The Experts below are selected from a list of 145119 Experts worldwide ranked by ideXlab platform
Shengyang Wang - One of the best experts on this subject based on the ideXlab platform.
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anti inflammation activity of fruit essential oil from cinnamomum insularimontanum hayata
Bioresource Technology, 2008Co-Authors: Chientsong Lin, Chijung Chen, Tingyu Lin, Judia Chen Tung, Shengyang WangAbstract:In this study, the fruit essential oil of Cinnamomum insularimontanum was prepared by using water distillation. Followed by GC–MS analysis, the composition of fruit essential oil was characterized. The main constituents of essential oil were a-pinene (9.45%), camphene (1.70%), b-pinene (4.30%), limonene (1.76%), citronellal (24.64%), citronellol (16.78%), and citral (35.89%). According to the results obtained from nitric oxide (NO) inhibitory activity Assay, crude essential oil and its dominant compound (citral) presented the significant NO production inhibitory activity, IC50 of crude essential oil and citral were 18.68 and 13.18 lg/mL, respectively. Moreover, based on the results obtained from the Protein Expression Assay, the Expression of IKK, iNOS, and nuclear NF-jB was decreased and IjBa was increased in dosedependent manners, it proved that the anti-inflammatory mechanism of citral was blocked via the NFjB pathway, but it could not efficiently suppress the activity on COX-2. In addition, citral exhibited a potent anti-inflammatory activity in the Assay of croton oil-induced mice ear edema, when the dosage was 0.1 and 0.3 mg per ear, the inflammation would reduce to 22% and 83%, respectively. The results presented that the fruit essential oil of C. insularimontanum and/or citral may have a great potential to develop the anti-inflammatory medicine in the future.
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antiinflammatory activity of lindera erythrocarpa fruits
Phytotherapy Research, 2008Co-Authors: Shengyang Wang, Xingyu Lan, Junhong Xiao, Jengchung Yang, Yiting Kao, Shangtzen ChangAbstract:In this study, in vitro and in vivo antiinflammatory activities of fruits from Lindera erythrocarpa Makino were evaluated. The ethyl acetate soluble fraction derived from the ethanol extract of L. erythrocarpa fruits inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS) induced NO in the murine macrophage cell line (RAW264.7) Assay, the EC(50) being 16.35 microg/mL. Four compounds, including lucidone (1), cis/trans-methylludicone (2), methyl linderone (3) and linderone (4) were identified from the active fraction based on the bioactivity-guided fractionation procedure. Of these lucidone possessed the strongest NO inhibitory activity with an EC(50) value of 4.22 microg/mL. Furthermore, results from the Protein Expression Assay demonstrated that lucidone suppressed iNOS and COX-2 Protein Expression in a dose-dependent manner. Lucidone also provided antiinflammatory activity in the croton oil-induced ear edema Assay. When it was applied topically at a dosage of 0.5 and 1 mg per ear, the percent edema reduction in treated mice was 44% and 25%, respectively. The results obtained in this study indicated that lucidone has a good potential to be developed as an antiinflammation agent.
Shangtzen Chang - One of the best experts on this subject based on the ideXlab platform.
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antiinflammatory activity of lindera erythrocarpa fruits
Phytotherapy Research, 2008Co-Authors: Shengyang Wang, Xingyu Lan, Junhong Xiao, Jengchung Yang, Yiting Kao, Shangtzen ChangAbstract:In this study, in vitro and in vivo antiinflammatory activities of fruits from Lindera erythrocarpa Makino were evaluated. The ethyl acetate soluble fraction derived from the ethanol extract of L. erythrocarpa fruits inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS) induced NO in the murine macrophage cell line (RAW264.7) Assay, the EC(50) being 16.35 microg/mL. Four compounds, including lucidone (1), cis/trans-methylludicone (2), methyl linderone (3) and linderone (4) were identified from the active fraction based on the bioactivity-guided fractionation procedure. Of these lucidone possessed the strongest NO inhibitory activity with an EC(50) value of 4.22 microg/mL. Furthermore, results from the Protein Expression Assay demonstrated that lucidone suppressed iNOS and COX-2 Protein Expression in a dose-dependent manner. Lucidone also provided antiinflammatory activity in the croton oil-induced ear edema Assay. When it was applied topically at a dosage of 0.5 and 1 mg per ear, the percent edema reduction in treated mice was 44% and 25%, respectively. The results obtained in this study indicated that lucidone has a good potential to be developed as an antiinflammation agent.
