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Ihuoma Eneli - One of the best experts on this subject based on the ideXlab platform.
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adolescents and parents perspectives of a revised Protein Sparing modified fast rpsmf for severe obesity
International Journal of Environmental Research and Public Health, 2019Co-Authors: Keeley J Pratt, Rosanna P Watowicz, Marnie Walston, Jennifer Cotto, Ihuoma EneliAbstract:The purpose of this pilot study was to assess the acceptability to adolescents (11–18 years old) and their parents using a revised Protein-Sparing modified fast (rPSMF) for 12 months as an intervention for severe obesity in a tertiary pediatric weight management clinic (PWMC). To assess acceptability (satisfaction, confidence) with the rPSMF protocol, surveys were completed by adolescents and parents at baseline, 1, 3, 6, and 12 months, with adolescent height and weight measured. Analyses were conducted to assess differences in satisfaction and confidence based on adolescent response (weight loss) and adherence to the rPSMF. Adolescents’ adherence with the rPSMF was close to 50% in the first 3 months, but dropped to 14.7% at 6 months. Adolescents were most confident with choosing low carbohydrate foods at baseline. Over 12 months, adolescents and parents reported weight loss as “the most liked” part of the rPSMF. Adolescents who were adherent were more satisfied with their weight loss than their non-adherent peers. Parents and adolescents reported lack of food variety and difficulty following the protocol as challenges with the rPSMF. Adolescents and their parents were able to follow the rPSMF protocol, with weight loss, but with decreased adherence over time.
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rationale and design of a pilot study to evaluate the acceptability and effectiveness of a revised Protein Sparing modified fast rpsmf for severe obesity in a pediatric tertiary care weight management clinic
Contemporary clinical trials communications, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Worthington, Kelly Tanner, Keeley J PrattAbstract:Abstract Aggressive dietary interventions may provide an accessible treatment option for children and adolescents with severe obesity who are not successful with traditional lifestyle behavioral interventions or do not want or qualify for weight loss surgery. One such intensive dietary option is the Protein Sparing modified fast (PSMF). The PSMF involves minimal carbohydrate intake to induce ketosis, while maintaining adequate or high Protein intake to minimize catabolism. The PSMF, under medical supervision, can be an effective and safe intervention for children and adolescents, yet the PSMF diet is not regularly used in the treatment of pediatric severe obesity. This paper describes the rationale and design for a pilot study to evaluate the acceptability and effectiveness of a revised PSMF (rPSMF) implemented as a weight loss treatment option for children and adolescents with severe obesity in a pediatric tertiary care weight management clinic. The primary aim of the study is to evaluate the acceptability of the rPSMF as assessed by adherence, satisfaction with the intervention, and participation rate using quantitative and qualitative methods. The secondary aim is to investigate the effectiveness of the rPSMF on improving a) anthropometric measures (weight, body mass index [BMI], BMI z-score); b) metabolic measures (lipid profile, glycosylated hemoglobin, liver function tests); and c) quality of life. Results of this study will provide guidance for the standardization of a pediatric rPSMF protocol in a clinic setting, delineate which factors improve or hinder adherence and weight loss and provide preliminary data for a multicenter randomized controlled trial. Clinicaltrials.gov identifier NCT03899311.
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using a revised Protein Sparing modified fast rpsmf for children and adolescents with severe obesity a pilot study
International Journal of Environmental Research and Public Health, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Rosanna P Watowicz, Keeley J Pratt, Jennifer Worthington, Kelly Tanner, Marnie WalstonAbstract:Treatment options are limited for children and adolescents with severe obesity. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet that can result in substantial weight loss. The aim of the study is to evaluate the adherence and efficacy of a revised PSMF (rPSMF) for severe obesity in a pediatric tertiary care weight-management program. The rPSMF with 1200-1800 calories, 40-60 g of carbohydrate/day and 1.2-1.5 g Protein/kg of ideal bodyweight was implemented over 12 months. Twenty-one participants enrolled in the study. Mean age 16.2 ± 1.4 years, females (76.2%) and mean weight at baseline was 119 ± 19.9 kg. Regardless of adherence to the rPSMF, the mean weight change at 1 month was -3.7 ± 3.5 kg, (range -13.5 kg to 0.9 kg); at 3 months was -5.5 ± 5.1 kg, (range -19.3 kg to 1.8 kg) and at 6 months was -4.7 ± 6.6 kg, (range -18.3 kg to 8.6 kg). At 12 months, the mean weight change was -1.3 ± 10.6 kg (range -17.7 kg to 14.8 kg). Parent and child-reported physical and psychosocial quality of life (HRQOL) improved. Despite limited adherence, the rPSMF diet resulted in clinically significant weight loss and improved HRQOL for children and adolescents with severe obesity.
