), a fatty acid found in foods of ruminant origin, have been associated with metabolic regulation and insulin sensitivity, which have in turn been related to Prostate Cancer progression and survivorship. Objective: To investigate whether circulating cis- and trans-palmitoleate, measured before and after Prostate Cancer Diagnosis, are related to Prostate Cancer-specific mortality among men diagnosed with non-metastatic Prostate Cancer. Methods: We employed a prospective study using pre-diagnostic whole blood samples collected in 1982 in 518 men who were later diagnosed with Prostate Cancer and followed for mortality. Proportional hazards regression was used to estimate relative risk (RR) and 95% confidence interval (CI) of Prostate Cancer-specific mortality across quartiles of pre-diagnostic palmitoleate concentrations. The multivariable model was adjusted for age at Diagnosis, BMI, smoking status, clinical characteristics and time interval between blood drawn and Prostate Cancer Diagnosis. Using a nested case-control design, we also assayed 148 post-diagnostic red blood cell samples collected in 1997 among 74 patients who subsequently died of the disease and 74 survivors, matched with age at Diagnosis and risk scores. Conditional logistic regression was used to estimate the RR (95%CI) of Prostate Cancer-specific mortality across tertiles of post-diagnostic palmitoleate levels after adjusting for BMI and smoking status. trans- and cis-palmitoleic acid concentrations were measured by gas chromatography. Results: Pre-diagnostic whole blood trans-palmitoleic acid and post-diagnostic red blood cell trans-palmitoleic acid levels were associated with lower Prostate Cancer-specific mortality. The adjusted RR (95%CI) of Prostate Cancer-specific mortality comparing top to bottom quartiles of pre-diagnostic 16:1n-7t was 0.35 (0.16-0.79; p-trend = 0.03). The adjusted RR (95%CI) comparing top to bottom tertiles of post-diagnostic 16:1n-7t levels was 0.26 (0.08-0.84; p-trend = 0.02). In contrast, cis-palmitoleic acid levels measured before and after Prostate Cancer Diagnosis were unrelated to disease-specific mortality. The pre-diagnostic cis-isomer, however, was significantly correlated with a lower level of adiponectin and higher levels of C-peptide, insulin-like growth factor binding protein 3, and pro-insulin. Conclusions: Pre- and post- diagnostic circulating trans-palmitoleic acid, but not cis-palmitoleic acid, was associated with lower Prostate Cancer-specific mortality among Prostate Cancer patients. Citation Format: Meng Yang, Stacey A. Kenfield, Hannia Campos, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Circulating cis- and trans- palmitoleic acid in relation to Prostate Cancer-specific mortality among Prostate Cancer patients. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1871. doi:10.1158/1538-7445.AM2015-1871
-
fat intake after Prostate Cancer Diagnosis and mortality in the physicians health study
Cancer Causes & Control, 2015Co-Authors: Erin L Van Blarigan, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Meng Yang, June M Chan, Jorge E ChavarroAbstract:Diet after Prostate Cancer Diagnosis may impact disease progression. We hypothesized that consuming saturated fat after Prostate Cancer Diagnosis would increase risk of mortality, and consuming vegetable fat after Diagnosis would lower the risk of mortality. This was a prospective study among 926 men with non-metastatic Prostate Cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of 5 years after Diagnosis and were followed for a median of 10 years after the questionnaire. We examined post-diagnostic saturated, monounsaturated, polyunsaturated, and trans fat, as well as animal and vegetable fat, intake in relation to all-cause and Prostate Cancer-specific mortality. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using multivariate Cox proportional hazards regression. We observed 333 deaths (56 Prostate Cancer deaths) during follow-up. Men who obtained 5 % more of their daily calories from saturated fat and 5 % less of their daily calories from carbohydrate after Diagnosis had a 1.8-fold increased risk of all-cause mortality (HR 1.81; 95 % CI 1.20, 2.74; p value 0.005) and a 2.8-fold increased risk of Prostate Cancer-specific mortality (HR 2.78; 95 % CI 1.01, 7.64; p value 0.05). Men who obtained 10 % more of their daily calories from vegetable fats and 10 % less of their daily calories from carbohydrates had a 33 % lower risk of all-cause mortality (HR 0.67; 95 % CI 0.47, 0.96; p value 0.03). Among men with non-metastatic Prostate Cancer, saturated fat intake may increase risk of death and vegetable fat intake may lower risk of death.
-
dietary patterns after Prostate Cancer Diagnosis in relation to disease specific and total mortality
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Jorge E Chavarro, Meir J Stampfer, Erin L Van Blarigan, Julie L BatistaAbstract:Men diagnosed with nonmetastatic Prostate Cancer have a long life expectancy, and many die of unrelated causes. It is therefore important to know to what extent post-diagnostic diet may affect disease-specific and overall mortality. A total of 926 men participating in the Physicians' Health Study diagnosed with nonmetastatic Prostate Cancer completed diet questionnaires for a median of 5.1 years after Diagnosis, and were followed thereafter to assess mortality for a median of 9.9 years since questionnaire completion. Two post-diagnostic dietary patterns were identified: a Prudent pattern, characterized by higher intake of vegetables, fruits, fish, legumes, and whole grains; and a Western pattern, characterized by higher intake of processed and red meats, high-fat dairy and refined grains. Cox regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). During 8,093 person-years of follow-up, 333 men died, 56 (17%) of Prostate Cancer. The Western pattern was significantly related to a higher risk of Prostate Cancer-specific and all-cause mortality. Comparing men in the highest versus the lowest quartile of the Western pattern, the HRs were 2.53 (95% CI, 1.00-6.42; Ptrend = 0.02) for Prostate Cancer-specific mortality and 1.67 (95% CI, 1.16-2.42; Ptrend = 0.01) for all-cause mortality. The Prudent pattern was associated with a significantly lower all-cause mortality (HRQuartile 4 vs. Quartile 1: 0.64; 95% CI, 0.44-0.93; Ptrend = 0.02); the relationship with Prostate Cancer-specific mortality was inverse but not statistically significant. A post-diagnostic Western dietary pattern was associated with higher Prostate Cancer-specific and all-cause mortality, whereas a Prudent dietary pattern was related to lower all-cause mortality after Prostate Cancer Diagnosis.
Jorge E Chavarro - One of the best experts on this subject based on the ideXlab platform.