Junhong Xiao - One of the best experts on this subject based on the ideXlab platform.
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antiinflammatory activity of lindera erythrocarpa fruits
Phytotherapy Research, 2008Co-Authors: Shengyang Wang, Xingyu Lan, Junhong Xiao, Jengchung Yang, Yiting Kao, Shangtzen ChangAbstract:In this study, in vitro and in vivo antiinflammatory activities of fruits from Lindera erythrocarpa Makino were evaluated. The ethyl acetate soluble fraction derived from the ethanol extract of L. erythrocarpa fruits inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS) induced NO in the murine macrophage cell line (RAW264.7) Assay, the EC(50) being 16.35 microg/mL. Four compounds, including lucidone (1), cis/trans-methylludicone (2), methyl linderone (3) and linderone (4) were identified from the active fraction based on the bioactivity-guided fractionation procedure. Of these lucidone possessed the strongest NO inhibitory activity with an EC(50) value of 4.22 microg/mL. Furthermore, results from the Protein Expression Assay demonstrated that lucidone suppressed iNOS and COX-2 Protein Expression in a dose-dependent manner. Lucidone also provided antiinflammatory activity in the croton oil-induced ear edema Assay. When it was applied topically at a dosage of 0.5 and 1 mg per ear, the percent edema reduction in treated mice was 44% and 25%, respectively. The results obtained in this study indicated that lucidone has a good potential to be developed as an antiinflammation agent.
Yiting Kao - One of the best experts on this subject based on the ideXlab platform.
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antiinflammatory activity of lindera erythrocarpa fruits
Phytotherapy Research, 2008Co-Authors: Shengyang Wang, Xingyu Lan, Junhong Xiao, Jengchung Yang, Yiting Kao, Shangtzen ChangAbstract:In this study, in vitro and in vivo antiinflammatory activities of fruits from Lindera erythrocarpa Makino were evaluated. The ethyl acetate soluble fraction derived from the ethanol extract of L. erythrocarpa fruits inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS) induced NO in the murine macrophage cell line (RAW264.7) Assay, the EC(50) being 16.35 microg/mL. Four compounds, including lucidone (1), cis/trans-methylludicone (2), methyl linderone (3) and linderone (4) were identified from the active fraction based on the bioactivity-guided fractionation procedure. Of these lucidone possessed the strongest NO inhibitory activity with an EC(50) value of 4.22 microg/mL. Furthermore, results from the Protein Expression Assay demonstrated that lucidone suppressed iNOS and COX-2 Protein Expression in a dose-dependent manner. Lucidone also provided antiinflammatory activity in the croton oil-induced ear edema Assay. When it was applied topically at a dosage of 0.5 and 1 mg per ear, the percent edema reduction in treated mice was 44% and 25%, respectively. The results obtained in this study indicated that lucidone has a good potential to be developed as an antiinflammation agent.
Xingyu Lan - One of the best experts on this subject based on the ideXlab platform.
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antiinflammatory activity of lindera erythrocarpa fruits
Phytotherapy Research, 2008Co-Authors: Shengyang Wang, Xingyu Lan, Junhong Xiao, Jengchung Yang, Yiting Kao, Shangtzen ChangAbstract:In this study, in vitro and in vivo antiinflammatory activities of fruits from Lindera erythrocarpa Makino were evaluated. The ethyl acetate soluble fraction derived from the ethanol extract of L. erythrocarpa fruits inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS) induced NO in the murine macrophage cell line (RAW264.7) Assay, the EC(50) being 16.35 microg/mL. Four compounds, including lucidone (1), cis/trans-methylludicone (2), methyl linderone (3) and linderone (4) were identified from the active fraction based on the bioactivity-guided fractionation procedure. Of these lucidone possessed the strongest NO inhibitory activity with an EC(50) value of 4.22 microg/mL. Furthermore, results from the Protein Expression Assay demonstrated that lucidone suppressed iNOS and COX-2 Protein Expression in a dose-dependent manner. Lucidone also provided antiinflammatory activity in the croton oil-induced ear edema Assay. When it was applied topically at a dosage of 0.5 and 1 mg per ear, the percent edema reduction in treated mice was 44% and 25%, respectively. The results obtained in this study indicated that lucidone has a good potential to be developed as an antiinflammation agent.