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using a modified Protein Sparing modified fast for treating severe obesity psmf a pilot study
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Cotto, Liset EstanislaoAbstract:Purpose: Approximately 6.0% of U.S. children have severe obesity, unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers. Therefore, the treatment options are limited. One alternative treatment approach is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. Although there is evidence for PSMF’s safety and efficacy in adults and a handful of pediatric studies, it is …
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adolescents and parents perspectives of a modified Protein Sparing modified fast psmf for adolescents with severe obesity
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Keeley J Pratt, Jennifer CottoAbstract:Purpose: Among U.S. adolescents, ages 12 to 19, 1 in 5 have obesity, and 1 in 11 have severe obesity. Unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers, and have limited access to bariatric surgery. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. However, this treatment option is not yet offered regularly to adolescents with severe obesity. The purpose of this study was …
Marnie Walston - One of the best experts on this subject based on the ideXlab platform.
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adolescents and parents perspectives of a revised Protein Sparing modified fast rpsmf for severe obesity
International Journal of Environmental Research and Public Health, 2019Co-Authors: Keeley J Pratt, Rosanna P Watowicz, Marnie Walston, Jennifer Cotto, Ihuoma EneliAbstract:The purpose of this pilot study was to assess the acceptability to adolescents (11–18 years old) and their parents using a revised Protein-Sparing modified fast (rPSMF) for 12 months as an intervention for severe obesity in a tertiary pediatric weight management clinic (PWMC). To assess acceptability (satisfaction, confidence) with the rPSMF protocol, surveys were completed by adolescents and parents at baseline, 1, 3, 6, and 12 months, with adolescent height and weight measured. Analyses were conducted to assess differences in satisfaction and confidence based on adolescent response (weight loss) and adherence to the rPSMF. Adolescents’ adherence with the rPSMF was close to 50% in the first 3 months, but dropped to 14.7% at 6 months. Adolescents were most confident with choosing low carbohydrate foods at baseline. Over 12 months, adolescents and parents reported weight loss as “the most liked” part of the rPSMF. Adolescents who were adherent were more satisfied with their weight loss than their non-adherent peers. Parents and adolescents reported lack of food variety and difficulty following the protocol as challenges with the rPSMF. Adolescents and their parents were able to follow the rPSMF protocol, with weight loss, but with decreased adherence over time.
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rationale and design of a pilot study to evaluate the acceptability and effectiveness of a revised Protein Sparing modified fast rpsmf for severe obesity in a pediatric tertiary care weight management clinic
Contemporary clinical trials communications, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Worthington, Kelly Tanner, Keeley J PrattAbstract:Abstract Aggressive dietary interventions may provide an accessible treatment option for children and adolescents with severe obesity who are not successful with traditional lifestyle behavioral interventions or do not want or qualify for weight loss surgery. One such intensive dietary option is the Protein Sparing modified fast (PSMF). The PSMF involves minimal carbohydrate intake to induce ketosis, while maintaining adequate or high Protein intake to minimize catabolism. The PSMF, under medical supervision, can be an effective and safe intervention for children and adolescents, yet the PSMF diet is not regularly used in the treatment of pediatric severe obesity. This paper describes the rationale and design for a pilot study to evaluate the acceptability and effectiveness of a revised PSMF (rPSMF) implemented as a weight loss treatment option for children and adolescents with severe obesity in a pediatric tertiary care weight management clinic. The primary aim of the study is to evaluate the acceptability of the rPSMF as assessed by adherence, satisfaction with the intervention, and participation rate using quantitative and qualitative methods. The secondary aim is to investigate the effectiveness of the rPSMF on improving a) anthropometric measures (weight, body mass index [BMI], BMI z-score); b) metabolic measures (lipid profile, glycosylated hemoglobin, liver function tests); and c) quality of life. Results of this study will provide guidance for the standardization of a pediatric rPSMF protocol in a clinic setting, delineate which factors improve or hinder adherence and weight loss and provide preliminary data for a multicenter randomized controlled trial. Clinicaltrials.gov identifier NCT03899311.