-
abstract a32 dairy intake in relation to disease specific and total mortality after Prostate Cancer Diagnosis
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Jorge E ChavarroAbstract:Introduction: Literature is limited regarding post-diagnostic dairy intake and Prostate Cancer survival. We evaluated dietary intake of total, high-fat, and low-fat dairy in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. Methods: We included 926 men from the Physicians9 Health Study diagnosed with non-metastatic Prostate Cancer from 1982 to 2012, who completed a food frequency questionnaire a median of 5.1 years after Diagnosis and were followed thereafter to assess mortality for a median of 9.9 years. Cox proportional hazards regression estimated the association between frequency categories of dairy intake and Prostate Cancer-specific and all-cause mortality. Person-years of follow-up were counted from the date of FFQ completion until death or end of follow-up, whichever came first. Models were adjusted for age at Diagnosis, total energy intake, vigorous exercise, body mass index, smoking status, clinical stage, Gleason score, Prostate specific antigen levels at Diagnosis, indicators for prudent dietary pattern and western dietary pattern, and time interval between Diagnosis and FFQ completion. Results: A total of 333 men died during follow-up, including 56 due to Prostate Cancer. Post-diagnosed dairy consumption was relatively limited, with medians of 1.7 servings/day for total dairy intake, 0.64 servings/day for high-fat dairy intake, and 1 serving/day for low-fat dairy intake. Men consuming dairy foods more than 3 times per day had a 76% higher risk of total mortality and a 144% increased risk of Prostate Cancer specific mortality than those consuming less than one dairy product per day (relative risk (RR)=1.76, 95% confidence interval (CI): 1.21, 2.55, Plinear-trend=0.001 for total mortality; RR=2.44, 95%CI: 0.99, 6.03, Plinear-trend=0.03 for disease-specific mortality). For total mortality, high-fat dairy intake (RR≥2 times/day vs Conclusions: Among men diagnosed with non-metastatic Prostate Cancer, post-diagnostic dairy food intake was associated with greater Prostate Cancer-specific and all-cause mortality. The associations of low-fat and high-fat dairy were comparable for Prostate Cancer-specific mortality, while intake of high-fat dairy products may be particularly detrimental for total mortality. Citation Format: Meng Yang, Stacey A. Kenfield, Erin L. Van Blarigan, Kathryn M. Wilson, Julie L. Batista, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Dairy intake in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A32.
-
abstract 1871 circulating cis and trans palmitoleic acid in relation to Prostate Cancer specific mortality among Prostate Cancer patients
Cancer Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Hannia Campos, Jorge E ChavarroAbstract:Background: Palmitoleic acid (16:1n-7c), a lipokine, and its trans isomer (16:1n-7t), a fatty acid found in foods of ruminant origin, have been associated with metabolic regulation and insulin sensitivity, which have in turn been related to Prostate Cancer progression and survivorship. Objective: To investigate whether circulating cis- and trans-palmitoleate, measured before and after Prostate Cancer Diagnosis, are related to Prostate Cancer-specific mortality among men diagnosed with non-metastatic Prostate Cancer. Methods: We employed a prospective study using pre-diagnostic whole blood samples collected in 1982 in 518 men who were later diagnosed with Prostate Cancer and followed for mortality. Proportional hazards regression was used to estimate relative risk (RR) and 95% confidence interval (CI) of Prostate Cancer-specific mortality across quartiles of pre-diagnostic palmitoleate concentrations. The multivariable model was adjusted for age at Diagnosis, BMI, smoking status, clinical characteristics and time interval between blood drawn and Prostate Cancer Diagnosis. Using a nested case-control design, we also assayed 148 post-diagnostic red blood cell samples collected in 1997 among 74 patients who subsequently died of the disease and 74 survivors, matched with age at Diagnosis and risk scores. Conditional logistic regression was used to estimate the RR (95%CI) of Prostate Cancer-specific mortality across tertiles of post-diagnostic palmitoleate levels after adjusting for BMI and smoking status. trans- and cis-palmitoleic acid concentrations were measured by gas chromatography. Results: Pre-diagnostic whole blood trans-palmitoleic acid and post-diagnostic red blood cell trans-palmitoleic acid levels were associated with lower Prostate Cancer-specific mortality. The adjusted RR (95%CI) of Prostate Cancer-specific mortality comparing top to bottom quartiles of pre-diagnostic 16:1n-7t was 0.35 (0.16-0.79; p-trend = 0.03). The adjusted RR (95%CI) comparing top to bottom tertiles of post-diagnostic 16:1n-7t levels was 0.26 (0.08-0.84; p-trend = 0.02). In contrast, cis-palmitoleic acid levels measured before and after Prostate Cancer Diagnosis were unrelated to disease-specific mortality. The pre-diagnostic cis-isomer, however, was significantly correlated with a lower level of adiponectin and higher levels of C-peptide, insulin-like growth factor binding protein 3, and pro-insulin. Conclusions: Pre- and post- diagnostic circulating trans-palmitoleic acid, but not cis-palmitoleic acid, was associated with lower Prostate Cancer-specific mortality among Prostate Cancer patients. Citation Format: Meng Yang, Stacey A. Kenfield, Hannia Campos, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Circulating cis- and trans- palmitoleic acid in relation to Prostate Cancer-specific mortality among Prostate Cancer patients. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1871. doi:10.1158/1538-7445.AM2015-1871
-
fat intake after Prostate Cancer Diagnosis and mortality in the physicians health study
Cancer Causes & Control, 2015Co-Authors: Erin L Van Blarigan, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Meng Yang, June M Chan, Jorge E ChavarroAbstract:Diet after Prostate Cancer Diagnosis may impact disease progression. We hypothesized that consuming saturated fat after Prostate Cancer Diagnosis would increase risk of mortality, and consuming vegetable fat after Diagnosis would lower the risk of mortality. This was a prospective study among 926 men with non-metastatic Prostate Cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of 5 years after Diagnosis and were followed for a median of 10 years after the questionnaire. We examined post-diagnostic saturated, monounsaturated, polyunsaturated, and trans fat, as well as animal and vegetable fat, intake in relation to all-cause and Prostate Cancer-specific mortality. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using multivariate Cox proportional hazards regression. We observed 333 deaths (56 Prostate Cancer deaths) during follow-up. Men who obtained 5 % more of their daily calories from saturated fat and 5 % less of their daily calories from carbohydrate after Diagnosis had a 1.8-fold increased risk of all-cause mortality (HR 1.81; 95 % CI 1.20, 2.74; p value 0.005) and a 2.8-fold increased risk of Prostate Cancer-specific mortality (HR 2.78; 95 % CI 1.01, 7.64; p value 0.05). Men who obtained 10 % more of their daily calories from vegetable fats and 10 % less of their daily calories from carbohydrates had a 33 % lower risk of all-cause mortality (HR 0.67; 95 % CI 0.47, 0.96; p value 0.03). Among men with non-metastatic Prostate Cancer, saturated fat intake may increase risk of death and vegetable fat intake may lower risk of death.
-
dietary patterns after Prostate Cancer Diagnosis in relation to disease specific and total mortality
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Jorge E Chavarro, Meir J Stampfer, Erin L Van Blarigan, Julie L BatistaAbstract:Men diagnosed with nonmetastatic Prostate Cancer have a long life expectancy, and many die of unrelated causes. It is therefore important to know to what extent post-diagnostic diet may affect disease-specific and overall mortality. A total of 926 men participating in the Physicians' Health Study diagnosed with nonmetastatic Prostate Cancer completed diet questionnaires for a median of 5.1 years after Diagnosis, and were followed thereafter to assess mortality for a median of 9.9 years since questionnaire completion. Two post-diagnostic dietary patterns were identified: a Prudent pattern, characterized by higher intake of vegetables, fruits, fish, legumes, and whole grains; and a Western pattern, characterized by higher intake of processed and red meats, high-fat dairy and refined grains. Cox regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). During 8,093 person-years of follow-up, 333 men died, 56 (17%) of Prostate Cancer. The Western pattern was significantly related to a higher risk of Prostate Cancer-specific and all-cause mortality. Comparing men in the highest versus the lowest quartile of the Western pattern, the HRs were 2.53 (95% CI, 1.00-6.42; Ptrend = 0.02) for Prostate Cancer-specific mortality and 1.67 (95% CI, 1.16-2.42; Ptrend = 0.01) for all-cause mortality. The Prudent pattern was associated with a significantly lower all-cause mortality (HRQuartile 4 vs. Quartile 1: 0.64; 95% CI, 0.44-0.93; Ptrend = 0.02); the relationship with Prostate Cancer-specific mortality was inverse but not statistically significant. A post-diagnostic Western dietary pattern was associated with higher Prostate Cancer-specific and all-cause mortality, whereas a Prudent dietary pattern was related to lower all-cause mortality after Prostate Cancer Diagnosis.
-
abstract 1263 dietary patterns after Prostate Cancer Diagnosis in relation to disease specific and total mortality
Cancer Research, 2014Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Erin L Van Blarigan, Julie L Kasperzyk, Jorge E ChavarroAbstract:Objective: We investigated the relation of post-diagnostic dietary patterns with Prostate Cancer-specific and all-cause mortality. Methods: 926 men participating in the Physicians9 Healthy Study diagnosed with non-metastatic Prostate Cancer completed a food frequency questionnaire (FFQ) a median of 5.1 years after Diagnosis, and were followed thereafter to assess mortality for a median of 9.9 years. Two dietary patterns, a Prudent and a Western pattern, were identified using principal component analysis. Multivariate Cox proportional hazards regression was used to estimate the relative hazard of Prostate Cancer-specific and all-cause mortality in relation to post-diagnostic dietary pattern scores. Models were adjusted for age at Diagnosis, time between Diagnosis and FFQ completion, energy intake, vigorous exercise, BMI, smoking status, and a modified D9Amico risk score. Results: We identified 333 deaths, 56 due to Prostate Cancer, during 8,093 person-years of follow-up. The Prudent pattern was characterized by higher intake of vegetables, fruits, fish, legumes and whole grains, while the Western pattern was characterized by higher intake of processed and red meats, potatoes, high-fat dairy and refined grains. Men in the highest quartile (Q4) of the Western pattern had a higher risk of Prostate Cancer-specific death than men in the lowest quartile (Q1) (Hazard ratio [HR]: 2.39; 95% Confidence Interval [CI]: 0.95, 6.00; P for linear trend=0.03). The association between the Western pattern and Prostate Cancer-specific mortality appeared to be driven by intake of potatoes (HR[Q4 vs Q1]: 2.85; 95% CI: 1.06, 7.62; P for linear trend=0.01). In addition, the Western pattern was associated with higher all-cause mortality (HR[Q4 vs Q1]: 1.73; 95% CI: 1.20, 2.49; P for linear trend=0.005). A Prudent pattern after Diagnosis was unrelated to Prostate Cancer-specific mortality but was associated with lower all-cause mortality (HR[Q4 vs Q1]: 0.60; 95% CI: 0.42, 0.88; P for linear trend=0.007). Conclusions: A Western dietary pattern may increase risk of Prostate Cancer-specific and all-cause mortality, whereas a Prudent dietary pattern may decrease the risk of all-cause mortality, all among men diagnosed with localized Prostate Cancer. Citation Format: Meng Yang, Stacey A. Kenfield, Erin L. Van Blarigan, Julie L. Kasperzyk, Howard D. Sesso, Jing Ma, Meir Stampfer, Jorge E. Chavarro. Dietary patterns after Prostate Cancer Diagnosis in relation to disease-specific and total mortality. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1263. doi:10.1158/1538-7445.AM2014-1263
Stacey A Kenfield - One of the best experts on this subject based on the ideXlab platform.