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using a revised Protein Sparing modified fast rpsmf for children and adolescents with severe obesity a pilot study
International Journal of Environmental Research and Public Health, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Rosanna P Watowicz, Keeley J Pratt, Jennifer Worthington, Kelly Tanner, Marnie WalstonAbstract:Treatment options are limited for children and adolescents with severe obesity. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet that can result in substantial weight loss. The aim of the study is to evaluate the adherence and efficacy of a revised PSMF (rPSMF) for severe obesity in a pediatric tertiary care weight-management program. The rPSMF with 1200-1800 calories, 40-60 g of carbohydrate/day and 1.2-1.5 g Protein/kg of ideal bodyweight was implemented over 12 months. Twenty-one participants enrolled in the study. Mean age 16.2 ± 1.4 years, females (76.2%) and mean weight at baseline was 119 ± 19.9 kg. Regardless of adherence to the rPSMF, the mean weight change at 1 month was -3.7 ± 3.5 kg, (range -13.5 kg to 0.9 kg); at 3 months was -5.5 ± 5.1 kg, (range -19.3 kg to 1.8 kg) and at 6 months was -4.7 ± 6.6 kg, (range -18.3 kg to 8.6 kg). At 12 months, the mean weight change was -1.3 ± 10.6 kg (range -17.7 kg to 14.8 kg). Parent and child-reported physical and psychosocial quality of life (HRQOL) improved. Despite limited adherence, the rPSMF diet resulted in clinically significant weight loss and improved HRQOL for children and adolescents with severe obesity.
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using a modified Protein Sparing modified fast for treating severe obesity psmf a pilot study
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Cotto, Liset EstanislaoAbstract:Purpose: Approximately 6.0% of U.S. children have severe obesity, unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers. Therefore, the treatment options are limited. One alternative treatment approach is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. Although there is evidence for PSMF’s safety and efficacy in adults and a handful of pediatric studies, it is …
Jennifer Cotto - One of the best experts on this subject based on the ideXlab platform.
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adolescents and parents perspectives of a revised Protein Sparing modified fast rpsmf for severe obesity
International Journal of Environmental Research and Public Health, 2019Co-Authors: Keeley J Pratt, Rosanna P Watowicz, Marnie Walston, Jennifer Cotto, Ihuoma EneliAbstract:The purpose of this pilot study was to assess the acceptability to adolescents (11–18 years old) and their parents using a revised Protein-Sparing modified fast (rPSMF) for 12 months as an intervention for severe obesity in a tertiary pediatric weight management clinic (PWMC). To assess acceptability (satisfaction, confidence) with the rPSMF protocol, surveys were completed by adolescents and parents at baseline, 1, 3, 6, and 12 months, with adolescent height and weight measured. Analyses were conducted to assess differences in satisfaction and confidence based on adolescent response (weight loss) and adherence to the rPSMF. Adolescents’ adherence with the rPSMF was close to 50% in the first 3 months, but dropped to 14.7% at 6 months. Adolescents were most confident with choosing low carbohydrate foods at baseline. Over 12 months, adolescents and parents reported weight loss as “the most liked” part of the rPSMF. Adolescents who were adherent were more satisfied with their weight loss than their non-adherent peers. Parents and adolescents reported lack of food variety and difficulty following the protocol as challenges with the rPSMF. Adolescents and their parents were able to follow the rPSMF protocol, with weight loss, but with decreased adherence over time.