-
mediterranean diet after Prostate Cancer Diagnosis and urinary and sexual functioning the health professionals follow up study
The Prostate, 2018Co-Authors: Scott R Bauer, Erin L Van Blarigan, June M Chan, Stacey A KenfieldAbstract:BACKGROUND: Men with Prostate Cancer often experience urinary and sexual dysfunction after treatment. Previous studies have demonstrated a relationship between dietary factors and these symptoms among men with diabetes or metabolic syndrome. However, there are limited data on whether diet after Prostate Cancer Diagnosis, including a Mediterranean dietary pattern, affects urinary and sexual function among Prostate Cancer survivors. METHODS: Men diagnosed with non-metastatic Prostate Cancer in the Health Professionals Follow-up Study (n = 2960) from 1986 to 2012 were prospectively followed for a median of 8.3 years after treatment. Participants completed validated dietary questionnaires every 4 years and a health-related quality of life assessment in 2010 or 2012. We used generalized linear models to examine associations between post-Diagnosis Mediterranean Diet Score (including individual score components and dietary fat subtypes) and quality of life domains (sexual functioning, urinary irritation/obstruction, urinary incontinence) assessed using the Expanded Prostate Cancer Index Composite Short Form (score 0-100; higher scores indicate better function). RESULTS: No statistically significant relationships were observed between the Mediterranean Diet Score after Prostate Cancer Diagnosis and urinary or sexual function. However, the associations did vary depending on pre-Diagnosis urinary and sexual dysfunction for urinary irritation/obstruction and sexual function scores, respectively (P-interactions < 0.0001). Men with higher post-Diagnosis vegetable intake reported higher urinary incontinence scores (72 vs 76 comparing lowest to highest quintile; P-trend = 0.003). Similarly, higher vegetable intake and lower polyunsaturated fat intake were associated with higher urinary irritation/obstruction scores (vegetable: 80 vs 84 comparing lowest to highest quintile, P-trend = 0.01; polyunsaturated fat: 84 vs 78 comparing lowest to highest quintile, P-trend = 0.005), however these associations were observed only among men with urinary symptoms prior to their Prostate Cancer Diagnosis. CONCLUSIONS: Among men with Prostate Cancer, diet intake after Diagnosis was not significantly associated with urinary or sexual function, although some relationships appeared to differ among men with and without symptoms prior to their Prostate Cancer Diagnosis. Higher vegetable intake and lower polyunsaturated fat intake after Prostate Cancer Diagnosis may be associated with better urinary function. However, this analysis was exploratory, and further research is needed to better delineate these relationships and guide dietary recommendations for men with Prostate Cancer.
-
milk and other dairy foods in relation to Prostate Cancer recurrence data from the Cancer of the Prostate strategic urologic research endeavor capsure
The Prostate, 2018Co-Authors: David Tat, Stacey A Kenfield, Erin L Van Blarigan, Janet E Cowan, Jeanette M Broering, Peter R Carroll, June M ChanAbstract:Background High-fat dairy, particularly whole milk, in healthy men may increase risk of aggressive Prostate Cancer. However, data are limited regarding dairy after Prostate Cancer Diagnosis. Method We conducted a prospective study among 1334 men with non-metastatic Prostate Cancer in the Cancer of the Prostate Strategic Urologic Research Endeavor. Men answered a food frequency questionnaire in 2004-2005 (median 2 years after Diagnosis) and were followed until 2016 for recurrence, defined as: Prostate Cancer death, bone metastases, biochemical recurrence, or secondary treatment. Multivariate Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% confidence intervals (CI) for associations between whole and low-fat milk; total, high-fat, and low-fat dairy; and other dairy items and risk of recurrence. Results During a median follow-up of 8 years, we observed 137 events. Men who consumed >4 servings/week versus 0-3 servings/month of whole milk had an 73% increased risk of recurrence (HR: 1.73; 95%CI: 1.00, 2.98; P-value = 0.04). Body mass index (BMI) modified the association (P-interaction = 0.01). Among men with a BMI ≥27 kg/m2, >4 servings/week versus 0-3 servings/month of whole milk was associated with a 3-fold higher risk of recurrence (HR: 2.96; 95%CI: 1.58, 5.54; P-value < 0.001). No association was seen in men with BMI <27 kg/m2. Low-fat milk and other dairy foods were not associated with recurrence. Conclusion In conclusion, whole milk consumption after Prostate Cancer Diagnosis was associated with increased risk of recurrence, particularly among very overweight or obese men. Men with Prostate Cancer who choose to drink milk should select non-fat or low-fat options.
-
dairy intake after Prostate Cancer Diagnosis in relation to disease specific and total mortality
International Journal of Cancer, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Meir J StampferAbstract:Information regarding postdiagnostic dairy intake and Prostate Cancer survival is limited. We evaluated intake of total, high-fat and low-fat dairy after Prostate Cancer Diagnosis in relation to disease-specific and total mortality. We included 926 men from the Physicians' Health Study diagnosed with non-metastatic Prostate Cancer between 1982 and 2000 who completed a diet questionnaire a median of 5 years after Diagnosis and were followed thereafter for a median of 10 years to assess mortality. Cox proportional hazards regression was used to estimate associations between dairy intake and Prostate Cancer specific and all-cause mortality. During 8,903 person-years of follow-up, 333 men died, 56 due to Prostate Cancer. Men consuming ≥3 servings/day of total dairy products had a 76% higher risk of total mortality and a 141% higher risk of Prostate Cancer-specific mortality compared to men who consumed less than 1 dairy product/day (hazard ratio (HR) = 1.76, 95% confidence interval (CI): 1.21, 2.55, ptrend < 0.001 for total mortality; HR = 2.41, 95% CI: 0.96, 6.02, ptrend = 0.04 for Prostate Cancer-specific mortality). The association between high-fat dairy and mortality risk appeared to be stronger than that of low-fat dairy, but the difference between them was not statistically significant (p for difference = 0.57 for Prostate Cancer-specific mortality and 0.56 for total mortality). Among men without metastases when diagnosed, higher intake of dairy foods after Prostate Cancer Diagnosis may be associated with increased Prostate Cancer-specific and all-cause mortality.
-
abstract a32 dairy intake in relation to disease specific and total mortality after Prostate Cancer Diagnosis
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Jorge E ChavarroAbstract:Introduction: Literature is limited regarding post-diagnostic dairy intake and Prostate Cancer survival. We evaluated dietary intake of total, high-fat, and low-fat dairy in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. Methods: We included 926 men from the Physicians9 Health Study diagnosed with non-metastatic Prostate Cancer from 1982 to 2012, who completed a food frequency questionnaire a median of 5.1 years after Diagnosis and were followed thereafter to assess mortality for a median of 9.9 years. Cox proportional hazards regression estimated the association between frequency categories of dairy intake and Prostate Cancer-specific and all-cause mortality. Person-years of follow-up were counted from the date of FFQ completion until death or end of follow-up, whichever came first. Models were adjusted for age at Diagnosis, total energy intake, vigorous exercise, body mass index, smoking status, clinical stage, Gleason score, Prostate specific antigen levels at Diagnosis, indicators for prudent dietary pattern and western dietary pattern, and time interval between Diagnosis and FFQ completion. Results: A total of 333 men died during follow-up, including 56 due to Prostate Cancer. Post-diagnosed dairy consumption was relatively limited, with medians of 1.7 servings/day for total dairy intake, 0.64 servings/day for high-fat dairy intake, and 1 serving/day for low-fat dairy intake. Men consuming dairy foods more than 3 times per day had a 76% higher risk of total mortality and a 144% increased risk of Prostate Cancer specific mortality than those consuming less than one dairy product per day (relative risk (RR)=1.76, 95% confidence interval (CI): 1.21, 2.55, Plinear-trend=0.001 for total mortality; RR=2.44, 95%CI: 0.99, 6.03, Plinear-trend=0.03 for disease-specific mortality). For total mortality, high-fat dairy intake (RR≥2 times/day vs Conclusions: Among men diagnosed with non-metastatic Prostate Cancer, post-diagnostic dairy food intake was associated with greater Prostate Cancer-specific and all-cause mortality. The associations of low-fat and high-fat dairy were comparable for Prostate Cancer-specific mortality, while intake of high-fat dairy products may be particularly detrimental for total mortality. Citation Format: Meng Yang, Stacey A. Kenfield, Erin L. Van Blarigan, Kathryn M. Wilson, Julie L. Batista, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Dairy intake in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A32.
-
abstract 1871 circulating cis and trans palmitoleic acid in relation to Prostate Cancer specific mortality among Prostate Cancer patients
Cancer Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Hannia Campos, Jorge E ChavarroAbstract:Background: Palmitoleic acid (16:1n-7c), a lipokine, and its trans isomer (16:1n-7t), a fatty acid found in foods of ruminant origin, have been associated with metabolic regulation and insulin sensitivity, which have in turn been related to Prostate Cancer progression and survivorship. Objective: To investigate whether circulating cis- and trans-palmitoleate, measured before and after Prostate Cancer Diagnosis, are related to Prostate Cancer-specific mortality among men diagnosed with non-metastatic Prostate Cancer. Methods: We employed a prospective study using pre-diagnostic whole blood samples collected in 1982 in 518 men who were later diagnosed with Prostate Cancer and followed for mortality. Proportional hazards regression was used to estimate relative risk (RR) and 95% confidence interval (CI) of Prostate Cancer-specific mortality across quartiles of pre-diagnostic palmitoleate concentrations. The multivariable model was adjusted for age at Diagnosis, BMI, smoking status, clinical characteristics and time interval between blood drawn and Prostate Cancer Diagnosis. Using a nested case-control design, we also assayed 148 post-diagnostic red blood cell samples collected in 1997 among 74 patients who subsequently died of the disease and 74 survivors, matched with age at Diagnosis and risk scores. Conditional logistic regression was used to estimate the RR (95%CI) of Prostate Cancer-specific mortality across tertiles of post-diagnostic palmitoleate levels after adjusting for BMI and smoking status. trans- and cis-palmitoleic acid concentrations were measured by gas chromatography. Results: Pre-diagnostic whole blood trans-palmitoleic acid and post-diagnostic red blood cell trans-palmitoleic acid levels were associated with lower Prostate Cancer-specific mortality. The adjusted RR (95%CI) of Prostate Cancer-specific mortality comparing top to bottom quartiles of pre-diagnostic 16:1n-7t was 0.35 (0.16-0.79; p-trend = 0.03). The adjusted RR (95%CI) comparing top to bottom tertiles of post-diagnostic 16:1n-7t levels was 0.26 (0.08-0.84; p-trend = 0.02). In contrast, cis-palmitoleic acid levels measured before and after Prostate Cancer Diagnosis were unrelated to disease-specific mortality. The pre-diagnostic cis-isomer, however, was significantly correlated with a lower level of adiponectin and higher levels of C-peptide, insulin-like growth factor binding protein 3, and pro-insulin. Conclusions: Pre- and post- diagnostic circulating trans-palmitoleic acid, but not cis-palmitoleic acid, was associated with lower Prostate Cancer-specific mortality among Prostate Cancer patients. Citation Format: Meng Yang, Stacey A. Kenfield, Hannia Campos, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Circulating cis- and trans- palmitoleic acid in relation to Prostate Cancer-specific mortality among Prostate Cancer patients. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1871. doi:10.1158/1538-7445.AM2015-1871
Meng Yang - One of the best experts on this subject based on the ideXlab platform.
-
dairy intake after Prostate Cancer Diagnosis in relation to disease specific and total mortality
International Journal of Cancer, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Meir J StampferAbstract:Information regarding postdiagnostic dairy intake and Prostate Cancer survival is limited. We evaluated intake of total, high-fat and low-fat dairy after Prostate Cancer Diagnosis in relation to disease-specific and total mortality. We included 926 men from the Physicians' Health Study diagnosed with non-metastatic Prostate Cancer between 1982 and 2000 who completed a diet questionnaire a median of 5 years after Diagnosis and were followed thereafter for a median of 10 years to assess mortality. Cox proportional hazards regression was used to estimate associations between dairy intake and Prostate Cancer specific and all-cause mortality. During 8,903 person-years of follow-up, 333 men died, 56 due to Prostate Cancer. Men consuming ≥3 servings/day of total dairy products had a 76% higher risk of total mortality and a 141% higher risk of Prostate Cancer-specific mortality compared to men who consumed less than 1 dairy product/day (hazard ratio (HR) = 1.76, 95% confidence interval (CI): 1.21, 2.55, ptrend < 0.001 for total mortality; HR = 2.41, 95% CI: 0.96, 6.02, ptrend = 0.04 for Prostate Cancer-specific mortality). The association between high-fat dairy and mortality risk appeared to be stronger than that of low-fat dairy, but the difference between them was not statistically significant (p for difference = 0.57 for Prostate Cancer-specific mortality and 0.56 for total mortality). Among men without metastases when diagnosed, higher intake of dairy foods after Prostate Cancer Diagnosis may be associated with increased Prostate Cancer-specific and all-cause mortality.