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using a modified Protein Sparing modified fast for treating severe obesity psmf a pilot study
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Cotto, Liset EstanislaoAbstract:Purpose: Approximately 6.0% of U.S. children have severe obesity, unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers. Therefore, the treatment options are limited. One alternative treatment approach is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. Although there is evidence for PSMF’s safety and efficacy in adults and a handful of pediatric studies, it is …
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adolescents and parents perspectives of a modified Protein Sparing modified fast psmf for adolescents with severe obesity
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Keeley J Pratt, Jennifer CottoAbstract:Purpose: Among U.S. adolescents, ages 12 to 19, 1 in 5 have obesity, and 1 in 11 have severe obesity. Unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers, and have limited access to bariatric surgery. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. However, this treatment option is not yet offered regularly to adolescents with severe obesity. The purpose of this study was …
Rosanna P Watowicz - One of the best experts on this subject based on the ideXlab platform.
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adolescents and parents perspectives of a revised Protein Sparing modified fast rpsmf for severe obesity
International Journal of Environmental Research and Public Health, 2019Co-Authors: Keeley J Pratt, Rosanna P Watowicz, Marnie Walston, Jennifer Cotto, Ihuoma EneliAbstract:The purpose of this pilot study was to assess the acceptability to adolescents (11–18 years old) and their parents using a revised Protein-Sparing modified fast (rPSMF) for 12 months as an intervention for severe obesity in a tertiary pediatric weight management clinic (PWMC). To assess acceptability (satisfaction, confidence) with the rPSMF protocol, surveys were completed by adolescents and parents at baseline, 1, 3, 6, and 12 months, with adolescent height and weight measured. Analyses were conducted to assess differences in satisfaction and confidence based on adolescent response (weight loss) and adherence to the rPSMF. Adolescents’ adherence with the rPSMF was close to 50% in the first 3 months, but dropped to 14.7% at 6 months. Adolescents were most confident with choosing low carbohydrate foods at baseline. Over 12 months, adolescents and parents reported weight loss as “the most liked” part of the rPSMF. Adolescents who were adherent were more satisfied with their weight loss than their non-adherent peers. Parents and adolescents reported lack of food variety and difficulty following the protocol as challenges with the rPSMF. Adolescents and their parents were able to follow the rPSMF protocol, with weight loss, but with decreased adherence over time.
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rationale and design of a pilot study to evaluate the acceptability and effectiveness of a revised Protein Sparing modified fast rpsmf for severe obesity in a pediatric tertiary care weight management clinic
Contemporary clinical trials communications, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Worthington, Kelly Tanner, Keeley J PrattAbstract:Abstract Aggressive dietary interventions may provide an accessible treatment option for children and adolescents with severe obesity who are not successful with traditional lifestyle behavioral interventions or do not want or qualify for weight loss surgery. One such intensive dietary option is the Protein Sparing modified fast (PSMF). The PSMF involves minimal carbohydrate intake to induce ketosis, while maintaining adequate or high Protein intake to minimize catabolism. The PSMF, under medical supervision, can be an effective and safe intervention for children and adolescents, yet the PSMF diet is not regularly used in the treatment of pediatric severe obesity. This paper describes the rationale and design for a pilot study to evaluate the acceptability and effectiveness of a revised PSMF (rPSMF) implemented as a weight loss treatment option for children and adolescents with severe obesity in a pediatric tertiary care weight management clinic. The primary aim of the study is to evaluate the acceptability of the rPSMF as assessed by adherence, satisfaction with the intervention, and participation rate using quantitative and qualitative methods. The secondary aim is to investigate the effectiveness of the rPSMF on improving a) anthropometric measures (weight, body mass index [BMI], BMI z-score); b) metabolic measures (lipid profile, glycosylated hemoglobin, liver function tests); and c) quality of life. Results of this study will provide guidance for the standardization of a pediatric rPSMF protocol in a clinic setting, delineate which factors improve or hinder adherence and weight loss and provide preliminary data for a multicenter randomized controlled trial. Clinicaltrials.gov identifier NCT03899311.