-
abstract a32 dairy intake in relation to disease specific and total mortality after Prostate Cancer Diagnosis
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Jorge E ChavarroAbstract:Introduction: Literature is limited regarding post-diagnostic dairy intake and Prostate Cancer survival. We evaluated dietary intake of total, high-fat, and low-fat dairy in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. Methods: We included 926 men from the Physicians9 Health Study diagnosed with non-metastatic Prostate Cancer from 1982 to 2012, who completed a food frequency questionnaire a median of 5.1 years after Diagnosis and were followed thereafter to assess mortality for a median of 9.9 years. Cox proportional hazards regression estimated the association between frequency categories of dairy intake and Prostate Cancer-specific and all-cause mortality. Person-years of follow-up were counted from the date of FFQ completion until death or end of follow-up, whichever came first. Models were adjusted for age at Diagnosis, total energy intake, vigorous exercise, body mass index, smoking status, clinical stage, Gleason score, Prostate specific antigen levels at Diagnosis, indicators for prudent dietary pattern and western dietary pattern, and time interval between Diagnosis and FFQ completion. Results: A total of 333 men died during follow-up, including 56 due to Prostate Cancer. Post-diagnosed dairy consumption was relatively limited, with medians of 1.7 servings/day for total dairy intake, 0.64 servings/day for high-fat dairy intake, and 1 serving/day for low-fat dairy intake. Men consuming dairy foods more than 3 times per day had a 76% higher risk of total mortality and a 144% increased risk of Prostate Cancer specific mortality than those consuming less than one dairy product per day (relative risk (RR)=1.76, 95% confidence interval (CI): 1.21, 2.55, Plinear-trend=0.001 for total mortality; RR=2.44, 95%CI: 0.99, 6.03, Plinear-trend=0.03 for disease-specific mortality). For total mortality, high-fat dairy intake (RR≥2 times/day vs Conclusions: Among men diagnosed with non-metastatic Prostate Cancer, post-diagnostic dairy food intake was associated with greater Prostate Cancer-specific and all-cause mortality. The associations of low-fat and high-fat dairy were comparable for Prostate Cancer-specific mortality, while intake of high-fat dairy products may be particularly detrimental for total mortality. Citation Format: Meng Yang, Stacey A. Kenfield, Erin L. Van Blarigan, Kathryn M. Wilson, Julie L. Batista, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Dairy intake in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A32.
-
abstract 1871 circulating cis and trans palmitoleic acid in relation to Prostate Cancer specific mortality among Prostate Cancer patients
Cancer Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Hannia Campos, Jorge E ChavarroAbstract:Background: Palmitoleic acid (16:1n-7c), a lipokine, and its trans isomer (16:1n-7t), a fatty acid found in foods of ruminant origin, have been associated with metabolic regulation and insulin sensitivity, which have in turn been related to Prostate Cancer progression and survivorship. Objective: To investigate whether circulating cis- and trans-palmitoleate, measured before and after Prostate Cancer Diagnosis, are related to Prostate Cancer-specific mortality among men diagnosed with non-metastatic Prostate Cancer. Methods: We employed a prospective study using pre-diagnostic whole blood samples collected in 1982 in 518 men who were later diagnosed with Prostate Cancer and followed for mortality. Proportional hazards regression was used to estimate relative risk (RR) and 95% confidence interval (CI) of Prostate Cancer-specific mortality across quartiles of pre-diagnostic palmitoleate concentrations. The multivariable model was adjusted for age at Diagnosis, BMI, smoking status, clinical characteristics and time interval between blood drawn and Prostate Cancer Diagnosis. Using a nested case-control design, we also assayed 148 post-diagnostic red blood cell samples collected in 1997 among 74 patients who subsequently died of the disease and 74 survivors, matched with age at Diagnosis and risk scores. Conditional logistic regression was used to estimate the RR (95%CI) of Prostate Cancer-specific mortality across tertiles of post-diagnostic palmitoleate levels after adjusting for BMI and smoking status. trans- and cis-palmitoleic acid concentrations were measured by gas chromatography. Results: Pre-diagnostic whole blood trans-palmitoleic acid and post-diagnostic red blood cell trans-palmitoleic acid levels were associated with lower Prostate Cancer-specific mortality. The adjusted RR (95%CI) of Prostate Cancer-specific mortality comparing top to bottom quartiles of pre-diagnostic 16:1n-7t was 0.35 (0.16-0.79; p-trend = 0.03). The adjusted RR (95%CI) comparing top to bottom tertiles of post-diagnostic 16:1n-7t levels was 0.26 (0.08-0.84; p-trend = 0.02). In contrast, cis-palmitoleic acid levels measured before and after Prostate Cancer Diagnosis were unrelated to disease-specific mortality. The pre-diagnostic cis-isomer, however, was significantly correlated with a lower level of adiponectin and higher levels of C-peptide, insulin-like growth factor binding protein 3, and pro-insulin. Conclusions: Pre- and post- diagnostic circulating trans-palmitoleic acid, but not cis-palmitoleic acid, was associated with lower Prostate Cancer-specific mortality among Prostate Cancer patients. Citation Format: Meng Yang, Stacey A. Kenfield, Hannia Campos, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Circulating cis- and trans- palmitoleic acid in relation to Prostate Cancer-specific mortality among Prostate Cancer patients. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1871. doi:10.1158/1538-7445.AM2015-1871
-
fat intake after Prostate Cancer Diagnosis and mortality in the physicians health study
Cancer Causes & Control, 2015Co-Authors: Erin L Van Blarigan, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Meng Yang, June M Chan, Jorge E ChavarroAbstract:Diet after Prostate Cancer Diagnosis may impact disease progression. We hypothesized that consuming saturated fat after Prostate Cancer Diagnosis would increase risk of mortality, and consuming vegetable fat after Diagnosis would lower the risk of mortality. This was a prospective study among 926 men with non-metastatic Prostate Cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of 5 years after Diagnosis and were followed for a median of 10 years after the questionnaire. We examined post-diagnostic saturated, monounsaturated, polyunsaturated, and trans fat, as well as animal and vegetable fat, intake in relation to all-cause and Prostate Cancer-specific mortality. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using multivariate Cox proportional hazards regression. We observed 333 deaths (56 Prostate Cancer deaths) during follow-up. Men who obtained 5 % more of their daily calories from saturated fat and 5 % less of their daily calories from carbohydrate after Diagnosis had a 1.8-fold increased risk of all-cause mortality (HR 1.81; 95 % CI 1.20, 2.74; p value 0.005) and a 2.8-fold increased risk of Prostate Cancer-specific mortality (HR 2.78; 95 % CI 1.01, 7.64; p value 0.05). Men who obtained 10 % more of their daily calories from vegetable fats and 10 % less of their daily calories from carbohydrates had a 33 % lower risk of all-cause mortality (HR 0.67; 95 % CI 0.47, 0.96; p value 0.03). Among men with non-metastatic Prostate Cancer, saturated fat intake may increase risk of death and vegetable fat intake may lower risk of death.
-
dietary patterns after Prostate Cancer Diagnosis in relation to disease specific and total mortality
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Jorge E Chavarro, Meir J Stampfer, Erin L Van Blarigan, Julie L BatistaAbstract:Men diagnosed with nonmetastatic Prostate Cancer have a long life expectancy, and many die of unrelated causes. It is therefore important to know to what extent post-diagnostic diet may affect disease-specific and overall mortality. A total of 926 men participating in the Physicians' Health Study diagnosed with nonmetastatic Prostate Cancer completed diet questionnaires for a median of 5.1 years after Diagnosis, and were followed thereafter to assess mortality for a median of 9.9 years since questionnaire completion. Two post-diagnostic dietary patterns were identified: a Prudent pattern, characterized by higher intake of vegetables, fruits, fish, legumes, and whole grains; and a Western pattern, characterized by higher intake of processed and red meats, high-fat dairy and refined grains. Cox regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). During 8,093 person-years of follow-up, 333 men died, 56 (17%) of Prostate Cancer. The Western pattern was significantly related to a higher risk of Prostate Cancer-specific and all-cause mortality. Comparing men in the highest versus the lowest quartile of the Western pattern, the HRs were 2.53 (95% CI, 1.00-6.42; Ptrend = 0.02) for Prostate Cancer-specific mortality and 1.67 (95% CI, 1.16-2.42; Ptrend = 0.01) for all-cause mortality. The Prudent pattern was associated with a significantly lower all-cause mortality (HRQuartile 4 vs. Quartile 1: 0.64; 95% CI, 0.44-0.93; Ptrend = 0.02); the relationship with Prostate Cancer-specific mortality was inverse but not statistically significant. A post-diagnostic Western dietary pattern was associated with higher Prostate Cancer-specific and all-cause mortality, whereas a Prudent dietary pattern was related to lower all-cause mortality after Prostate Cancer Diagnosis.
Howard D Sesso - One of the best experts on this subject based on the ideXlab platform.
-
dairy intake after Prostate Cancer Diagnosis in relation to disease specific and total mortality
International Journal of Cancer, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Meir J StampferAbstract:Information regarding postdiagnostic dairy intake and Prostate Cancer survival is limited. We evaluated intake of total, high-fat and low-fat dairy after Prostate Cancer Diagnosis in relation to disease-specific and total mortality. We included 926 men from the Physicians' Health Study diagnosed with non-metastatic Prostate Cancer between 1982 and 2000 who completed a diet questionnaire a median of 5 years after Diagnosis and were followed thereafter for a median of 10 years to assess mortality. Cox proportional hazards regression was used to estimate associations between dairy intake and Prostate Cancer specific and all-cause mortality. During 8,903 person-years of follow-up, 333 men died, 56 due to Prostate Cancer. Men consuming ≥3 servings/day of total dairy products had a 76% higher risk of total mortality and a 141% higher risk of Prostate Cancer-specific mortality compared to men who consumed less than 1 dairy product/day (hazard ratio (HR) = 1.76, 95% confidence interval (CI): 1.21, 2.55, ptrend < 0.001 for total mortality; HR = 2.41, 95% CI: 0.96, 6.02, ptrend = 0.04 for Prostate Cancer-specific mortality). The association between high-fat dairy and mortality risk appeared to be stronger than that of low-fat dairy, but the difference between them was not statistically significant (p for difference = 0.57 for Prostate Cancer-specific mortality and 0.56 for total mortality). Among men without metastases when diagnosed, higher intake of dairy foods after Prostate Cancer Diagnosis may be associated with increased Prostate Cancer-specific and all-cause mortality.
-
abstract a32 dairy intake in relation to disease specific and total mortality after Prostate Cancer Diagnosis
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Erin L Van Blarigan, Kathryn M Wilson, Julie L Batista, Jorge E ChavarroAbstract:Introduction: Literature is limited regarding post-diagnostic dairy intake and Prostate Cancer survival. We evaluated dietary intake of total, high-fat, and low-fat dairy in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. Methods: We included 926 men from the Physicians9 Health Study diagnosed with non-metastatic Prostate Cancer from 1982 to 2012, who completed a food frequency questionnaire a median of 5.1 years after Diagnosis and were followed thereafter to assess mortality for a median of 9.9 years. Cox proportional hazards regression estimated the association between frequency categories of dairy intake and Prostate Cancer-specific and all-cause mortality. Person-years of follow-up were counted from the date of FFQ completion until death or end of follow-up, whichever came first. Models were adjusted for age at Diagnosis, total energy intake, vigorous exercise, body mass index, smoking status, clinical stage, Gleason score, Prostate specific antigen levels at Diagnosis, indicators for prudent dietary pattern and western dietary pattern, and time interval between Diagnosis and FFQ completion. Results: A total of 333 men died during follow-up, including 56 due to Prostate Cancer. Post-diagnosed dairy consumption was relatively limited, with medians of 1.7 servings/day for total dairy intake, 0.64 servings/day for high-fat dairy intake, and 1 serving/day for low-fat dairy intake. Men consuming dairy foods more than 3 times per day had a 76% higher risk of total mortality and a 144% increased risk of Prostate Cancer specific mortality than those consuming less than one dairy product per day (relative risk (RR)=1.76, 95% confidence interval (CI): 1.21, 2.55, Plinear-trend=0.001 for total mortality; RR=2.44, 95%CI: 0.99, 6.03, Plinear-trend=0.03 for disease-specific mortality). For total mortality, high-fat dairy intake (RR≥2 times/day vs Conclusions: Among men diagnosed with non-metastatic Prostate Cancer, post-diagnostic dairy food intake was associated with greater Prostate Cancer-specific and all-cause mortality. The associations of low-fat and high-fat dairy were comparable for Prostate Cancer-specific mortality, while intake of high-fat dairy products may be particularly detrimental for total mortality. Citation Format: Meng Yang, Stacey A. Kenfield, Erin L. Van Blarigan, Kathryn M. Wilson, Julie L. Batista, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Dairy intake in relation to disease-specific and total mortality after Prostate Cancer Diagnosis. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A32.