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using a revised Protein Sparing modified fast rpsmf for children and adolescents with severe obesity a pilot study
International Journal of Environmental Research and Public Health, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Rosanna P Watowicz, Keeley J Pratt, Jennifer Worthington, Kelly Tanner, Marnie WalstonAbstract:Treatment options are limited for children and adolescents with severe obesity. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet that can result in substantial weight loss. The aim of the study is to evaluate the adherence and efficacy of a revised PSMF (rPSMF) for severe obesity in a pediatric tertiary care weight-management program. The rPSMF with 1200-1800 calories, 40-60 g of carbohydrate/day and 1.2-1.5 g Protein/kg of ideal bodyweight was implemented over 12 months. Twenty-one participants enrolled in the study. Mean age 16.2 ± 1.4 years, females (76.2%) and mean weight at baseline was 119 ± 19.9 kg. Regardless of adherence to the rPSMF, the mean weight change at 1 month was -3.7 ± 3.5 kg, (range -13.5 kg to 0.9 kg); at 3 months was -5.5 ± 5.1 kg, (range -19.3 kg to 1.8 kg) and at 6 months was -4.7 ± 6.6 kg, (range -18.3 kg to 8.6 kg). At 12 months, the mean weight change was -1.3 ± 10.6 kg (range -17.7 kg to 14.8 kg). Parent and child-reported physical and psychosocial quality of life (HRQOL) improved. Despite limited adherence, the rPSMF diet resulted in clinically significant weight loss and improved HRQOL for children and adolescents with severe obesity.
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using a modified Protein Sparing modified fast for treating severe obesity psmf a pilot study
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Cotto, Liset EstanislaoAbstract:Purpose: Approximately 6.0% of U.S. children have severe obesity, unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers. Therefore, the treatment options are limited. One alternative treatment approach is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. Although there is evidence for PSMF’s safety and efficacy in adults and a handful of pediatric studies, it is …
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the Protein Sparing modified fast for adolescents with severe obesity a case series
ICAN: Infant Child & Adolescent Nutrition, 2015Co-Authors: Rosanna P Watowicz, Ihuoma Eneli, Alexis L Tindall, Jessica C HummelAbstract:Background. Severely obese youth respond poorly to current conventional lifestyle interventions when compared with their overweight and obese peers. The Protein-Sparing modified fast (PSMF) intervention is a reduced-calorie, low-carbohydrate, high-Protein diet that is thought to improve weight loss. The objective of this study is to describe 2 inpatient cases and 1 outpatient case that used the PSMF for adolescents. Methods. Three patients followed a PSMF for approximately 12 to 52 weeks, initially consuming 20 to 40 grams of carbohydrate per day for the first 12 weeks. Two of these patients were admitted as inpatients for the first 2 to 4 weeks of the diet. Results. The PSMF led to rapid weight loss and a decrease in body mass index. For 2 patients, there was an improvement in liver function tests or liver disease following the PSMF diet. All the patients demonstrated an improvement in some abnormal laboratory indices, for example, liver function tests and hemoglobin A1c, but had a clinically insignifica...
Keeley J Pratt - One of the best experts on this subject based on the ideXlab platform.
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adolescents and parents perspectives of a revised Protein Sparing modified fast rpsmf for severe obesity
International Journal of Environmental Research and Public Health, 2019Co-Authors: Keeley J Pratt, Rosanna P Watowicz, Marnie Walston, Jennifer Cotto, Ihuoma EneliAbstract:The purpose of this pilot study was to assess the acceptability to adolescents (11–18 years old) and their parents using a revised Protein-Sparing modified fast (rPSMF) for 12 months as an intervention for severe obesity in a tertiary pediatric weight management clinic (PWMC). To assess acceptability (satisfaction, confidence) with the rPSMF protocol, surveys were completed by adolescents and parents at baseline, 1, 3, 6, and 12 months, with adolescent height and weight measured. Analyses were conducted to assess differences in satisfaction and confidence based on adolescent response (weight loss) and adherence to the rPSMF. Adolescents’ adherence with the rPSMF was close to 50% in the first 3 months, but dropped to 14.7% at 6 months. Adolescents were most confident with choosing low carbohydrate foods at baseline. Over 12 months, adolescents and parents reported weight loss as “the most liked” part of the rPSMF. Adolescents who were adherent were more satisfied with their weight loss than their non-adherent peers. Parents and adolescents reported lack of food variety and difficulty following the protocol as challenges with the rPSMF. Adolescents and their parents were able to follow the rPSMF protocol, with weight loss, but with decreased adherence over time.