-
abstract 1871 circulating cis and trans palmitoleic acid in relation to Prostate Cancer specific mortality among Prostate Cancer patients
Cancer Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Hannia Campos, Jorge E ChavarroAbstract:Background: Palmitoleic acid (16:1n-7c), a lipokine, and its trans isomer (16:1n-7t), a fatty acid found in foods of ruminant origin, have been associated with metabolic regulation and insulin sensitivity, which have in turn been related to Prostate Cancer progression and survivorship. Objective: To investigate whether circulating cis- and trans-palmitoleate, measured before and after Prostate Cancer Diagnosis, are related to Prostate Cancer-specific mortality among men diagnosed with non-metastatic Prostate Cancer. Methods: We employed a prospective study using pre-diagnostic whole blood samples collected in 1982 in 518 men who were later diagnosed with Prostate Cancer and followed for mortality. Proportional hazards regression was used to estimate relative risk (RR) and 95% confidence interval (CI) of Prostate Cancer-specific mortality across quartiles of pre-diagnostic palmitoleate concentrations. The multivariable model was adjusted for age at Diagnosis, BMI, smoking status, clinical characteristics and time interval between blood drawn and Prostate Cancer Diagnosis. Using a nested case-control design, we also assayed 148 post-diagnostic red blood cell samples collected in 1997 among 74 patients who subsequently died of the disease and 74 survivors, matched with age at Diagnosis and risk scores. Conditional logistic regression was used to estimate the RR (95%CI) of Prostate Cancer-specific mortality across tertiles of post-diagnostic palmitoleate levels after adjusting for BMI and smoking status. trans- and cis-palmitoleic acid concentrations were measured by gas chromatography. Results: Pre-diagnostic whole blood trans-palmitoleic acid and post-diagnostic red blood cell trans-palmitoleic acid levels were associated with lower Prostate Cancer-specific mortality. The adjusted RR (95%CI) of Prostate Cancer-specific mortality comparing top to bottom quartiles of pre-diagnostic 16:1n-7t was 0.35 (0.16-0.79; p-trend = 0.03). The adjusted RR (95%CI) comparing top to bottom tertiles of post-diagnostic 16:1n-7t levels was 0.26 (0.08-0.84; p-trend = 0.02). In contrast, cis-palmitoleic acid levels measured before and after Prostate Cancer Diagnosis were unrelated to disease-specific mortality. The pre-diagnostic cis-isomer, however, was significantly correlated with a lower level of adiponectin and higher levels of C-peptide, insulin-like growth factor binding protein 3, and pro-insulin. Conclusions: Pre- and post- diagnostic circulating trans-palmitoleic acid, but not cis-palmitoleic acid, was associated with lower Prostate Cancer-specific mortality among Prostate Cancer patients. Citation Format: Meng Yang, Stacey A. Kenfield, Hannia Campos, Howard D. Sesso, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro. Circulating cis- and trans- palmitoleic acid in relation to Prostate Cancer-specific mortality among Prostate Cancer patients. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1871. doi:10.1158/1538-7445.AM2015-1871
-
fat intake after Prostate Cancer Diagnosis and mortality in the physicians health study
Cancer Causes & Control, 2015Co-Authors: Erin L Van Blarigan, Stacey A Kenfield, Howard D Sesso, Meir J Stampfer, Meng Yang, June M Chan, Jorge E ChavarroAbstract:Diet after Prostate Cancer Diagnosis may impact disease progression. We hypothesized that consuming saturated fat after Prostate Cancer Diagnosis would increase risk of mortality, and consuming vegetable fat after Diagnosis would lower the risk of mortality. This was a prospective study among 926 men with non-metastatic Prostate Cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of 5 years after Diagnosis and were followed for a median of 10 years after the questionnaire. We examined post-diagnostic saturated, monounsaturated, polyunsaturated, and trans fat, as well as animal and vegetable fat, intake in relation to all-cause and Prostate Cancer-specific mortality. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using multivariate Cox proportional hazards regression. We observed 333 deaths (56 Prostate Cancer deaths) during follow-up. Men who obtained 5 % more of their daily calories from saturated fat and 5 % less of their daily calories from carbohydrate after Diagnosis had a 1.8-fold increased risk of all-cause mortality (HR 1.81; 95 % CI 1.20, 2.74; p value 0.005) and a 2.8-fold increased risk of Prostate Cancer-specific mortality (HR 2.78; 95 % CI 1.01, 7.64; p value 0.05). Men who obtained 10 % more of their daily calories from vegetable fats and 10 % less of their daily calories from carbohydrates had a 33 % lower risk of all-cause mortality (HR 0.67; 95 % CI 0.47, 0.96; p value 0.03). Among men with non-metastatic Prostate Cancer, saturated fat intake may increase risk of death and vegetable fat intake may lower risk of death.
-
dietary patterns after Prostate Cancer Diagnosis in relation to disease specific and total mortality
Cancer Prevention Research, 2015Co-Authors: Meng Yang, Stacey A Kenfield, Howard D Sesso, Jorge E Chavarro, Meir J Stampfer, Erin L Van Blarigan, Julie L BatistaAbstract:Men diagnosed with nonmetastatic Prostate Cancer have a long life expectancy, and many die of unrelated causes. It is therefore important to know to what extent post-diagnostic diet may affect disease-specific and overall mortality. A total of 926 men participating in the Physicians' Health Study diagnosed with nonmetastatic Prostate Cancer completed diet questionnaires for a median of 5.1 years after Diagnosis, and were followed thereafter to assess mortality for a median of 9.9 years since questionnaire completion. Two post-diagnostic dietary patterns were identified: a Prudent pattern, characterized by higher intake of vegetables, fruits, fish, legumes, and whole grains; and a Western pattern, characterized by higher intake of processed and red meats, high-fat dairy and refined grains. Cox regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). During 8,093 person-years of follow-up, 333 men died, 56 (17%) of Prostate Cancer. The Western pattern was significantly related to a higher risk of Prostate Cancer-specific and all-cause mortality. Comparing men in the highest versus the lowest quartile of the Western pattern, the HRs were 2.53 (95% CI, 1.00-6.42; Ptrend = 0.02) for Prostate Cancer-specific mortality and 1.67 (95% CI, 1.16-2.42; Ptrend = 0.01) for all-cause mortality. The Prudent pattern was associated with a significantly lower all-cause mortality (HRQuartile 4 vs. Quartile 1: 0.64; 95% CI, 0.44-0.93; Ptrend = 0.02); the relationship with Prostate Cancer-specific mortality was inverse but not statistically significant. A post-diagnostic Western dietary pattern was associated with higher Prostate Cancer-specific and all-cause mortality, whereas a Prudent dietary pattern was related to lower all-cause mortality after Prostate Cancer Diagnosis.