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rationale and design of a pilot study to evaluate the acceptability and effectiveness of a revised Protein Sparing modified fast rpsmf for severe obesity in a pediatric tertiary care weight management clinic
Contemporary clinical trials communications, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Marnie Walston, Rosanna P Watowicz, Jennifer Worthington, Kelly Tanner, Keeley J PrattAbstract:Abstract Aggressive dietary interventions may provide an accessible treatment option for children and adolescents with severe obesity who are not successful with traditional lifestyle behavioral interventions or do not want or qualify for weight loss surgery. One such intensive dietary option is the Protein Sparing modified fast (PSMF). The PSMF involves minimal carbohydrate intake to induce ketosis, while maintaining adequate or high Protein intake to minimize catabolism. The PSMF, under medical supervision, can be an effective and safe intervention for children and adolescents, yet the PSMF diet is not regularly used in the treatment of pediatric severe obesity. This paper describes the rationale and design for a pilot study to evaluate the acceptability and effectiveness of a revised PSMF (rPSMF) implemented as a weight loss treatment option for children and adolescents with severe obesity in a pediatric tertiary care weight management clinic. The primary aim of the study is to evaluate the acceptability of the rPSMF as assessed by adherence, satisfaction with the intervention, and participation rate using quantitative and qualitative methods. The secondary aim is to investigate the effectiveness of the rPSMF on improving a) anthropometric measures (weight, body mass index [BMI], BMI z-score); b) metabolic measures (lipid profile, glycosylated hemoglobin, liver function tests); and c) quality of life. Results of this study will provide guidance for the standardization of a pediatric rPSMF protocol in a clinic setting, delineate which factors improve or hinder adherence and weight loss and provide preliminary data for a multicenter randomized controlled trial. Clinicaltrials.gov identifier NCT03899311.
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using a revised Protein Sparing modified fast rpsmf for children and adolescents with severe obesity a pilot study
International Journal of Environmental Research and Public Health, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Rosanna P Watowicz, Keeley J Pratt, Jennifer Worthington, Kelly Tanner, Marnie WalstonAbstract:Treatment options are limited for children and adolescents with severe obesity. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet that can result in substantial weight loss. The aim of the study is to evaluate the adherence and efficacy of a revised PSMF (rPSMF) for severe obesity in a pediatric tertiary care weight-management program. The rPSMF with 1200-1800 calories, 40-60 g of carbohydrate/day and 1.2-1.5 g Protein/kg of ideal bodyweight was implemented over 12 months. Twenty-one participants enrolled in the study. Mean age 16.2 ± 1.4 years, females (76.2%) and mean weight at baseline was 119 ± 19.9 kg. Regardless of adherence to the rPSMF, the mean weight change at 1 month was -3.7 ± 3.5 kg, (range -13.5 kg to 0.9 kg); at 3 months was -5.5 ± 5.1 kg, (range -19.3 kg to 1.8 kg) and at 6 months was -4.7 ± 6.6 kg, (range -18.3 kg to 8.6 kg). At 12 months, the mean weight change was -1.3 ± 10.6 kg (range -17.7 kg to 14.8 kg). Parent and child-reported physical and psychosocial quality of life (HRQOL) improved. Despite limited adherence, the rPSMF diet resulted in clinically significant weight loss and improved HRQOL for children and adolescents with severe obesity.
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adolescents and parents perspectives of a modified Protein Sparing modified fast psmf for adolescents with severe obesity
Pediatrics, 2019Co-Authors: Ihuoma Eneli, Alexis Tindall, Keeley J Pratt, Jennifer CottoAbstract:Purpose: Among U.S. adolescents, ages 12 to 19, 1 in 5 have obesity, and 1 in 11 have severe obesity. Unfortunately, youth with severe obesity respond poorly to current conventional lifestyle interventions when compared to their overweight and obese peers, and have limited access to bariatric surgery. One alternative treatment is the Protein-Sparing modified fast (PSMF), a low-carbohydrate, high-Protein diet shown to result in substantial and potentially sustainable weight loss. However, this treatment option is not yet offered regularly to adolescents with severe obesity. The purpose of this study was …
